AIRE Deficiency

Autoimmune diseases affecting multiple endocrine organs. Type I is characterized by childhood onset and chronic mucocutaneous candidiasis (CANDIDIASIS, CHRONIC MUCOCUTANEOUS), while type II exhibits any combination of adrenal insufficiency (ADDISON'S DISEASE), lymphocytic thyroiditis (THYROIDITIS, AUTOIMMUNE;), HYPOPARATHYROIDISM; and gonadal failure. In both types organ-specific ANTIBODIES against a variety of ENDOCRINE GLANDS have been detected. The type II syndrome differs from type I in that it is associated with HLA-A1 and B8 haplotypes, onset is usually in adulthood, and candidiasis is not present.

Synonym
Schmidt's Syndrome
Schmidt Syndrome
Autoimmune Polyglandular Syndrome, Type I
Autoimmune Polyendocrine Syndrome, Type 2
Autoimmune Polyendocrine Syndrome, Type II
Autoimmune Polyendocrinopathy Syndrome Type 1
Autoimmune Polyglandular Syndrome, Type 3
Polyendocrinopathy-Candidiasis-Ectodermal-Dystrophy, Autoimmune
Autoimmune Polyendocrinopathy with Candidiasis and Ectodermal Dystrophy
Polyglandular Autoimmune Syndrome, Type I
Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy
Polyglandular Autoimmune Syndrome, Type 3
Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal-Dystrophy
Autoimmune Polyglandular Syndrome Type I
Polyglandular Deficiency Syndrome, Type 2
Autoimmune Polyglandular Syndrome Type II
Autoimmune Polyglandular Syndrome Type III
Diabetes Mellitus, Addison's Disease, Myxedema
Autoimmune Syndrome Type I, Polyglandular
Polyglandular Autoimmune Syndrome, Type 1
Autoimmune Syndrome Type III, Polyglandular
Diabetes Mellitus, Addison Disease, Myxedema
APECED
APS Type 1
Autoimmune Syndrome Type II, Polyglandular
Autoimmune Polyglandular Syndrome, Type 1
Polyglandular Autoimmune Syndrome, Type 2
AIRE Deficiency
Polyglandular Type III Autoimmune Syndrome
Polyglandular Type II Autoimmune Syndrome
Polyendocrine Autoimmune Syndrome, Type II
Multiple Endocrine Deficiency Syndrome, Type 2
Polyendocrinopathies, Autoimmune
Polyglandular Type I Autoimmune Syndrome

Excerpt	Reference
"Schmidt's syndrome is characterized by the existence of adrenal insufficiency and lymphocytic thyroiditis, yet, it can also be accompanied of some other autoimmune diseases."	( Barrón-Vallejo, J; Esparza Iturbide, JA; Kuttothara, A; Méndez Espinosa, G, 1998)
"APECED is caused by alteration in a single gene, named the autoimmune regulator (AIRE) gene."	( Asakura, Y; Horikawa, R; Katsumata, N; Kitanaka, S; Sato, U; Tanaka, T, 2004)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	29 (13.49)	12.5806
2000's	81 (37.67)	18.1394
2010's	82 (38.14)	28.8240
2020's	23 (10.70)	9.53

Drug	Relationship Strength	Studies
acetaldehyde	low	3
curdlan	low	1
salicylic acid	low	3
cytosine	low	3
pyridoxal phosphate	low	3
pyruvic acid	low	1
thymine	low	2
uric acid	low	1
1-anilino-8-naphthalenesulfonate	low	1
aspirin	low	2
atenolol	low	1
azathioprine	low	10
diclofenac	low	1
valproic acid	low	1
fentanyl	low	1
fluconazole	low	6
gentamicin	low	1
ibuprofen	low	1
isoproterenol	low	1
ketoconazole	low	2
miconazole	low	2
apnea	low	1
procainamide	low	1
propranolol	low	2
risperidone	low	1
prednisolone	low	11
thymidine	low	1
thyroxine	low	32
aldosterone	low	2
prednisone	low	9
dehydroepiandrosterone	low	3
triiodothyronine	low	1
alanine	low	1
serine	low	1
glutamine	low	1
adenosine monophosphate	low	1
methionine	low	1
colchicine	low	1
asparagine	low	2
medroxyprogesterone acetate	low	1
threonine	low	1
arginine	low	1
methylprednisolone	low	6
calcium gluconate	low	1
fluorometholone	low	1
dihydralazine	low	1
dehydroepiandrosterone sulfate	low	2
calcium citrate	low	1
technetium	low	1
europium	low	1
rhamnose	low	1
carbimazole	low	2
bromocriptine	low	1
cetylpyridinium chloride anhydrous	low	1
fludrocortisone	low	15
ursodeoxycholic acid	low	1
transferrin	low	1
ribavirin	low	2
itraconazole	low	2
glucose, (beta-d)-isomer	low	1
diphenylcyclopropenone	low	1
fluorodeoxyglucose f18	low	1
adosterol	low	1
3-(trimethoxysilyl)propylamine	low	1
methotrexate	low	1
7-(n-(3-aminopropyl)amino)heptan-2-one	low	1
olmesartan	low	3
cortisone	low	2
trimethoprim, sulfamethoxazole drug combination	low	1
epiglucan	low	1
acetyl coenzyme a	low	1
retinol	low	1
tacrolimus	low	3
mycophenolic acid	low	2
riboflavin	low	1
etomidate	low	1
methimazole	low	4
terbinafine	low	1
cystine	low	1
calcitriol	low	3
cholecalciferol	low	1
genistein	low	1
amphotericin b	low	3
pulmicort	low	3
sirolimus	low	4
sulfur	low	1
cysteine	low	2
phosphorus	low	2
g(m1) ganglioside	low	1
lactulose	low	1
nystatin a1	low	1
losartan potassium	low	1
pituitrin	low	1
acid phosphatase	low	1
cosyntropin	low	3
cholecystokinin	low	3
gastrins	low	2
glucagon	low	1
insulin glulisine	low	1
c-peptide	low	2
potassium iodate	low	1
transforming growth factor beta	low	1
phytoestrogens	low	1
vitamin b 12	low	3
cyclosporine	low	10
peptide yy	low	1
dacarbazine	low	1
eye	low	3
filipin	low	1

Protein Targets (1,290)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
acid sphingomyelinase	3	0	0	3
thioredoxin reductase	18	0	0	18
USP1 protein, partial	15	0	0	15
TDP1 protein	36	0	0	36
vitamin D3 receptor isoform VDRA	11	0	0	11
importin subunit beta-1 isoform 1	3	0	0	3
flap endonuclease 1	9	0	0	9
serine/threonine-protein kinase PLK1	3	0	0	3
snurportin-1	3	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	7	0	0	7
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
DNA polymerase eta isoform 1	3	0	0	3
DNA polymerase iota isoform a (long)	10	0	0	10
urokinase-type plasminogen activator precursor	5	0	0	5
plasminogen precursor	5	0	0	5
urokinase plasminogen activator surface receptor precursor	5	0	0	5
geminin	32	0	0	32
DNA polymerase kappa isoform 1	9	0	0	9
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Mitogen-activated protein kinase 13	0	1	0	1
Beta-lactamase	0	4	0	4
Transthyretin	0	2	2	8
Fatty acid-binding protein, intestinal	0	3	1	4
Fatty acid-binding protein, adipocyte	0	1	1	2
Cyclin-A2	0	1	0	1
Cannabinoid receptor 1	0	0	1	1
Cyclin-dependent kinase 2	0	1	3	4
Choline O-acetyltransferase	0	2	0	2
Mitogen-activated protein kinase 12	0	1	0	1
Guanine nucleotide-binding protein G	5	0	0	5
Fatty acid-binding protein 5	0	0	1	1
Fatty acid-binding protein 5	0	0	1	1
Mitogen-activated protein kinase 11	0	1	1	2
Mitogen-activated protein kinase 14	0	2	1	3
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase	0	1	0	1
acetylcholinesterase	9	0	0	9
hypoxia-inducible factor 1 alpha subunit	11	0	0	11
RAR-related orphan receptor gamma	23	0	0	23
SMAD family member 2	10	0	0	10
SMAD family member 3	10	0	0	10
GLI family zinc finger 3	22	0	0	22
AR protein	38	0	0	38
caspase 7, apoptosis-related cysteine protease	3	0	0	3
thyroid stimulating hormone receptor	12	0	0	12
estrogen receptor 2 (ER beta)	14	0	0	14
nuclear receptor subfamily 1, group I, member 3	21	0	0	21
progesterone receptor	20	0	0	20
glucocorticoid receptor [Homo sapiens]	33	0	0	33
retinoic acid nuclear receptor alpha variant 1	27	0	0	27
retinoid X nuclear receptor alpha	22	0	0	22
estrogen-related nuclear receptor alpha	31	0	0	31
farnesoid X nuclear receptor	20	0	0	20
pregnane X nuclear receptor	27	0	0	27
estrogen nuclear receptor alpha	43	0	0	43
peroxisome proliferator-activated receptor delta	19	0	0	19
peroxisome proliferator activated receptor gamma	26	0	0	26
vitamin D (1,25- dihydroxyvitamin D3) receptor	19	0	0	19
caspase-3	3	0	0	3
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	23	0	0	23
thyroid stimulating hormone receptor	10	0	0	10
activating transcription factor 6	14	0	0	14
thyrotropin-releasing hormone receptor	3	0	0	3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	9	0	0	9
v-jun sarcoma virus 17 oncogene homolog (avian)	15	0	0	15
Histone H2A.x	11	0	0	11
Caspase-7	2	0	0	2
caspase-3	2	0	0	2
thyroid hormone receptor beta isoform 2	24	0	0	24
heat shock protein beta-1	10	0	0	10
nuclear factor erythroid 2-related factor 2 isoform 1	30	0	0	30
Voltage-dependent calcium channel gamma-2 subunit	15	0	0	15
Cellular tumor antigen p53	31	0	0	31
Glutamate receptor 2	15	1	0	16
ATPase family AAA domain-containing protein 5	14	0	0	14
Ataxin-2	16	0	0	16
N-alpha-acetyltransferase 50	0	0	1	1
Chain A, Glycogen Phosphorylase B	0	0	1	1
Chain B, Glycogen Phosphorylase B	0	0	1	1
Chain A, ADP-dependent glucokinase	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, phosphodiesterase-nucleotide pyrophosphatase	0	1	0	1
Chain A, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
Chain B, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
Chain A, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
regulator of G-protein signaling 4	6	0	0	6
euchromatic histone-lysine N-methyltransferase 2	29	0	0	29
2'-deoxynucleoside 5'-phosphate N-hydrolase 1	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
2'-deoxynucleoside 5'-phosphate N-hydrolase 1	0	1	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	1	2
Transient receptor potential cation channel subfamily M member 2	0	1	0	1
Alcohol dehydrogenase E chain	0	1	0	1
Alcohol dehydrogenase S chain	0	1	0	1
L-lactate dehydrogenase A chain	0	1	1	2
Adenylate kinase isoenzyme 1	0	0	0	1
Fructose-1,6-bisphosphatase 1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	0	0	1
Fructose-1,6-bisphosphatase 1	0	1	0	1
2-dehydropantoate 2-reductase	0	1	1	2
Inosine-5'-monophosphate dehydrogenase	0	1	0	1
Cytochrome P450 2C9	0	13	1	16
Proto-oncogene tyrosine-protein kinase Src	0	2	1	3
Amine oxidase [flavin-containing] B	0	1	0	1
5'-nucleotidase	0	0	0	1
Adenylate kinase 2, mitochondrial	0	1	0	2
GTP:AMP phosphotransferase AK3, mitochondrial	0	0	0	1
Adenosine receptor A1	0	7	1	8
Adenylate kinase isoenzyme 1	0	1	0	2
P2Y purinoceptor 2	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	3	4
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	1	2
Adenylate kinase 2, mitochondrial	0	0	1	2
Glycine--tRNA ligase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	3	4
Adenosine deaminase-like protein	0	0	0	1
Protease	0	1	1	2
P2Y purinoceptor 11	0	0	1	1
Histamine H3 receptor	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	1	2
5'-AMP-activated protein kinase subunit gamma-2	0	0	2	3
5'-AMP-activated protein kinase subunit beta-1	0	0	2	3
ATP-dependent phosphofructokinase	11	0	0	11
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	11	0	0	11
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	10	0	0	10
Carbonic anhydrase 1	0	5	0	8
Carbonic anhydrase 2	0	5	1	9
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	1	2
Proton-coupled amino acid transporter 1	0	2	0	2
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	1	0	2
thyroid hormone receptor beta isoform a	8	0	0	8
nuclear factor erythroid 2-related factor 2 isoform 2	10	0	0	10
Sex hormone-binding globulin	0	0	5	5
Corticosteroid-binding globulin	0	4	0	4
Mineralocorticoid receptor	0	5	4	9
Androgen receptor	0	15	0	15
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	3
Chain A, HADH2 protein	10	0	0	10
Chain B, HADH2 protein	10	0	0	10
Chain A, Cruzipain	5	0	0	5
interleukin 8	10	0	0	10
phosphopantetheinyl transferase	10	0	0	10
GLS protein	11	0	0	11
tumor necrosis factor	2	0	0	2
peripheral myelin protein 22	19	0	0	19
lamin isoform A-delta10	23	0	0	23
Cytochrome P450 1A2	0	3	0	4
Cytochrome P450 3A4	0	14	0	17
Cytochrome P450 2D6	0	6	0	6
Cytochrome P450 2C19	0	5	0	5
Nuclear receptor ROR-gamma	10	0	0	10
Potassium voltage-gated channel subfamily H member 2	0	7	0	7
Aurora kinase B	0	1	1	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	4	0	5
ATAD5 protein, partial	8	0	0	8
Microtubule-associated protein tau	11	0	0	11
arylsulfatase A	7	0	0	7
Bloom syndrome protein isoform 1	7	0	0	7
D(1A) dopamine receptor	4	0	0	4
neuropeptide S receptor isoform A	4	0	0	4
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
NFKB1 protein, partial	3	0	0	3
alpha-galactosidase	3	0	0	3
cytochrome P450 2C19 precursor	7	0	0	7
chromobox protein homolog 1	15	0	0	15
muscarinic acetylcholine receptor M1	9	0	0	9
lethal factor (plasmid)	8	0	0	8
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
Neutral amino acid transporter A	0	3	0	3
Neutral amino acid transporter B(0)	0	3	0	3
Carbonic anhydrase-like protein, putative	0	0	0	2
Amino acid transporter	0	3	0	3
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, 2-oxoglutarate Oxygenase	6	0	0	6
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
aldehyde dehydrogenase 1 family, member A1	18	0	0	18
hypothetical protein, conserved	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	20	0	0	20
EWS/FLI fusion protein	11	0	0	11
cytochrome P450 2D6	12	0	0	12
glucocerebrosidase	5	0	0	5
Rac1 protein	0	0	1	1
IDH1	9	0	0	9
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	7	0	0	7
Prostaglandin-H2 D-isomerase	0	1	0	1
ATP-binding cassette sub-family C member 3	0	22	0	22
Multidrug resistance-associated protein 4	0	23	0	25
Solute carrier family 22 member 6	0	3	0	3
Prostaglandin G/H synthase 1	0	4	0	4
Prostaglandin G/H synthase 2	0	3	0	3
Bile salt export pump	0	37	0	37
Epidermal growth factor receptor	0	4	1	5
Fatty acid-binding protein, liver	0	5	0	5
Integrin beta-3	2	1	0	3
Myeloperoxidase	0	2	0	2
Prostaglandin G/H synthase 1	0	4	0	4
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	2	1	0	3
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	6	0	6
Adenosine receptor A1	0	2	0	2
Adenosine receptor A2a	0	3	0	3
Substance-P receptor	0	3	0	3
Prostaglandin G/H synthase 2	0	7	0	7
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	2	0	2
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	14	2	3	19
Prostaglandin G/H synthase 2	0	4	0	4
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 20	0	5	0	5
Solute carrier family 22 member 6	0	5	0	5
Canalicular multispecific organic anion transporter 1	0	21	0	21
Sigma non-opioid intracellular receptor 1	0	6	1	7
Sigma non-opioid intracellular receptor 1	0	1	1	2
Beta-1 adrenergic receptor	0	1	3	6
Gamma-aminobutyric acid receptor subunit pi	14	1	3	18
Urease	0	1	0	1
Beta-2 adrenergic receptor	0	6	4	11
Beta-1 adrenergic receptor	0	10	3	13
Beta-3 adrenergic receptor	0	5	3	8
Gamma-aminobutyric acid receptor subunit beta-1	14	1	3	18
Gamma-aminobutyric acid receptor subunit delta	14	1	3	18
Gamma-aminobutyric acid receptor subunit gamma-2	14	1	3	18
5-hydroxytryptamine receptor 1A	0	9	2	12
Gamma-aminobutyric acid receptor subunit alpha-5	14	1	3	18
Gamma-aminobutyric acid receptor subunit alpha-3	14	1	3	18
Gamma-aminobutyric acid receptor subunit gamma-1	14	1	3	18
Gamma-aminobutyric acid receptor subunit alpha-2	14	1	3	18
Alpha-1D adrenergic receptor	0	7	2	10
Gamma-aminobutyric acid receptor subunit alpha-4	14	1	3	18
Gamma-aminobutyric acid receptor subunit gamma-3	14	1	3	18
Gamma-aminobutyric acid receptor subunit alpha-6	14	1	3	18
Alpha-1A adrenergic receptor	0	4	3	8
Alpha-1B adrenergic receptor	0	2	2	5
Gamma-aminobutyric acid receptor subunit beta-3	14	1	3	18
Gamma-aminobutyric acid receptor subunit beta-2	14	1	3	18
TAR DNA-binding protein 43	9	0	0	9
Beta-2 adrenergic receptor	0	1	4	6
GABA theta subunit	14	1	3	18
Gamma-aminobutyric acid receptor subunit epsilon	14	1	3	18
Chain A, Ferritin light chain	8	0	0	8
Fumarate hydratase	6	0	0	6
thioredoxin glutathione reductase	4	0	0	4
G	13	0	0	13
polyprotein	6	0	0	6
P53	2	0	0	2
aryl hydrocarbon receptor	14	0	0	14
peripheral myelin protein 22 isoform 1	6	0	0	6
hemoglobin subunit beta	1	0	0	1
cellular tumor antigen p53 isoform a	4	0	0	4
survival motor neuron protein isoform d	13	0	0	13
cytochrome P450 3A4 isoform 1	14	0	0	14
M-phase phosphoprotein 8	5	0	0	5
muscleblind-like protein 1 isoform 1	6	0	0	6
Bile salt export pump	0	10	0	10
Interferon beta	17	0	0	17
HLA class I histocompatibility antigen, B alpha chain	13	0	0	13
Inositol hexakisphosphate kinase 1	13	0	0	13
Protein-arginine deiminase type-4	0	2	0	2
cytochrome P450 2C9, partial	13	0	0	13
core protein, partial	0	1	0	1
histone acetyltransferase KAT2A isoform 1	6	0	0	6
Solute carrier organic anion transporter family member 1B3	0	4	0	8
Solute carrier organic anion transporter family member 1B1	0	6	0	10
Genome polyprotein	0	1	1	2
dopamine D1 receptor	3	0	0	3
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
5-hydroxytryptamine receptor 4	0	10	0	10
ATP-dependent translocase ABCB1	0	7	0	7
ATP-dependent translocase ABCB1	0	11	1	14
5-hydroxytryptamine receptor 1A	0	3	2	5
Alpha-2A adrenergic receptor	0	11	2	14
D(2) dopamine receptor	0	9	2	11
Alpha-2B adrenergic receptor	0	8	1	10
Alpha-2C adrenergic receptor	0	5	2	8
D	0	2	0	2
D(3) dopamine receptor	0	3	0	3
Alpha-2B adrenergic receptor	0	4	1	5
ATP-dependent translocase ABCB1	0	7	0	7
D(1A) dopamine receptor	0	8	1	9
Alpha-2C adrenergic receptor	0	4	1	5
Alpha-2A adrenergic receptor	0	4	1	5
D(1B) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 2A	0	10	2	12
5-hydroxytryptamine receptor 2C	0	10	2	12
5-hydroxytryptamine receptor 1B	0	9	0	9
D(4) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	8	0	8
Alpha-synuclein	5	2	0	7
5-hydroxytryptamine receptor 2B	0	8	1	9
5-hydroxytryptamine receptor 6	0	7	1	8
D(2) dopamine receptor	0	3	1	4
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Chain A, Beta-lactamase	7	0	0	7
Vitamin D3 receptor	0	0	1	1
PPM1D protein	5	0	0	5
mitogen-activated protein kinase 1	6	0	0	6
nuclear receptor ROR-gamma isoform 1	14	0	0	14
Vitamin D-binding protein	0	0	1	1
Androgen receptor	0	7	2	10
Vitamin D3 receptor	0	3	4	10
Vitamin D3 receptor	0	1	1	3
Retinoic acid receptor RXR-alpha	0	0	3	3
Kappa-type opioid receptor	0	2	1	3
Vitamin D3 receptor	0	0	2	2
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	2	1	3
Vitamin D3 receptor	0	1	1	2
Transporter	0	2	0	2
Vitamin D3 receptor A	0	0	2	2
Lactoperoxidase	0	2	0	2
67.9K protein	7	0	0	7
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
Caspase-2	0	0	1	1
Inositol monophosphatase 1	3	0	0	3
Luciferase	9	0	0	9
15-lipoxygenase, partial	6	0	0	6
60 kDa chaperonin	0	2	0	2
60 kDa heat shock protein, mitochondrial	0	2	0	2
Glycine receptor subunit alpha-1	0	0	2	2
10 kDa heat shock protein, mitochondrial	0	2	0	2
Thiosulfate sulfurtransferase	0	2	0	2
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
endonuclease IV	2	0	0	2
PAX8	0	0	0	1
pregnane X receptor	6	0	0	6
Thrombopoietin	4	0	0	4
Smad3	5	0	0	5
nuclear receptor subfamily 1, group I, member 2	10	0	0	10
cytochrome P450 2D6 isoform 1	3	0	0	3
nuclear receptor subfamily 0 group B member 1	0	1	0	1
cytochrome P450 2C9 precursor	3	0	0	3
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
ras-related protein Rab-9A	2	0	0	2
steroidogenic factor 1	0	1	0	1
caspase-1 isoform alpha precursor	3	0	0	3
Solute carrier family 22 member 3	0	2	0	2
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Plasma kallikrein	0	0	0	1
Tubulin beta-4A chain	0	2	2	5
Tubulin beta chain	0	2	2	5
Tubulin alpha-3C chain	0	2	2	5
Serine/threonine-protein kinase pim-1	0	1	1	2
Histamine H2 receptor	5	0	1	6
Tubulin alpha-1B chain	0	2	2	5
Tubulin alpha-4A chain	0	2	2	5
Tubulin beta-4B chain	0	2	2	5
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	2	2	5
Tubulin beta-2A chain	0	2	2	5
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	2	2	5
Tubulin beta-2B chain	0	2	0	2
Tubulin alpha-3E chain	0	2	2	5
Tubulin alpha-1A chain	0	2	2	5
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
CREB-binding protein	1	0	0	1
Tubulin alpha-1C chain	0	2	2	5
Tubulin beta-6 chain	0	2	2	5
Tubulin beta-2B chain	0	2	2	5
Tubulin beta-1 chain	0	2	2	5
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
Glucocorticoid receptor	0	14	5	25
Glycine receptor subunit alpha-1	0	14	0	14
Glycine receptor subunit beta	0	14	0	14
Glycine receptor subunit alpha-2	0	14	0	14
Glycine receptor subunit alpha-3	0	14	0	14
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
Multidrug and toxin extrusion protein 1	0	3	0	3
Deoxycytidine kinase	0	0	0	1
Matrix metalloproteinase-9	0	2	0	2
Isocitrate lyase	0	1	0	1
Beta-glucuronidase	0	1	0	1
Beta-glucuronidase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	4	0	4
G-protein coupled bile acid receptor 1	0	0	3	3
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
NPC1-like intracellular cholesterol transporter 1	0	0	1	1
Solute carrier organic anion transporter family member 1A4	0	2	0	5
Solute carrier organic anion transporter family member 1A5	0	0	0	3
Steryl-sulfatase	0	0	0	1
Multidrug resistance-associated protein 1	0	0	0	2
Solute carrier organic anion transporter family member 1A2	0	0	0	3
Solute carrier organic anion transporter family member 1A3	0	0	0	4
ATP-binding cassette sub-family C member 11	0	0	0	2
Solute carrier family 22 member 11	0	0	0	2
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Aldo-keto reductase family 1 member B10	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	1	0	4
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Dihydrofolate reductase	0	4	0	5
Cytochrome c oxidase subunit 2	0	1	0	1
Albumin	0	4	3	7
Interleukin-8	0	1	0	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Aldo-keto reductase family 1 member B1	0	3	0	3
UDP-glucuronosyltransferase 2B7	0	2	0	6
UDP-glucuronosyltransferase 1-6	0	2	0	3
UDP-glucuronosyltransferase 1A1	0	4	0	5
UDP-glucuronosyltransferase 1A4	0	1	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
C-X-C chemokine receptor type 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	3
UDP-glucuronosyltransferase 1A3	0	0	0	2
UDP-glucuronosyltransferase 2B10	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Cytochrome P450 2J2	0	5	0	5
Prostaglandin G/H synthase 2	0	2	0	2
Carbonic anhydrase 9	0	2	0	2
Solute carrier family 22 member 6	0	3	0	5
Prostaglandin G/H synthase 1	0	2	0	3
P2Y purinoceptor 12	0	1	0	1
UDP-glucuronosyltransferase 1A7	0	1	0	2
UDP-glucuronosyltransferase 1A10	0	1	0	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
ADP-ribose glycohydrolase MACROD2	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
Aspartate aminotransferase, cytoplasmic	0	1	0	1
huntingtin isoform 2	2	0	0	2
Spike glycoprotein	11	0	1	12
Acetylcholine receptor subunit alpha	0	1	0	1
Acetylcholine receptor subunit beta	0	1	0	1
Acetylcholine receptor subunit gamma	0	1	0	1
Acetylcholine receptor subunit delta	0	1	0	1
Acetylcholine receptor subunit delta	0	1	0	1
Acetylcholine receptor subunit alpha	0	1	0	1
Acetylcholine receptor subunit gamma	0	1	0	1
Acetylcholine receptor subunit beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	1	3
Cytochrome P450 11B1, mitochondrial	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	1	3
Cytochrome P450 11B2, mitochondrial	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-2	0	2	1	3
Transporter	0	2	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	6	0	0	6
Solute carrier family 22 member 1	0	4	0	5
Nuclear receptor subfamily 1 group I member 2	0	0	6	6
Amine oxidase [flavin-containing] A	0	2	0	2
D(4) dopamine receptor	0	5	0	5
Amine oxidase [flavin-containing] B	0	2	0	2
Delta-type opioid receptor	0	2	0	2
Delta-type opioid receptor	0	3	0	3
Mu-type opioid receptor	0	3	1	4
Kappa-type opioid receptor	0	2	0	2
Histamine H1 receptor	0	3	0	3
Mu-type opioid receptor	0	5	2	7
Delta-type opioid receptor	0	7	1	8
Kappa-type opioid receptor	0	5	1	6
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	3	1	4
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
apical membrane antigen 1, AMA1	3	0	0	3
unnamed protein product	0	1	0	1
transcriptional regulator ERG isoform 3	5	0	0	5
heat shock protein HSP 90-alpha isoform 2	0	0	0	2
bcl-2-like protein 11 isoform 1	0	0	1	1
Histone deacetylase 3	0	3	0	3
Rap guanine nucleotide exchange factor 3	3	0	0	3
Chymotrypsinogen A	0	3	0	3
Steroid 17-alpha-hydroxylase/17,20 lyase	0	4	0	4
Heme oxygenase 1	0	2	0	2
Lanosterol 14-alpha demethylase	0	1	1	2
Aromatase	0	5	0	5
Heme oxygenase 2	0	2	0	2
Malate dehydrogenase, cytoplasmic	0	3	0	3
Histone deacetylase 4	0	3	0	3
Cytochrome P450 144	0	0	3	3
Steroid C26-monooxygenase	0	0	3	3
Steroid C26-monooxygenase	0	0	3	3
Mycocyclosin synthase	0	0	2	2
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	2	2
Histone deacetylase 1	0	3	0	3
Lanosterol 14-alpha demethylase	0	5	2	7
Sterol 14-alpha demethylase	0	0	1	1
Sterol 14-alpha demethylase	0	1	1	2
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	3	0	3
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	3	0	3
14-alpha sterol demethylase	0	0	1	1
Histone deacetylase 8	0	3	0	3
Histone deacetylase 6	0	3	0	3
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	3	0	3
heat shock protein 90, putative	0	0	0	2
likely tRNA 2'-phosphotransferase	0	1	0	1
GALC protein	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	5	0	0	5
lysosomal alpha-glucosidase preproprotein	1	0	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Chain A, Estrogen receptor 1 (alpha)	0	1	0	1
Chain A, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
glp-1 receptor, partial	6	0	0	6
BRCA1	1	0	0	1
Neuraminidase	0	1	0	1
Parkin	2	0	0	2
Alpha-mannosidase	0	1	0	1
pyruvate kinase	1	0	0	1
hexokinase-4 isoform 1	2	0	0	2
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
histone deacetylase 9 isoform 3	1	0	0	1
glucokinase regulatory protein	2	0	0	2
glycogen synthase kinase-3 beta isoform 1	0	0	2	2
DNA polymerase beta	2	0	0	2
tyrosine-protein kinase Yes	1	0	0	1
pyruvate kinase PKM isoform b	1	0	0	1
Maltase-glucoamylase, intestinal	0	2	0	2
Steroid hormone receptor ERR2	0	1	0	1
Tyrosine-protein kinase ABL1	0	1	2	3
Pancreatic triacylglycerol lipase	0	1	0	1
Triosephosphate isomerase	0	1	0	1
Estrogen receptor	0	6	2	8
Tyrosine-protein kinase Fyn	0	2	1	3
Cyclin-dependent kinase 1	0	1	1	2
Ornithine decarboxylase	1	0	0	1
Sialidase	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 1	0	1	0	1
Tyrosinase	0	1	0	1
Steroid hormone receptor ERR1	0	1	0	1
Cyclin-dependent kinase 4	0	1	1	2
Ornithine decarboxylase	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
Cystic fibrosis transmembrane conductance regulator	0	0	1	1
17-beta-hydroxysteroid dehydrogenase type 1	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 4	0	1	0	1
G2/mitotic-specific cyclin-B1	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Protein kinase C alpha type	0	1	1	2
cAMP-dependent protein kinase catalytic subunit alpha	0	1	1	2
Amine oxidase [flavin-containing] A	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
G1/S-specific cyclin-D1	0	1	0	1
Thromboxane-A synthase	0	3	0	3
Cruzipain	0	1	0	1
DNA (cytosine-5)-methyltransferase 1	0	2	0	2
Dipeptidyl peptidase 4	0	1	0	1
Proteasome subunit beta type-5	0	1	0	1
Adenosine receptor A2a	0	6	1	7
Sodium-dependent serotonin transporter	0	3	0	3
RAC-alpha serine/threonine-protein kinase	0	1	1	2
Cystic fibrosis transmembrane conductance regulator	0	0	1	1
Testosterone 17-beta-dehydrogenase 3	0	1	0	1
17-beta-hydroxysteroid dehydrogenase type 2	0	1	0	1
Acetylcholinesterase	0	1	0	1
Alpha-glucosidase MAL32	0	1	0	1
Signal transducer and activator of transcription 3	0	1	0	1
Tyrosine-protein kinase CSK	0	1	1	2
Tyrosine-protein kinase ABL2	0	1	1	2
Tyrosine-protein kinase SYK	0	1	1	2
Dual specificity mitogen-activated protein kinase kinase 4	0	1	0	1
Quinone oxidoreductase	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Cytoplasmic tyrosine-protein kinase BMX	0	1	0	1
Death-associated protein kinase 1	0	1	0	1
Mitogen-activated protein kinase 10	0	1	1	2
Oxysterols receptor LXR-beta	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	0	2
MO15-related protein kinase Pfmrk	0	1	0	1
Sodium-dependent dopamine transporter	0	6	0	6
Aldehyde oxidase	0	1	0	1
Oxysterols receptor LXR-alpha	0	1	0	1
Tissue alpha-L-fucosidase	0	1	0	1
Substance-K receptor	0	1	0	1
Integrase	0	1	0	1
Estrogen receptor beta	0	6	2	8
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)	0	1	0	1
Prenyltransferase homolog	0	0	0	1
Carboxylic ester hydrolase	0	1	0	1
Dipeptidyl peptidase 3	0	1	0	1
DNA (cytosine-5)-methyltransferase 3-like	0	2	0	2
Sialidase-2	0	1	0	1
DNA (cytosine-5)-methyltransferase 3A	0	2	0	2
Glycogen phosphorylase, muscle form	0	1	0	1
Asialoglycoprotein receptor 1	0	1	1	2
Chain A, Glutamine Binding Protein	0	0	1	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
Asc-type amino acid transporter 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	5	0	5
nonstructural protein 1	3	0	0	3
Acid-sensing ion channel 3	0	1	0	1
Albumin	0	1	0	1
Albumin	0	0	2	2
Cholinesterase	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	3
Acetylcholinesterase	0	5	0	5
Prostaglandin G/H synthase 1	0	1	0	1
Caspase-1	0	1	0	1
Aldo-keto reductase family 1 member C3	0	2	0	2
Caspase-3	0	1	0	1
Caspase-4	0	1	0	1
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Acid-sensing ion channel 1	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Solute carrier family 22 member 8	0	3	0	4
Dehydrogenase/reductase SDR family member 9	0	1	0	1
NPYLR7B	0	0	2	2
beta-2 adrenergic receptor	1	0	0	1
Beta-2 adrenergic receptor	0	4	1	6
Alpha-1B adrenergic receptor	0	6	1	7
Beta-1 adrenergic receptor	0	5	2	9
Beta-2 adrenergic receptor	0	0	1	1
Alpha-1D adrenergic receptor	0	4	1	5
Beta-adrenergic receptor kinase 1	0	0	2	2
Beta-3 adrenergic receptor	0	0	1	1
Beta-3 adrenergic receptor	0	3	1	4
Vasopressin V1a receptor	0	0	1	1
Beta-1 adrenergic receptor	0	2	1	3
Alpha-1A adrenergic receptor	0	6	1	7
D(1A) dopamine receptor	1	0	0	1
Beta-2 adrenergic receptor	0	2	0	2
Taste receptor type 2 member 38	0	0	2	3
Taste receptor type 2 member 39	0	0	1	1
Taste receptor type 2 member 40	0	0	1	1
Taste receptor type 2 member 41	0	0	1	1
Taste receptor type 2 member 43	0	0	1	1
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 45	0	0	1	1
Taste receptor type 2 member 46	0	0	1	1
Taste receptor type 2 member 30	0	0	1	1
Taste receptor type 2 member 19	0	0	1	1
Taste receptor type 2 member 20	0	0	1	1
Taste receptor type 2 member 50	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Oxytocin receptor	0	0	1	1
Glutamate receptor ionotropic, NMDA 2A	0	0	1	1
Glutamate receptor ionotropic, NMDA 2B	0	0	1	1
Glutamate receptor ionotropic, NMDA 2C	0	0	1	1
Beta-2 adrenergic receptor	0	1	1	2
Glutamate receptor ionotropic, NMDA 2D	0	0	1	1
Taste receptor type 2 member 42	0	0	1	1
Glutamate receptor ionotropic, NMDA 3B	0	0	1	1
Taste receptor type 2 member 16	0	0	1	1
Taste receptor type 2 member 14	0	0	1	1
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 10	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 8	0	0	1	1
Taste receptor type 2 member 7	0	0	1	1
Taste receptor type 2 member 5	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Taste receptor type 2 member 3	0	0	1	1
Taste receptor type 2 member 1	0	0	1	1
Glutamate receptor ionotropic, NMDA 3A	0	0	1	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Estrogen receptor beta	0	1	0	2
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	1	0	1
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	2	0	2
Cytochrome P450 26A1	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Camphor 5-monooxygenase	0	0	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Epoxide hydrolase 1	0	0	0	2
Aldo-keto reductase family 1 member B1	0	7	0	7
Muscarinic acetylcholine receptor M2	0	6	1	7
Cytochrome P450 2C11	0	1	0	1
Steroid 21-hydroxylase	0	1	0	1
Cytochrome P450 2C8	0	2	0	2
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	1	0	1
5-hydroxytryptamine receptor 2A	0	4	0	4
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Cytochrome P450 2A2	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Translocator protein	0	1	0	1
Cytochrome P450 7A1	0	1	0	1
Estrogen receptor	0	1	0	2
Substance-K receptor	0	4	0	4
Sodium-dependent noradrenaline transporter	0	6	0	6
Histamine H2 receptor	0	8	0	8
Gonadotropin-releasing hormone receptor	0	1	1	2
Sodium-dependent serotonin transporter	0	7	0	7
Type-1 angiotensin II receptor	0	1	0	1
Cytochrome P450 4F2	0	1	0	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	1	0	1
Sodium/bile acid cotransporter	0	3	0	3
Cytochrome P450 7A1	0	1	0	1
Lanosterol 14-alpha demethylase	0	2	0	2
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
5-hydroxytryptamine receptor 1A	0	2	0	2
Type-1 angiotensin II receptor	0	1	0	1
PINK1	1	0	0	1
Progesterone receptor	0	5	1	7
Androgen receptor	0	0	1	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Polyphenol oxidase 2	0	3	0	5
Dopamine beta-hydroxylase	0	2	0	2
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	3
5-hydroxytryptamine receptor 2C	0	3	0	4
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	2	0	0	2
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
Vpr	1	0	0	1
Metabotropic glutamate receptor 6	0	1	0	1
Acetylcholinesterase	0	2	0	2
Cytochrome P450 1A2	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Muscarinic acetylcholine receptor M4	0	3	0	3
Adenosine receptor A3	0	4	1	5
Muscarinic acetylcholine receptor M1	0	4	1	5
Muscarinic acetylcholine receptor M3	0	5	1	6
Cannabinoid receptor 1	0	2	0	2
Aromatase	0	0	1	1
Substance-P receptor	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Melanocortin receptor 4	0	2	0	2
Melanocortin receptor 5	0	2	0	2
Melanocortin receptor 3	0	2	0	2
Type-2 angiotensin II receptor	0	2	0	2
Beta-lactamase TEM	0	1	0	1
Cholinesterase	0	2	0	2
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Calcium release-activated calcium channel protein 1	0	1	0	1
methionyl-tRNA synthetase, putative	0	1	0	1
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	2	1	3
Glutamate receptor 1	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor 4	0	1	0	1
Inosine-5'-monophosphate dehydrogenase 1	0	2	0	2
Peroxisome proliferator-activated receptor gamma	0	0	5	5
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
UDP-glucuronosyltransferase 1A8	0	0	0	1
Platelet glycoprotein VI	0	0	1	1
Hsf1 protein	0	0	1	2
Synaptic vesicle glycoprotein 2A	0	1	0	1
luciferase	0	0	0	1
Glucocorticoid receptor	0	2	1	3
Glucocorticoid receptor	0	0	1	1
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	1	1	2
Nociceptin receptor	0	0	1	1
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 2	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	3	0	3
Sterol O-acyltransferase 1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Acetylcholinesterase	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1S	0	3	0	3
Solute carrier family 22 member 1	0	2	0	2
Solute carrier family 22 member 2	0	2	0	2
Solute carrier family 22 member 4	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Endothelin-1 receptor	0	1	1	2
5-hydroxytryptamine receptor 1B	0	2	1	3
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	1	1	2
5-hydroxytryptamine receptor 7	0	2	1	3
Vasopressin V1a receptor	0	1	1	2
5-hydroxytryptamine receptor 7	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	2	0	2
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
NADH-cytochrome b5 reductase 3	0	1	0	1
Thyroid peroxidase	0	1	0	1
Interleukin-5	0	1	0	1
Interleukin-5	0	1	0	1
Interleukin-5 receptor subunit alpha	0	1	0	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 1	0	1	0	1
P2X purinoceptor 4	0	0	1	1
Trans-sialidase	0	1	0	1
Trans-sialidase	0	1	0	1
P2X purinoceptor 2	0	0	1	1
Monocarboxylate transporter 4	0	0	0	1
Monocarboxylate transporter 2	0	0	0	1
Monocarboxylate transporter 1	0	0	0	1
C-terminal-binding protein 2	0	1	0	1
Monocarboxylate transporter 2	0	1	0	1
Prolyl 4-hydroxylase	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Amyloid-beta precursor protein	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
NS5	0	0	1	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
Polymerase basic protein 2	0	0	1	1
RNA-directed RNA polymerase catalytic subunit	0	0	1	1
Polymerase acidic protein	0	0	2	2
Procathepsin L	0	0	1	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Adenosylhomocysteinase	0	0	0	2
Adenosine receptor A1	0	1	0	1
Genome polyprotein	0	0	1	1
Angiotensin-converting enzyme 2	0	0	1	1
Chain A, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain B, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain H, Immunoglobulin Igg1 Heavy chain	0	0	1	1
Chain L, Immunoglobulin Igg1 Lambda Light Chain	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain C, DODECIN	0	0	1	1
Chain E, DODECIN	0	0	1	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
Riboflavin-binding protein	0	1	1	2
Muscarinic acetylcholine receptor M5	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Sodium-dependent dopamine transporter	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
D(2) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Multidrug and toxin extrusion protein 2	0	1	0	1
Histamine H3 receptor	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Carbonic anhydrase 12	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Carbonic anhydrase 4	0	1	0	1
Carbonic anhydrase 6	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase 7	0	1	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
Pyruvate kinase PKM	0	0	1	1
Bone morphogenetic protein receptor type-1B	0	0	1	1
Cell division cycle 7-related protein kinase	0	0	1	1
Serine/threonine-protein kinase PLK4	0	0	1	1
ATP-dependent RNA helicase DDX3X	0	0	1	1
Pyridoxal kinase	0	0	1	1
Citron Rho-interacting kinase	0	0	1	1
Serine/threonine-protein kinase Chk1	0	0	1	1
Aurora kinase A	0	0	1	1
Cyclin-G-associated kinase	0	0	1	1
Ephrin type-B receptor 6	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 3	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 2	0	0	1	1
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	1	1
Dynamin-like 120 kDa protein, mitochondrial	0	0	1	1
Tyrosine-protein kinase JAK2	0	0	1	1
Eukaryotic translation initiation factor 5B	0	0	1	1
Rho-associated protein kinase 2	0	0	1	1
Serine/threonine-protein kinase ULK1	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	1	1
Ribosomal protein S6 kinase alpha-5	0	0	1	1
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	1	1
Ribosomal protein S6 kinase alpha-4	0	0	1	1
Serine/threonine-protein kinase 16	0	0	1	1
Cyclin-dependent kinase-like 5	0	0	1	1
Serine/threonine-protein kinase 10	0	0	1	1
Serine/threonine-protein kinase D3	0	0	1	1
Structural maintenance of chromosomes protein 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 6	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	1	1
Serine/threonine-protein kinase LATS1	0	0	1	1
Serine/threonine-protein kinase PAK 4	0	0	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
High affinity nerve growth factor receptor	0	0	1	1
ADP/ATP translocase 2	0	0	1	1
Protein kinase C beta type	0	0	1	1
Insulin receptor	0	0	1	1
Tyrosine-protein kinase Lck	0	0	1	1
Eukaryotic translation initiation factor 4E	0	0	1	1
Glycogen phosphorylase, liver form	0	0	1	1
Tyrosine-protein kinase Fes/Fps	0	0	1	1
Adenine phosphoribosyltransferase	0	0	1	1
Tyrosine-protein kinase Yes	0	0	1	1
Tyrosine-protein kinase Lyn	0	0	1	1
Proto-oncogene tyrosine-protein kinase receptor Ret	0	0	1	1
Insulin-like growth factor 1 receptor	0	0	1	1
Signal recognition particle receptor subunit alpha	0	0	1	1
Cytochrome c1, heme protein, mitochondrial	0	0	1	1
Hepatocyte growth factor receptor	0	0	1	1
Tyrosine-protein kinase HCK	0	0	1	1
Platelet-derived growth factor receptor beta	0	0	1	1
Tyrosine-protein kinase Fgr	0	0	1	1
Serine/threonine-protein kinase A-Raf	0	0	1	1
Glycogen phosphorylase, brain form	0	0	1	1
Breakpoint cluster region protein	0	0	1	1
Fibroblast growth factor receptor 1	0	0	1	1
DNA topoisomerase 2-alpha	0	0	1	1
ADP/ATP translocase 3	0	0	1	1
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	1	1
Serine/threonine-protein kinase B-raf	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	1	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	0	1	1
Tyrosine-protein kinase Fer	0	0	1	1
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	1	1
Casein kinase II subunit alpha'	0	0	1	1
Ras-related protein Rab-6A	0	0	1	1
Ephrin type-A receptor 1	0	0	1	1
Multifunctional protein ADE2	0	0	1	1
cAMP-dependent protein kinase catalytic subunit beta	0	0	1	1
Ferrochelatase, mitochondrial	0	0	1	1
Ribosomal protein S6 kinase beta-1	0	0	1	1
Tyrosine-protein kinase JAK1	0	0	1	1
Probable ATP-dependent RNA helicase DDX6	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	1	0	1
Mitogen-activated protein kinase 3	0	0	1	1
MAP/microtubule affinity-regulating kinase 3	0	0	1	1
Deoxycytidine kinase	0	0	1	1
Mitogen-activated protein kinase 1	0	0	1	1
Ephrin type-A receptor 2	0	0	1	1
Ephrin type-B receptor 2	0	0	1	1
Non-receptor tyrosine-protein kinase TYK2	0	0	1	1
UMP-CMP kinase	0	0	1	1
Phosphatidylethanolamine-binding protein 1	0	0	1	1
Wee1-like protein kinase	0	0	1	1
Heme oxygenase 2	0	0	1	1
S-adenosylmethionine synthase isoform type-2	0	0	1	1
DnaJ homolog subfamily A member 1	0	0	1	1
RAC-beta serine/threonine-protein kinase	0	0	1	1
Dual specificity protein kinase TTK	0	0	1	1
DNA replication licensing factor MCM4	0	0	1	1
Myosin-10	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 2	0	0	1	1
Receptor-type tyrosine-protein kinase FLT3	0	0	1	1
Bone morphogenetic protein receptor type-1A	0	0	1	1
Activin receptor type-1B	0	0	1	1
TGF-beta receptor type-1	0	0	1	1
Serine/threonine-protein kinase receptor R3	0	0	1	1
TGF-beta receptor type-2	0	0	1	1
Electron transfer flavoprotein subunit beta	0	0	1	1
Glycine--tRNA ligase	0	0	1	1
Protein kinase C iota type	0	0	1	1
Exosome RNA helicase MTR4	0	0	1	1
Serine/threonine-protein kinase mTOR	0	2	1	3
Tyrosine-protein kinase Tec	0	0	1	1
Tyrosine-protein kinase FRK	0	0	1	1
G protein-coupled receptor kinase 6	0	0	1	1
26S proteasome regulatory subunit 6B	0	0	1	1
Mitogen-activated protein kinase 8	0	0	1	1
Mitogen-activated protein kinase 9	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 3	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	1	1
Casein kinase I isoform alpha	0	0	1	1
Casein kinase I isoform delta	0	0	1	1
MAP kinase-activated protein kinase 2	0	0	1	1
Elongation factor Tu, mitochondrial	0	0	1	1
Choline-phosphate cytidylyltransferase A	0	0	1	1
Cysteine--tRNA ligase, cytoplasmic	0	0	1	1
Casein kinase I isoform epsilon	0	0	1	1
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	1	1
Dual specificity protein kinase CLK1	0	0	1	1
Dual specificity protein kinase CLK2	0	0	1	1
Dual specificity protein kinase CLK3	0	0	1	1
Glycogen synthase kinase-3 alpha	0	0	1	1
Glycogen synthase kinase-3 beta	0	0	1	1
Cyclin-dependent kinase 7	0	0	1	1
Cyclin-dependent kinase 9	0	0	1	1
Ras-related protein Rab-27A	0	0	1	1
Interleukin-1 receptor-associated kinase 1	0	0	1	1
Ribosomal protein S6 kinase alpha-3	0	0	1	1
Serine/threonine-protein kinase Nek2	0	0	1	1
Serine/threonine-protein kinase Nek3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 6	0	0	1	1
Serine/threonine-protein kinase PLK1	0	0	1	1
LIM domain kinase 1	0	0	1	1
LIM domain kinase 2	0	0	1	1
Tyrosine--tRNA ligase, cytoplasmic	0	0	1	1
Ephrin type-B receptor 3	0	0	1	1
Ephrin type-A receptor 5	0	0	1	1
Ephrin type-B receptor 4	0	0	1	1
Ephrin type-A receptor 4	0	0	1	1
Adenosine kinase	0	0	1	1
Ras-related protein Rab-10	0	0	1	1
Actin-related protein 3	0	0	1	1
Actin-related protein 2	0	0	1	1
GTP-binding nuclear protein Ran	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	4	2	6
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	2	2
Casein kinase I isoform gamma-2	0	0	1	1
Cyclin-dependent kinase 6	0	0	1	1
Cyclin-dependent-like kinase 5	0	0	1	1
Cyclin-dependent kinase 16	0	0	1	1
Cyclin-dependent kinase 17	0	0	1	1
ATP-dependent 6-phosphofructokinase, platelet type	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 1	0	0	1	1
DNA topoisomerase 2-beta	0	0	1	1
Protein kinase C theta type	0	0	1	1
Activin receptor type-1	0	0	1	1
Macrophage-stimulating protein receptor	0	0	1	1
Focal adhesion kinase 1	0	0	1	1
Protein kinase C zeta type	0	0	1	1
Protein kinase C delta type	0	0	1	1
Tyrosine-protein kinase BTK	0	0	1	1
Cyclin-dependent kinase 18	0	0	1	1
Activated CDC42 kinase 1	0	0	1	1
Epithelial discoidin domain-containing receptor 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	1	1
Tyrosine-protein kinase Mer	0	0	1	1
Serine/threonine-protein kinase 4	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase 7	0	0	1	1
Serine/threonine-protein kinase PAK 2	0	0	1	1
Serine/threonine-protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 1	0	0	1	1
Integrin-linked protein kinase	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	2	0	2
Rho-associated protein kinase 1	0	0	1	1
Non-receptor tyrosine-protein kinase TNK1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	1	1
Activin receptor type-2B	0	0	1	1
Bone morphogenetic protein receptor type-2	0	0	1	1
Protein-tyrosine kinase 6	0	0	1	1
cGMP-dependent protein kinase 1	0	0	1	1
Cyclin-dependent kinase 13	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	1	1
Protein-tyrosine kinase 2-beta	0	0	1	1
Maternal embryonic leucine zipper kinase	0	0	1	1
Structural maintenance of chromosomes protein 1A	0	0	1	1
Chromodomain-helicase-DNA-binding protein 4	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 1	0	0	1	1
Delta(24)-sterol reductase	0	0	1	1
Ribosomal protein S6 kinase alpha-1	0	0	1	1
Dual specificity testis-specific protein kinase 1	0	0	1	1
Myosin light chain kinase, smooth muscle	0	0	1	1
Serine/threonine-protein kinase STK11	0	0	1	1
Serine/threonine-protein kinase N1	0	0	1	1
Serine/threonine-protein kinase N2	0	0	1	1
Calcium/calmodulin-dependent protein kinase type IV	0	0	1	1
Mitogen-activated protein kinase kinase kinase 11	0	0	1	1
Discoidin domain-containing receptor 2	0	0	1	1
AP2-associated protein kinase 1	0	0	1	1
Myosin light chain kinase 3	0	0	1	1
Uncharacterized aarF domain-containing protein kinase 5	0	0	1	1
Programmed cell death protein 4	0	0	1	1
Putative heat shock protein HSP 90-beta 2	0	0	1	1
Serine/threonine-protein kinase MRCK alpha	0	0	1	1
Serine/threonine-protein kinase MRCK gamma	0	0	1	1
Acyl-CoA dehydrogenase family member 10	0	0	1	1
Serine/threonine-protein kinase N3	0	0	1	1
Serine/threonine-protein kinase ULK3	0	0	1	1
Uncharacterized protein FLJ45252	0	0	1	1
Acyl-CoA dehydrogenase family member 11	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	1	1
Serine/threonine-protein kinase MARK2	0	0	1	1
ATP-dependent RNA helicase DHX30	0	0	1	1
Serine/threonine-protein kinase TAO1	0	0	1	1
STE20-related kinase adapter protein alpha	0	0	1	1
Myosin-14	0	0	1	1
AarF domain-containing protein kinase 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	1	1
MAP kinase-activated protein kinase 5	0	0	1	1
Regulatory-associated protein of mTOR	0	1	0	1
Misshapen-like kinase 1	0	0	1	1
Atypical kinase COQ8A, mitochondrial	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	1	1
Mitogen-activated protein kinase 15	0	0	1	1
Serine/threonine-protein kinase Nek9	0	0	1	1
ATP-dependent RNA helicase DDX1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	1	1
MAP/microtubule affinity-regulating kinase 4	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1G	0	0	1	1
Serine/threonine-protein kinase Nek1	0	0	1	1
PAS domain-containing serine/threonine-protein kinase	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	1	1
EKC/KEOPS complex subunit TP53RK	0	0	1	1
Dual specificity testis-specific protein kinase 2	0	0	1	1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase kinase kinase 3	0	0	1	1
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	1	1
Target of rapamycin complex subunit LST8	0	1	0	1
Nucleolar GTP-binding protein 1	0	0	1	1
Serine/threonine-protein kinase D2	0	0	1	1
RNA cytidine acetyltransferase	0	0	1	1
Serine/threonine-protein kinase SIK2	0	0	1	1
STE20-like serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO3	0	0	1	1
dCTP pyrophosphatase 1	0	0	1	1
Dual specificity protein kinase CLK4	0	0	1	1
Casein kinase I isoform gamma-1	0	0	1	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Phenylalanine--tRNA ligase beta subunit	0	0	1	1
Isoleucine--tRNA ligase, mitochondrial	0	0	1	1
BMP-2-inducible protein kinase	0	0	1	1
Obg-like ATPase 1	0	0	1	1
Midasin	0	0	1	1
Interleukin-1 receptor-associated kinase 4	0	0	1	1
Mitogen-activated protein kinase kinase kinase 20	0	0	1	1
Cyclin-dependent kinase 12	0	0	1	1
Serine/threonine-protein kinase 26	0	0	1	1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	1	1
Serine/threonine-protein kinase NLK	0	0	1	1
Serine/threonine-protein kinase TBK1	0	0	1	1
Septin-9	0	0	1	1
Ribosomal protein S6 kinase alpha-6	0	0	1	1
TRAF2 and NCK-interacting protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO2	0	0	1	1
Serine/threonine-protein kinase ICK	0	0	1	1
RAC-gamma serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase SIK3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 2	0	0	1	1
Thyroid hormone receptor-associated protein 3	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 3	0	0	1	1
Serine/threonine-protein kinase MRCK beta	0	0	1	1
Interleukin-1 receptor-associated kinase 3	0	0	1	1
Serine/threonine-protein kinase 24	0	0	1	1
Casein kinase I isoform gamma-3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 4	0	0	1	1
Cytochrome P450 3A5	0	1	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
cystic fibrosis transmembrane conductance regulator	0	1	0	1
C-8 sterol isomerase	0	1	0	1
Squalene monooxygenase	0	1	0	1
Squalene monooxygenase	0	2	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Thymidine kinase	0	1	0	2
Thymidine kinase, cytosolic	0	2	0	4
Thymidine kinase	0	1	0	2
Thymidine phosphorylase	0	0	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Thymidine phosphorylase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidine kinase	0	0	0	1
Thymidine phosphorylase	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Thyroid hormone receptor alpha	0	2	3	5
Thyroid hormone receptor beta	0	2	3	5
Proliferating cell nuclear antigen	0	2	0	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	2
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	1	2
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Prothrombin	0	0	1	1
Thyroid hormone receptor beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
Ubiquitin carboxyl-terminal hydrolase 2	0	1	0	1
Ileal sodium/bile acid cotransporter	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
M1-family alanyl aminopeptidase	0	1	0	1
Cocaine esterase	0	1	0	1
Cytochrome P450 2A6	0	1	0	1
Tissue factor	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Liver carboxylesterase 1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(34)

Research Excerpts

Overview

Research

Studies (215)

Protein Targets (1,290)

AIRE Deficiency

Synonyms(34)

Research Excerpts

Overview

Research

Studies (215)

Drugs Studied (130)

Protein Targets (1,290)