Page last updated: 2024-10-27

fluconazole and Rhabdomyolysis

fluconazole has been researched along with Rhabdomyolysis in 8 studies

Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.
fluconazole : A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.

Rhabdomyolysis: Necrosis or disintegration of skeletal muscle often followed by myoglobinuria.

Research Excerpts

ExcerptRelevanceReference
" When intravenous fluconazole was added for treating a fungal infection, rhabdomyolysis developed 2 weeks later."7.83Rhabdomyolysis caused by the moderate CYP3A4 inhibitor fluconazole in a patient on stable atorvastatin therapy: a case report and literature review. ( Chang, HJ; Hsiao, SH; Hsieh, TH; Kao, SM; Wu, TJ; Yeh, PY, 2016)
" After administration of atorvastatin, amiodarone, and fluconazole, rhabdomyolysis developed with electrolyte disturbances (hyperphosphatemia, hyopcalcemia) and a massive increase in creatine kinase and myoglobin."7.77[Rhabdomyolysis associated with atorvastatin combined with amiodarone and fluconazole]. ( Bruggisser, M; Franz, CC; Krähenbühl, S; Rätz Bravo, AE, 2011)
"Rhabdomyolysis is a potential adverse consequence of statin therapy."5.35Rhabdomyolysis induced by simvastatin-fluconazole combination. ( Abuzetun, JY; Hazin, R; Porter, J; Suker, M, 2008)
" After administration of atorvastatin, amiodarone, and fluconazole, rhabdomyolysis developed with electrolyte disturbances (hyperphosphatemia, hyopcalcemia) and a massive increase in creatine kinase and myoglobin."3.77[Rhabdomyolysis associated with atorvastatin combined with amiodarone and fluconazole]. ( Bruggisser, M; Franz, CC; Krähenbühl, S; Rätz Bravo, AE, 2011)
"Exertional rhabdomyolysis is a common condition with potentially life-threatening consequences; early recognition can prevent severe downstream complications."1.51Exertional Rhabdomyolysis in a Long-Distance Migrant. ( Andreae, MC; Fernando, DB; McVane, BA; Strayer, RJ, 2019)
"Rhabdomyolysis is a serious complication of statin treatment."1.46Weakness and pain in arms and legs · dark urine · history of vertebral osteomyelitis · Dx? ( Brateanu, A; Charokopos, A; Muhammad, T; Surbhi, S, 2017)
"Rhabdomyolysis was suspected and both drugs were discontinued."1.43[Myopathy in a patient during simvastatin and fluconazole treatment]. ( Junker, P; Lydolph, MC; Pedersen, JK; Somnier, F, 2016)
"Rhabdomyolysis is a potential adverse consequence of statin therapy."1.35Rhabdomyolysis induced by simvastatin-fluconazole combination. ( Abuzetun, JY; Hazin, R; Porter, J; Suker, M, 2008)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (37.50)29.6817
2010's5 (62.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
McVane, BA1
Andreae, MC1
Fernando, DB1
Strayer, RJ1
Hsiao, SH1
Chang, HJ1
Hsieh, TH1
Kao, SM1
Yeh, PY1
Wu, TJ1
Pedersen, JK1
Lydolph, MC1
Somnier, F1
Junker, P1
Charokopos, A1
Muhammad, T1
Surbhi, S1
Brateanu, A1
Findling, O1
Meier, N1
Sellner, J1
Nedeltchev, K1
Arnold, M1
Franz, CC1
Bruggisser, M1
Krähenbühl, S1
Rätz Bravo, AE1
Kahri, J1
Valkonen, M1
Bäcklund, T1
Vuoristo, M1
Kivistö, KT1
Hazin, R1
Abuzetun, JY1
Suker, M1
Porter, J1

Other Studies

8 other studies available for fluconazole and Rhabdomyolysis

ArticleYear
Exertional Rhabdomyolysis in a Long-Distance Migrant.
    The Journal of emergency medicine, 2019, Volume: 56, Issue:5

    Topics: Acute Kidney Injury; Anti-Bacterial Agents; Clindamycin; Creatine Kinase; Female; Fluconazole; Human

2019
Rhabdomyolysis caused by the moderate CYP3A4 inhibitor fluconazole in a patient on stable atorvastatin therapy: a case report and literature review.
    Journal of clinical pharmacy and therapeutics, 2016, Volume: 41, Issue:5

    Topics: Aged; Atorvastatin; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Female; Fluconazole; Human

2016
[Myopathy in a patient during simvastatin and fluconazole treatment].
    Ugeskrift for laeger, 2016, Sep-26, Volume: 178, Issue:39

    Topics: Aged; Antifungal Agents; Drug Interactions; Female; Fluconazole; Humans; Hydroxymethylglutaryl-CoA R

2016
Weakness and pain in arms and legs · dark urine · history of vertebral osteomyelitis · Dx?
    The Journal of family practice, 2017, Volume: 66, Issue:3

    Topics: Adult; Arm; Cytochrome P-450 CYP3A Inhibitors; Diagnosis, Differential; Drug Interactions; Drug-Rela

2017
Clinical reasoning: rhabdomyolysis after combined treatment with simvastatin and fluconazole.
    Neurology, 2008, Oct-07, Volume: 71, Issue:15

    Topics: Aged; Anticholesteremic Agents; Antifungal Agents; Candidiasis; Diagnosis, Differential; Drug Therap

2008
[Rhabdomyolysis associated with atorvastatin combined with amiodarone and fluconazole].
    Praxis, 2011, Mar-02, Volume: 100, Issue:5

    Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Anticholesteremic Agents; Antifungal Agents; Atorvastatin;

2011
Rhabdomyolysis in a patient receiving atorvastatin and fluconazole.
    European journal of clinical pharmacology, 2005, Volume: 60, Issue:12

    Topics: Antifungal Agents; Atorvastatin; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Drug Sy

2005
Rhabdomyolysis induced by simvastatin-fluconazole combination.
    Journal of the National Medical Association, 2008, Volume: 100, Issue:4

    Topics: Acute Kidney Injury; Aged; Antifungal Agents; Biomarkers; Creatine Kinase; Drug Interactions; Drug T

2008