fluconazole has been researched along with Histoplasmosis in 79 studies
Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.
fluconazole : A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.
Histoplasmosis: Infection resulting from exposure to the fungus HISTOPLASMA. It is worldwide in distribution and particularly common in the central and eastern states, especially areas around the Ohio and Mississippi River valleys.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We assessed the efficacy of oral fluconazole (200-800 mg daily) in the treatment of non-life-threatening acute pulmonary histoplasmosis, chronic pulmonary histoplasmosis, or disseminated histoplasmosis in patients without human immunodeficiency virus infection." | 9.08 | Fluconazole therapy for histoplasmosis. The National Institute of Allergy and Infectious Diseases Mycoses Study Group. ( Cloud, GA; Dismukes, WE; Girard, WM; Hamill, RJ; Kauffman, CA; McKinsey, DS; Pappas, PG; Sharkey, PK; Thomas, CJ, 1996) |
| "Eighty-eight immunocompetent patients with deep mycoses from eight countries were evaluated with the same protocol for efficacy of fluconazole monotherapy." | 9.07 | A Pan-American 5-year study of fluconazole therapy for deep mycoses in the immunocompetent host. Pan-American Study Group. ( Arathoon, EG; Borelli, D; Bran, JL; Castro, LG; Diaz, M; Franco, L; Montero-Gei, F; Negroni, R; Restrepo, A; Sampaio, SA, 1992) |
| "In sequential clinical trials of treatment for histoplasmosis in patients with acquired immunodeficiency syndrome, therapy with fluconazole failed in a higher proportion of patients than did therapy with itraconazole." | 7.71 | Emergence of resistance to fluconazole as a cause of failure during treatment of histoplasmosis in patients with acquired immunodeficiency disease syndrome. ( Brizendine, E; Connolly, P; Hafner, R; Smedema, M; Wheat, LJ, 2001) |
| "Ravuconazole (RCZ) was evaluated for efficacy in comparison to fluconazole (FCZ) and itraconazole (ITZ) in murine models of disseminated histoplasmosis." | 7.71 | Efficacy of ravuconazole in treatment of systemic murine histoplasmosis. ( Calderon, L; Clemons, KV; Martinez, M; Stevens, DA, 2002) |
| "To assess the effectiveness of fluconazole for suppression of relapse of histoplasmosis in patients with acquired immunodeficiency syndrome (AIDS)." | 7.69 | Prevention of relapse of histoplasmosis with fluconazole in patients with the acquired immunodeficiency syndrome. ( Baker, R; Black, J; Driks, M; Israel, K; Katz, B; Lancaster, D; McKinsey, D; Norris, S; Traeger, D; Wheat, J, 1994) |
| "This study assesses the efficacy and safety of fluconazole therapy in patients with acquired immunodeficiency syndrome (AIDS) and mild to moderately severe manifestations of disseminated histoplasmosis." | 7.69 | Treatment of histoplasmosis with fluconazole in patients with acquired immunodeficiency syndrome. National Institute of Allergy and Infectious Diseases Acquired Immunodeficiency Syndrome Clinical Trials Group and Mycoses Study Group. ( Bamberger, D; Chen, D; Cheung, T; Dismukes, W; Hafner, R; Hamill, R; Hyslop, N; Johnson, P; Kauffman, C; Koletar, S; Korzun, A; Lai, KK; Larsen, RA; MaWhinney, S; McKinsey, D; Pappas, P; Powderly, W; Saag, M; Schneider, D; Shakan, KJ; Squires, K; Stansell, J; Wheat, J, 1997) |
| "Fluconazole (UK-49,858) was compared with amphotericin B in treating histoplasmosis in female AKR mice immunosuppressed with either cyclophosphamide or cortisone." | 7.67 | Comparison of fluconazole and amphotericin B in treating histoplasmosis in immunosuppressed mice. ( Kobayashi, GS; Medoff, G; Travis, SJ, 1987) |
| "Fluconazole was compared with ketoconazole and with amphotericin B in treatment of pulmonary histoplasmosis in immunologically intact mice and in congenitally athymic nude mice." | 7.67 | Treatment of murine histoplasmosis with UK 49,858 (fluconazole). ( Ahrens, J; Graybill, JR; Palou, E, 1986) |
| "In separate trials in patients with AIDS, clinical response was similar with itraconazole (85%) and fluconazole (74%)." | 5.31 | Antigen clearance during treatment of disseminated histoplasmosis with itraconazole versus fluconazole in patients with AIDS. ( Brizendine, E; Connolly, P; Haddad, N; Hafner, R; Le Monte, A; Wheat, LJ, 2002) |
| "We assessed the efficacy of oral fluconazole (200-800 mg daily) in the treatment of non-life-threatening acute pulmonary histoplasmosis, chronic pulmonary histoplasmosis, or disseminated histoplasmosis in patients without human immunodeficiency virus infection." | 5.08 | Fluconazole therapy for histoplasmosis. The National Institute of Allergy and Infectious Diseases Mycoses Study Group. ( Cloud, GA; Dismukes, WE; Girard, WM; Hamill, RJ; Kauffman, CA; McKinsey, DS; Pappas, PG; Sharkey, PK; Thomas, CJ, 1996) |
| "Eighty-eight immunocompetent patients with deep mycoses from eight countries were evaluated with the same protocol for efficacy of fluconazole monotherapy." | 5.07 | A Pan-American 5-year study of fluconazole therapy for deep mycoses in the immunocompetent host. Pan-American Study Group. ( Arathoon, EG; Borelli, D; Bran, JL; Castro, LG; Diaz, M; Franco, L; Montero-Gei, F; Negroni, R; Restrepo, A; Sampaio, SA, 1992) |
| "These findings support careful monitoring for relapse in patients receiving voriconazole treatment for histoplasmosis, particularly in those who were previously treated with fluconazole." | 3.73 | Activity of newer triazoles against Histoplasma capsulatum from patients with AIDS who failed fluconazole. ( Brizendine, E; Connolly, P; Durkin, M; Goldman, M; Mann, P; McNicholas, PM; Patel, R; Smedema, M; Wheat, LJ, 2006) |
| "In sequential clinical trials of treatment for histoplasmosis in patients with acquired immunodeficiency syndrome, therapy with fluconazole failed in a higher proportion of patients than did therapy with itraconazole." | 3.71 | Emergence of resistance to fluconazole as a cause of failure during treatment of histoplasmosis in patients with acquired immunodeficiency disease syndrome. ( Brizendine, E; Connolly, P; Hafner, R; Smedema, M; Wheat, LJ, 2001) |
| "Ravuconazole (RCZ) was evaluated for efficacy in comparison to fluconazole (FCZ) and itraconazole (ITZ) in murine models of disseminated histoplasmosis." | 3.71 | Efficacy of ravuconazole in treatment of systemic murine histoplasmosis. ( Calderon, L; Clemons, KV; Martinez, M; Stevens, DA, 2002) |
| "A 49-year-old man with disseminated histoplasmosis (pulmonary and central nervous system involvement) successfully treated with ketoconazole and fluconazole combination is reported." | 3.70 | [Disseminated histoplasmosis caused by Histoplasma capsulatum with cerebral involvement occurring 13 years after the primary infection]. ( Astoul, P; Bérard, H; Boutin, C; Cho, K; Cuguillière, A; Frenay, C, 1999) |
| "This study assesses the efficacy and safety of fluconazole therapy in patients with acquired immunodeficiency syndrome (AIDS) and mild to moderately severe manifestations of disseminated histoplasmosis." | 3.69 | Treatment of histoplasmosis with fluconazole in patients with acquired immunodeficiency syndrome. National Institute of Allergy and Infectious Diseases Acquired Immunodeficiency Syndrome Clinical Trials Group and Mycoses Study Group. ( Bamberger, D; Chen, D; Cheung, T; Dismukes, W; Hafner, R; Hamill, R; Hyslop, N; Johnson, P; Kauffman, C; Koletar, S; Korzun, A; Lai, KK; Larsen, RA; MaWhinney, S; McKinsey, D; Pappas, P; Powderly, W; Saag, M; Schneider, D; Shakan, KJ; Squires, K; Stansell, J; Wheat, J, 1997) |
| "The efficacy of D0870 was studied in a murine model of systemic histoplasmosis and was compared with that of fluconazole." | 3.69 | Efficacy of the triazole D0870 in a murine model of systemic histoplasmosis. ( Clemons, KV; Stevens, DA, 1995) |
| "To assess the effectiveness of fluconazole for suppression of relapse of histoplasmosis in patients with acquired immunodeficiency syndrome (AIDS)." | 3.69 | Prevention of relapse of histoplasmosis with fluconazole in patients with the acquired immunodeficiency syndrome. ( Baker, R; Black, J; Driks, M; Israel, K; Katz, B; Lancaster, D; McKinsey, D; Norris, S; Traeger, D; Wheat, J, 1994) |
| "An AIDS patient with disseminated histoplasmosis who improved during treatment with fluconazole but remained fungemic and subsequently relapsed is described." | 3.69 | Hypothesis on the mechanism of resistance to fluconazole in Histoplasma capsulatum. ( Connolly, P; Le Monte, A; Marichal, P; Vanden Bossche, H; Wheat, J, 1997) |
| "Fluconazole (UK-49,858) was compared with amphotericin B in treating histoplasmosis in female AKR mice immunosuppressed with either cyclophosphamide or cortisone." | 3.67 | Comparison of fluconazole and amphotericin B in treating histoplasmosis in immunosuppressed mice. ( Kobayashi, GS; Medoff, G; Travis, SJ, 1987) |
| "Fluconazole was compared with ketoconazole and with amphotericin B in treatment of pulmonary histoplasmosis in immunologically intact mice and in congenitally athymic nude mice." | 3.67 | Treatment of murine histoplasmosis with UK 49,858 (fluconazole). ( Ahrens, J; Graybill, JR; Palou, E, 1986) |
| "20 patients (18 men, 2 women), 10 of whom were HIV +, were given Fluconazole (F) for either systemic candidiasis (13 cases), histoplasmosis (1), or cryptococcosis (6)." | 3.67 | [Value of fluconazole in the treatment of systemic yeast infection]. ( Bernard, E; Carles, M; Dellamonica, P; Fournier, JP; Toussaint-Gari, M, 1989) |
| "Fluconazole treatment was successful in 53% of the patients." | 2.67 | Efficacy of fluconazole in the treatment of systemic fungal infections. ( Milatovic, D; Voss, A, 1992) |
| "Treatment with fluconazole was initiated, and the patient's symptoms gradually improved." | 2.45 | [Central nervous system histoplasmosis]. ( Hamada, M; Tsuji, S, 2009) |
| "Disseminated histoplasmosis is an AIDS-defining illness that occurs in about 5% of AIDS patients residing in histoplasmosis-endemic areas of the United States (the Mississippi and Ohio river valleys)." | 2.39 | Disseminated histoplasmosis in persons infected with human immunodeficiency virus. ( Hajjeh, RA, 1995) |
| "Histoplasmosis is a frequent complication of HIV infection and is usually the result of reactivation." | 2.39 | Oral histoplasmosis in a patient infected with HIV. A case report. ( Durham, T; Johansson, SL; Kaufman, L; Swindells, S, 1994) |
| "Histoplasmosis has become an important mycosis in regions of endemicity in North and Central America." | 2.39 | Histoplasmosis: recognition and treatment. ( Wheat, J, 1994) |
| "In patients with AIDS with cryptococcosis, prompt diagnosis is essential." | 2.39 | Management of systemic manifestations of fungal disease in patients with AIDS. ( Stevens, DA, 1994) |
| "Histoplasmosis has emerged as the leading opportunistic infection in patients with AIDS from Indianapolis." | 2.38 | Histoplasmosis in Indianapolis. ( Wheat, LJ, 1992) |
| "Histoplasmosis is the second most common fungal infection reported among domestic felines in the United States." | 1.56 | Mediastinal histoplasmosis with cardiac involvement in a cat. ( Anselmi, C; Boyd, N; Pohlman, L; Thomason, J, 2020) |
| "Laryngeal histoplasmosis is very rare among patients with HIV and very few cases have so far been documented." | 1.37 | Hoarseness of voice in an AIDS patient: a rare presenting feature of disseminated histoplasmosis. ( Palfrey, J; Randall, CJ; Rowen, D; Sanmani, L, 2011) |
| "Only disseminated histoplasmosis is recognized as causing a different reaction which consists of ingestion of organisms by macrophages without granuloma formation." | 1.36 | Biopsy findings in acute pulmonary histoplasmosis: unusual histologic features in 4 cases mimicking lymphomatoid granulomatosis. ( Katzenstein, AL; Mukhopadhyay, S, 2010) |
| "A case of cutaneous histoplasmosis is reported in an 80-year-old man with rheumatoid arthritis who had been treated with steroid therapy for 15 years." | 1.31 | Case report. Primary cutaneous histoplasmosis in an immunosuppressed patient. ( Castelli, A; Laurini, L; Massai, L; Romano, C, 2000) |
| "In separate trials in patients with AIDS, clinical response was similar with itraconazole (85%) and fluconazole (74%)." | 1.31 | Antigen clearance during treatment of disseminated histoplasmosis with itraconazole versus fluconazole in patients with AIDS. ( Brizendine, E; Connolly, P; Haddad, N; Hafner, R; Le Monte, A; Wheat, LJ, 2002) |
| "Fluconazole was less effective as a single agent than was amphotericin B, despite the greater penetration of fluconazole into brain tissues." | 1.31 | Antifungal therapy for central nervous system histoplasmosis, using a newly developed intracranial model of infection. ( Brizendine, E; Connolly, PA; Durkin, MM; Haynes, RR; LeMonte, AM; Smedema, ML; Wheat, LJ, 2002) |
| "Histoplasmosis is an important cause of morbidity and death in HIV-infected patients." | 1.30 | Histoplasmosis: update 1998. ( Brooks, JT; Wheat, LJ, 1998) |
| "She developed pancytopaenia and disseminated intravascular coagulation." | 1.30 | Disseminated histoplasmosis in a non-immunocompromised child. ( Hasliza, M; Hussain, IH; Lim, CB; Nur Atiqah, NA, 1999) |
| "The use of preventive treatment for fungal infections is cautioned due to the possibility of resistance to treatment." | 1.29 | Fungal infection overview. ( , 1995) |
| "We report here a case of Histoplasma capsulatum infection in such a Hong Kong Chinese patient who presented with fever and peritonitis." | 1.28 | Histoplasma capsulatum infection associated with continuous ambulatory peritoneal dialysis. ( Chan, PC; Chau, SP; Cheng, IK; Lim, W, 1991) |
| " The differences in the efficacies of the triazoles appeared to be due to differences in their pharmacokinetics and the dosage schedule that was used." | 1.28 | In vitro and in vivo activities of Sch 39304, fluconazole, and amphotericin B against Histoplasma capsulatum. ( Kobayashi, GS; Medoff, G; Rinaldi, MG; Travis, SJ, 1990) |
| "Treatment with amphotericin B followed by fluconazole was effective." | 1.28 | Disseminated histoplasmosis in a Danish patient with AIDS. ( Franzmann, M; Mathiesen, LR; Smith, E, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (7.59) | 18.7374 |
| 1990's | 38 (48.10) | 18.2507 |
| 2000's | 26 (32.91) | 29.6817 |
| 2010's | 7 (8.86) | 24.3611 |
| 2020's | 2 (2.53) | 2.80 |
| Authors | Studies |
|---|---|
| Murray, M | 1 |
| Hine, P | 1 |
| Boyd, N | 1 |
| Thomason, J | 1 |
| Pohlman, L | 1 |
| Anselmi, C | 1 |
| Spec, A | 1 |
| Connolly, P | 5 |
| Montejano, R | 1 |
| Wheat, LJ | 9 |
| Brilhante, RSN | 1 |
| Guedes, GMM | 1 |
| Silva, MLQD | 1 |
| Castelo-Branco, DSCM | 1 |
| Cordeiro, RA | 2 |
| Sidrim, JJC | 1 |
| Rocha, MFG | 1 |
| Hamada, M | 1 |
| Tsuji, S | 1 |
| Pereira, GH | 1 |
| Pádua, SS | 1 |
| Park, MV | 1 |
| Muller, RP | 1 |
| Passos, RM | 1 |
| Menezes, Y | 1 |
| Mehta, V | 1 |
| De, A | 1 |
| Balachandran, C | 1 |
| Monga, P | 1 |
| Mukhopadhyay, S | 1 |
| Katzenstein, AL | 1 |
| Addidle, M | 1 |
| Pynn, J | 1 |
| Skellern, P | 1 |
| Kasuga, T | 1 |
| Grimwade, K | 1 |
| Clemans, JM | 1 |
| Deitz, KL | 1 |
| Riedesel, EA | 1 |
| Yaeger, MJ | 1 |
| Legendre, AM | 1 |
| Sanmani, L | 1 |
| Randall, CJ | 1 |
| Palfrey, J | 1 |
| Rowen, D | 1 |
| Brilhante, RS | 1 |
| Fechine, MA | 1 |
| Mesquita, JR | 1 |
| Rocha, MF | 1 |
| Monteiro, AJ | 1 |
| Lima, RA | 1 |
| Caetano, ÉP | 1 |
| Pereira, JF | 1 |
| Castelo-Branco, DS | 1 |
| Camargo, ZP | 1 |
| Sidrim, JJ | 1 |
| Kurowski, R | 1 |
| Ostapchuk, M | 1 |
| Nasr, SH | 1 |
| Koscica, J | 1 |
| Markowitz, GS | 1 |
| D'Agati, VD | 1 |
| Richter, M | 1 |
| Hauser, B | 1 |
| Kaps, S | 1 |
| Spiess, BM | 1 |
| Levi, GC | 1 |
| Pozzi, CM | 1 |
| Hirschheimer, SM | 1 |
| Chahade, WH | 1 |
| Gomes, HR | 1 |
| Granato, C | 1 |
| McDonald, HR | 1 |
| Joseph Wheat, L | 1 |
| Pietrobon, D | 1 |
| Negro-Marquínez, L | 1 |
| Kilstein, J | 1 |
| Galíndez, J | 1 |
| Greca, A | 1 |
| Battagliotti, C | 1 |
| Jenny-Avital, E | 2 |
| Musial, CE | 1 |
| Gasparetto, EL | 1 |
| Carvalho Neto, Ad | 1 |
| Alberton, J | 1 |
| Davaus, T | 1 |
| Pianovski, MA | 1 |
| Yamauchi, E | 1 |
| Torres, LF | 1 |
| Bun Navy, K | 1 |
| Prem Prey, S | 1 |
| Lynen, L | 1 |
| Sovanna, P | 1 |
| Bell, JD | 1 |
| Harwell, JI | 1 |
| Smedema, M | 2 |
| Durkin, M | 1 |
| Brizendine, E | 4 |
| Mann, P | 1 |
| Patel, R | 1 |
| McNicholas, PM | 1 |
| Goldman, M | 1 |
| Shimamoto, A | 1 |
| Takao, M | 1 |
| Shomura, S | 1 |
| Tarukawa, T | 1 |
| Shimpo, H | 1 |
| Chipungu, GA | 1 |
| Christians, SJ | 1 |
| Oliver, SP | 1 |
| Lewin, SR | 1 |
| Street, AC | 1 |
| Clemons, KV | 2 |
| Stevens, DA | 3 |
| Wan, P | 1 |
| Yan, QH | 1 |
| Gao, C | 1 |
| Becherer, PR | 1 |
| Sokol-Anderson, M | 1 |
| Joist, JH | 1 |
| Milligan, T | 1 |
| Wheat, J | 4 |
| Norris, S | 1 |
| McKinsey, D | 2 |
| Lancaster, D | 1 |
| Katz, B | 1 |
| Black, J | 1 |
| Driks, M | 1 |
| Baker, R | 1 |
| Israel, K | 1 |
| Traeger, D | 1 |
| Bridge, KS | 1 |
| Goodpasture, HC | 1 |
| Swindells, S | 1 |
| Durham, T | 1 |
| Johansson, SL | 1 |
| Kaufman, L | 1 |
| Maholtz, MS | 1 |
| Dauber, JH | 1 |
| Yousem, SA | 1 |
| Drew, RH | 1 |
| Sharkey-Mathis, PK | 1 |
| Velez, J | 1 |
| Fetchick, R | 1 |
| Graybill, JR | 4 |
| Hajjeh, RA | 1 |
| Walsh, TJ | 1 |
| Gonzalez, C | 1 |
| Lyman, CA | 1 |
| Chanock, SJ | 1 |
| Pizzo, PA | 1 |
| McKinsey, DS | 1 |
| Kauffman, CA | 1 |
| Pappas, PG | 1 |
| Cloud, GA | 1 |
| Girard, WM | 1 |
| Sharkey, PK | 1 |
| Hamill, RJ | 2 |
| Thomas, CJ | 1 |
| Dismukes, WE | 1 |
| Marichal, P | 1 |
| Vanden Bossche, H | 1 |
| Le Monte, A | 2 |
| MaWhinney, S | 1 |
| Hafner, R | 3 |
| Chen, D | 1 |
| Korzun, A | 1 |
| Shakan, KJ | 1 |
| Johnson, P | 1 |
| Hamill, R | 1 |
| Bamberger, D | 1 |
| Pappas, P | 1 |
| Stansell, J | 1 |
| Koletar, S | 1 |
| Squires, K | 1 |
| Larsen, RA | 1 |
| Cheung, T | 1 |
| Hyslop, N | 1 |
| Lai, KK | 1 |
| Schneider, D | 1 |
| Kauffman, C | 1 |
| Saag, M | 1 |
| Dismukes, W | 1 |
| Powderly, W | 1 |
| Katz, BJ | 1 |
| Scott, WE | 1 |
| Folk, JC | 1 |
| Berenguer Berenguer, J | 1 |
| Najvar, LK | 1 |
| Bocanegra, R | 2 |
| Hector, RF | 1 |
| Luther, MF | 1 |
| Najvar, L | 1 |
| Fothergill, A | 1 |
| de las Heras, FG | 1 |
| de Pauw, BE | 1 |
| Meunier, F | 1 |
| Onwuasoigwe, O | 1 |
| Knapp, S | 1 |
| Turnherr, M | 1 |
| Dekan, G | 1 |
| Willinger, B | 1 |
| Stingl, G | 1 |
| Rieger, A | 1 |
| Bérard, H | 1 |
| Astoul, P | 1 |
| Frenay, C | 1 |
| Cuguillière, A | 1 |
| Cho, K | 1 |
| Boutin, C | 1 |
| Romano, C | 1 |
| Castelli, A | 1 |
| Laurini, L | 1 |
| Massai, L | 1 |
| LeMonte, AM | 2 |
| Washum, KE | 1 |
| Smedema, ML | 2 |
| Schnizlein-Bick, C | 1 |
| Kohler, SM | 1 |
| Hasliza, M | 1 |
| Nur Atiqah, NA | 1 |
| Lim, CB | 1 |
| Hussain, IH | 1 |
| Brooks, JT | 1 |
| Briand, V | 1 |
| Lortholary, O | 2 |
| André, MH | 1 |
| Haddad, N | 1 |
| Mignogna, MD | 1 |
| Fedele, S | 1 |
| Lo Russo, L | 1 |
| Ruoppo, E | 1 |
| Lo Muzio, L | 1 |
| Martinez, M | 1 |
| Calderon, L | 1 |
| Haynes, RR | 1 |
| Connolly, PA | 1 |
| Durkin, MM | 1 |
| Darouiche, RO | 1 |
| Cadle, RM | 1 |
| Zenon, GJ | 1 |
| Weinert, MF | 1 |
| Lidsky, MD | 1 |
| Schaberg, T | 1 |
| Lode, H | 1 |
| Milatovic, D | 1 |
| Voss, A | 1 |
| Diaz, M | 1 |
| Negroni, R | 1 |
| Montero-Gei, F | 1 |
| Castro, LG | 1 |
| Sampaio, SA | 1 |
| Borelli, D | 1 |
| Restrepo, A | 1 |
| Franco, L | 1 |
| Bran, JL | 1 |
| Arathoon, EG | 1 |
| Tiraboschi, I | 1 |
| Casas Parera, I | 1 |
| Pikielny, R | 1 |
| Scattini, G | 1 |
| Micheli, F | 1 |
| Pottage, JC | 1 |
| Sha, BE | 1 |
| Lim, W | 1 |
| Chau, SP | 1 |
| Chan, PC | 1 |
| Cheng, IK | 1 |
| Kobayashi, GS | 3 |
| Travis, SJ | 2 |
| Rinaldi, MG | 1 |
| Medoff, G | 3 |
| Bernard, E | 1 |
| Carles, M | 1 |
| Toussaint-Gari, M | 1 |
| Fournier, JP | 1 |
| Dellamonica, P | 1 |
| Smith, E | 1 |
| Franzmann, M | 1 |
| Mathiesen, LR | 1 |
| Travis, S | 1 |
| Palou, E | 1 |
| Ahrens, J | 1 |
| Polak, A | 1 |
| Dixon, DM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open Intravenous Multiple Dose, Multi-Center Study to Investigate the Pharmacokinetics, Safety and Toleration of Voriconazole in Children Aged 2-12 Years Who Require Treatment for the Prevention of Systemic Fungal Infection[NCT00005912] | Phase 1 | 48 participants | Interventional | 2000-06-30 | Completed | ||
| A Phase II Trial to Evaluate the Safety and Tolerability of Nebulised Amphotericin B Lipid Complex (ABELCET®) in the Prophylaxis of Invasive Pulmonary Aspergillosis During Prolonged Neutropenia in Paediatric Patients With Acute Leukaemia[NCT01615809] | Phase 2 | 32 participants (Actual) | Interventional | 2011-10-31 | Completed | ||
| Phase I Study of the Safety, Tolerance, and Pharmacokinetics of FK463 in Immunocompromised Children With Fever and Neutropenia[NCT00001790] | Phase 1 | 120 participants | Interventional | 1998-10-31 | Completed | ||
| Pilot Study to Determine the Feasibility of Fluconazole for Induction Treatment and Suppression of Relapse of Histoplasmosis in Patients With the Acquired Immunodeficiency Syndrome[NCT00000627] | 90 participants | Interventional | Completed | ||||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The incidence of invasive pulmonary aspergillosis during the Abelcet® prophylactic treatment period was assessed by the relation between the number of patients with invasive pulmonary aspergillosis and the number of paediatric patients on prophylaxis with Acute Leukaemia (AL) undergoing intensive chemotherapy. (NCT01615809)
Timeframe: at the Baseline visit (week 1) and at the end of the profilaxis treatment phase, up to 6 weeks
| Intervention | participants (Number) |
|---|---|
| Amphotericin B (ABELCET®) | 3 |
Percentage of deaths related to Invasive Pulmonary Aspergillosis during the prophylactic treatment period with Abelcet® in paediatric patients with Acute Leukaemia undergoing intensive chemotherapy. (NCT01615809)
Timeframe: at the Baseline visit (week 1) and at the end of the profilaxis treatment phase, up to 6 weeks
| Intervention | percentage of deaths (Number) |
|---|---|
| Amphotericin B (ABELCET®) | 0 |
is assessed by the proportion of patients who discontinue prophylactic treatment with Abelcet® due to an adverse event that is related or not to the study drug or for intolerability to it. The last week of treatment will have a different calendar for each participant, depending on the number of cicles needed by each patient (it has been anticipated up to 5 cicles of 2-6 weeks each). (NCT01615809)
Timeframe: at the Baseline visit (week 1) and during the Last week of treatment, up to 6 weeks
| Intervention | participants (Number) |
|---|---|
| Amphotericin B (ABELCET®) | 0 |
16 reviews available for fluconazole and Histoplasmosis
| Article | Year |
|---|---|
Treating progressive disseminated histoplasmosis in people living with HIV.
Topics: Amphotericin B; Anti-HIV Agents; Antifungal Agents; Cohort Studies; Deoxycholic Acid; Drug Administr | 2020 |
[Central nervous system histoplasmosis].
Topics: Antifungal Agents; Central Nervous System Fungal Infections; Cerebrospinal Fluid; Diagnosis, Differe | 2009 |
Overview of histoplasmosis.
Topics: Amphotericin B; Antifungal Agents; Diagnosis, Differential; Fluconazole; Histoplasmosis; Humans; Itr | 2002 |
[Disseminated histoplasmosis and AIDS in an Argentine hospital: clinical manifestations, diagnosis and treatment].
Topics: Adolescent; Adult; AIDS-Related Opportunistic Infections; Amphotericin B; Antifungal Agents; Argenti | 2004 |
Diagnosis and management of central nervous system histoplasmosis.
Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; Amphotericin B; Antifungal Agents; Female; Fluconaz | 2005 |
Histoplasmosis: recognition and treatment.
Topics: Amphotericin B; Fluconazole; Histoplasmosis; Humans; Itraconazole; Ketoconazole; Serologic Tests | 1994 |
Management of systemic manifestations of fungal disease in patients with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Amphotericin B; Coccidioidomycosis; Cryptococcosis; Drug Therapy | 1994 |
Oral histoplasmosis in a patient infected with HIV. A case report.
Topics: Adult; AIDS-Related Opportunistic Infections; Fluconazole; Histoplasmosis; Humans; Male; Metronidazo | 1994 |
Pharmacotherapy of disseminated histoplasmosis in patients with AIDS.
Topics: AIDS-Related Opportunistic Infections; Amphotericin B; Antifungal Agents; Clinical Trials as Topic; | 1993 |
Disseminated histoplasmosis in persons infected with human immunodeficiency virus.
Topics: AIDS-Related Opportunistic Infections; Antifungal Agents; Fluconazole; Histoplasmosis; Humans; Incid | 1995 |
Invasive fungal infections in children: recent advances in diagnosis and treatment.
Topics: Amphotericin B; Aspergillosis; Candidiasis; Child; Coccidioidomycosis; Cytokines; Diagnosis, Differe | 1996 |
Invasive fungal infections in children: recent advances in diagnosis and treatment.
Topics: Amphotericin B; Aspergillosis; Candidiasis; Child; Coccidioidomycosis; Cytokines; Diagnosis, Differe | 1996 |
Invasive fungal infections in children: recent advances in diagnosis and treatment.
Topics: Amphotericin B; Aspergillosis; Candidiasis; Child; Coccidioidomycosis; Cytokines; Diagnosis, Differe | 1996 |
Invasive fungal infections in children: recent advances in diagnosis and treatment.
Topics: Amphotericin B; Aspergillosis; Candidiasis; Child; Coccidioidomycosis; Cytokines; Diagnosis, Differe | 1996 |
Invasive fungal infections in children: recent advances in diagnosis and treatment.
Topics: Amphotericin B; Aspergillosis; Candidiasis; Child; Coccidioidomycosis; Cytokines; Diagnosis, Differe | 1996 |
Invasive fungal infections in children: recent advances in diagnosis and treatment.
Topics: Amphotericin B; Aspergillosis; Candidiasis; Child; Coccidioidomycosis; Cytokines; Diagnosis, Differe | 1996 |
Invasive fungal infections in children: recent advances in diagnosis and treatment.
Topics: Amphotericin B; Aspergillosis; Candidiasis; Child; Coccidioidomycosis; Cytokines; Diagnosis, Differe | 1996 |
Invasive fungal infections in children: recent advances in diagnosis and treatment.
Topics: Amphotericin B; Aspergillosis; Candidiasis; Child; Coccidioidomycosis; Cytokines; Diagnosis, Differe | 1996 |
Invasive fungal infections in children: recent advances in diagnosis and treatment.
Topics: Amphotericin B; Aspergillosis; Candidiasis; Child; Coccidioidomycosis; Cytokines; Diagnosis, Differe | 1996 |
[Commonly used antifungal agents in the treatment of systemic mycoses].
Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Blastomycosis; Candidiasis; Clinical Trials as Top | 1995 |
The challenge of invasive fungal infection.
Topics: AIDS-Related Opportunistic Infections; Amphotericin B; Antifungal Agents; Aspergillosis; Candidiasis | 1999 |
A case of oral localized histoplasmosis in an immunocompetent patient.
Topics: Adult; Antifungal Agents; Fluconazole; Follow-Up Studies; Histoplasma; Histoplasmosis; Humans; Immun | 2001 |
Histoplasmosis in Indianapolis.
Topics: Amphotericin B; Disease Outbreaks; Fluconazole; Histoplasmosis; Humans; Indiana; Itraconazole; Ketoc | 1992 |
[Therapy of pulmonary mycoses].
Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillosis, Allergic Bronchopulmonary; Blastomy | 1992 |
3 trials available for fluconazole and Histoplasmosis
| Article | Year |
|---|---|
Fluconazole therapy for histoplasmosis. The National Institute of Allergy and Infectious Diseases Mycoses Study Group.
Topics: Female; Fluconazole; Follow-Up Studies; Histoplasmosis; Humans; Male; Multicenter Studies as Topic; | 1996 |
Efficacy of fluconazole in the treatment of systemic fungal infections.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aspergillosis; Candidiasis; Female; Fluconazole; Fungemi | 1992 |
A Pan-American 5-year study of fluconazole therapy for deep mycoses in the immunocompetent host. Pan-American Study Group.
Topics: Adolescent; Adult; Aged; Chromoblastomycosis; Coccidioidomycosis; Female; Fluconazole; Fungi; Histop | 1992 |
60 other studies available for fluconazole and Histoplasmosis
| Article | Year |
|---|---|
Mediastinal histoplasmosis with cardiac involvement in a cat.
Topics: Animals; Antifungal Agents; Biopsy, Fine-Needle; Cat Diseases; Cats; Diagnosis, Differential; Echoca | 2020 |
In vitro activity of isavuconazole against fluconazole-resistant isolates of Histoplasma capsulatum.
Topics: Antifungal Agents; Drug Resistance, Fungal; Fluconazole; Histoplasma; Histoplasmosis; Humans; Microb | 2018 |
A proposal for antifungal epidemiological cut-off values against Histoplasma capsulatum var. capsulatum based on the susceptibility of isolates from HIV-infected patients with disseminated histoplasmosis in Northeast Brazil.
Topics: Amphotericin B; Antifungal Agents; Brazil; Caspofungin; Echinocandins; Fluconazole; Histoplasma; His | 2018 |
Chronic meningitis by histoplasmosis: report of a child with acute myeloid leukemia.
Topics: Acute Disease; Adolescent; Amphotericin B; Antifungal Agents; Chronic Disease; Deoxycholic Acid; Dru | 2008 |
Mucocutaneous histoplasmosis in HIV with an atypical ecthyma like presentation.
Topics: Adult; Agricultural Workers' Diseases; AIDS-Related Opportunistic Infections; Anti-Bacterial Agents; | 2009 |
Biopsy findings in acute pulmonary histoplasmosis: unusual histologic features in 4 cases mimicking lymphomatoid granulomatosis.
Topics: Adult; Antifungal Agents; Biopsy; Diagnosis, Differential; Female; Fluconazole; Granuloma; Histiocyt | 2010 |
Chronic disseminated histoplasmosis with prolonged latency.
Topics: Adrenal Glands; Aged, 80 and over; Chronic Disease; Fatal Outcome; Fluconazole; Histoplasma; Histopl | 2010 |
Retroperitoneal pyogranulomatous and fibrosing inflammation secondary to fungal infections in two dogs.
Topics: Animals; Anti-Bacterial Agents; Antifungal Agents; Blastomyces; Blastomycosis; Dog Diseases; Dogs; D | 2011 |
Hoarseness of voice in an AIDS patient: a rare presenting feature of disseminated histoplasmosis.
Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Antifungal Agents; Fluconazole; Histoplasm | 2011 |
Histoplasmosis in HIV-positive patients in Ceará, Brazil: clinical-laboratory aspects and in vitro antifungal susceptibility of Histoplasma capsulatum isolates.
Topics: Adult; AIDS-Related Opportunistic Infections; Amphotericin B; Antifungal Agents; Brazil; Caspofungin | 2012 |
Granulomatous interstitial nephritis.
Topics: Anti-Inflammatory Agents; Antifungal Agents; Antigens, Fungal; Diagnosis, Differential; Drug Combina | 2003 |
Keratitis due to Histoplasma spp. in a horse.
Topics: Animals; Antifungal Agents; Diagnosis, Differential; Fluconazole; Histoplasma; Histoplasmosis; Horse | 2003 |
[Central nervous system involvement by histoplasmosis as the unique manifestation of this disease in immunocompetent patients: presentation of two cases].
Topics: Adult; Antifungal Agents; Central Nervous System Fungal Infections; Child; Female; Fluconazole; Hist | 2003 |
Diagnostic and therapeutic challenges.
Topics: Adolescent; Antifungal Agents; Choroiditis; Complement Fixation Tests; Diagnosis, Differential; Eye | 2003 |
Therapy for severe histoplasmosis: what's best?
Topics: Amphotericin B; Antifungal Agents; Chemistry, Pharmaceutical; Drug Combinations; Fluconazole; Histop | 2004 |
Successful discontinuation of high-dose fluconazole for Histoplasma capsulatum meningitis in an AIDS patient after sustained immune reconstitution.
Topics: Acquired Immunodeficiency Syndrome; Anti-Retroviral Agents; Antifungal Agents; CD4 Lymphocyte Count; | 2004 |
[Histoplasmoma as isolated central nervous system lesion in an immunocompetent patient].
Topics: Adolescent; Antifungal Agents; Biopsy; Central Nervous System Fungal Infections; Fluconazole; Histop | 2005 |
The first reported cases of disseminated histoplasmosis in Cambodia, complicated by multiple opportunistic infections.
Topics: Adult; AIDS-Related Opportunistic Infections; Amphotericin B; Antifungal Agents; Cambodia; Female; F | 2005 |
Activity of newer triazoles against Histoplasma capsulatum from patients with AIDS who failed fluconazole.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Opportunistic Infections; Amino Acid Substitution; | 2006 |
Pulmonary histoplasmosis as an example of imported mycoses in Japan.
Topics: Bolivia; Fluconazole; Histoplasmosis; Humans; Japan; Lung Diseases, Fungal; Male; Middle Aged; Trave | 2007 |
Cutaneous cryptococcosis erroneously diagnosed as Histoplasma capsulatum infection.
Topics: Adult; AIDS-Related Opportunistic Infections; Antifungal Agents; Cryptococcosis; Diagnostic Errors; | 2008 |
Disseminated histoplasmosis: successful maintenance therapy with oral fluconazole.
Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Adult; Australia; El Salvador; Female; Flu | 1995 |
Efficacy of the triazole D0870 in a murine model of systemic histoplasmosis.
Topics: Animals; Antifungal Agents; Female; Fluconazole; Histoplasmosis; Liver; Mice; Spleen; Triazoles | 1995 |
[Case report of pulmonary histoplasmosis].
Topics: Adult; Fluconazole; Histoplasmosis; Humans; Lung Diseases, Fungal; Male | 1994 |
Gastrointestinal histoplasmosis presenting as hematochezia in human immunodeficiency virus-infected hemophilic patients.
Topics: Acquired Immunodeficiency Syndrome; Amphotericin B; Diagnosis, Differential; Fluconazole; Gastrointe | 1994 |
Prevention of relapse of histoplasmosis with fluconazole in patients with the acquired immunodeficiency syndrome.
Topics: AIDS-Related Opportunistic Infections; Fluconazole; Histoplasmosis; Humans; Recurrence; Retrospectiv | 1994 |
Disseminated histoplasmosis treated with fluconazole.
Topics: Acute Disease; Fluconazole; Histoplasmosis; Humans; Male; Middle Aged | 1994 |
Case report: fluconazole therapy in histoplasma mediastinal granuloma.
Topics: Adult; Fluconazole; Granuloma; Histoplasmosis; Humans; Male; Mediastinal Diseases | 1994 |
Histoplasmosis in the acquired immunodeficiency syndrome (AIDS): treatment with itraconazole and fluconazole.
Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; Amphotericin B; Antifungal Agents; Fluconazole; His | 1993 |
Hypothesis on the mechanism of resistance to fluconazole in Histoplasma capsulatum.
Topics: Adult; AIDS-Related Opportunistic Infections; Antifungal Agents; Drug Resistance, Microbial; Ergoste | 1997 |
Systemic antifungal drugs.
Topics: Amphotericin B; Anorexia; Antifungal Agents; Aspergillosis; Blastomycosis; Candidiasis; Coccidioidom | 1997 |
Treatment of histoplasmosis with fluconazole in patients with acquired immunodeficiency syndrome. National Institute of Allergy and Infectious Diseases Acquired Immunodeficiency Syndrome Clinical Trials Group and Mycoses Study Group.
Topics: Adult; AIDS-Related Opportunistic Infections; Antifungal Agents; Disease-Free Survival; Female; Fluc | 1997 |
Acute histoplasmosis choroiditis in 2 immunocompetent brothers.
Topics: Acute Disease; Antibodies, Fungal; Antifungal Agents; Antigens, Fungal; Child, Preschool; Choroiditi | 1997 |
Efficacy of nikkomycin Z in the treatment of murine histoplasmosis.
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Antifungal Agents; Fluconazole; Histoplasmosis; Mal | 1998 |
Activities of sordarins in murine histoplasmosis.
Topics: Amphotericin B; Animals; Antifungal Agents; Fluconazole; Histoplasma; Histoplasmosis; Indenes; Kidne | 1999 |
Fluconazole in the therapy of multiple osteomyelitis in African histoplasmosis.
Topics: Administration, Oral; Antifungal Agents; Child; Fluconazole; Histoplasmosis; Humans; Male; Nigeria; | 1999 |
A case of HIV-associated cerebral histoplasmosis successfully treated with fluconazole.
Topics: Adult; AIDS-Related Opportunistic Infections; Antifungal Agents; Brain Diseases; Central Nervous Sys | 1999 |
[Disseminated histoplasmosis caused by Histoplasma capsulatum with cerebral involvement occurring 13 years after the primary infection].
Topics: Antifungal Agents; Brain; Brain Diseases; Central Nervous System Fungal Infections; Fluconazole; His | 1999 |
Case report. Primary cutaneous histoplasmosis in an immunosuppressed patient.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents; Antifungal Agents; Arthritis, Rheumatoid; Dermato | 2000 |
Amphotericin B combined with itraconazole or fluconazole for treatment of histoplasmosis.
Topics: Amphotericin B; Animals; Drug Interactions; Drug Therapy, Combination; Female; Fluconazole; Histopla | 2000 |
Disseminated histoplasmosis in a non-immunocompromised child.
Topics: Amphotericin B; Anti-Bacterial Agents; Antifungal Agents; Bone Marrow; Child, Preschool; Disseminate | 1999 |
Fungal infection overview.
Topics: AIDS-Related Opportunistic Infections; Amphotericin B; Antifungal Agents; Blastomycosis; Candidiasis | 1995 |
Histoplasmosis: update 1998.
Topics: AIDS-Related Opportunistic Infections; Amphotericin B; Antifungal Agents; Central Nervous System Dis | 1998 |
[Endemic mycotic infections].
Topics: Adult; AIDS-Related Opportunistic Infections; Amphotericin B; Antifungal Agents; Blastomycosis; Cocc | 2001 |
[Visceral mycotic infections. In clinical practice].
Topics: Amphotericin B; Antifungal Agents; Candidiasis; Cryptococcosis; Fluconazole; Flucytosine; Histoplasm | 2001 |
Emergence of resistance to fluconazole as a cause of failure during treatment of histoplasmosis in patients with acquired immunodeficiency disease syndrome.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Opportunistic Infections; Antifungal Agents; Diseas | 2001 |
Antigen clearance during treatment of disseminated histoplasmosis with itraconazole versus fluconazole in patients with AIDS.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Opportunistic Infections; Antifungal Agents; Antige | 2002 |
Efficacy of ravuconazole in treatment of systemic murine histoplasmosis.
Topics: Animals; Antifungal Agents; Colony Count, Microbial; Female; Fluconazole; Histoplasmosis; Itraconazo | 2002 |
Antifungal therapy for central nervous system histoplasmosis, using a newly developed intracranial model of infection.
Topics: Amphotericin B; Animals; Antifungal Agents; Brain; Central Nervous System Fungal Infections; Disease | 2002 |
Articular histoplasmosis.
Topics: Administration, Oral; Aged; Arthritis, Infectious; Cartilage, Articular; Fluconazole; Histoplasma; H | 1992 |
Chronic Histoplasma capsulatum infection of the central nervous system successfully treated with fluconazole.
Topics: Cerebrospinal Fluid Shunts; Diagnosis, Differential; Fluconazole; Histoplasmosis; Humans; Hydrocepha | 1992 |
Development of histoplasmosis in a human immunodeficiency virus-infected patient receiving fluconazole.
Topics: Cryptococcosis; Fluconazole; Histoplasmosis; HIV Infections; Humans; Male; Meningitis; Middle Aged | 1991 |
Histoplasma capsulatum infection associated with continuous ambulatory peritoneal dialysis.
Topics: Amphotericin B; Fluconazole; Flucytosine; Histoplasma; Histoplasmosis; Humans; Kidney Failure, Chron | 1991 |
In vitro and in vivo activities of Sch 39304, fluconazole, and amphotericin B against Histoplasma capsulatum.
Topics: Amphotericin B; Animals; Antifungal Agents; Female; Fluconazole; Histoplasma; Histoplasmosis; Leukop | 1990 |
[Value of fluconazole in the treatment of systemic yeast infection].
Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; Candidiasis; Cryptococcosis; Female; Fluconazole; H | 1989 |
Disseminated histoplasmosis in a Danish patient with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; Amphotericin B; Denmark; Fluconazole; Histiocytes; Histop | 1989 |
Comparison of fluconazole and amphotericin B in treating histoplasmosis in immunosuppressed mice.
Topics: Amphotericin B; Animals; Antifungal Agents; Cyclophosphamide; Female; Fluconazole; Histoplasmosis; H | 1987 |
Comparison of the in vitro and in vivo activity of the bis-triazole derivative UK 49,858 with that of amphotericin B against Histoplasma capsulatum.
Topics: Amphotericin B; Animals; Fluconazole; Histoplasma; Histoplasmosis; In Vitro Techniques; Mice; Microb | 1986 |
Treatment of murine histoplasmosis with UK 49,858 (fluconazole).
Topics: Animals; Antifungal Agents; Female; Fluconazole; Histoplasmosis; Ketoconazole; Lung Diseases, Fungal | 1986 |
Fungistatic and fungicidal effects of amphotericin B, ketoconazole and fluconazole (UK 49,858) against histoplasma capsulatum in vitro and in vivo.
Topics: Amphotericin B; Animals; Antifungal Agents; Culture Techniques; Fluconazole; Histoplasma; Histoplasm | 1987 |