9-(2,3-dihydroxypropyl)adenine, (s)-isomer profile

ID Source	ID
PubMed CID	73124
CHEMBL ID	494759
SCHEMBL ID	936286
MeSH ID	M0313164

Synonym
1,2-propanediol, 3-(6-amino-9h-purin-9-yl)-, (s)-
9-d-(2,3-dihydroxypropyl)adenine
s-dihydroxypropyladenine
9-(s)-(2,3-dihydroxypropyl)adenine
(s)-3-(6-amino-9h-purin-9-yl)-1,2-propanediol
brn 0990757
(s)-9-(2,3-dihydroxypropyl)adenine
(2s)-3-(6-aminopurin-9-yl)propane-1,2-diol
dhpa, (s)-dhpa
54262-83-8
(2s)-3-(6-amino-9h-purin-9-yl)propane-1,2-diol
9-(1,2-dihydroxypropyl)adenine
CHEMBL494759
5-26-16-00201 (beilstein handbook reference)
bdbm50366323
SCHEMBL936286
DTXSID80969282
3-(6-amino-9h-purin-9-yl)propane-1,2-diol
(s)-3-(6-amino-9h-purin-9-yl)propane-1,2-diol

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Adenosine receptor A3	Homo sapiens (human)	Ki	100.0000	0.0000	0.9306	10.0000	AID418503
Adenosine receptor A2a	Homo sapiens (human)	Ki	8.5000	0.0000	1.0609	9.7920	AID418501
Adenosine receptor A2b	Homo sapiens (human)	Ki	30.0000	0.0002	1.6352	10.0000	AID418502
Adenosine receptor A1	Homo sapiens (human)	Ki	100.0000	0.0002	0.9316	10.0000	AID418500
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
inflammatory response	Adenosine receptor A3	Homo sapiens (human)
signal transduction	Adenosine receptor A3	Homo sapiens (human)
activation of adenylate cyclase activity	Adenosine receptor A3	Homo sapiens (human)
regulation of heart contraction	Adenosine receptor A3	Homo sapiens (human)
negative regulation of cell population proliferation	Adenosine receptor A3	Homo sapiens (human)
response to wounding	Adenosine receptor A3	Homo sapiens (human)
regulation of norepinephrine secretion	Adenosine receptor A3	Homo sapiens (human)
negative regulation of cell migration	Adenosine receptor A3	Homo sapiens (human)
negative regulation of NF-kappaB transcription factor activity	Adenosine receptor A3	Homo sapiens (human)
presynaptic modulation of chemical synaptic transmission	Adenosine receptor A3	Homo sapiens (human)
G protein-coupled adenosine receptor signaling pathway	Adenosine receptor A3	Homo sapiens (human)
synaptic transmission, dopaminergic	Adenosine receptor A2a	Homo sapiens (human)
response to amphetamine	Adenosine receptor A2a	Homo sapiens (human)
regulation of DNA-templated transcription	Adenosine receptor A2a	Homo sapiens (human)
phagocytosis	Adenosine receptor A2a	Homo sapiens (human)
apoptotic process	Adenosine receptor A2a	Homo sapiens (human)
inflammatory response	Adenosine receptor A2a	Homo sapiens (human)
cellular defense response	Adenosine receptor A2a	Homo sapiens (human)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway	Adenosine receptor A2a	Homo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathway	Adenosine receptor A2a	Homo sapiens (human)
protein kinase C-activating G protein-coupled receptor signaling pathway	Adenosine receptor A2a	Homo sapiens (human)
cell-cell signaling	Adenosine receptor A2a	Homo sapiens (human)
synaptic transmission, cholinergic	Adenosine receptor A2a	Homo sapiens (human)
central nervous system development	Adenosine receptor A2a	Homo sapiens (human)
blood coagulation	Adenosine receptor A2a	Homo sapiens (human)
sensory perception	Adenosine receptor A2a	Homo sapiens (human)
locomotory behavior	Adenosine receptor A2a	Homo sapiens (human)
blood circulation	Adenosine receptor A2a	Homo sapiens (human)
negative regulation of cell population proliferation	Adenosine receptor A2a	Homo sapiens (human)
response to xenobiotic stimulus	Adenosine receptor A2a	Homo sapiens (human)
response to inorganic substance	Adenosine receptor A2a	Homo sapiens (human)
positive regulation of glutamate secretion	Adenosine receptor A2a	Homo sapiens (human)
positive regulation of acetylcholine secretion, neurotransmission	Adenosine receptor A2a	Homo sapiens (human)
regulation of norepinephrine secretion	Adenosine receptor A2a	Homo sapiens (human)
response to purine-containing compound	Adenosine receptor A2a	Homo sapiens (human)
response to caffeine	Adenosine receptor A2a	Homo sapiens (human)
positive regulation of synaptic transmission, GABAergic	Adenosine receptor A2a	Homo sapiens (human)
synaptic transmission, glutamatergic	Adenosine receptor A2a	Homo sapiens (human)
positive regulation of urine volume	Adenosine receptor A2a	Homo sapiens (human)
vasodilation	Adenosine receptor A2a	Homo sapiens (human)
eating behavior	Adenosine receptor A2a	Homo sapiens (human)
negative regulation of vascular permeability	Adenosine receptor A2a	Homo sapiens (human)
negative regulation of neuron apoptotic process	Adenosine receptor A2a	Homo sapiens (human)
positive regulation of circadian sleep/wake cycle, sleep	Adenosine receptor A2a	Homo sapiens (human)
negative regulation of alpha-beta T cell activation	Adenosine receptor A2a	Homo sapiens (human)
astrocyte activation	Adenosine receptor A2a	Homo sapiens (human)
neuron projection morphogenesis	Adenosine receptor A2a	Homo sapiens (human)
positive regulation of protein secretion	Adenosine receptor A2a	Homo sapiens (human)
negative regulation of inflammatory response	Adenosine receptor A2a	Homo sapiens (human)
regulation of mitochondrial membrane potential	Adenosine receptor A2a	Homo sapiens (human)
membrane depolarization	Adenosine receptor A2a	Homo sapiens (human)
regulation of calcium ion transport	Adenosine receptor A2a	Homo sapiens (human)
positive regulation of synaptic transmission, glutamatergic	Adenosine receptor A2a	Homo sapiens (human)
excitatory postsynaptic potential	Adenosine receptor A2a	Homo sapiens (human)
inhibitory postsynaptic potential	Adenosine receptor A2a	Homo sapiens (human)
prepulse inhibition	Adenosine receptor A2a	Homo sapiens (human)
apoptotic signaling pathway	Adenosine receptor A2a	Homo sapiens (human)
presynaptic modulation of chemical synaptic transmission	Adenosine receptor A2a	Homo sapiens (human)
positive regulation of long-term synaptic potentiation	Adenosine receptor A2a	Homo sapiens (human)
positive regulation of apoptotic signaling pathway	Adenosine receptor A2a	Homo sapiens (human)
G protein-coupled adenosine receptor signaling pathway	Adenosine receptor A2a	Homo sapiens (human)
G protein-coupled adenosine receptor signaling pathway	Adenosine receptor A2b	Homo sapiens (human)
positive regulation of chronic inflammatory response to non-antigenic stimulus	Adenosine receptor A2b	Homo sapiens (human)
G protein-coupled receptor signaling pathway	Adenosine receptor A2b	Homo sapiens (human)
activation of adenylate cyclase activity	Adenosine receptor A2b	Homo sapiens (human)
positive regulation of vascular endothelial growth factor production	Adenosine receptor A2b	Homo sapiens (human)
positive regulation of cGMP-mediated signaling	Adenosine receptor A2b	Homo sapiens (human)
cGMP-mediated signaling	Adenosine receptor A2b	Homo sapiens (human)
positive regulation of chemokine production	Adenosine receptor A2b	Homo sapiens (human)
positive regulation of interleukin-6 production	Adenosine receptor A2b	Homo sapiens (human)
mast cell degranulation	Adenosine receptor A2b	Homo sapiens (human)
positive regulation of mast cell degranulation	Adenosine receptor A2b	Homo sapiens (human)
relaxation of vascular associated smooth muscle	Adenosine receptor A2b	Homo sapiens (human)
presynaptic modulation of chemical synaptic transmission	Adenosine receptor A2b	Homo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathway	Adenosine receptor A2b	Homo sapiens (human)
vasodilation	Adenosine receptor A2b	Homo sapiens (human)
temperature homeostasis	Adenosine receptor A1	Homo sapiens (human)
response to hypoxia	Adenosine receptor A1	Homo sapiens (human)
G protein-coupled adenosine receptor signaling pathway	Adenosine receptor A1	Homo sapiens (human)
regulation of respiratory gaseous exchange by nervous system process	Adenosine receptor A1	Homo sapiens (human)
negative regulation of acute inflammatory response	Adenosine receptor A1	Homo sapiens (human)
negative regulation of leukocyte migration	Adenosine receptor A1	Homo sapiens (human)
positive regulation of peptide secretion	Adenosine receptor A1	Homo sapiens (human)
positive regulation of systemic arterial blood pressure	Adenosine receptor A1	Homo sapiens (human)
negative regulation of systemic arterial blood pressure	Adenosine receptor A1	Homo sapiens (human)
regulation of glomerular filtration	Adenosine receptor A1	Homo sapiens (human)
protein targeting to membrane	Adenosine receptor A1	Homo sapiens (human)
phagocytosis	Adenosine receptor A1	Homo sapiens (human)
inflammatory response	Adenosine receptor A1	Homo sapiens (human)
signal transduction	Adenosine receptor A1	Homo sapiens (human)
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	Adenosine receptor A1	Homo sapiens (human)
cell-cell signaling	Adenosine receptor A1	Homo sapiens (human)
nervous system development	Adenosine receptor A1	Homo sapiens (human)
negative regulation of cell population proliferation	Adenosine receptor A1	Homo sapiens (human)
response to inorganic substance	Adenosine receptor A1	Homo sapiens (human)
negative regulation of glutamate secretion	Adenosine receptor A1	Homo sapiens (human)
response to purine-containing compound	Adenosine receptor A1	Homo sapiens (human)
lipid catabolic process	Adenosine receptor A1	Homo sapiens (human)
negative regulation of synaptic transmission, GABAergic	Adenosine receptor A1	Homo sapiens (human)
positive regulation of nucleoside transport	Adenosine receptor A1	Homo sapiens (human)
negative regulation of neurotrophin production	Adenosine receptor A1	Homo sapiens (human)
positive regulation of protein dephosphorylation	Adenosine receptor A1	Homo sapiens (human)
vasodilation	Adenosine receptor A1	Homo sapiens (human)
negative regulation of circadian sleep/wake cycle, non-REM sleep	Adenosine receptor A1	Homo sapiens (human)
negative regulation of apoptotic process	Adenosine receptor A1	Homo sapiens (human)
positive regulation of potassium ion transport	Adenosine receptor A1	Homo sapiens (human)
positive regulation of MAPK cascade	Adenosine receptor A1	Homo sapiens (human)
negative regulation of hormone secretion	Adenosine receptor A1	Homo sapiens (human)
cognition	Adenosine receptor A1	Homo sapiens (human)
leukocyte migration	Adenosine receptor A1	Homo sapiens (human)
detection of temperature stimulus involved in sensory perception of pain	Adenosine receptor A1	Homo sapiens (human)
negative regulation of lipid catabolic process	Adenosine receptor A1	Homo sapiens (human)
positive regulation of lipid catabolic process	Adenosine receptor A1	Homo sapiens (human)
regulation of sensory perception of pain	Adenosine receptor A1	Homo sapiens (human)
negative regulation of synaptic transmission, glutamatergic	Adenosine receptor A1	Homo sapiens (human)
fatty acid homeostasis	Adenosine receptor A1	Homo sapiens (human)
excitatory postsynaptic potential	Adenosine receptor A1	Homo sapiens (human)
long-term synaptic depression	Adenosine receptor A1	Homo sapiens (human)
mucus secretion	Adenosine receptor A1	Homo sapiens (human)
negative regulation of mucus secretion	Adenosine receptor A1	Homo sapiens (human)
triglyceride homeostasis	Adenosine receptor A1	Homo sapiens (human)
regulation of cardiac muscle cell contraction	Adenosine receptor A1	Homo sapiens (human)
apoptotic signaling pathway	Adenosine receptor A1	Homo sapiens (human)
regulation of presynaptic cytosolic calcium ion concentration	Adenosine receptor A1	Homo sapiens (human)
negative regulation of long-term synaptic potentiation	Adenosine receptor A1	Homo sapiens (human)
negative regulation of long-term synaptic depression	Adenosine receptor A1	Homo sapiens (human)
G protein-coupled receptor signaling pathway	Adenosine receptor A1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
G protein-coupled adenosine receptor activity	Adenosine receptor A3	Homo sapiens (human)
G protein-coupled adenosine receptor activity	Adenosine receptor A2a	Homo sapiens (human)
protein binding	Adenosine receptor A2a	Homo sapiens (human)
calmodulin binding	Adenosine receptor A2a	Homo sapiens (human)
lipid binding	Adenosine receptor A2a	Homo sapiens (human)
enzyme binding	Adenosine receptor A2a	Homo sapiens (human)
type 5 metabotropic glutamate receptor binding	Adenosine receptor A2a	Homo sapiens (human)
identical protein binding	Adenosine receptor A2a	Homo sapiens (human)
protein-containing complex binding	Adenosine receptor A2a	Homo sapiens (human)
alpha-actinin binding	Adenosine receptor A2a	Homo sapiens (human)
G protein-coupled adenosine receptor activity	Adenosine receptor A2b	Homo sapiens (human)
protein binding	Adenosine receptor A2b	Homo sapiens (human)
G protein-coupled receptor activity	Adenosine receptor A2b	Homo sapiens (human)
G protein-coupled receptor binding	Adenosine receptor A1	Homo sapiens (human)
purine nucleoside binding	Adenosine receptor A1	Homo sapiens (human)
protein binding	Adenosine receptor A1	Homo sapiens (human)
heat shock protein binding	Adenosine receptor A1	Homo sapiens (human)
G-protein beta/gamma-subunit complex binding	Adenosine receptor A1	Homo sapiens (human)
heterotrimeric G-protein binding	Adenosine receptor A1	Homo sapiens (human)
protein heterodimerization activity	Adenosine receptor A1	Homo sapiens (human)
G protein-coupled adenosine receptor activity	Adenosine receptor A1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
plasma membrane	Adenosine receptor A3	Homo sapiens (human)
presynaptic membrane	Adenosine receptor A3	Homo sapiens (human)
Schaffer collateral - CA1 synapse	Adenosine receptor A3	Homo sapiens (human)
dendrite	Adenosine receptor A3	Homo sapiens (human)
plasma membrane	Adenosine receptor A3	Homo sapiens (human)
synapse	Adenosine receptor A3	Homo sapiens (human)
plasma membrane	Adenosine receptor A2a	Homo sapiens (human)
intermediate filament	Adenosine receptor A2a	Homo sapiens (human)
plasma membrane	Adenosine receptor A2a	Homo sapiens (human)
membrane	Adenosine receptor A2a	Homo sapiens (human)
dendrite	Adenosine receptor A2a	Homo sapiens (human)
axolemma	Adenosine receptor A2a	Homo sapiens (human)
asymmetric synapse	Adenosine receptor A2a	Homo sapiens (human)
presynaptic membrane	Adenosine receptor A2a	Homo sapiens (human)
neuronal cell body	Adenosine receptor A2a	Homo sapiens (human)
postsynaptic membrane	Adenosine receptor A2a	Homo sapiens (human)
presynaptic active zone	Adenosine receptor A2a	Homo sapiens (human)
glutamatergic synapse	Adenosine receptor A2a	Homo sapiens (human)
plasma membrane	Adenosine receptor A2b	Homo sapiens (human)
Schaffer collateral - CA1 synapse	Adenosine receptor A2b	Homo sapiens (human)
presynapse	Adenosine receptor A2b	Homo sapiens (human)
glutamatergic synapse	Adenosine receptor A2b	Homo sapiens (human)
plasma membrane	Adenosine receptor A2b	Homo sapiens (human)
plasma membrane	Adenosine receptor A1	Homo sapiens (human)
plasma membrane	Adenosine receptor A1	Homo sapiens (human)
basolateral plasma membrane	Adenosine receptor A1	Homo sapiens (human)
axolemma	Adenosine receptor A1	Homo sapiens (human)
asymmetric synapse	Adenosine receptor A1	Homo sapiens (human)
presynaptic membrane	Adenosine receptor A1	Homo sapiens (human)
neuronal cell body	Adenosine receptor A1	Homo sapiens (human)
terminal bouton	Adenosine receptor A1	Homo sapiens (human)
dendritic spine	Adenosine receptor A1	Homo sapiens (human)
calyx of Held	Adenosine receptor A1	Homo sapiens (human)
postsynaptic membrane	Adenosine receptor A1	Homo sapiens (human)
presynaptic active zone	Adenosine receptor A1	Homo sapiens (human)
synapse	Adenosine receptor A1	Homo sapiens (human)
dendrite	Adenosine receptor A1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (376)

Assay ID	Title	Year	Journal	Article
AID87131	Antiviral activity was measured against Coxsackie virus B4 in HeLa cells.	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID463995	Antiviral activity against Sindbis virus infected in african green monkey Vero cells assessed as protection from virus-induced cytopathogenicity after 2 to 3 days by MTT assay	2010	European journal of medicinal chemistry, Mar, Volume: 45, Issue:3	Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid.
AID209958	Inhibition of Vesicular stomatitis virus induced cytopathicity in T-21 cells.	1985	Journal of medicinal chemistry, Mar, Volume: 28, Issue:3	Alkyl esters of 3-adenin-9-yl-2-hydroxypropanoic acid: a new class of broad-spectrum antiviral agents.
AID280205	Cytotoxicity against Vero cells assessed as alteration in cell morphology	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
AID81742	Inhibition of Vesicular stomatitis virus induced cytopathicity in HEp-2 cells.	1985	Journal of medicinal chemistry, Mar, Volume: 28, Issue:3	Alkyl esters of 3-adenin-9-yl-2-hydroxypropanoic acid: a new class of broad-spectrum antiviral agents.
AID217975	50% effective concentration required to reduce vaccinia virus-induced cytopathicity	1997	Journal of medicinal chemistry, May-23, Volume: 40, Issue:11	Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues.
AID64101	Minimum inhibitory concentration (MIC) required to reduce McIntyre strain of HSV-1 induced cytopathogenicity by 50% in E6SM cells	1992	Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8	Synthesis and antiviral activity of acyclic nucleosides with a 3(S),5-dihydroxypentyl or 4(R)-methoxy-3(S),5-dihydroxypentyl side chain.
AID216344	Inhibition of parainfluenza virus-3 induced cytopathicity in vero cells.	1985	Journal of medicinal chemistry, Mar, Volume: 28, Issue:3	Alkyl esters of 3-adenin-9-yl-2-hydroxypropanoic acid: a new class of broad-spectrum antiviral agents.
AID463996	Antiviral activity against Human coxsackievirus B4 infected in african green monkey Vero cells assessed as protection from virus-induced cytopathogenicity after 2 days by MTT assay	2010	European journal of medicinal chemistry, Mar, Volume: 45, Issue:3	Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid.
AID162241	The minimum inhibitory concentration required to reduce polio virus type I induced cytopathogenicity in primary rabbit kidney cells by 50%	1984	Journal of medicinal chemistry, Dec, Volume: 27, Issue:12	Synthesis and biological evaluation of 6-amino-1H-pyrrolo[3,2-c]pyridin-4(5H)-one (3,7-dideazaguanine).
AID220033	Antiviral activity against coxsackie B4 in Vero cell culture lines	1992	Journal of medicinal chemistry, Nov-27, Volume: 35, Issue:24	Synthesis and antiviral activity of some new S-adenosyl-L-homocysteine derivatives.
AID205132	Inhibitory concentration required against replication of small pox virus (strain India 3a) in Vero cells	2004	Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12	A new approach to the synthesis of optically active alkylated adenine derivatives.
AID416749	Antiviral activity against VSV in human HeLa cells assessed as protection against virus-induced cytopathicity	2009	Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7	Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus.
AID86491	Inhibition of Vesicular stomatitis virus induced cytopathicity in in HeLa cells.	1985	Journal of medicinal chemistry, Mar, Volume: 28, Issue:3	Alkyl esters of 3-adenin-9-yl-2-hydroxypropanoic acid: a new class of broad-spectrum antiviral agents.
AID155597	The minimum inhibitory concentration required to reduce parainfluenza virus type 3 induced cytopathogenicity in primary rabbit kidney cells by 50%	1984	Journal of medicinal chemistry, Dec, Volume: 27, Issue:12	Synthesis and biological evaluation of 6-amino-1H-pyrrolo[3,2-c]pyridin-4(5H)-one (3,7-dideazaguanine).
AID218401	Minimum inhibitory concentration required to reduce Coxsackie virus B4 induced cytopathogenicity by 50% in african green monkey (VeroB) cells	1989	Journal of medicinal chemistry, May, Volume: 32, Issue:5	Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin.
AID84792	50% effective concentration required to reduce herpes simplex virus-2 (HSV-2 G strain)-induced cytopathicity	1997	Journal of medicinal chemistry, May-23, Volume: 40, Issue:11	Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues.
AID85883	50% effective concentration required to reduce herpes simplex virus-1 (HSV-1 KOS strain)-induced cytopathicity	1997	Journal of medicinal chemistry, May-23, Volume: 40, Issue:11	Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues.
AID464185	Cytotoxicity against Sindbis virus infected african green monkey Vero cells by trypan blue exclusion method	2010	European journal of medicinal chemistry, Mar, Volume: 45, Issue:3	Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid.
AID64095	Minimum inhibitory concentration (MIC) required to reduce 196 strain of HSV-2 induced cytopathogenicity by 50% in E6SM cells	1992	Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8	Synthesis and antiviral activity of acyclic nucleosides with a 3(S),5-dihydroxypentyl or 4(R)-methoxy-3(S),5-dihydroxypentyl side chain.
AID216956	Effective concentration required to inhibit parainfluenza-3 virus-induced cytopathicity by 50% in Vero cell lines	2001	Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17	Synthesis, mechanism of action, and antiviral activity of a new series of covalent mechanism-based inhibitors of S-adenosyl-L-homocysteine hydrolase.
AID383523	Antiviral activity against Coxsackie virus B4 in african green monkey Vero cells assessed as reduction of virus-induced cytopathogenicity	2008	European journal of medicinal chemistry, Feb, Volume: 43, Issue:2	Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents.
AID166694	Inhibition of Vesicular stomatitis virus induced cytopathicity in RK13 cells.	1985	Journal of medicinal chemistry, Mar, Volume: 28, Issue:3	Alkyl esters of 3-adenin-9-yl-2-hydroxypropanoic acid: a new class of broad-spectrum antiviral agents.
AID216538	The minimum inhibitory concentration required to reduce VSV induced cytopathogenicity in primary rabbit kidney cells by 50%	1984	Journal of medicinal chemistry, Dec, Volume: 27, Issue:12	Synthesis and biological evaluation of 6-amino-1H-pyrrolo[3,2-c]pyridin-4(5H)-one (3,7-dideazaguanine).
AID156849	Minimum inhibitory concentration required to reduce vaccinia virus induced cytopathogenicity by 50% in primary rabbit kidney cells (PRK)	1989	Journal of medicinal chemistry, May, Volume: 32, Issue:5	Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin.
AID416748	Antiviral activity against RSV Long in human HeLa cells assessed as protection against virus-induced cytopathicity	2009	Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7	Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus.
AID303234	Antiviral activity against Reovirus 1 in Vero cells reduction of virus-induced cytopathogenicity after 4 days	2007	Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23	Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.
AID383530	Antiviral activity against Parainfluenza 3 virus in african green monkey Vero cells assessed as reduction of virus-induced cytopathogenicity	2008	European journal of medicinal chemistry, Feb, Volume: 43, Issue:2	Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents.
AID634756	Antiviral activity against Reovirus-1 infected in african green monkey Vero cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID204964	The minimum inhibitory concentration required to reduce Sindbis virus induced cytopathogenicity in primary rabbit kidney cells by 50%	1984	Journal of medicinal chemistry, Dec, Volume: 27, Issue:12	Synthesis and biological evaluation of 6-amino-1H-pyrrolo[3,2-c]pyridin-4(5H)-one (3,7-dideazaguanine).
AID280195	Antiviral activity against coxsackie B4 virus in Vero cells assessed as inhibition of virus-induced cytopathicity	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
AID634753	Antiviral activity against thymidine kinase-positive Varicella Zoster virus Oka infected in human HEL cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID216342	Inhibition of Vesicular stomatitis virus induced cytopathicity in Vero cells.	1985	Journal of medicinal chemistry, Mar, Volume: 28, Issue:3	Alkyl esters of 3-adenin-9-yl-2-hydroxypropanoic acid: a new class of broad-spectrum antiviral agents.
AID156541	Inhibition of Vesicular stomatitis virus induced cytopathicity in in PRK cells.	1985	Journal of medicinal chemistry, Mar, Volume: 28, Issue:3	Alkyl esters of 3-adenin-9-yl-2-hydroxypropanoic acid: a new class of broad-spectrum antiviral agents.
AID216341	Inhibition of Sindbis virus induced cytopathicity in in vero cells.	1985	Journal of medicinal chemistry, Mar, Volume: 28, Issue:3	Alkyl esters of 3-adenin-9-yl-2-hydroxypropanoic acid: a new class of broad-spectrum antiviral agents.
AID634832	Antiviral activity against Influenza A virus H1N1 infected in MDCK cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID634760	Antiviral activity against Vesicular stomatitis virus infected in human Hela cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID228408	Antiviral activity against reovirus type 1 in Vero cell culture lines	1992	Journal of medicinal chemistry, Nov-27, Volume: 35, Issue:24	Synthesis and antiviral activity of some new S-adenosyl-L-homocysteine derivatives.
AID87155	Minimum inhibitory concentration against Vesicular stomatitis virus in HeLa cell cultures	1989	Journal of medicinal chemistry, Aug, Volume: 32, Issue:8	Synthesis and antiviral activity of 3'-C-cyano-3'-deoxynucleosides.
AID33367	Minimum cytotoxic concentration required to cause a microscopically detectable alteration of normal cell morphology and show antiviral activity in african green monkey (Vero B) cells	1989	Journal of medicinal chemistry, May, Volume: 32, Issue:5	Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin.
AID125073	Inhibitory concentration required against Monkeypox virus in Vero cell culture	2004	Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12	A new approach to the synthesis of optically active alkylated adenine derivatives.
AID432174	Cytotoxicity against human HeLa cells assessed as minimum cytotoxic concentration required to cause microscopically detectable alteration in normal cell morphology	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis and antiviral activity of new pyrazole and thiazole derivatives.
AID218404	Minimum inhibitory concentration required to reduce parainfluenza virus-3 induced cytopathogenicity by 50% in african green monkey (VeroB) cells	1989	Journal of medicinal chemistry, May, Volume: 32, Issue:5	Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin.
AID87502	Evaluation for antiviral activity against herpes simplex virus type 1 (strain KOS) in primary rabbit kidney cell culture	1986	Journal of medicinal chemistry, Jul, Volume: 29, Issue:7	Structure-activity relationship of novel oligopeptide antiviral and antitumor agents related to netropsin and distamycin.
AID218511	Effective concentration required to reduce reovirus-1-induced cytopathicity in vero cells	1997	Journal of medicinal chemistry, May-23, Volume: 40, Issue:11	Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues.
AID280191	Antiviral activity against MSV in mouse C3H cells assessed as inhibition of virus-induced transformation after 6 days	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
AID766687	Antiviral activity against Punta Toro virus infected in african green monkey Vero cells assessed as reduction in virus-induced cytopathogenicity	2013	European journal of medicinal chemistry, Sep, Volume: 67	Regioselective synthesis of 6-substituted-2-amino-5-bromo-4(3H)-pyrimidinones and evaluation of their antiviral activity.
AID83439	Minimum inhibitory concentration which is required to reduce virus-induced cytopathogenicity by 50% against Vesicular stomatitis virus in human kidney,	1985	Journal of medicinal chemistry, Mar, Volume: 28, Issue:3	Alkyl esters of 3-adenin-9-yl-2-hydroxypropanoic acid: a new class of broad-spectrum antiviral agents.
AID539924	Antiviral activity against Coxsackie virus B4 infected in african green monkey Vero cells assessed as protection against virus-induced cytopathogenicity after 2 days	2010	European journal of medicinal chemistry, Nov, Volume: 45, Issue:11	Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones.
AID634835	Antiviral activity against Felid herpesvirus 1 infected in CrFK cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID87822	Evaluation for antiviral activity against herpes simplex virus type 2 (strain G) in primary rabbit kidney cell culture	1986	Journal of medicinal chemistry, Jul, Volume: 29, Issue:7	Structure-activity relationship of novel oligopeptide antiviral and antitumor agents related to netropsin and distamycin.
AID416764	Cytotoxicity against human HeLa cells assessed as drug level causing microscopically detectable alteration of normal cell morphology after 3 days	2009	Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7	Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus.
AID303230	Antiviral activity against Coxsackie virus B4 in HeLa cells assessed as reduction of virus-induced cytopathogenicity	2007	Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23	Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.
AID419603	Antiviral activity against Reovirus 1 infected in african green monkey Vero cells assessed as reduction in virus-induced cytopathogenicity after 3 days	2009	European journal of medicinal chemistry, Jun, Volume: 44, Issue:6	Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives.
AID257896	Antiviral activity against Sindbis virus in vero cells	2006	Journal of medicinal chemistry, Jan-26, Volume: 49, Issue:2	Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators.
AID218131	The minimum inhibitory concentration required to reduce vaccinia virus induced cytopathogenicity in primary rabbit kidney cells by 50%	1984	Journal of medicinal chemistry, Dec, Volume: 27, Issue:12	Synthesis and biological evaluation of 6-amino-1H-pyrrolo[3,2-c]pyridin-4(5H)-one (3,7-dideazaguanine).
AID41565	Inhibition of Vesicular stomatitis virus induced cytopathicity in BALB/3T3 cells.	1985	Journal of medicinal chemistry, Mar, Volume: 28, Issue:3	Alkyl esters of 3-adenin-9-yl-2-hydroxypropanoic acid: a new class of broad-spectrum antiviral agents.
AID165545	Inhibitory effects on DNA, RNA, and Protein synthesis in rabbit kidney cells was evaluated for incorporation of [4,5-3H]leucine	1985	Journal of medicinal chemistry, Mar, Volume: 28, Issue:3	Alkyl esters of 3-adenin-9-yl-2-hydroxypropanoic acid: a new class of broad-spectrum antiviral agents.
AID419597	Cytotoxicity against human HeLa cells assessed as alteration in cell morphology	2009	European journal of medicinal chemistry, Jun, Volume: 44, Issue:6	Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives.
AID291034	Antiviral activity against reovirus1 virus in Vero cells assessed as reduction of virus plaque formation after 7 days	2007	Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13	Novel C-6 fluorinated acyclic side chain pyrimidine derivatives: synthesis, (1)H and (13)C NMR conformational studies, and antiviral and cytostatic evaluations.
AID284540	Antiviral activity against in Vesicular stomatitis virus- induced cytopathogenicity in HeLa cells	2007	Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2	The novel C-5 aryl, alkenyl, and alkynyl substituted uracil derivatives of L-ascorbic acid: synthesis, cytostatic, and antiviral activity evaluations.
AID84237	50% effective concentration required to reduce herpes simplex virus-1 (HSV- (TK) VMW 1837 strain)-induced cytopathicity	1997	Journal of medicinal chemistry, May-23, Volume: 40, Issue:11	Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues.
AID88354	Effective concentration required to inhibit Coxsackie virus B4-induced cytopathicity by 50% in HeLa cell lines	2001	Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17	Synthesis, mechanism of action, and antiviral activity of a new series of covalent mechanism-based inhibitors of S-adenosyl-L-homocysteine hydrolase.
AID216345	Inhibition of Reo virus-1 induced cytopathicity in vero cells.	1985	Journal of medicinal chemistry, Mar, Volume: 28, Issue:3	Alkyl esters of 3-adenin-9-yl-2-hydroxypropanoic acid: a new class of broad-spectrum antiviral agents.
AID217271	Minimum inhibitory concentration required to elicit microscopically visible cell morphology in Vero cell lines	2001	Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17	Synthesis, mechanism of action, and antiviral activity of a new series of covalent mechanism-based inhibitors of S-adenosyl-L-homocysteine hydrolase.
AID1135906	Antiviral activity against Vaccinia virus infected in rabbit primary kidney cells assessed as inhibition of viral cytopathogenicity after 3 days	1979	Journal of medicinal chemistry, May, Volume: 22, Issue:5	Antiviral activity of aliphatic nucleoside analogues: structure-function relationship.
AID383524	Antiviral activity against Punta Toro virus in african green monkey Vero cells assessed as reduction of virus-induced cytopathogenicity	2008	European journal of medicinal chemistry, Feb, Volume: 43, Issue:2	Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents.
AID539932	Antiviral activity against Respiratory syncytial virus infected in human HeLa cells assessed as protection against virus-induced cytopathogenicity after 2 days	2010	European journal of medicinal chemistry, Nov, Volume: 45, Issue:11	Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones.
AID634831	Antiviral activity against Respiratory syncytial virus infected in human HeLa cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID548435	Antiviral activity against Respiratory syncytial virus infected in human HeLa cells assessed as inhibition of virus induced cytopathicity by visual scoring of CPE	2010	European journal of medicinal chemistry, Dec, Volume: 45, Issue:12	4-[1-(Substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzenesulfonic acids: synthesis, antimicrobial activity, QSAR studies, and antiviral evaluation.
AID88355	Effective concentration required to inhibit respiratory synaptial (RSV) virus-induced cytopathicity by 50% in HeLa cell lines	2001	Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17	Synthesis, mechanism of action, and antiviral activity of a new series of covalent mechanism-based inhibitors of S-adenosyl-L-homocysteine hydrolase.
AID218402	Minimum inhibitory concentration required to reduce Sindbis virus induced cytopathogenicity by 50% in african green monkey (VeroB) cells	1989	Journal of medicinal chemistry, May, Volume: 32, Issue:5	Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin.
AID303233	Antiviral activity against Parainfluenza 3 in Vero cells reduction of virus-induced cytopathogenicity after 4 days	2007	Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23	Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.
AID1113465	Cytotoxicity against Homo sapiens (human) HeLa cells assessed as change in cellular morphology	2013	Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 22, Issue:4	Synthesis and biological evaluation of 2-(5-substituted-1-((diethylamino)methyl)-2-oxoindolin-3-ylidene)-
AID766693	Antiviral activity against Coxsackievirus B4 infected in human HeLa cells assessed as reduction in virus-induced cytopathogenicity	2013	European journal of medicinal chemistry, Sep, Volume: 67	Regioselective synthesis of 6-substituted-2-amino-5-bromo-4(3H)-pyrimidinones and evaluation of their antiviral activity.
AID768194	Antiviral activity against Reovirus-1 infected in african green monkey Vero cells assessed as reduction of virus-induced cytopathogenicity	2013	European journal of medicinal chemistry, Aug, Volume: 66	Synthesis of 4-aminoquinoline-pyrimidine hybrids as potent antimalarials and their mode of action studies.
AID156696	Concentration required for microscopically detectable alteration of the normal cell morphology in PRK cells.	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID432184	Antiviral activity against Punta Toro virus infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathicity after 3 days	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis and antiviral activity of new pyrazole and thiazole derivatives.
AID419604	Antiviral activity against Sindbis virus infected in african green monkey Vero cells assessed as reduction in virus-induced cytopathogenicity after 3 days	2009	European journal of medicinal chemistry, Jun, Volume: 44, Issue:6	Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives.
AID64097	Minimum inhibitory concentration (MIC) required to reduce F strain of HSV-1 induced cytopathogenicity by 50% in E6SM cells	1992	Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8	Synthesis and antiviral activity of acyclic nucleosides with a 3(S),5-dihydroxypentyl or 4(R)-methoxy-3(S),5-dihydroxypentyl side chain.
AID156848	Minimum inhibitory concentration required to reduce herpes simplex virus-1 (KOS) induced cytopathogenicity by 50% in primary rabbit kidney cells(PRK)	1989	Journal of medicinal chemistry, May, Volume: 32, Issue:5	Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin.
AID165546	Inhibitory effects on DNA, RNA, and Protein synthesis in rabbit kidney cells was evaluated for incorporation of [5-3H]-Urd	1985	Journal of medicinal chemistry, Mar, Volume: 28, Issue:3	Alkyl esters of 3-adenin-9-yl-2-hydroxypropanoic acid: a new class of broad-spectrum antiviral agents.
AID634750	Antiviral activity against Vesicular stomatitis virus infected in human HEL cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID634837	Antiviral activity against Human immunodeficiency virus 2 infected in human CEM cells assessed as inhibition of virus-induced giant cell formation after 4 days by microscopic analysis	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID489677	Antiviral activity against RSV infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS assay	2010	European journal of medicinal chemistry, Jul, Volume: 45, Issue:7	Benzylidene/2-chlorobenzylidene hydrazides: synthesis, antimicrobial activity, QSAR studies and antiviral evaluation.
AID257901	Antiviral activity against Vesicular stomatitis virus in HeLa cells	2006	Journal of medicinal chemistry, Jan-26, Volume: 49, Issue:2	Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators.
AID658744	Antiviral activity against Coxsackie virus B4 infected in human HeLa cells assessed as inhibition of virus-induced cytopathogenicity after 4 days	2012	European journal of medicinal chemistry, Jun, Volume: 52	2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies.
AID156692	Antiviral activity was measured against vesicular stomatitis virus in rabbit kidney cells.	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID418500	Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cells	2009	Bioorganic & medicinal chemistry, Apr-01, Volume: 17, Issue:7	8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands.
AID658743	Antiviral activity against Vesicular stomatitis virus infected in HeLa cells assessed as inhibition of virus-induced cytopathogenicity after 4 days	2012	European journal of medicinal chemistry, Jun, Volume: 52	2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies.
AID434319	Antiviral activity against Punta Toro virus infected in african green monkey Vero cells assessed as protection against virus-induced cytopathogenicity	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide.
AID768195	Cytotoxicity against human HeLa cells	2013	European journal of medicinal chemistry, Aug, Volume: 66	Synthesis of 4-aminoquinoline-pyrimidine hybrids as potent antimalarials and their mode of action studies.
AID1113461	Cytotoxicity against Chlorocebus aethiops (African green monkey) Vero cells assessed as change in cellular morphology	2013	Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 22, Issue:4	Synthesis and biological evaluation of 2-(5-substituted-1-((diethylamino)methyl)-2-oxoindolin-3-ylidene)-
AID463994	Antiviral activity against PIV 3 infected in african green monkey Vero cells assessed as protection from virus-induced cytopathogenicity after 6 to 7 days by MTT assay	2010	European journal of medicinal chemistry, Mar, Volume: 45, Issue:3	Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid.
AID548429	Cytotoxicity against human HeLa cells assessed as cell viability by MTS assay	2010	European journal of medicinal chemistry, Dec, Volume: 45, Issue:12	4-[1-(Substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzenesulfonic acids: synthesis, antimicrobial activity, QSAR studies, and antiviral evaluation.
AID383506	Cytotoxicity against human HeLa cells	2008	European journal of medicinal chemistry, Feb, Volume: 43, Issue:2	Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents.
AID275075	Antiviral activity against Sindbis virus in Vero cells	2006	Journal of medicinal chemistry, Dec-28, Volume: 49, Issue:26	Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine.
AID297313	Antiviral activity against Parainfluenza 3 virus in Vero cells assessed as reduction of virus-induced cytopathogenicity	2007	Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17	Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives.
AID228985	Antiviral activity against semliki forest virus (SFV) in Vero cell culture lines	1992	Journal of medicinal chemistry, Nov-27, Volume: 35, Issue:24	Synthesis and antiviral activity of some new S-adenosyl-L-homocysteine derivatives.
AID218384	Minimum inhibitory concentration against parainfluenza 3 virus in Vero cell cultures	1989	Journal of medicinal chemistry, Aug, Volume: 32, Issue:8	Synthesis and antiviral activity of 3'-C-cyano-3'-deoxynucleosides.
AID768190	Cytotoxicity against african green monkey Vero cells	2013	European journal of medicinal chemistry, Aug, Volume: 66	Synthesis of 4-aminoquinoline-pyrimidine hybrids as potent antimalarials and their mode of action studies.
AID634755	Antiviral activity against Parainfluenza-3 virus infected in african green monkey Vero cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID658615	Antiviral activity against Coxsackie virus B4 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathogenicity after 4 days	2012	European journal of medicinal chemistry, Jun, Volume: 52	2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies.
AID303232	Antiviral activity against RSV in HeLa cells assessed as reduction of virus-induced cytopathogenicity	2007	Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23	Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.
AID634747	Antiviral activity against Herpes simplex virus 2 G infected in human HEL cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID634759	Antiviral activity against Punta Toro virus infected in african green monkey Vero cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID766689	Antiviral activity against Sindbis virus infected in african green monkey Vero cells assessed as reduction in virus-induced cytopathogenicity	2013	European journal of medicinal chemistry, Sep, Volume: 67	Regioselective synthesis of 6-substituted-2-amino-5-bromo-4(3H)-pyrimidinones and evaluation of their antiviral activity.
AID275071	Antiviral activity against Coxsackie B4 virus in HeLa cells	2006	Journal of medicinal chemistry, Dec-28, Volume: 49, Issue:26	Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine.
AID165547	Inhibitory effects on DNA, RNA, and Protein synthesis in rabbit kidney cells was evaluated for incorporation of [methyl-3H]dThd]	1985	Journal of medicinal chemistry, Mar, Volume: 28, Issue:3	Alkyl esters of 3-adenin-9-yl-2-hydroxypropanoic acid: a new class of broad-spectrum antiviral agents.
AID86348	Cytotoxic concentration against HeLa cells.	1985	Journal of medicinal chemistry, Mar, Volume: 28, Issue:3	Alkyl esters of 3-adenin-9-yl-2-hydroxypropanoic acid: a new class of broad-spectrum antiviral agents.
AID156850	Minimum inhibitory concentration required to reduce vesicular stomatitis virus induced cytopathogenicity by 50% in primary rabbit kidney cells (PRK)	1989	Journal of medicinal chemistry, May, Volume: 32, Issue:5	Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin.
AID434312	Antiviral activity against Vesicular stomatitis virus infected in human HeLa cells assessed as protection against virus-induced cytopathogenicity	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide.
AID280204	Cytotoxicity against HeLa cells assessed as alteration in cell morphology	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
AID634838	Antiviral activity against Human immunodeficiency virus 1 infected in human CEM cells assessed as inhibition of virus-induced giant cell formation after 4 days by microscopic analysis	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID658611	Cytotoxicity against african green monkey Vero cells assessed as minimum compound concentration required to causes microscopically detectable alteration of normal cell morphology	2012	European journal of medicinal chemistry, Jun, Volume: 52	2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies.
AID1113460	Antiviral activity against Human parainfluenza virus 3 infected African green monkey Vero cells assessed as reduction of virus-induced cytopathic effect after 3 days by colorimetric formazan-based MTS assay	2013	Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 22, Issue:4	Synthesis and biological evaluation of 2-(5-substituted-1-((diethylamino)methyl)-2-oxoindolin-3-ylidene)-
AID464176	Cytotoxicity against Human coxsackievirus B4 infected human HeLa cells by trypan blue exclusion method	2010	European journal of medicinal chemistry, Mar, Volume: 45, Issue:3	Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid.
AID419598	Antiviral activity against VSV infected in human HeLa cells assessed as reduction in virus-induced cytopathogenicity after 3 days	2009	European journal of medicinal chemistry, Jun, Volume: 44, Issue:6	Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives.
AID63946	Minimum cytotoxic concentration (MCC) required to cause a microscopically detectable alteration of normal cell morphology against E6SM cells	1992	Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8	Synthesis and antiviral activity of acyclic nucleosides with a 3(S),5-dihydroxypentyl or 4(R)-methoxy-3(S),5-dihydroxypentyl side chain.
AID166671	Evaluation for antiviral activity in primary rabbit kidney cell culture	1986	Journal of medicinal chemistry, Jul, Volume: 29, Issue:7	Structure-activity relationship of novel oligopeptide antiviral and antitumor agents related to netropsin and distamycin.
AID54500	The minimum inhibitory concentration required to reduce Coxsackie virus type B4 induced cytopathogenicity in primary rabbit kidney cells by 50%	1984	Journal of medicinal chemistry, Dec, Volume: 27, Issue:12	Synthesis and biological evaluation of 6-amino-1H-pyrrolo[3,2-c]pyridin-4(5H)-one (3,7-dideazaguanine).
AID634748	Antiviral activity against thymidine kinase-deficient acv-resistant Herpes simplex virus 1 KOS infected in human HEL cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID419599	Antiviral activity against Coxsackievirus B4 infected in human HeLa cells assessed as reduction in virus-induced cytopathogenicity after 3 days	2009	European journal of medicinal chemistry, Jun, Volume: 44, Issue:6	Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives.
AID634749	Antiviral activity against Vaccinia virus infected in human HEL cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID634836	Antiviral activity against Feline coronavirus infected in CrFK cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID1113462	Antiviral activity against Respiratory syncytial virus infected human HeLa cells assessed as reduction of virus-induced cytopathic effect after 3 days by colorimetric formazan-based MTS assay	2013	Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 22, Issue:4	Synthesis and biological evaluation of 2-(5-substituted-1-((diethylamino)methyl)-2-oxoindolin-3-ylidene)-
AID275074	Antiviral activity against reovirus 1 in Vero cells	2006	Journal of medicinal chemistry, Dec-28, Volume: 49, Issue:26	Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine.
AID303237	Cytotoxicity against HeLa cells assessed as alteration in morphology after 3 days	2007	Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23	Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.
AID464183	Cytotoxicity against PIV 3 infected african green monkey Vero cells by trypan blue exclusion method	2010	European journal of medicinal chemistry, Mar, Volume: 45, Issue:3	Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid.
AID275076	Antiviral activity against Punta Toro virus in Vero cells	2006	Journal of medicinal chemistry, Dec-28, Volume: 49, Issue:26	Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine.
AID108464	The minimum inhibitory concentration required to reduce measles virus induced cytopathogenicity in primary rabbit kidney cells by 50%	1984	Journal of medicinal chemistry, Dec, Volume: 27, Issue:12	Synthesis and biological evaluation of 6-amino-1H-pyrrolo[3,2-c]pyridin-4(5H)-one (3,7-dideazaguanine).
AID1113464	Antiviral activity against Human coxsackievirus B4 infected human HeLa cells assessed as reduction of virus-induced cytopathic effect after 3 days by colorimetric formazan-based MTS assay	2013	Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 22, Issue:4	Synthesis and biological evaluation of 2-(5-substituted-1-((diethylamino)methyl)-2-oxoindolin-3-ylidene)-
AID257891	Antiviral activity against Vaccinia virus in HEL cells	2006	Journal of medicinal chemistry, Jan-26, Volume: 49, Issue:2	Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators.
AID463997	Antiviral activity against Punta Toro virus infected in african green monkey Vero cells assessed as protection from virus-induced cytopathogenicity by MTT assay	2010	European journal of medicinal chemistry, Mar, Volume: 45, Issue:3	Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid.
AID47066	Inhibition of Vesicular stomatitis virus induced cytopathicity in CV-1 cells.	1985	Journal of medicinal chemistry, Mar, Volume: 28, Issue:3	Alkyl esters of 3-adenin-9-yl-2-hydroxypropanoic acid: a new class of broad-spectrum antiviral agents.
AID419605	Antiviral activity against Coxsackievirus B4 infected in african green monkey Vero cells assessed as reduction in virus-induced cytopathogenicity after 3 days	2009	European journal of medicinal chemistry, Jun, Volume: 44, Issue:6	Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives.
AID86487	Minimum inhibitory concentration required to elicit microscopically visible cell morphology in HeLa cell lines	2001	Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17	Synthesis, mechanism of action, and antiviral activity of a new series of covalent mechanism-based inhibitors of S-adenosyl-L-homocysteine hydrolase.
AID87156	Minimum inhibitory concentration against polio virus 1 in HeLa cell cultures	1989	Journal of medicinal chemistry, Aug, Volume: 32, Issue:8	Synthesis and antiviral activity of 3'-C-cyano-3'-deoxynucleosides.
AID63951	Compounds was evaluated for its inhibitory effect on cytopathogenicity of vaccinia virus (VV) in E6SM cells	1992	Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8	Synthesis and antiviral activity of acyclic nucleosides with a 3(S),5-dihydroxypentyl or 4(R)-methoxy-3(S),5-dihydroxypentyl side chain.
AID275072	Antiviral activity against RSV in HeLa cells	2006	Journal of medicinal chemistry, Dec-28, Volume: 49, Issue:26	Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine.
AID218512	Effective concentration required to reduce sindbis virus-induced cytopathicity in vero cells	1997	Journal of medicinal chemistry, May-23, Volume: 40, Issue:11	Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues.
AID63603	Inhibition of Vesicular stomatitis virus induced cytopathicity in E6SM cells.	1985	Journal of medicinal chemistry, Mar, Volume: 28, Issue:3	Alkyl esters of 3-adenin-9-yl-2-hydroxypropanoic acid: a new class of broad-spectrum antiviral agents.
AID88275	The minimum inhibitory concentration required to reduce HSV-1(KOS) induced cytopathogenicity in primary rabbit kidney cells by 50%	1984	Journal of medicinal chemistry, Dec, Volume: 27, Issue:12	Synthesis and biological evaluation of 6-amino-1H-pyrrolo[3,2-c]pyridin-4(5H)-one (3,7-dideazaguanine).
AID489678	Antiviral activity against Coxsackie virus B4 infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS assay	2010	European journal of medicinal chemistry, Jul, Volume: 45, Issue:7	Benzylidene/2-chlorobenzylidene hydrazides: synthesis, antimicrobial activity, QSAR studies and antiviral evaluation.
AID464175	Cytotoxicity against VSV infected human HeLa cells by trypan blue exclusion method	2010	European journal of medicinal chemistry, Mar, Volume: 45, Issue:3	Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid.
AID548431	Antiviral activity against Vesicular stomatitis virus infected in human HeLa cells assessed as inhibition of virus induced cytopathicity by visual scoring of CPE	2010	European journal of medicinal chemistry, Dec, Volume: 45, Issue:12	4-[1-(Substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzenesulfonic acids: synthesis, antimicrobial activity, QSAR studies, and antiviral evaluation.
AID87135	Antiviral activity was measured against polio virus-1 in HeLa cells.	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID419602	Antiviral activity against Parainfluenza-3 virus infected in african green monkey Vero cells assessed as reduction in virus-induced cytopathogenicity after 3 days	2009	European journal of medicinal chemistry, Jun, Volume: 44, Issue:6	Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives.
AID434318	Antiviral activity against Coxsackievirus B4 infected in african green monkey Vero cells assessed as protection against virus-induced cytopathogenicity	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide.
AID1113458	Antiviral activity against Sendai virus infected African green monkey Vero cells assessed as reduction of virus-induced cytopathic effect after 3 days by colorimetric formazan-based MTS assay	2013	Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 22, Issue:4	Synthesis and biological evaluation of 2-(5-substituted-1-((diethylamino)methyl)-2-oxoindolin-3-ylidene)-
AID64098	Minimum inhibitory concentration (MIC) required to reduce G strain of HSV-2 induced cytopathogenicity by 50% in E6SM cells	1992	Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8	Synthesis and antiviral activity of acyclic nucleosides with a 3(S),5-dihydroxypentyl or 4(R)-methoxy-3(S),5-dihydroxypentyl side chain.
AID54326	Inhibitory concentration required against Cowpox virus in Vero cell culture	2004	Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12	A new approach to the synthesis of optically active alkylated adenine derivatives.
AID280203	Cytotoxicity against E6SM cells assessed as alteration in cell morphology	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
AID229236	Antiviral activity against vesicular stomatitis virus (VSV) in primary rabbit kidney (PRK) / embryonic skin-muscle (E6SM) fibroblast culture lines	1992	Journal of medicinal chemistry, Nov-27, Volume: 35, Issue:24	Synthesis and antiviral activity of some new S-adenosyl-L-homocysteine derivatives.
AID63602	Minimum inhibitory concentration required to effect a microscopically visible change of cell morphology in human embryonic skin-muscle (E6SM) cell culture.	1997	Journal of medicinal chemistry, May-23, Volume: 40, Issue:11	Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues.
AID280196	Antiviral activity against RSV Long in HeLa cells assessed as inhibition of virus-induced cytopathicity	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
AID383522	Cytotoxicity against african green monkey Vero cells	2008	European journal of medicinal chemistry, Feb, Volume: 43, Issue:2	Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents.
AID634761	Antiviral activity against Coxsackievirus B4 infected in human HeLa cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID548432	Antiviral activity against Vesicular stomatitis virus infected in human HeLa cells assessed as inhibition of virus induced cytopathicity after 2 to 4 days by MTS assay	2010	European journal of medicinal chemistry, Dec, Volume: 45, Issue:12	4-[1-(Substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzenesulfonic acids: synthesis, antimicrobial activity, QSAR studies, and antiviral evaluation.
AID1252407	Antiviral activity against Punta Toro virus expressed in African green monkey Vero cells assessed as reduction in cytopathogenicity	2015	European journal of medicinal chemistry, Sep-18, Volume: 102	Novel halogenated 3-deazapurine, 7-deazapurine and alkylated 9-deazapurine derivatives of L-ascorbic or imino-L-ascorbic acid: Synthesis, antitumour and antiviral activity evaluations.
AID416769	Antiviral activity against Reovirus 1 in african green monkey Vero cells assessed as protection against virus-induced cytopathicity	2009	Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7	Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus.
AID432183	Antiviral activity against Coxsackievirus B4 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathicity after 3 days	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis and antiviral activity of new pyrazole and thiazole derivatives.
AID434321	Cytotoxicity against african green monkey Vero cells assessed as change in cell morphology	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide.
AID64096	Minimum inhibitory concentration (MIC) required to reduce B2006 strain of TK-HSV-1 induced cytopathogenicity by 50% in E6SM cells	1992	Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8	Synthesis and antiviral activity of acyclic nucleosides with a 3(S),5-dihydroxypentyl or 4(R)-methoxy-3(S),5-dihydroxypentyl side chain.
AID383507	Antiviral activity against vesicular stomatitis virus in human HeLa cells assessed as inhibition of virus-induced cytopathogenicity	2008	European journal of medicinal chemistry, Feb, Volume: 43, Issue:2	Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents.
AID658616	Antiviral activity against Punta Toro virus infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathogenicity after 4 days	2012	European journal of medicinal chemistry, Jun, Volume: 52	2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies.
AID416768	Antiviral activity against Parainfluenza virus type 3 in african green monkey Vero cells assessed as protection against virus-induced cytopathicity	2009	Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7	Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus.
AID416766	Antiviral activity against Coxsackievirus B4 in human HeLa cells assessed as protection against virus-induced cytopathicity	2009	Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7	Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus.
AID766708	Cytotoxicity against human HeLa cells assessed as morphological changes	2013	European journal of medicinal chemistry, Sep, Volume: 67	Regioselective synthesis of 6-substituted-2-amino-5-bromo-4(3H)-pyrimidinones and evaluation of their antiviral activity.
AID539929	Cytotoxicity against human HeLa cells assessed as minimum concentration required to cause microscopically detectable alteration after 2 days	2010	European journal of medicinal chemistry, Nov, Volume: 45, Issue:11	Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones.
AID464177	Cytotoxicity against Respiratory syncytial virus infected human HeLa cells by trypan blue exclusion method	2010	European journal of medicinal chemistry, Mar, Volume: 45, Issue:3	Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid.
AID291037	Antiviral activity against coxsackie B4 virus in HeLa cells assessed as reduction of virus plaque formation after 7 days	2007	Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13	Novel C-6 fluorinated acyclic side chain pyrimidine derivatives: synthesis, (1)H and (13)C NMR conformational studies, and antiviral and cytostatic evaluations.
AID303238	Cytotoxicity against Vero cells assessed as alteration in morphology after 3 days	2007	Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23	Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.
AID85279	Antiviral activity against HSV-2(G) strain in primary rabbit kidney (PRK) / embryonic skin-muscle (E6SM) fibroblast culture lines	1992	Journal of medicinal chemistry, Nov-27, Volume: 35, Issue:24	Synthesis and antiviral activity of some new S-adenosyl-L-homocysteine derivatives.
AID539930	Antiviral activity against Vesicular stomatitis virus infected in human HeLa cells assessed as protection against virus-induced cytopathogenicity after 2 days	2010	European journal of medicinal chemistry, Nov, Volume: 45, Issue:11	Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones.
AID303229	Antiviral activity against VSV in HeLa cells assessed as reduction of virus-induced cytopathogenicity	2007	Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23	Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.
AID216958	Effective concentration required to inhibit respiratory synaptial (RSV) virus-induced cytopathicity by 50% in Vero cell lines	2001	Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17	Synthesis, mechanism of action, and antiviral activity of a new series of covalent mechanism-based inhibitors of S-adenosyl-L-homocysteine hydrolase.
AID768197	Antiviral activity against Respiratory syncytial virus infected in human HeLa cells assessed as reduction of virus-induced cytopathogenicity	2013	European journal of medicinal chemistry, Aug, Volume: 66	Synthesis of 4-aminoquinoline-pyrimidine hybrids as potent antimalarials and their mode of action studies.
AID88296	The minimum inhibitory concentration required to reduce HSV-2 (G) induced cytopathogenicity in primary rabbit kidney cells by 50%	1984	Journal of medicinal chemistry, Dec, Volume: 27, Issue:12	Synthesis and biological evaluation of 6-amino-1H-pyrrolo[3,2-c]pyridin-4(5H)-one (3,7-dideazaguanine).
AID548445	Cytotoxicity against african green monkey Vero cells assessed as altered cell morphology	2010	European journal of medicinal chemistry, Dec, Volume: 45, Issue:12	4-[1-(Substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzenesulfonic acids: synthesis, antimicrobial activity, QSAR studies, and antiviral evaluation.
AID87139	Concentration required for microscopically detectable alteration of the normal cell morphology in HeLa cells.	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID226094	Minimum inhibitory concentration against Herpes simplex virus 1(KOS) in primary rabbit kidney cell cultures	1989	Journal of medicinal chemistry, Aug, Volume: 32, Issue:8	Synthesis and antiviral activity of 3'-C-cyano-3'-deoxynucleosides.
AID87161	Minimum inhibitory concentration required to reduce Coxsackie virus B4 induced cytopathogenicity by 50% in HeLa cells	1989	Journal of medicinal chemistry, May, Volume: 32, Issue:5	Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin.
AID257890	Antiviral activity against Herpes simplex virus 2 G strain in HEL cells	2006	Journal of medicinal chemistry, Jan-26, Volume: 49, Issue:2	Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators.
AID768199	Antiviral activity against Vesicular stomatitis virus infected in human HeLa cells assessed as reduction of virus-induced cytopathogenicity	2013	European journal of medicinal chemistry, Aug, Volume: 66	Synthesis of 4-aminoquinoline-pyrimidine hybrids as potent antimalarials and their mode of action studies.
AID539923	Antiviral activity against Sindbis virus infected in african green monkey Vero cells assessed as protection against virus-induced cytopathogenicity after 2 days	2010	European journal of medicinal chemistry, Nov, Volume: 45, Issue:11	Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones.
AID156846	Minimum inhibitory concentration required to reduce herpes simplex virus-2(G) induced cytopathogenicity by 50% in primary rabbit kidney cells (PRK)	1989	Journal of medicinal chemistry, May, Volume: 32, Issue:5	Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin.
AID284539	Antiviral activity against Punta Toro virus-induced cytopathogenicity in Vero cells	2007	Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2	The novel C-5 aryl, alkenyl, and alkynyl substituted uracil derivatives of L-ascorbic acid: synthesis, cytostatic, and antiviral activity evaluations.
AID1252406	Antiviral activity against Coxsackievirus B4 expressed in African green monkey Vero cells assessed as reduction in cytopathogenicity	2015	European journal of medicinal chemistry, Sep-18, Volume: 102	Novel halogenated 3-deazapurine, 7-deazapurine and alkylated 9-deazapurine derivatives of L-ascorbic or imino-L-ascorbic acid: Synthesis, antitumour and antiviral activity evaluations.
AID226097	Minimum inhibitory concentration against Vesicular stomatitis virus in primary rabbit kidney cell cultures	1989	Journal of medicinal chemistry, Aug, Volume: 32, Issue:8	Synthesis and antiviral activity of 3'-C-cyano-3'-deoxynucleosides.
AID216343	Inhibition of Measles virus induced cytopathicity in vero cells.	1985	Journal of medicinal chemistry, Mar, Volume: 28, Issue:3	Alkyl esters of 3-adenin-9-yl-2-hydroxypropanoic acid: a new class of broad-spectrum antiviral agents.
AID84236	50% effective concentration required to reduce herpes simplex virus-1 (HSV- (TK) B2006 strain)-induced cytopathicity	1997	Journal of medicinal chemistry, May-23, Volume: 40, Issue:11	Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues.
AID634834	Antiviral activity against Influenza B virus infected in MDCK cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID218431	Antiviral activity was measured against Rhino virus-9 in human diploid (WI-38) cells.	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID416770	Antiviral activity against Sindbis virus in african green monkey Vero cells assessed as protection against virus-induced cytopathicity	2009	Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7	Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus.
AID87142	Minimum cytotoxic concentration required to cause a microscopically detectable alteration of normal cell morphology and show antiviral activity in HeLa cells	1989	Journal of medicinal chemistry, May, Volume: 32, Issue:5	Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin.
AID87154	Minimum inhibitory concentration against Coxsackie virus B4 in HeLa cell cultures	1989	Journal of medicinal chemistry, Aug, Volume: 32, Issue:8	Synthesis and antiviral activity of 3'-C-cyano-3'-deoxynucleosides.
AID766695	Antiviral activity against Vesicular stomatitis virus infected in human HeLa cells assessed as reduction in virus-induced cytopathogenicity	2013	European journal of medicinal chemistry, Sep, Volume: 67	Regioselective synthesis of 6-substituted-2-amino-5-bromo-4(3H)-pyrimidinones and evaluation of their antiviral activity.
AID539931	Antiviral activity against Coxsackie virus B4 infected in human HeLa cells assessed as protection against virus-induced cytopathogenicity after 2 days	2010	European journal of medicinal chemistry, Nov, Volume: 45, Issue:11	Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones.
AID280199	Antiviral activity against sindbis virus in Vero cells assessed as inhibition of virus-induced cytopathicity	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
AID280206	Cytotoxicity against C3H cells assessed as alteration in cell morphology	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
AID768196	Antiviral activity against Parainfluenza-3 virus infected in african green monkey Vero cells assessed as reduction of virus-induced cytopathogenicity	2013	European journal of medicinal chemistry, Aug, Volume: 66	Synthesis of 4-aminoquinoline-pyrimidine hybrids as potent antimalarials and their mode of action studies.
AID1113456	Antiviral activity against Punta Toro virus infected in African green monkey Vero cells assessed as reduction of virus-induced cytopathic effect after 3 days by colorimetric formazan-based MTS assay	2013	Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 22, Issue:4	Synthesis and biological evaluation of 2-(5-substituted-1-((diethylamino)methyl)-2-oxoindolin-3-ylidene)-
AID226095	Minimum inhibitory concentration against Herpes simplex virus 2 (G) in primary rabbit kidney cell cultures	1989	Journal of medicinal chemistry, Aug, Volume: 32, Issue:8	Synthesis and antiviral activity of 3'-C-cyano-3'-deoxynucleosides.
AID156540	Inhibition of Vaccinia virus induced cytopathicity in in PRK cells.	1985	Journal of medicinal chemistry, Mar, Volume: 28, Issue:3	Alkyl esters of 3-adenin-9-yl-2-hydroxypropanoic acid: a new class of broad-spectrum antiviral agents.
AID257887	Antiviral activity against vero cells	2006	Journal of medicinal chemistry, Jan-26, Volume: 49, Issue:2	Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators.
AID548434	Antiviral activity against coxsackievirus B4 infected in human HeLa cells assessed as inhibition of virus induced cytopathicity after 2 to 4 days by MTS assay	2010	European journal of medicinal chemistry, Dec, Volume: 45, Issue:12	4-[1-(Substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzenesulfonic acids: synthesis, antimicrobial activity, QSAR studies, and antiviral evaluation.
AID419606	Antiviral activity against Punta Toro virus infected in african green monkey Vero cells assessed as reduction in virus-induced cytopathogenicity after 3 days	2009	European journal of medicinal chemistry, Jun, Volume: 44, Issue:6	Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives.
AID86490	Inhibition of polio virus 1 induced cytopathicity in in HeLa cells.	1985	Journal of medicinal chemistry, Mar, Volume: 28, Issue:3	Alkyl esters of 3-adenin-9-yl-2-hydroxypropanoic acid: a new class of broad-spectrum antiviral agents.
AID291035	Antiviral activity against sindbis virus in Vero cells assessed as reduction of virus plaque formation after 7 days	2007	Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13	Novel C-6 fluorinated acyclic side chain pyrimidine derivatives: synthesis, (1)H and (13)C NMR conformational studies, and antiviral and cytostatic evaluations.
AID82116	Antiviral activity against HIV-1 was determined; No inhibition	1990	Journal of medicinal chemistry, Sep, Volume: 33, Issue:9	Synthesis of new (+-)-3,5-dihydroxypentyl nucleoside analogues from 1-amino-5-(benzyloxy)pentan-3-ol and their antiviral evaluation.
AID303236	Antiviral activity against Punta Toro virus in Vero cells reduction of virus-induced cytopathogenicity after 4 days	2007	Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23	Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.
AID297321	Antiviral activity against Punta Toro virus in Vero cells assessed as reduction of virus-induced cytopathogenicity	2007	Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17	Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives.
AID434315	Antiviral activity against Parainfluenza-3 virus infected in african green monkey Vero cells assessed as protection against virus-induced cytopathogenicity	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide.
AID229234	Antiviral activity against vesicular stomatitis virus (VSV) in HeLa cell culture lines,	1992	Journal of medicinal chemistry, Nov-27, Volume: 35, Issue:24	Synthesis and antiviral activity of some new S-adenosyl-L-homocysteine derivatives.
AID634757	Antiviral activity against Sindbis virus infected in african green monkey Vero cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID284537	Antiviral activity against Sindbis virus-induced cytopathogenicity in Vero cells	2007	Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2	The novel C-5 aryl, alkenyl, and alkynyl substituted uracil derivatives of L-ascorbic acid: synthesis, cytostatic, and antiviral activity evaluations.
AID297319	Antiviral activity against Sindbis virus in Vero cells assessed as reduction of virus-induced cytopathogenicity	2007	Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17	Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives.
AID768192	Antiviral activity against Sindbis virus infected in african green monkey Vero cells assessed as reduction of virus-induced cytopathogenicity	2013	European journal of medicinal chemistry, Aug, Volume: 66	Synthesis of 4-aminoquinoline-pyrimidine hybrids as potent antimalarials and their mode of action studies.
AID257889	Antiviral activity against Herpes simplex virus 1 KOS strain in HEL cells	2006	Journal of medicinal chemistry, Jan-26, Volume: 49, Issue:2	Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators.
AID766692	Antiviral activity against Respiratory syncytial virus Long infected in human HeLa cells assessed as reduction in virus-induced cytopathogenicity	2013	European journal of medicinal chemistry, Sep, Volume: 67	Regioselective synthesis of 6-substituted-2-amino-5-bromo-4(3H)-pyrimidinones and evaluation of their antiviral activity.
AID275089	Cytotoxicity against Vero cells	2006	Journal of medicinal chemistry, Dec-28, Volume: 49, Issue:26	Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine.
AID275073	Antiviral activity against para influenza 3 virus in Vero cells	2006	Journal of medicinal chemistry, Dec-28, Volume: 49, Issue:26	Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine.
AID418502	Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated adenylyl cyclase activity	2009	Bioorganic & medicinal chemistry, Apr-01, Volume: 17, Issue:7	8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands.
AID766690	Antiviral activity against Reovirus-1 infected in african green monkey Vero cells assessed as reduction in virus-induced cytopathogenicity	2013	European journal of medicinal chemistry, Sep, Volume: 67	Regioselective synthesis of 6-substituted-2-amino-5-bromo-4(3H)-pyrimidinones and evaluation of their antiviral activity.
AID383531	Antiviral activity against Reo virus 1 in african green monkey Vero cells assessed as reduction of virus-induced cytopathogenicity	2008	European journal of medicinal chemistry, Feb, Volume: 43, Issue:2	Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents.
AID1252402	Cytotoxicity against African green monkey Vero cells assessed as alteration in cell morphology by microscopy	2015	European journal of medicinal chemistry, Sep-18, Volume: 102	Novel halogenated 3-deazapurine, 7-deazapurine and alkylated 9-deazapurine derivatives of L-ascorbic or imino-L-ascorbic acid: Synthesis, antitumour and antiviral activity evaluations.
AID1252403	Antiviral activity against Parainfluenza virus 3 expressed in African green monkey Vero cells assessed as reduction in cytopathogenicity	2015	European journal of medicinal chemistry, Sep-18, Volume: 102	Novel halogenated 3-deazapurine, 7-deazapurine and alkylated 9-deazapurine derivatives of L-ascorbic or imino-L-ascorbic acid: Synthesis, antitumour and antiviral activity evaluations.
AID383508	Antiviral activity against Coxsackie virus B4 in human HeLa cells assessed as inhibition of virus-induced cytopathogenicity	2008	European journal of medicinal chemistry, Feb, Volume: 43, Issue:2	Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents.
AID418501	Displacement of [3H]NECA from human adenosine A2A receptor expressed in CHO cells	2009	Bioorganic & medicinal chemistry, Apr-01, Volume: 17, Issue:7	8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands.
AID228284	Cytotoxic concentration at which cell viability was reduced by 50%	2004	Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12	A new approach to the synthesis of optically active alkylated adenine derivatives.
AID218033	Antiviral activity was measured against Sindbis virus in african green monkey kidney (Vero B) cells.	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID658745	Antiviral activity against Respiratory syncytial virus infected in human HeLa cells assessed as inhibition of virus-induced cytopathogenicity after 4 days	2012	European journal of medicinal chemistry, Jun, Volume: 52	2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies.
AID634746	Antiviral activity against Herpes simplex virus 1 KOS infected in human HEL cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID63952	Compounds was evaluated for its inhibitory effect on cytopathogenicity of vesicular stomatitis virus (VSV) in E6SM cells	1992	Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8	Synthesis and antiviral activity of acyclic nucleosides with a 3(S),5-dihydroxypentyl or 4(R)-methoxy-3(S),5-dihydroxypentyl side chain.
AID539925	Antiviral activity against Punta Toro virus infected in african green monkey Vero cells assessed as protection against virus-induced cytopathogenicity after 2 days	2010	European journal of medicinal chemistry, Nov, Volume: 45, Issue:11	Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones.
AID218509	Effective concentration required to reduce coxsackie virus B4-induced cytopathicity in vero cells	1997	Journal of medicinal chemistry, May-23, Volume: 40, Issue:11	Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues.
AID416771	Antiviral activity against Punta Toro virus in african green monkey Vero cells assessed as protection against virus-induced cytopathicity	2009	Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7	Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus.
AID218510	Effective concentration required to reduce parainfluenza-3-induced cytopathicity in vero cells	1997	Journal of medicinal chemistry, May-23, Volume: 40, Issue:11	Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues.
AID303231	Antiviral activity against Coxsackie virus B4 in Vero cells assessed as reduction of virus-induced cytopathogenicity	2007	Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23	Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.
AID257888	Antiviral activity against HeLa cells	2006	Journal of medicinal chemistry, Jan-26, Volume: 49, Issue:2	Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators.
AID225768	Antiviral activity against polio virus type 1 in HeLa cell culture lines	1992	Journal of medicinal chemistry, Nov-27, Volume: 35, Issue:24	Synthesis and antiviral activity of some new S-adenosyl-L-homocysteine derivatives.
AID216955	Effective concentration required to inhibit Punta Toro virus-induced cytopathicity by 50% in Vero cell lines	2001	Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17	Synthesis, mechanism of action, and antiviral activity of a new series of covalent mechanism-based inhibitors of S-adenosyl-L-homocysteine hydrolase.
AID548449	Antiviral activity against Coxsackie virus B4 infected in african green monkey Vero cells assessed as inhibition of virus induced cytopathicity after 2 to 4 days by MTS assay	2010	European journal of medicinal chemistry, Dec, Volume: 45, Issue:12	4-[1-(Substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzenesulfonic acids: synthesis, antimicrobial activity, QSAR studies, and antiviral evaluation.
AID86489	Inhibition of Coxsackie B4 virus induced cytopathicity in HeLa cells.	1985	Journal of medicinal chemistry, Mar, Volume: 28, Issue:3	Alkyl esters of 3-adenin-9-yl-2-hydroxypropanoic acid: a new class of broad-spectrum antiviral agents.
AID217892	Minimum inhibitory concentration against Coxsackie virus B4 in Vero cell cultures	1989	Journal of medicinal chemistry, Aug, Volume: 32, Issue:8	Synthesis and antiviral activity of 3'-C-cyano-3'-deoxynucleosides.
AID768198	Antiviral activity against Coxsackievirus B4 infected in human HeLa cells assessed as reduction of virus-induced cytopathogenicity	2013	European journal of medicinal chemistry, Aug, Volume: 66	Synthesis of 4-aminoquinoline-pyrimidine hybrids as potent antimalarials and their mode of action studies.
AID434314	Antiviral activity against RSV infected in human HeLa cells assessed as protection against virus-induced cytopathogenicity	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide.
AID432179	Cytotoxicity against african green monkey Vero cells assessed as minimum cytotoxic concentration required to cause microscopically detectable alteration in normal cell morphology	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis and antiviral activity of new pyrazole and thiazole derivatives.
AID291036	Antiviral activity against Punta Toro virus in Vero cells assessed as reduction of virus plaque formation after 7 days	2007	Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13	Novel C-6 fluorinated acyclic side chain pyrimidine derivatives: synthesis, (1)H and (13)C NMR conformational studies, and antiviral and cytostatic evaluations.
AID658742	Cytotoxicity against human HeLa cells assessed as minimum compound concentration required to causes microscopically detectable alteration of normal cell morphology	2012	European journal of medicinal chemistry, Jun, Volume: 52	2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies.
AID217894	Minimum inhibitory concentration against Sindbis virus in Vero cell cultures	1989	Journal of medicinal chemistry, Aug, Volume: 32, Issue:8	Synthesis and antiviral activity of 3'-C-cyano-3'-deoxynucleosides.
AID548430	Cytotoxicity against human HeLa cells assessed as altered cell morphology	2010	European journal of medicinal chemistry, Dec, Volume: 45, Issue:12	4-[1-(Substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzenesulfonic acids: synthesis, antimicrobial activity, QSAR studies, and antiviral evaluation.
AID1113463	Antiviral activity against Vesicular stomatitis virus infected human HeLa cells assessed as reduction of virus-induced cytopathic effect after 3 days by colorimetric formazan-based MTS assay	2013	Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 22, Issue:4	Synthesis and biological evaluation of 2-(5-substituted-1-((diethylamino)methyl)-2-oxoindolin-3-ylidene)-
AID463982	Antiviral activity against Reovirus 1 infected in african green monkey Vero cells assessed as protection from virus-induced cytopathogenicity after 6 to 7 days by MTT assay	2010	European journal of medicinal chemistry, Mar, Volume: 45, Issue:3	Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid.
AID548447	Antiviral activity against Reovirus 1 virus infected in african green monkey Vero cells assessed as inhibition of virus induced cytopathicity after 2 to 4 days by MTS assay	2010	European journal of medicinal chemistry, Dec, Volume: 45, Issue:12	4-[1-(Substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzenesulfonic acids: synthesis, antimicrobial activity, QSAR studies, and antiviral evaluation.
AID658612	Antiviral activity against Parainfluenza-3 virus infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathogenicity after 4 days	2012	European journal of medicinal chemistry, Jun, Volume: 52	2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies.
AID434313	Antiviral activity against Coxsackievirus B4 infected in human HeLa cells assessed as protection against virus-induced cytopathogenicity	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide.
AID658614	Antiviral activity against Sindbis virus infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathogenicity after 4 days	2012	European journal of medicinal chemistry, Jun, Volume: 52	2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies.
AID90940	Antiviral activity against HCMV was determined; No inhibition	1990	Journal of medicinal chemistry, Sep, Volume: 33, Issue:9	Synthesis of new (+-)-3,5-dihydroxypentyl nucleoside analogues from 1-amino-5-(benzyloxy)pentan-3-ol and their antiviral evaluation.
AID218029	Antiviral activity was measured against Coxsackie virus B4 in african green monkey kidney (Vero B) cells.	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID1113459	Antiviral activity against Mammalian orthoreovirus 1 infected African green monkey Vero cells assessed as reduction of virus-induced cytopathic effect after 3 days by colorimetric formazan-based MTS assay	2013	Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 22, Issue:4	Synthesis and biological evaluation of 2-(5-substituted-1-((diethylamino)methyl)-2-oxoindolin-3-ylidene)-
AID432181	Antiviral activity against Reovirus 1 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathicity after 3 days	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis and antiviral activity of new pyrazole and thiazole derivatives.
AID1252404	Antiviral activity against Reovirus 1 expressed in African green monkey Vero cells assessed as reduction in cytopathogenicity	2015	European journal of medicinal chemistry, Sep-18, Volume: 102	Novel halogenated 3-deazapurine, 7-deazapurine and alkylated 9-deazapurine derivatives of L-ascorbic or imino-L-ascorbic acid: Synthesis, antitumour and antiviral activity evaluations.
AID64102	Minimum inhibitory concentration (MIC) required to reduce VMW 1837 strain of TK-HSV-1 induced cytopathogenicity by 50% in E6SM cells	1992	Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8	Synthesis and antiviral activity of acyclic nucleosides with a 3(S),5-dihydroxypentyl or 4(R)-methoxy-3(S),5-dihydroxypentyl side chain.
AID218031	Antiviral activity was measured against Reo virus-1 in african green monkey kidney (Vero B) cells.	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID464186	Cytotoxicity against Human coxsackievirus B4 infected african green monkey Vero cells by trypan blue exclusion method	2010	European journal of medicinal chemistry, Mar, Volume: 45, Issue:3	Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid.
AID280190	Antiviral activity against HIV2 ROD in human CEM cells assessed as inhibition of virus-induced cytopathicity	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
AID42108	Inhibition of Vesicular stomatitis virus induced cytopathicity in BS-C-1 cells.	1985	Journal of medicinal chemistry, Mar, Volume: 28, Issue:3	Alkyl esters of 3-adenin-9-yl-2-hydroxypropanoic acid: a new class of broad-spectrum antiviral agents.
AID257897	Antiviral activity against Coxsackie virus B4 in vero cells	2006	Journal of medicinal chemistry, Jan-26, Volume: 49, Issue:2	Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators.
AID658613	Antiviral activity against Reovirus-1 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathogenicity after 4 days	2012	European journal of medicinal chemistry, Jun, Volume: 52	2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies.
AID548450	Antiviral activity against Punta Toro virus infected in african green monkey Vero cells assessed as inhibition of virus induced cytopathicity after 2 to 4 days by MTS assay	2010	European journal of medicinal chemistry, Dec, Volume: 45, Issue:12	4-[1-(Substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzenesulfonic acids: synthesis, antimicrobial activity, QSAR studies, and antiviral evaluation.
AID280198	Antiviral activity against reovirus1 in Vero cells assessed as inhibition of virus-induced cytopathicity	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
AID84402	Antiviral activity against HSV-1(KOS) strain in primary rabbit kidney (PRK) / embryonic skin-muscle (E6SM) fibroblast culture lines	1992	Journal of medicinal chemistry, Nov-27, Volume: 35, Issue:24	Synthesis and antiviral activity of some new S-adenosyl-L-homocysteine derivatives.
AID218035	Concentration required for microscopically detectable alteration of the normal cell morphology in Vero B cells.	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID464187	Cytotoxicity against Punta Toro virus infected african green monkey Vero cells by trypan blue exclusion method	2010	European journal of medicinal chemistry, Mar, Volume: 45, Issue:3	Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid.
AID199174	The minimum inhibitory concentration required to reduce reovirus type I induced cytopathogenicity in primary rabbit kidney cells by 50%	1984	Journal of medicinal chemistry, Dec, Volume: 27, Issue:12	Synthesis and biological evaluation of 6-amino-1H-pyrrolo[3,2-c]pyridin-4(5H)-one (3,7-dideazaguanine).
AID87140	Minimum cytotoxic concentration in HeLa cell cultures	1989	Journal of medicinal chemistry, Aug, Volume: 32, Issue:8	Synthesis and antiviral activity of 3'-C-cyano-3'-deoxynucleosides.
AID634754	Antiviral activity against thymidine kinase-deficient Varicella Zoster virus 07/1 infected in human HEL cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID768191	Antiviral activity against Punts virus B4 infected in african green monkey Vero cells assessed as reduction of virus-induced cytopathogenicity	2013	European journal of medicinal chemistry, Aug, Volume: 66	Synthesis of 4-aminoquinoline-pyrimidine hybrids as potent antimalarials and their mode of action studies.
AID634833	Antiviral activity against Influenza A virus H3N2 infected in MDCK cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID226341	Antiviral activity against sindbis virus in Vero cell culture lines	1992	Journal of medicinal chemistry, Nov-27, Volume: 35, Issue:24	Synthesis and antiviral activity of some new S-adenosyl-L-homocysteine derivatives.
AID64099	Minimum inhibitory concentration (MIC) required to reduce KOS strain of HSV-1 induced cytopathogenicity by 50% in E6SM cells	1992	Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8	Synthesis and antiviral activity of acyclic nucleosides with a 3(S),5-dihydroxypentyl or 4(R)-methoxy-3(S),5-dihydroxypentyl side chain.
AID1135905	Antiviral activity against Vesicular stomatitis virus infected in rabbit primary kidney cells assessed as inhibition of viral cytopathogenicity after 2 days	1979	Journal of medicinal chemistry, May, Volume: 22, Issue:5	Antiviral activity of aliphatic nucleoside analogues: structure-function relationship.
AID257895	Antiviral activity against Reovirus 1 in vero cells	2006	Journal of medicinal chemistry, Jan-26, Volume: 49, Issue:2	Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators.
AID216196	Cytotoxic concentration against Vero cells.	1985	Journal of medicinal chemistry, Mar, Volume: 28, Issue:3	Alkyl esters of 3-adenin-9-yl-2-hydroxypropanoic acid: a new class of broad-spectrum antiviral agents.
AID464184	Cytotoxicity against Reovirus 1 infected african green monkey Vero cells by trypan blue exclusion method	2010	European journal of medicinal chemistry, Mar, Volume: 45, Issue:3	Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid.
AID432178	Antiviral activity against RSV infected in human HeLa cells assessed as inhibition of virus-induced cytopathicity after 3 days	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis and antiviral activity of new pyrazole and thiazole derivatives.
AID416767	Antiviral activity against Coxsackievirus B4 in african green monkey Vero cells assessed as protection against virus-induced cytopathicity	2009	Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7	Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus.
AID218430	Antiviral activity was measured against Rhino virus-1A in human diploid (WI-38) cells.	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID284538	Antiviral activity against Coxsackie virus B4-induced cytopathogenicity in Vero cells	2007	Bioorganic & medicinal chemistry, Jan-15, Volume: 15, Issue:2	The novel C-5 aryl, alkenyl, and alkynyl substituted uracil derivatives of L-ascorbic acid: synthesis, cytostatic, and antiviral activity evaluations.
AID539922	Antiviral activity against Reovirus-1 infected in african green monkey Vero cells assessed as protection against virus-induced cytopathogenicity after 2 days	2010	European journal of medicinal chemistry, Nov, Volume: 45, Issue:11	Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones.
AID548436	Antiviral activity against Respiratory syncytial virus infected in human HeLa cells assessed as inhibition of virus induced cytopathicity after 2 to 4 days by MTS assay	2010	European journal of medicinal chemistry, Dec, Volume: 45, Issue:12	4-[1-(Substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzenesulfonic acids: synthesis, antimicrobial activity, QSAR studies, and antiviral evaluation.
AID280200	Antiviral activity against punta toro virus in Vero cells assessed as inhibition of virus-induced cytopathicity	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
AID229026	Antiviral activity against vaccinia virus (VV) in primary rabbit kidney (PRK) / embryonic skin-muscle (E6SM) fibroblast culture lines	1992	Journal of medicinal chemistry, Nov-27, Volume: 35, Issue:24	Synthesis and antiviral activity of some new S-adenosyl-L-homocysteine derivatives.
AID418503	Displacement of [3H]NECA from human adenosine A3 receptor expressed in CHO cells	2009	Bioorganic & medicinal chemistry, Apr-01, Volume: 17, Issue:7	8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands.
AID216406	Evaluation for antiviral activity against vesion stomatitis virus in primary rabbit kidney cell culture	1986	Journal of medicinal chemistry, Jul, Volume: 29, Issue:7	Structure-activity relationship of novel oligopeptide antiviral and antitumor agents related to netropsin and distamycin.
AID434306	Cytotoxicity against human HeLa cells assessed as change in cell morphology	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide.
AID217893	Minimum inhibitory concentration against forest virus in Vero cell cultures	1989	Journal of medicinal chemistry, Aug, Volume: 32, Issue:8	Synthesis and antiviral activity of 3'-C-cyano-3'-deoxynucleosides.
AID280193	Antiviral activity against VSV in HeLa cells assessed as inhibition of virus-induced cytopathicity	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
AID416765	Cytotoxicity against african green monkey Vero cells assessed as drug level causing microscopically detectable alteration of normal cell morphology after 3 days	2009	Journal of medicinal chemistry, Apr-09, Volume: 52, Issue:7	Indolylarylsulfones bearing natural and unnatural amino acids. Discovery of potent inhibitors of HIV-1 non-nucleoside wild type and resistant mutant strains reverse transcriptase and coxsackie B4 virus.
AID766688	Antiviral activity against Coxsackievirus B4 infected in african green monkey Vero cells assessed as reduction in virus-induced cytopathogenicity	2013	European journal of medicinal chemistry, Sep, Volume: 67	Regioselective synthesis of 6-substituted-2-amino-5-bromo-4(3H)-pyrimidinones and evaluation of their antiviral activity.
AID218406	Minimum inhibitory concentration required to reduce semliki forest virus induced cytopathogenicity by 50% in african green monkey (VeroB) cells	1989	Journal of medicinal chemistry, May, Volume: 32, Issue:5	Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin.
AID156691	Antiviral activity was measured against vaccinia virus in rabbit kidney cells.	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID434316	Antiviral activity against Reovirus 1 infected in african green monkey Vero cells assessed as protection against virus-induced cytopathogenicity	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide.
AID257893	Antiviral activity against herpes simplex virus 1 TK- KOS ACVr strain in HEL cells	2006	Journal of medicinal chemistry, Jan-26, Volume: 49, Issue:2	Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators.
AID539921	Antiviral activity against Para influenza-3 virus infected in african green monkey Vero cells assessed as protection against virus-induced cytopathogenicity after 2 days	2010	European journal of medicinal chemistry, Nov, Volume: 45, Issue:11	Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones.
AID257900	Antiviral activity against Coxsackie virus B4 in HeLa cells	2006	Journal of medicinal chemistry, Jan-26, Volume: 49, Issue:2	Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators.
AID432180	Antiviral activity against Parainfluenza virus type 3 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathicity after 3 days	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis and antiviral activity of new pyrazole and thiazole derivatives.
AID766691	Antiviral activity against Parainfluenza virus 3 infected in african green monkey Vero cells assessed as reduction in virus-induced cytopathogenicity	2013	European journal of medicinal chemistry, Sep, Volume: 67	Regioselective synthesis of 6-substituted-2-amino-5-bromo-4(3H)-pyrimidinones and evaluation of their antiviral activity.
AID768193	Antiviral activity against Coxsackievirus B4 infected in african green monkey Vero cells assessed as reduction of virus-induced cytopathogenicity	2013	European journal of medicinal chemistry, Aug, Volume: 66	Synthesis of 4-aminoquinoline-pyrimidine hybrids as potent antimalarials and their mode of action studies.
AID156687	Antiviral activity was measured against Herpes simplex virus (HSV-1 KOS) in rabbit kidney cells.	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID548446	Antiviral activity against parainfluenza-3 virus infected in african green monkey Vero cells assessed as inhibition of virus induced cytopathicity after 2 to 4 days by MTS assay	2010	European journal of medicinal chemistry, Dec, Volume: 45, Issue:12	4-[1-(Substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzenesulfonic acids: synthesis, antimicrobial activity, QSAR studies, and antiviral evaluation.
AID634752	Antiviral activity against Human cytomegalovirus Davis infected in human HEL cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID1113457	Antiviral activity against Human coxsackievirus B4 infected African green monkey Vero cells assessed as reduction of virus-induced cytopathic effect after 3 days by colorimetric formazan-based MTS assay	2013	Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, , Volume: 22, Issue:4	Synthesis and biological evaluation of 2-(5-substituted-1-((diethylamino)methyl)-2-oxoindolin-3-ylidene)-
AID218405	Minimum inhibitory concentration required to reduce reovirus-1 induced cytopathogenicity by 50% in african green monkey (VeroB)cells	1989	Journal of medicinal chemistry, May, Volume: 32, Issue:5	Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin.
AID217883	Minimum cytotoxic concentration in Vero cell cultures	1989	Journal of medicinal chemistry, Aug, Volume: 32, Issue:8	Synthesis and antiviral activity of 3'-C-cyano-3'-deoxynucleosides.
AID419600	Antiviral activity against RSV infected in human HeLa cells assessed as reduction in virus-induced cytopathogenicity after 3 days	2009	European journal of medicinal chemistry, Jun, Volume: 44, Issue:6	Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives.
AID463983	Antiviral activity against VSV infected in human HeLa cells assessed as protection from virus-induced cytopathogenicity after 1 to 2 days by MTT assay	2010	European journal of medicinal chemistry, Mar, Volume: 45, Issue:3	Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid.
AID766707	Cytotoxicity against african green monkey Vero cells assessed as morphological changes	2013	European journal of medicinal chemistry, Sep, Volume: 67	Regioselective synthesis of 6-substituted-2-amino-5-bromo-4(3H)-pyrimidinones and evaluation of their antiviral activity.
AID226096	Minimum inhibitory concentration against Vaccinia virus in primary rabbit kidney cell cultures	1989	Journal of medicinal chemistry, Aug, Volume: 32, Issue:8	Synthesis and antiviral activity of 3'-C-cyano-3'-deoxynucleosides.
AID548448	Antiviral activity against Sindbis virus infected in african green monkey Vero cells assessed as inhibition of virus induced cytopathicity after 2 to 4 days by MTS assay	2010	European journal of medicinal chemistry, Dec, Volume: 45, Issue:12	4-[1-(Substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzenesulfonic acids: synthesis, antimicrobial activity, QSAR studies, and antiviral evaluation.
AID257892	Antiviral activity against Vesicular stomatitis virus in HEL cells	2006	Journal of medicinal chemistry, Jan-26, Volume: 49, Issue:2	Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators.
AID383532	Antiviral activity against Sindbis virus in african green monkey Vero cells assessed as reduction of virus-induced cytopathogenicity	2008	European journal of medicinal chemistry, Feb, Volume: 43, Issue:2	Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents.
AID156688	Antiviral activity was measured against Herpes simplex virus (HSV-2 G) in rabbit kidney cells.	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID539920	Cytotoxicity against african green monkey Vero cells assessed as minimum concentration required to cause microscopically detectable alteration after 2 days	2010	European journal of medicinal chemistry, Nov, Volume: 45, Issue:11	Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones.
AID275088	Cytotoxicity against HeLa cells	2006	Journal of medicinal chemistry, Dec-28, Volume: 49, Issue:26	Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine.
AID463981	Antiviral activity against Human coxsackievirus B4 infected in human HeLa cells assessed as protection from virus-induced cytopathogenicity after 2 days by MTT assay	2010	European journal of medicinal chemistry, Mar, Volume: 45, Issue:3	Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid.
AID257886	Antiviral activity against HEL cells	2006	Journal of medicinal chemistry, Jan-26, Volume: 49, Issue:2	Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators.
AID387602	Cytotoxicity against human HeLa cells assessed as alteration in cell morphology by MTS assay	2008	Bioorganic & medicinal chemistry, Sep-15, Volume: 16, Issue:18	Synthesis and antiviral evaluation of acyclic azanucleosides developed from sulfanilamide as a lead structure.
AID64100	Minimum inhibitory concentration (MIC) required to reduce Lyons strain of HSV-2 induced cytopathogenicity by 50% in E6SM cells	1992	Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8	Synthesis and antiviral activity of acyclic nucleosides with a 3(S),5-dihydroxypentyl or 4(R)-methoxy-3(S),5-dihydroxypentyl side chain.
AID387582	Cytotoxicity against african green monkey Vero cells assessed as alteration in cell morphology by MTS assay	2008	Bioorganic & medicinal chemistry, Sep-15, Volume: 16, Issue:18	Synthesis and antiviral evaluation of acyclic azanucleosides developed from sulfanilamide as a lead structure.
AID280194	Antiviral activity against coxsackie B4 virus in HeLa cells assessed as inhibition of virus-induced cytopathicity	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
AID224916	Antiviral activity against parainfluenza virus type 3 in Vero cell culture lines	1992	Journal of medicinal chemistry, Nov-27, Volume: 35, Issue:24	Synthesis and antiviral activity of some new S-adenosyl-L-homocysteine derivatives.
AID432177	Antiviral activity against Coxsackievirus B4 infected in human HeLa cells assessed as inhibition of virus-induced cytopathicity after 3 days	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis and antiviral activity of new pyrazole and thiazole derivatives.
AID87136	Antiviral activity was measured against vesicular stomatitis virus in HeLa cells.	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID257894	Antiviral activity against Parainfluenza-3 virus in vero cells	2006	Journal of medicinal chemistry, Jan-26, Volume: 49, Issue:2	Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators.
AID489679	Cytotoxicity against human HeLa cells after 3 days by MTS assay	2010	European journal of medicinal chemistry, Jul, Volume: 45, Issue:7	Benzylidene/2-chlorobenzylidene hydrazides: synthesis, antimicrobial activity, QSAR studies and antiviral evaluation.
AID220034	Antiviral activity against coxsackie B4 virus in HeLa cell culture lines	1992	Journal of medicinal chemistry, Nov-27, Volume: 35, Issue:24	Synthesis and antiviral activity of some new S-adenosyl-L-homocysteine derivatives.
AID303235	Antiviral activity against Sindbis virus in Vero cells reduction of virus-induced cytopathogenicity after 4 days	2007	Journal of medicinal chemistry, Nov-15, Volume: 50, Issue:23	Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity.
AID218030	Antiviral activity was measured against Parainfluenza virus-3 in african green monkey kidney (Vero B) cells.	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID218032	Antiviral activity was measured against forest virus in african green monkey kidney (Vero B) cells.	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID218513	Effective concentration required to reduce vesicular stomatitis virus (VSV)-induced cytopathicity in vero cells	1997	Journal of medicinal chemistry, May-23, Volume: 40, Issue:11	Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxaldehydes and oximes synthesized from adenosine and sugar-modified analogues.
AID217979	Inhibitory concentration required against vaccinia virus in Vero cell culture	2004	Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12	A new approach to the synthesis of optically active alkylated adenine derivatives.
AID383509	Antiviral activity against respiratory syncytial virus in human HeLa cells assessed as inhibition of virus-induced cytopathogenicity	2008	European journal of medicinal chemistry, Feb, Volume: 43, Issue:2	Synthesis of some novel thiourea derivatives obtained from 5-[(4-aminophenoxy)methyl]-4-alkyl/aryl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and evaluation as antiviral/anti-HIV and anti-tuberculosis agents.
AID634758	Antiviral activity against Coxsackievirus B4 infected in african green monkey Vero cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID216436	Concentration required for microscopically detectable alteration of the normal cell morphology in Wi-38 cells.	1986	Journal of medicinal chemistry, Feb, Volume: 29, Issue:2	Systematic synthesis and biological evaluation of alpha- and beta-D-xylofuranosyl nucleosides of the five naturally occurring bases in nucleic acids and related analogues.
AID228479	Compound was tested for toxicity; No toxicity was observed	2004	Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12	A new approach to the synthesis of optically active alkylated adenine derivatives.
AID167890	Minimum cytotoxic concentration in primary rabbit kidney cell cultures	1989	Journal of medicinal chemistry, Aug, Volume: 32, Issue:8	Synthesis and antiviral activity of 3'-C-cyano-3'-deoxynucleosides.
AID161449	Minimum cytotoxic concentration required to cause a microscopically detectable alteration of normal cell morphology and show antiviral activity in primary rabbit kidney (PRK) cells	1989	Journal of medicinal chemistry, May, Volume: 32, Issue:5	Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin.
AID297317	Antiviral activity against RSV in HeLa cells assessed as reduction of virus-induced cytopathogenicity	2007	Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17	Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives.
AID297318	Antiviral activity against Reovirus 1 in Vero cells assessed as reduction of virus-induced cytopathogenicity	2007	Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17	Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives.
AID280189	Antiviral activity against HIV1 3B in human CEM cells assessed as inhibition of virus-induced cytopathicity	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
AID257899	Antiviral activity against Respiratory syncytial virus in HeLa cells	2006	Journal of medicinal chemistry, Jan-26, Volume: 49, Issue:2	Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators.
AID432182	Antiviral activity against Sindbis virus infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathicity after 3 days postinfection	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis and antiviral activity of new pyrazole and thiazole derivatives.
AID489680	Antiviral activity against VSV infected in human HeLa cells assessed as inhibition of virus-induced cytopathic effect after 3 days by MTS assay	2010	European journal of medicinal chemistry, Jul, Volume: 45, Issue:7	Benzylidene/2-chlorobenzylidene hydrazides: synthesis, antimicrobial activity, QSAR studies and antiviral evaluation.
AID297312	Antiviral activity against VSV in HeLa cells assessed as reduction of virus-induced cytopathogenicity	2007	Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17	Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives.
AID432175	Antiviral activity against Vesicular stomatitis virus infected in human HeLa cells assessed as inhibition of virus-induced cytopathicity after 3 days	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis and antiviral activity of new pyrazole and thiazole derivatives.
AID297320	Antiviral activity against Coxsackie virus B4 in Vero cells assessed as reduction of virus-induced cytopathogenicity	2007	Journal of medicinal chemistry, Aug-23, Volume: 50, Issue:17	Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives.
AID88356	Effective concentration required to inhibit vesicular stomatitis virus (VSV)-induced cytopathicity by 50% in HeLa cell lines	2001	Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17	Synthesis, mechanism of action, and antiviral activity of a new series of covalent mechanism-based inhibitors of S-adenosyl-L-homocysteine hydrolase.
AID463988	Antiviral activity against Respiratory syncytial virus infected in human HeLa cells assessed as protection from virus-induced cytopathogenicity after 4 days by MTT assay	2010	European journal of medicinal chemistry, Mar, Volume: 45, Issue:3	Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid.
AID257898	Antiviral activity against Punta Toro virus in vero cells	2006	Journal of medicinal chemistry, Jan-26, Volume: 49, Issue:2	Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators.
AID217994	Evaluation for antiviral activity against vaccinia virus in primary rabbit kidney cell culture	1986	Journal of medicinal chemistry, Jul, Volume: 29, Issue:7	Structure-activity relationship of novel oligopeptide antiviral and antitumor agents related to netropsin and distamycin.
AID87163	Minimum inhibitory concentration required to reduce vesicular stomatitis virus induced cytopathogenicity by 50% in HeLa cells	1989	Journal of medicinal chemistry, May, Volume: 32, Issue:5	Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin.
AID156538	Cytotoxic concentration against PRK cells.	1985	Journal of medicinal chemistry, Mar, Volume: 28, Issue:3	Alkyl esters of 3-adenin-9-yl-2-hydroxypropanoic acid: a new class of broad-spectrum antiviral agents.
AID634751	Antiviral activity against Human cytomegalovirus AD169 infected in human HEL cells assessed as inhibition of viral plaque formation at 250 uM	2012	European journal of medicinal chemistry, Jan, Volume: 47, Issue:1	Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker.
AID87162	Minimum inhibitory concentration required to reduce polio virus -1 induced cytopathogenicity by 50% in HeLa cells	1989	Journal of medicinal chemistry, May, Volume: 32, Issue:5	Synthesis, DNA binding, and biological evaluation of synthetic precursors and novel analogues of netropsin.
AID548433	Antiviral activity against coxsackievirus B4 infected in human HeLa cells assessed as inhibition of virus induced cytopathicity by visual scoring of CPE	2010	European journal of medicinal chemistry, Dec, Volume: 45, Issue:12	4-[1-(Substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzenesulfonic acids: synthesis, antimicrobial activity, QSAR studies, and antiviral evaluation.
AID419601	Cytotoxicity against african green monkey Vero cells assessed as alteration in cell morphology	2009	European journal of medicinal chemistry, Jun, Volume: 44, Issue:6	Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives.
AID217896	Minimum inhibitory concentration against reovirus in Vero cell cultures	1989	Journal of medicinal chemistry, Aug, Volume: 32, Issue:8	Synthesis and antiviral activity of 3'-C-cyano-3'-deoxynucleosides.
AID1252405	Antiviral activity against Sindbis virus expressed in African green monkey Vero cells assessed as reduction in cytopathogenicity	2015	European journal of medicinal chemistry, Sep-18, Volume: 102	Novel halogenated 3-deazapurine, 7-deazapurine and alkylated 9-deazapurine derivatives of L-ascorbic or imino-L-ascorbic acid: Synthesis, antitumour and antiviral activity evaluations.
AID216957	Effective concentration required to inhibit reovirus-induced cytopathicity by 50% in Vero cell lines	2001	Journal of medicinal chemistry, Aug-16, Volume: 44, Issue:17	Synthesis, mechanism of action, and antiviral activity of a new series of covalent mechanism-based inhibitors of S-adenosyl-L-homocysteine hydrolase.
AID156539	Inhibition of HSV-1 induced cytopathicity in in PRK cells.	1985	Journal of medicinal chemistry, Mar, Volume: 28, Issue:3	Alkyl esters of 3-adenin-9-yl-2-hydroxypropanoic acid: a new class of broad-spectrum antiviral agents.
AID291033	Antiviral activity against parainfluenza 3 virus in Vero cells assessed as reduction of virus plaque formation after 7 days	2007	Journal of medicinal chemistry, Jun-28, Volume: 50, Issue:13	Novel C-6 fluorinated acyclic side chain pyrimidine derivatives: synthesis, (1)H and (13)C NMR conformational studies, and antiviral and cytostatic evaluations.
AID434317	Antiviral activity against Sindbis virus infected in african green monkey Vero cells assessed as protection against virus-induced cytopathogenicity	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide.
AID280197	Antiviral activity against parainfluenza3 virus in Vero cells assessed as inhibition of virus-induced cytopathicity	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	7 (18.92)	18.7374
1990's	4 (10.81)	18.2507
2000's	16 (43.24)	29.6817
2010's	10 (27.03)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	37 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
9-ethyladenine [no description available]	2.05	1
1,3-dipropyl-8-cyclopentylxanthine DPCPX : An oxopurine that is 7H-xanthine substituted at positions 1 and 3 by propyl groups and at position 8 by a cyclohexyl group.	2.05	1	oxopurine	adenosine A1 receptor antagonist; EC 3.1.4.* (phosphoric diester hydrolase) inhibitor
amantadine amant: an antiviral compound consisting of an adamantane derivative chemically linked to a water-solube polyanioic matrix; structure in first source	3.57	8	adamantanes; primary aliphatic amine	analgesic; antiparkinson drug; antiviral drug; dopaminergic agent; NMDA receptor antagonist; non-narcotic analgesic
chloroquine Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.	2.48	2	aminoquinoline; organochlorine compound; secondary amino compound; tertiary amino compound	anticoronaviral agent; antimalarial; antirheumatic drug; autophagy inhibitor; dermatologic drug
ciprofloxacin Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.	2.05	1	aminoquinoline; cyclopropanes; fluoroquinolone antibiotic; N-arylpiperazine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone; zwitterion	antibacterial drug; antiinfective agent; antimicrobial agent; DNA synthesis inhibitor; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; environmental contaminant; topoisomerase IV inhibitor; xenobiotic
stallimycin [no description available]	1.97	1
fluconazole Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.. fluconazole : A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.	2.75	3	conazole antifungal drug; difluorobenzene; tertiary alcohol; triazole antifungal drug	environmental contaminant; P450 inhibitor; xenobiotic
fluorouracil Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.	2.11	1	nucleobase analogue; organofluorine compound	antimetabolite; antineoplastic agent; environmental contaminant; immunosuppressive agent; radiosensitizing agent; xenobiotic
netropsin Netropsin: A basic polypeptide isolated from Streptomyces netropsis. It is cytotoxic and its strong, specific binding to A-T areas of DNA is useful to genetics research.	1.97	1
nevirapine Nevirapine: A potent, non-nucleoside reverse transcriptase inhibitor used in combination with nucleoside analogues for treatment of HIV INFECTIONS and AIDS.. nevirapine : A dipyridodiazepine that is 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepine which is substituted by methyl, oxo, and cyclopropyl groups at positions 4, 6, and 11, respectively. A non-nucleoside reverse transcriptase inhibitor with activity against HIV-1, it is used in combination with other antiretrovirals for the treatment of HIV infection.	2.05	1	cyclopropanes; dipyridodiazepine	antiviral drug; HIV-1 reverse transcriptase inhibitor
norfloxacin Norfloxacin: A synthetic fluoroquinolone (FLUOROQUINOLONES) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA GYRASE.. norfloxacin : A quinolinemonocarboxylic acid with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase.	2.05	1	fluoroquinolone antibiotic; N-arylpiperazine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone	antibacterial drug; DNA synthesis inhibitor; environmental contaminant; xenobiotic
ofloxacin Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.. 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.. ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.	2.08	1	3-oxo monocarboxylic acid; N-arylpiperazine; N-methylpiperazine; organofluorine compound; oxazinoquinoline
rimantadine Rimantadine: An RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza.	3.57	8	alkylamine
idoxuridine [no description available]	1.95	1	organoiodine compound; pyrimidine 2'-deoxyribonucleoside	antiviral drug; DNA synthesis inhibitor
tubercidin Tubercidin: An antibiotic purine ribonucleoside that readily substitutes for adenosine in the biological system, but its incorporation into DNA and RNA has an inhibitory effect on the metabolism of these nucleic acids.. tubercidin : An N-glycosylpyrrolopyrimidine that is adenosine in which the in the 5-membered ring that is not attached to the ribose moiety is replaced by a carbon. Tubercidin is produced in the culture broth of Streptomyces tubericidus.	3.07	5	antibiotic antifungal agent; N-glycosylpyrrolopyrimidine; ribonucleoside	antimetabolite; antineoplastic agent; bacterial metabolite
cytarabine [no description available]	2.36	2	beta-D-arabinoside; monosaccharide derivative; pyrimidine nucleoside	antimetabolite; antineoplastic agent; antiviral agent; immunosuppressive agent
cordycepin [no description available]	1.98	1	3'-deoxyribonucleoside; adenosines	antimetabolite; nucleoside antibiotic
arginine Arginine: An essential amino acid that is physiologically active in the L-form.. arginine : An alpha-amino acid that is glycine in which the alpha-is substituted by a 3-guanidinopropyl group.	2.05	1	arginine; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid	biomarker; Escherichia coli metabolite; micronutrient; mouse metabolite; nutraceutical
2'-deoxyadenosine 2'-deoxyformycin A: RN not in Chemline 9/85; RN and structure given in first source	1.98	1	purine 2'-deoxyribonucleoside; purines 2'-deoxy-D-ribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
stavudine Stavudine: A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.. stavudine : A nucleoside analogue obtained by formal dehydration across positions 2 and 3 of thymidine. An inhibitor of HIV-1 reverse transcriptase	2.03	1	dihydrofuran; nucleoside analogue; organic molecular entity	antimetabolite; antiviral agent; EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
9-benzyladenine [no description available]	2.05	1
vidarabine adenine arabinoside : A purine nucleoside in which adenine is attached to arabinofuranose via a beta-N(9)-glycosidic bond.	2.36	2	beta-D-arabinoside; purine nucleoside	antineoplastic agent; bacterial metabolite; nucleoside antibiotic
3-deazaadenosine 3-deazaadenosine: RN given refers to parent cpd.	1.98	1
ampicillin trihydrate [no description available]	2.05	1	hydrate
zidovudine Zidovudine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.. zidovudine : A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase.	2.03	1	azide; pyrimidine 2',3'-dideoxyribonucleoside	antimetabolite; antiviral drug; HIV-1 reverse transcriptase inhibitor
ribavirin Rebetron: Rebetron is tradename	4.76	30	1-ribosyltriazole; aromatic amide; monocarboxylic acid amide; primary carboxamide	anticoronaviral agent; antiinfective agent; antimetabolite; antiviral agent; EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
3-deazaguanine 3-deazaguanine: structure	1.96	1
adefovir adefovir: inhibitor of African swine fever virus. adefovir(1-) : A organophosphonate oxoanion obtained by removal of a proton from the phosphonate group of adefovir, a nucleoside reverse transcriptase inhibitor. It is the major microspecies at pH 7.3 (according to Marvin v 6.2.0.).. adefovir : A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens has been replaced by a 2-(6-amino-9H-purin-9-yl)ethoxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(t-butoxycarbonyloxymethyl) ester (dipivoxil ester) prodrug is used to treat chronic hepatitis B viral infection.	2.4	2	6-aminopurines; ether; phosphonic acids	antiviral drug; DNA synthesis inhibitor; drug metabolite; HIV-1 reverse transcriptase inhibitor; nephrotoxic agent
cidofovir anhydrous Cidofovir: An acyclic nucleoside phosphonate that acts as a competitive inhibitor of viral DNA polymerases. It is used in the treatment of RETINITIS caused by CYTOMEGALOVIRUS INFECTIONS and may also be useful for treating HERPESVIRUS INFECTIONS.. cidofovir anhydrous : Cytosine substituted at the 1 position by a 3-hydroxy-2-(phosphonomethoxy)propyl group (S configuration). A nucleoside analogue, it is an injectable antiviral used for the treatment of cytomegalovirus (CMV) retinitis in AIDS patients.	4.25	17	phosphonic acids; pyrimidone	anti-HIV agent; antineoplastic agent; antiviral drug; photosensitizing agent
efavirenz efavirenz: HIV-1 reverse transcriptase inhibitor. efavirenz : 1,4-Dihydro-2H-3,1-benzoxazin-2-one substituted at the 4 position by cyclopropylethynyl and trifluoromethyl groups (S configuration) and at the 6 position by chlorine. A non-nucleoside reverse transcriptase inhibitor with activity against HIV, it is used with other antiretrovirals for combination therapy of HIV infection.	2.05	1	acetylenic compound; benzoxazine; cyclopropanes; organochlorine compound; organofluorine compound	antiviral drug; HIV-1 reverse transcriptase inhibitor
oseltamivir Oseltamivir: An acetamido cyclohexene that is a structural homolog of SIALIC ACID and inhibits NEURAMINIDASE.. oseltamivir : A cyclohexenecarboxylate ester that is the ethyl ester of oseltamivir acid. An antiviral prodrug (it is hydrolysed to the active free carboxylic acid in the liver), it is used to slow the spread of influenza.	3.67	9	acetamides; amino acid ester; cyclohexenecarboxylate ester; primary amino compound	antiviral drug; EC 3.2.1.18 (exo-alpha-sialidase) inhibitor; environmental contaminant; prodrug; xenobiotic
2-phenylimidazole [no description available]	2.05	1
9-methyladenine 9-methyladenine : Adenine substituted with a methyl group at position N-9.	2.05	1	methyladenine	metabolite
7-methyladenine 7-methyladenine: potential marker for monitoring exposure to methylatingcarcinogens. 7-methyladenine : Adenine substituted with a methyl group at position N-7.	2.05	1	methyladenine	metabolite
9-(s)-(3-hydroxy-2-(phosphonomethoxy)propyl)adenine [no description available]	1.97	1
3-deazaaristeromycin 3-deazaaristeromycin: antagonist of S-adenosylhomocysteinase	2.66	3
8-bromoadenine 8-bromoadenine: affects DNA repair	2.05	1
9-(2,3-dihydroxypropyl)adenine [no description available]	1.95	1
cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine: prodrug for HPMPC; specific name and structure not given in first source	2.03	1
1-deazaadenosine 1-deazaadenosine: inhibits nucleic acid & protein synthesis; structure given in first source	1.99	1
cyclic-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine cyclic-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine: specific name and structure not given in first source	2.02	1
adenosine-5'-carboxaldehyde adenosine-5'-carboxaldehyde: potent inhibitor of S-adenosyl-L-homocysteine hydrolase; structure given in first source. 5'-dehydroadenosine : A member of the class of adenosines that is 5'-dehydro derivative of adenosine.	1.99	1	adenosines
ribothymidine ribothymidine : A methyluridine having a single methyl substituent at the 5-position on the uracil ring.	1.96	1	methyluridine	antigen; Escherichia coli metabolite; human metabolite
brivudine brivudine: anti-herpes agent	4.49	22
dactinomycin Dactinomycin: A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)	2.03	1	actinomycin	mutagen
melphalan Melphalan: An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.. melphalan : A phenylalanine derivative comprising L-phenylalanine having [bis(2-chloroethyl)amino group at the 4-position on the phenyl ring.	2.08	1	L-phenylalanine derivative; nitrogen mustard; non-proteinogenic L-alpha-amino acid; organochlorine compound	alkylating agent; antineoplastic agent; carcinogenic agent; drug allergen; immunosuppressive agent
tenofovir tenofovir (anhydrous) : A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens is replaced by a [(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(isopropyloxycarbonyloxymethyl) ester (disoproxil ester) prodrug is used as the fumaric acid salt in combination therapy for the treatment of HIV infection.	2.03	1	nucleoside analogue; phosphonic acids	antiviral drug; drug metabolite; HIV-1 reverse transcriptase inhibitor
thiocarlide thiocarlide: major descriptor (68-85); on-line search PHENYLTHIOUREA/AA (68-85); Index Medicus search THIOCARLIDE (68-85); Antitubercular Agent	2.04	1	thioureas
quinine [no description available]	2.07	1	cinchona alkaloid	antimalarial; muscle relaxant; non-narcotic analgesic
artesunate artesunic acid: RN given for (3R-(3alpha,5abeta,6beta,8abeta,9alpha,10alpha,12beta,(2aR*))-isomer; succinic ester of artemether	2.48	2	artemisinin derivative; cyclic acetal; dicarboxylic acid monoester; hemisuccinate; semisynthetic derivative; sesquiterpenoid	antimalarial; antineoplastic agent; ferroptosis inducer
gentamicin sulfate [no description available]	2.05	1
clavulanate potassium potassium clavulanate : A potassium salt having clavulanate as the counterion. It acts as a suicide inhibitor of bacterial beta-lactamase enzymes and has only weak anitbiotic activity when administered alone. However it can be used in combination with amoxicillin trihydrate (under the trade name Augmentin) for treatment of a variety of bacterial infections, where it prevents antibiotic inactivation by microbial lactamases.	2.08	1	potassium salt	antibacterial drug; antimicrobial agent; EC 3.5.2.6 (beta-lactamase) inhibitor
acyclovir Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.. acyclovir : An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections.	4.33	19	2-aminopurines; oxopurine	antimetabolite; antiviral drug
ganciclovir [no description available]	4.57	24	2-aminopurines; oxopurine	antiinfective agent; antiviral drug
penciclovir penciclovir : A member of the class of 2-aminopurines that is guanine in which the hydrogen at position 9 is substituted by a 4-hydroxy-3-(hydroxymethyl)but-1-yl group. An antiviral drug, it is administered topically for treatment of herpes labialis. A prodrug, famciclovir, is used for oral administration.	1.97	1	2-aminopurines; propane-1,3-diols	antiviral drug
buciclovir buciclovir: structure given in first source	1.97	1
9-(4-hydroxybutyl)guanine [no description available]	1.97	1
9-(4-hydroxy-2-(hydroxymethyl)butyl)guanine 9-(4-hydroxy-2-(hydroxymethyl)butyl)guanine: structure given in first source	1.97	1
adenallene adenallene: structure given in first source; inhibits replication and cytopathic effects of HIV in vitro	1.97	1

Condition	Relationship Strength	Studies
HIV Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.	1.97	1
Leukemia L 1210 [description not available]	2.38	2
Experimental Mammary Neoplasms [description not available]	1.99	1
Cytomegalovirus A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.	2.43	2

9-(2,3-dihydroxypropyl)adenine, (s)-isomer

Cross-References

Synonyms (19)

Protein Targets (4)

Inhibition Measurements

Biological Processes (105)

Molecular Functions (16)

Ceullar Components (18)

Bioassays (376)

Research

Studies (37)

Market Indicators

Research Demand Index: 11.23

Study Types

9-(2,3-dihydroxypropyl)adenine, (s)-isomer

Cross-References

Synonyms (19)

Protein Targets (4)

Inhibition Measurements

Biological Processes (105)

Molecular Functions (16)

Ceullar Components (18)

Bioassays (376)

Research

Studies (37)

Market Indicators

Research Demand Index: 11.23

Study Types

Related Drugs (59)

Related Conditions (4)