Page last updated: 2024-12-06

ampicillin trihydrate

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Ampicillin trihydrate is a semi-synthetic penicillin antibiotic that is commonly used to treat bacterial infections. It is a derivative of penicillin V, with a benzyl group replaced by a phenylacetyl group. Ampicillin trihydrate is effective against a wide range of gram-positive and gram-negative bacteria, including Streptococcus, Staphylococcus, Escherichia coli, and Salmonella. It works by inhibiting the synthesis of peptidoglycan, an essential component of bacterial cell walls. Ampicillin trihydrate is typically administered orally or intravenously. It is well-absorbed from the gastrointestinal tract and has a moderate half-life. It is important to note that ampicillin trihydrate can cause side effects, such as diarrhea, nausea, and rash. In some cases, it can also lead to allergic reactions, including anaphylaxis. Ampicillin trihydrate is often studied to investigate its effectiveness against various bacterial infections, as well as its potential interactions with other drugs.'

Cross-References

ID SourceID
PubMed CID23565
CHEMBL ID453388
CHEBI ID31209
MeSH IDM0330776

Synonyms (70)

Synonym
penbritin
(2s,5r,6r)-6-{[(2r)-2-amino-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate
NCGC00023282-03
trafarbiot
ccris 267
amcap
amperil
4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(((2r)-aminophenylacetyl)amino)-3,3-dimethyl-7-oxo-, trihydrate, (2s,5r,6r)-
4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((aminophenylacetyl)amino)-3,3-dimethyl-7-oxo-, trihydrate, (2s-(2alpha,5alpha,6beta(s*)))-
alpha-aminobenzylpenicillin trihydrate
cymbi
aminobenzylpenicillin trihydrate
ampinova
(d-(-)-alpha-aminobenzyl)penicillin trihydrate
4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-, trihydrate, d- (-)-
ampicillin 3-wasser
ampicillin trihydrate
ampicillin, meets usp testing specifications
ampicillin hydrate (jp17)
7177-48-2
amcill (tn)
D01251
ampicillin/ampicillin trihydrate
6beta-[(2r)-2-amino-2-phenylacetamido]-2,2-dimethylpenam-3alpha-carboxylic acid trihydrate
CHEBI:31209 ,
ampicillin trihydrate, 96.0-100.5% anhydrous basis (hplc)
(2s,5r,6r)-6-[[(2r)-2-amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate
ampicillin/ampicillin monohydrate
CHEMBL453388
ampicillin hydrate
HMS1568G10
HMS2095G10
dtxsid9020083 ,
NCGC00258700-01
dtxcid4083
tox21_201148
S4148
hxq6a1n7r6 ,
unii-hxq6a1n7r6
ampicillin trihydrate [usp-rs]
ampicillin trihydrate [mart.]
ampicillin trihydrate [ep monograph]
ampicillin/ampicillin trihydrate [orange book]
ampicillin trihydrate [vandf]
ampicillin trihydrate [green book]
ampicillin trihydrate [who-ip]
4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(((2r)-2-amino-2-phenylacetyl)amino)-3,3-dimethyl-7-oxo-, hydrate (1:3), (2s,5r,6r)-
ampicillin trihydrate [mi]
ampicillin hydrate [jan]
ampicillin trihydrate [who-dd]
AKOS015915153
CCG-220114
KS-5251
RXDALBZNGVATNY-CWLIKTDRSA-N
mfcd00072036
(2s,5r,6r)-6-[[(2r)-2-amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;trihydrate
ampicillin trihydrate, european pharmacopoeia (ep) reference standard
(2s,5r,6r)-6-((r)-2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate
ampicillin trihydrate, vetranal(tm), analytical standard
ampicillin trihydrate, united states pharmacopeia (usp) reference standard
ampicillin trihydrate, pharmaceutical secondary standard; certified reference material
ampicillin trihydrate; brl-1341
sr-01000000061
SR-01000000061-4
ampicilline trihydrate
HMS3712G10
ampicillin trihydrate, british pharmacopoeia (bp) reference standard
Q27114210
(2s,5r,6r)-6-((r)-2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacidtrihydrate
d-(-)--aminobenzylpenicillin (trihydrate)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
hydrateAn addition compound that contains water in weak chemical combination with another compound.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (9)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency3.98110.003245.467312,589.2998AID2517
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency22.38720.004023.8416100.0000AID485290
Chain A, ATP-DEPENDENT DNA HELICASE Q1Homo sapiens (human)Potency7.94330.125919.1169125.8920AID2549
Chain A, CruzipainTrypanosoma cruziPotency15.84890.002014.677939.8107AID1476
LuciferasePhotinus pyralis (common eastern firefly)Potency99.60780.007215.758889.3584AID1224835
thyroid stimulating hormone receptorHomo sapiens (human)Potency12.58930.001318.074339.8107AID926; AID938
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency50.11870.001019.414170.9645AID588537
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency45.18770.000627.21521,122.0200AID651741; AID743202
Nuclear receptor ROR-gammaHomo sapiens (human)Potency18.83360.026622.448266.8242AID651802
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (13)

Processvia Protein(s)Taxonomy
negative regulation of transcription by RNA polymerase IINuclear receptor ROR-gammaHomo sapiens (human)
xenobiotic metabolic processNuclear receptor ROR-gammaHomo sapiens (human)
regulation of glucose metabolic processNuclear receptor ROR-gammaHomo sapiens (human)
regulation of steroid metabolic processNuclear receptor ROR-gammaHomo sapiens (human)
intracellular receptor signaling pathwayNuclear receptor ROR-gammaHomo sapiens (human)
circadian regulation of gene expressionNuclear receptor ROR-gammaHomo sapiens (human)
cellular response to sterolNuclear receptor ROR-gammaHomo sapiens (human)
positive regulation of circadian rhythmNuclear receptor ROR-gammaHomo sapiens (human)
regulation of fat cell differentiationNuclear receptor ROR-gammaHomo sapiens (human)
positive regulation of DNA-templated transcriptionNuclear receptor ROR-gammaHomo sapiens (human)
adipose tissue developmentNuclear receptor ROR-gammaHomo sapiens (human)
T-helper 17 cell differentiationNuclear receptor ROR-gammaHomo sapiens (human)
regulation of transcription by RNA polymerase IINuclear receptor ROR-gammaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (10)

Processvia Protein(s)Taxonomy
RNA polymerase II cis-regulatory region sequence-specific DNA bindingNuclear receptor ROR-gammaHomo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specificNuclear receptor ROR-gammaHomo sapiens (human)
DNA-binding transcription repressor activity, RNA polymerase II-specificNuclear receptor ROR-gammaHomo sapiens (human)
DNA-binding transcription factor activityNuclear receptor ROR-gammaHomo sapiens (human)
protein bindingNuclear receptor ROR-gammaHomo sapiens (human)
oxysterol bindingNuclear receptor ROR-gammaHomo sapiens (human)
zinc ion bindingNuclear receptor ROR-gammaHomo sapiens (human)
ligand-activated transcription factor activityNuclear receptor ROR-gammaHomo sapiens (human)
sequence-specific double-stranded DNA bindingNuclear receptor ROR-gammaHomo sapiens (human)
nuclear receptor activityNuclear receptor ROR-gammaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (4)

Processvia Protein(s)Taxonomy
nucleusNuclear receptor ROR-gammaHomo sapiens (human)
nucleoplasmNuclear receptor ROR-gammaHomo sapiens (human)
nuclear bodyNuclear receptor ROR-gammaHomo sapiens (human)
chromatinNuclear receptor ROR-gammaHomo sapiens (human)
nucleusNuclear receptor ROR-gammaHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (72)

Assay IDTitleYearJournalArticle
AID620137Antimicrobial activity against Pseudomonas aeruginosa IFO 3448 after 24 hrs by two fold serial dilution method2011European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
Synthesis of novel 6-phenyl-2,4-disubstituted pyrimidine-5-carbonitriles as potential antimicrobial agents.
AID395109Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 to 48 hrs by twofold serial dilution method2009Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6
Azole antimicrobial pharmacophore-based tetrazoles: synthesis and biological evaluation as potential antimicrobial and anticonvulsant agents.
AID620130Antimicrobial activity against Escherichia coli IFO 3301 at 100 ug/disc after 24 hrs by agar disc diffusion method2011European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
Synthesis of novel 6-phenyl-2,4-disubstituted pyrimidine-5-carbonitriles as potential antimicrobial agents.
AID352090Antimicrobial activity against multidrug-resistant Klebsiella pneumoniae after 24 hrs2009European journal of medicinal chemistry, Feb, Volume: 44, Issue:2
Synthesis, biological evaluation and 2D-QSAR analysis of benzoxazoles as antimicrobial agents.
AID395774Antibacterial activity against gentamicin-resistant Pseudomonas aeruginosa isolate after 24 hrs by twofold serial dilution technique2008European journal of medicinal chemistry, Nov, Volume: 43, Issue:11
Synthesis, antimicrobial activity, pharmacophore analysis of some new 2-(substitutedphenyl/benzyl)-5-[(2-benzofuryl)carboxamido]benzoxazoles.
AID620129Antimicrobial activity against Micrococcus luteus IFO 3232 at 100 ug/disc after 24 hrs by agar disc diffusion method2011European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
Synthesis of novel 6-phenyl-2,4-disubstituted pyrimidine-5-carbonitriles as potential antimicrobial agents.
AID463985Antibacterial activity against Escherichia coli after 24 hrs by broth microdilution method2010European journal of medicinal chemistry, Mar, Volume: 45, Issue:3
Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid.
AID620136Antimicrobial activity against Escherichia coli IFO 3301 after 24 hrs by two fold serial dilution method2011European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
Synthesis of novel 6-phenyl-2,4-disubstituted pyrimidine-5-carbonitriles as potential antimicrobial agents.
AID395772Antibacterial activity against Klebsiella pneumoniae isolate containing extended spectrum beta lactamase after 24 hrs by twofold serial dilution technique2008European journal of medicinal chemistry, Nov, Volume: 43, Issue:11
Synthesis, antimicrobial activity, pharmacophore analysis of some new 2-(substitutedphenyl/benzyl)-5-[(2-benzofuryl)carboxamido]benzoxazoles.
AID293590Antibacterial activity against Bacillus subtilis ATCC 6633 assessed after 24 hrs by serial dilution method2007Bioorganic & medicinal chemistry, Mar-01, Volume: 15, Issue:5
Synthesis and biological evaluation of new N-(2-hydroxy-4(or 5)-nitro/aminophenyl)benzamides and phenylacetamides as antimicrobial agents.
AID346311Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by twofold serial dilution method2009Bioorganic & medicinal chemistry, Jan-15, Volume: 17, Issue:2
Design and synthesis of some thiazolyl and thiadiazolyl derivatives of antipyrine as potential non-acidic anti-inflammatory, analgesic and antimicrobial agents.
AID620134Antimicrobial activity against Bacillus subtilis IFO 3007 after 24 hrs by two fold serial dilution method2011European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
Synthesis of novel 6-phenyl-2,4-disubstituted pyrimidine-5-carbonitriles as potential antimicrobial agents.
AID293585Antibacterial activity against Bacillus subtilis isolate assessed after 24 hrs by serial dilution method2007Bioorganic & medicinal chemistry, Mar-01, Volume: 15, Issue:5
Synthesis and biological evaluation of new N-(2-hydroxy-4(or 5)-nitro/aminophenyl)benzamides and phenylacetamides as antimicrobial agents.
AID395110Antibacterial activity against Klebsiella pneumoniae isolate after 24 to 48 hrs by twofold serial dilution method2009Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6
Azole antimicrobial pharmacophore-based tetrazoles: synthesis and biological evaluation as potential antimicrobial and anticonvulsant agents.
AID293584Antibacterial activity against Escherichia coli isolate assessed after 24 hrs by by serial dilution method2007Bioorganic & medicinal chemistry, Mar-01, Volume: 15, Issue:5
Synthesis and biological evaluation of new N-(2-hydroxy-4(or 5)-nitro/aminophenyl)benzamides and phenylacetamides as antimicrobial agents.
AID395107Antibacterial activity against Micrococcus luteus ATCC 21881 after 24 to 48 hrs by twofold serial dilution method2009Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6
Azole antimicrobial pharmacophore-based tetrazoles: synthesis and biological evaluation as potential antimicrobial and anticonvulsant agents.
AID346310Antimicrobial activity against Escherichia coli ATCC 25922 after 24 hrs by twofold serial dilution method2009Bioorganic & medicinal chemistry, Jan-15, Volume: 17, Issue:2
Design and synthesis of some thiazolyl and thiadiazolyl derivatives of antipyrine as potential non-acidic anti-inflammatory, analgesic and antimicrobial agents.
AID620133Antimicrobial activity against Staphylococcus aureus IFO 3060 after 24 hrs by two fold serial dilution method2011European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
Synthesis of novel 6-phenyl-2,4-disubstituted pyrimidine-5-carbonitriles as potential antimicrobial agents.
AID371459Antimicrobial activity against Staphylococcus aureus isolate after 24 hrs by disk diffusion method2008European journal of medicinal chemistry, Jul, Volume: 43, Issue:7
Synthesis and biological activity of some new benzoxazoles.
AID395108Antibacterial activity against Escherichia coli ATCC 25922 after 24 to 48 hrs by twofold serial dilution method2009Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6
Azole antimicrobial pharmacophore-based tetrazoles: synthesis and biological evaluation as potential antimicrobial and anticonvulsant agents.
AID352094Antimicrobial activity against Bacillus subtilis ATCC 6633 after 24 hrs2009European journal of medicinal chemistry, Feb, Volume: 44, Issue:2
Synthesis, biological evaluation and 2D-QSAR analysis of benzoxazoles as antimicrobial agents.
AID395781Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by twofold serial dilution technique2008European journal of medicinal chemistry, Nov, Volume: 43, Issue:11
Synthesis, antimicrobial activity, pharmacophore analysis of some new 2-(substitutedphenyl/benzyl)-5-[(2-benzofuryl)carboxamido]benzoxazoles.
AID293582Antibacterial activity against Klebsiella pneumoniae isolate assessed after 24 hrs by serial dilution method2007Bioorganic & medicinal chemistry, Mar-01, Volume: 15, Issue:5
Synthesis and biological evaluation of new N-(2-hydroxy-4(or 5)-nitro/aminophenyl)benzamides and phenylacetamides as antimicrobial agents.
AID293588Antibacterial activity against Pseudomonas aeruginosa ATCC 25853 assessed after 24 hrs by serial dilution method2007Bioorganic & medicinal chemistry, Mar-01, Volume: 15, Issue:5
Synthesis and biological evaluation of new N-(2-hydroxy-4(or 5)-nitro/aminophenyl)benzamides and phenylacetamides as antimicrobial agents.
AID620131Antimicrobial activity against Pseudomonas aeruginosa IFO 3448 at 100 ug/disc after 24 hrs by agar disc diffusion method2011European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
Synthesis of novel 6-phenyl-2,4-disubstituted pyrimidine-5-carbonitriles as potential antimicrobial agents.
AID1527479Antimicrobial activity against Staphylococcus aureus ATCC 19433 assessed as reduction in microbial growth after 24 to 48 hrs by microdilution susceptibility test2020European journal of medicinal chemistry, Jan-01, Volume: 185Structure-activity relationships (SAR) of triazine derivatives: Promising antimicrobial agents.
AID346308Antimicrobial activity against Bacillus subtilis NRRL B-14819 after 24 hrs by twofold serial dilution method2009Bioorganic & medicinal chemistry, Jan-15, Volume: 17, Issue:2
Design and synthesis of some thiazolyl and thiadiazolyl derivatives of antipyrine as potential non-acidic anti-inflammatory, analgesic and antimicrobial agents.
AID395106Antibacterial activity against Bacillus subtilis NRRL B-14819 after 24 to 48 hrs by twofold serial dilution method2009Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6
Azole antimicrobial pharmacophore-based tetrazoles: synthesis and biological evaluation as potential antimicrobial and anticonvulsant agents.
AID395105Antibacterial activity against Staphylococcus aureus ATCC 6538 after 24 to 48 hrs by twofold serial dilution method2009Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6
Azole antimicrobial pharmacophore-based tetrazoles: synthesis and biological evaluation as potential antimicrobial and anticonvulsant agents.
AID352093Antimicrobial activity against Pseudomonas aeruginosa ATCC 25853 after 24 hrs2009European journal of medicinal chemistry, Feb, Volume: 44, Issue:2
Synthesis, biological evaluation and 2D-QSAR analysis of benzoxazoles as antimicrobial agents.
AID371466Antimicrobial activity against Pseudomonas aeruginosa ATCC 25853 after 24 hrs by disk diffusion method2008European journal of medicinal chemistry, Jul, Volume: 43, Issue:7
Synthesis and biological activity of some new benzoxazoles.
AID346309Antimicrobial activity against Micrococcus luteus ATCC 21881of after 24 hrs by twofold serial dilution method2009Bioorganic & medicinal chemistry, Jan-15, Volume: 17, Issue:2
Design and synthesis of some thiazolyl and thiadiazolyl derivatives of antipyrine as potential non-acidic anti-inflammatory, analgesic and antimicrobial agents.
AID346312Antimicrobial activity against Klebsiella pneumoniae clinical isolate after 24 hrs by twofold serial dilution method2009Bioorganic & medicinal chemistry, Jan-15, Volume: 17, Issue:2
Design and synthesis of some thiazolyl and thiadiazolyl derivatives of antipyrine as potential non-acidic anti-inflammatory, analgesic and antimicrobial agents.
AID352091Antimicrobial activity against Escherichia coli ATCC 25922 after 24 hrs2009European journal of medicinal chemistry, Feb, Volume: 44, Issue:2
Synthesis, biological evaluation and 2D-QSAR analysis of benzoxazoles as antimicrobial agents.
AID620054Antimicrobial activity against Staphylococcus aureus IFO 3060 at 100 ug/disc after 24 hrs by agar disc diffusion method2011European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
Synthesis of novel 6-phenyl-2,4-disubstituted pyrimidine-5-carbonitriles as potential antimicrobial agents.
AID1527478Antimicrobial activity against Escherichia coli ATCC 25922 assessed as reduction in microbial growth after 24 to 48 hrs by microdilution susceptibility test2020European journal of medicinal chemistry, Jan-01, Volume: 185Structure-activity relationships (SAR) of triazine derivatives: Promising antimicrobial agents.
AID620128Antimicrobial activity against Bacillus subtilis IFO 3007 at 100 ug/disc after 24 hrs by agar disc diffusion method2011European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
Synthesis of novel 6-phenyl-2,4-disubstituted pyrimidine-5-carbonitriles as potential antimicrobial agents.
AID395773Antibacterial activity against Klebsiella pneumoniae RSHM 574 after 24 hrs by twofold serial dilution technique2008European journal of medicinal chemistry, Nov, Volume: 43, Issue:11
Synthesis, antimicrobial activity, pharmacophore analysis of some new 2-(substitutedphenyl/benzyl)-5-[(2-benzofuryl)carboxamido]benzoxazoles.
AID1076978Antibacterial activity against Bacillus subtilis ATCC 6633 assessed as growth inhibition after 48 hrs by two-fold serial dilution assay2014European journal of medicinal chemistry, Apr-09, Volume: 76Bifunctional ethyl 2-amino-4-methylthiazole-5-carboxylate derivatives: synthesis and in vitro biological evaluation as antimicrobial and anticancer agents.
AID293583Antibacterial activity against Pseudomonas aeruginosa isolate assessed after 24 hrs by serial dilution method2007Bioorganic & medicinal chemistry, Mar-01, Volume: 15, Issue:5
Synthesis and biological evaluation of new N-(2-hydroxy-4(or 5)-nitro/aminophenyl)benzamides and phenylacetamides as antimicrobial agents.
AID395775Antibacterial activity against Pseudomonas aeruginosa ATCC 25853 after 24 hrs by twofold serial dilution technique2008European journal of medicinal chemistry, Nov, Volume: 43, Issue:11
Synthesis, antimicrobial activity, pharmacophore analysis of some new 2-(substitutedphenyl/benzyl)-5-[(2-benzofuryl)carboxamido]benzoxazoles.
AID352096Antimicrobial activity against Staphylococcus aureus ATCC 25923 after 24 hrs2009European journal of medicinal chemistry, Feb, Volume: 44, Issue:2
Synthesis, biological evaluation and 2D-QSAR analysis of benzoxazoles as antimicrobial agents.
AID371465Antimicrobial activity against Klebsiella pneumoniae after 24 hrs by disk diffusion method2008European journal of medicinal chemistry, Jul, Volume: 43, Issue:7
Synthesis and biological activity of some new benzoxazoles.
AID463984Antibacterial activity against Streptococcus viridans after 24 hrs by broth microdilution method2010European journal of medicinal chemistry, Mar, Volume: 45, Issue:3
Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid.
AID371461Antimicrobial activity against Bacillus subtilis isolate after 24 hrs by disk diffusion method2008European journal of medicinal chemistry, Jul, Volume: 43, Issue:7
Synthesis and biological activity of some new benzoxazoles.
AID293586Antibacterial activity against Staphylococcus aureus isolate assessed after 24 hrs by serial dilution method2007Bioorganic & medicinal chemistry, Mar-01, Volume: 15, Issue:5
Synthesis and biological evaluation of new N-(2-hydroxy-4(or 5)-nitro/aminophenyl)benzamides and phenylacetamides as antimicrobial agents.
AID346307Antimicrobial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by twofold serial dilution method2009Bioorganic & medicinal chemistry, Jan-15, Volume: 17, Issue:2
Design and synthesis of some thiazolyl and thiadiazolyl derivatives of antipyrine as potential non-acidic anti-inflammatory, analgesic and antimicrobial agents.
AID395778Antibacterial activity against ceftriaxone-resistant Bacillus subtilis isolate after 24 hrs by twofold serial dilution technique2008European journal of medicinal chemistry, Nov, Volume: 43, Issue:11
Synthesis, antimicrobial activity, pharmacophore analysis of some new 2-(substitutedphenyl/benzyl)-5-[(2-benzofuryl)carboxamido]benzoxazoles.
AID1076976Antibacterial activity against Escherichia coli ATCC 25922 assessed as growth inhibition after 48 hrs by two-fold serial dilution assay2014European journal of medicinal chemistry, Apr-09, Volume: 76Bifunctional ethyl 2-amino-4-methylthiazole-5-carboxylate derivatives: synthesis and in vitro biological evaluation as antimicrobial and anticancer agents.
AID463987Antibacterial activity against Proteus mirabilis after 24 hrs by broth microdilution method2010European journal of medicinal chemistry, Mar, Volume: 45, Issue:3
Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid.
AID352095Antimicrobial activity against ceftriazone-resistant Bacillus subtilis after 24 hrs2009European journal of medicinal chemistry, Feb, Volume: 44, Issue:2
Synthesis, biological evaluation and 2D-QSAR analysis of benzoxazoles as antimicrobial agents.
AID293587Antibacterial activity against Klebsiella pneumoniae RSHM 574 assessed after 24 hrs by serial dilution method2007Bioorganic & medicinal chemistry, Mar-01, Volume: 15, Issue:5
Synthesis and biological evaluation of new N-(2-hydroxy-4(or 5)-nitro/aminophenyl)benzamides and phenylacetamides as antimicrobial agents.
AID395779Antibacterial activity against Bacillus subtilis ATCC 6633 after 24 hrs by twofold serial dilution technique2008European journal of medicinal chemistry, Nov, Volume: 43, Issue:11
Synthesis, antimicrobial activity, pharmacophore analysis of some new 2-(substitutedphenyl/benzyl)-5-[(2-benzofuryl)carboxamido]benzoxazoles.
AID1076974Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as growth inhibition after 48 hrs by two-fold serial dilution assay2014European journal of medicinal chemistry, Apr-09, Volume: 76Bifunctional ethyl 2-amino-4-methylthiazole-5-carboxylate derivatives: synthesis and in vitro biological evaluation as antimicrobial and anticancer agents.
AID371460Antimicrobial activity against Bacillus subtilis ATCC 6633 after 24 hrs by disk diffusion method2008European journal of medicinal chemistry, Jul, Volume: 43, Issue:7
Synthesis and biological activity of some new benzoxazoles.
AID352092Antimicrobial activity against multidrug-resistant Escherichia coli after 24 hrs2009European journal of medicinal chemistry, Feb, Volume: 44, Issue:2
Synthesis, biological evaluation and 2D-QSAR analysis of benzoxazoles as antimicrobial agents.
AID293591Antibacterial activity against Staphylococcus aureus ATCC 25923 assessed after 24 hrs by serial dilution method2007Bioorganic & medicinal chemistry, Mar-01, Volume: 15, Issue:5
Synthesis and biological evaluation of new N-(2-hydroxy-4(or 5)-nitro/aminophenyl)benzamides and phenylacetamides as antimicrobial agents.
AID293589Antibacterial activity against Escherichia coli ATCC 25922 assessed after 24 hrs by serial dilution method2007Bioorganic & medicinal chemistry, Mar-01, Volume: 15, Issue:5
Synthesis and biological evaluation of new N-(2-hydroxy-4(or 5)-nitro/aminophenyl)benzamides and phenylacetamides as antimicrobial agents.
AID395777Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs by twofold serial dilution technique2008European journal of medicinal chemistry, Nov, Volume: 43, Issue:11
Synthesis, antimicrobial activity, pharmacophore analysis of some new 2-(substitutedphenyl/benzyl)-5-[(2-benzofuryl)carboxamido]benzoxazoles.
AID352089Antimicrobial activity against Klebsiella pneumoniae RSHM 574 after 24 hrs2009European journal of medicinal chemistry, Feb, Volume: 44, Issue:2
Synthesis, biological evaluation and 2D-QSAR analysis of benzoxazoles as antimicrobial agents.
AID352097Antimicrobial activity against multidrug-resistant Staphylococcus aureus after 24 hrs2009European journal of medicinal chemistry, Feb, Volume: 44, Issue:2
Synthesis, biological evaluation and 2D-QSAR analysis of benzoxazoles as antimicrobial agents.
AID395776Antibacterial activity against Escherichia coli isolate containing extended spectrum beta lactamase after 24 hrs by twofold serial dilution technique2008European journal of medicinal chemistry, Nov, Volume: 43, Issue:11
Synthesis, antimicrobial activity, pharmacophore analysis of some new 2-(substitutedphenyl/benzyl)-5-[(2-benzofuryl)carboxamido]benzoxazoles.
AID1076980Antibacterial activity against Staphylococcus aureus ATCC 6538 assessed as growth inhibition after 48 hrs by two-fold serial dilution assay2014European journal of medicinal chemistry, Apr-09, Volume: 76Bifunctional ethyl 2-amino-4-methylthiazole-5-carboxylate derivatives: synthesis and in vitro biological evaluation as antimicrobial and anticancer agents.
AID371463Antimicrobial activity against Escherichia coli isolate after 24 hrs by disk diffusion method2008European journal of medicinal chemistry, Jul, Volume: 43, Issue:7
Synthesis and biological activity of some new benzoxazoles.
AID371464Antimicrobial activity against Klebsiella pneumoniae RSHM 574 after 24 hrs by disk diffusion method2008European journal of medicinal chemistry, Jul, Volume: 43, Issue:7
Synthesis and biological activity of some new benzoxazoles.
AID463986Antibacterial activity against Klebsiella pneumoniae after 24 hrs by broth microdilution method2010European journal of medicinal chemistry, Mar, Volume: 45, Issue:3
Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid.
AID620135Antimicrobial activity against Micrococcus luteus IFO 3232 after 24 hrs by two fold serial dilution method2011European journal of medicinal chemistry, Sep, Volume: 46, Issue:9
Synthesis of novel 6-phenyl-2,4-disubstituted pyrimidine-5-carbonitriles as potential antimicrobial agents.
AID371458Antimicrobial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by disk diffusion method2008European journal of medicinal chemistry, Jul, Volume: 43, Issue:7
Synthesis and biological activity of some new benzoxazoles.
AID371462Antimicrobial activity against Escherichia coli ATCC 25922 after 24 hrs by disk diffusion method2008European journal of medicinal chemistry, Jul, Volume: 43, Issue:7
Synthesis and biological activity of some new benzoxazoles.
AID395780Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate after 24 hrs by twofold serial dilution technique2008European journal of medicinal chemistry, Nov, Volume: 43, Issue:11
Synthesis, antimicrobial activity, pharmacophore analysis of some new 2-(substitutedphenyl/benzyl)-5-[(2-benzofuryl)carboxamido]benzoxazoles.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (50.00)29.6817
2010's5 (41.67)24.3611
2020's1 (8.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 61.00

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index61.00 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index4.37 (4.65)
Search Engine Demand Index96.73 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (61.00)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (8.33%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (91.67%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]