Page last updated: 2024-10-27

fluconazole and Co-infection

fluconazole has been researched along with Co-infection in 27 studies

Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.
fluconazole : A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.

Research Excerpts

ExcerptRelevanceReference
"Cryptococcal antigen screening is recommended among people living with AIDS when entering HIV care with a CD4 count of <100 cells/μl, and preemptive fluconazole monotherapy treatment is recommended for those with subclinical cryptococcal antigenemia."5.20Increased Antifungal Drug Resistance in Clinical Isolates of Cryptococcus neoformans in Uganda. ( Achan, B; Akampurira, A; Alhadab, AA; Boulware, DR; Hullsiek, KH; McDonald, TR; Meya, DB; Nielsen, K; Okagaki, LH; Rhein, JR; Smith, KD, 2015)
" provided a novel perspective by identifying synergism between fluconazole and bacterial antagonism in the context of Candida albicans-Pseudomonas aeruginosa co-infection."4.12Competition for Iron during Polymicrobial Infections May Increase Antifungal Drug Susceptibility-How Will It Impact Treatment Options? ( Pohl, CH, 2022)
" Clinical features and outcome were compared in 25 (41%) Candida-positive patients (6 (22%) fluconazole-resistant Candida glabrata) and 36 patients without Candida infection."3.81Positive peritoneal fluid fungal cultures in postoperative peritonitis after bariatric surgery. ( Chochillon, C; Desmard, M; Houze, S; Marmuse, JP; Montravers, P; Ribeiro-Parenti, L; Zappella, N, 2015)
"The prevalence of fungal secondary infections among COVID-19 patients and efficacy of antifungal therapy used in such patients is still unknown."2.82Antifungal therapy in the management of fungal secondary infections in COVID-19 patients: A systematic review and meta-analysis. ( Kumar, TMP; Pathakamuri, N; Ramaswamy, S; Ramesh, M; Sah, SK; Shariff, A; Srikanth, MS; Undela, K, 2022)
" The objective of this study was to compare the survival benefit between 5-FC (flucytosine) and fluconazole as second-line drugs given in combination with AmB."2.50Comparison of flucytosine and fluconazole combined with amphotericin B for the treatment of HIV-associated cryptococcal meningitis: a systematic review and meta-analysis. ( Lin, DF; Lu, X; Shen, C; Yao, ZW, 2014)
"Polymicrobial infections are challenging to treat because we don't fully understand how pathogens interact during infection and how these interactions affect drug efficacy."1.72Pseudomonas Synergizes with Fluconazole against ( Dagher, AM; Hattab, S; Wheeler, RT, 2022)
" The objective of this study was to find an effective drug combination to treat dual-species cultures of fungi and bacteria."1.72Synergistic Effects of Fluconazole Combined with Doxycycline Against Dual-Species Cultures of ( Gao, Y; Gong, L; Li, X; Lun, Z; Xu, A; Zhang, Z, 2022)
"The present study showed that mixed infections exist and could be of particular importance for care outcomes."1.51Cryptococcus genetic diversity and mixed infections in Ivorian HIV patients: A follow up study. ( Bellet, V; Bertout, S; Chabrol, A; Delaporte, E; Doumbia, A; Drakulovski, P; Kakou, A; Kassi, FK; Krasteva, D; Landman, R; Menan, HEI; Reynes, J; Roger, F, 2019)
"Fluconazole was not effective against preformed mixed- Candida species biofilms while amphotericin B was potent."1.48Dynamics of Mixed- Candida Species Biofilms in Response to Antifungals. ( Herrera, M; Kadosh, D; Li, X; Mintz, J; Vipulanandan, G; Wickes, BL; Wiederhold, NP, 2018)
"There predominant combinations of mixed infection were 14 Candida albicans/Candida glabrata, 13 C."1.48Mixed yeast infections in Taiwan. ( Chen, PN; Chu, WL; Lin, CC; Lo, HJ; Yang, YL; Zhou, ZL, 2018)
"Cryptococcosis is an important opportunistic infection of organ transplant recipients."1.48Cryptococcoma of a transplanted kidney in a patient presenting with recurrent urinary tract infection: a case report. ( Greeff, L; Karusseit, VOL; Lengano, T; Muranda, AZ; Sathekge, MM, 2018)
"Fungal endocarditis was confirmed by culturing of the resected vegetation showing mixed growth of Candida albicans and Candida tropicalis, although three consecutive blood cultures were negative for Candida species."1.39Endocarditis due to a co-infection of Candida albicans and Candida tropicalis in a drug abuser. ( Abbasi, K; Anvari, MS; Badali, H; Boroumand, M; Fesharaki, SH; Haghani, I; Kargar, ML; Meis, JF; Mousavi, B, 2013)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's18 (66.67)24.3611
2020's9 (33.33)2.80

Authors

AuthorsStudies
Hattab, S1
Dagher, AM1
Wheeler, RT1
Pohl, CH1
Gao, Y2
Zhang, Z1
Lun, Z1
Gong, L1
Xu, A1
Li, X2
Sah, SK1
Shariff, A1
Pathakamuri, N1
Ramaswamy, S1
Ramesh, M1
Undela, K1
Srikanth, MS1
Kumar, TMP1
Yazdanpanah, S2
Ahmadi, M2
Zare, Z2
Nikoupour, H2
Arabsheybani, S2
Jabrodini, A2
Eghtedarnejad, E2
Chamanpara, P2
Geramizadeh, B2
Anbardar, MH2
Malekizadeh, Z2
Gashtasebi, M2
Mohsenzadeh, M2
Shafiekhani, M2
Zomorodian, K2
Kassi, FK1
Drakulovski, P1
Bellet, V1
Roger, F1
Chabrol, A1
Krasteva, D1
Doumbia, A1
Landman, R1
Kakou, A1
Reynes, J1
Delaporte, E1
Menan, HEI1
Bertout, S1
Rujirachun, P1
Sangwongwanich, J1
Chayakulkeeree, M1
Sadamatsu, H1
Takahashi, K1
Tashiro, H1
Ogusu, S1
Haraguchi, T1
Nakashima, C1
Nakamura, T1
Sueoka-Aragane, N1
Saconi, ES1
de Carvalho, VC1
de Oliveira, PRD1
Lima, ALLM1
Xie, O1
Streitberg, R1
Hughes, C1
Stuart, R1
Graham, M1
Vipulanandan, G1
Herrera, M1
Wiederhold, NP1
Mintz, J1
Wickes, BL1
Kadosh, D1
Yang, YL1
Chu, WL1
Lin, CC1
Zhou, ZL1
Chen, PN1
Lo, HJ1
Ren, X1
Liu, W2
Liu, Y1
Muranda, AZ1
Greeff, L1
Sathekge, MM1
Lengano, T1
Karusseit, VOL1
Loyse, A1
Burry, J1
Cohn, J1
Ford, N1
Chiller, T1
Ribeiro, I1
Koulla-Shiro, S1
Mghamba, J1
Ramadhani, A1
Nyirenda, R1
Aliyu, SH1
Wilson, D1
Le, T1
Oladele, R1
Lesikari, S1
Muzoora, C1
Kalata, N1
Temfack, E1
Mapoure, Y1
Sini, V1
Chanda, D1
Shimwela, M1
Lakhi, S1
Ngoma, J1
Gondwe-Chunda, L1
Perfect, C1
Shroufi, A1
Andrieux-Meyer, I1
Chan, A1
Schutz, C1
Hosseinipour, M1
Van der Horst, C1
Klausner, JD1
Boulware, DR2
Heyderman, R1
Lalloo, D1
Day, J1
Jarvis, JN2
Rodrigues, M1
Jaffar, S1
Denning, D1
Migone, C1
Doherty, M1
Lortholary, O1
Dromer, F1
Stack, M1
Molloy, SF2
Bicanic, T1
van Oosterhout, J1
Mwaba, P1
Kanyama, C1
Kouanfack, C1
Mfinanga, S1
Govender, N1
Harrison, TS2
Tambe, S1
Zambare, U1
Nayak, C1
Ergin, G1
Deger, SM1
Guz, G1
Fesharaki, SH1
Haghani, I1
Mousavi, B1
Kargar, ML1
Boroumand, M1
Anvari, MS1
Abbasi, K1
Meis, JF1
Badali, H1
Yao, ZW1
Lu, X1
Shen, C1
Lin, DF1
Kamikawa, Y1
Mori, Y1
Nagayama, T1
Fujisaki, J1
Hirabayashi, D1
Sakamoto, R1
Hamada, T1
Sugihara, K1
Li, H1
Zhang, C1
Liu, P1
Sun, S1
Kong, EF1
Kucharíková, S1
Van Dijck, P1
Peters, BM1
Shirtliff, ME1
Jabra-Rizk, MA1
Zappella, N1
Desmard, M1
Chochillon, C1
Ribeiro-Parenti, L1
Houze, S1
Marmuse, JP1
Montravers, P1
Molefi, M1
Chofle, AA1
Kalluvya, S1
Changalucha, JM1
Cainelli, F1
Leeme, T1
Lekwape, N1
Goldberg, DW1
Haverkamp, M1
Bisson, GP1
Perfect, JR1
Letang, E1
Fenner, L1
Meintjes, G1
Burton, R1
Makadzange, T1
Ndhlovu, CE1
Hope, W1
Smith, KD1
Achan, B1
Hullsiek, KH1
McDonald, TR1
Okagaki, LH1
Alhadab, AA1
Akampurira, A1
Rhein, JR1
Meya, DB1
Nielsen, K1
Tati, S1
Davidow, P1
McCall, A1
Hwang-Wong, E1
Rojas, IG1
Cormack, B1
Edgerton, M1
Ben-Ami, R1
Olshtain-Pops, K1
Krieger, M1
Oren, I1
Bishara, J1
Dan, M1
Wiener-Well, Y1
Weinberger, M1
Zimhony, O1
Chowers, M1
Weber, G1
Potasman, I1
Chazan, B1
Kassis, I1
Shalit, I1
Block, C1
Keller, N1
Kontoyiannis, DP1
Giladi, M1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Adjunctive Sertraline for the Treatment of HIV-Associated Cryptococcal Meningitis[NCT01802385]Phase 3460 participants (Actual)Interventional2015-03-09Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Center for Epidemiologic Studies in Depression (CES-D) Scale

Center for Epidemiologic Studies in Depression (CES-D) scale at 14 weeks. CES-D scores are based on a 20 item survey with total scores ranging from 0 to 60. Higher scores suggest a greater presence of depressive symptoms. A CES-D score of 16 or higher is interpreted to indicate a risk for depression. (NCT01802385)
Timeframe: 14 weeks

Interventionscore on a scale (Mean)
Placebo16.6
Sertraline 400mg13.2

Count of Participants With Cerebrospinal Fluid Sterility

Number of participants with sterile cerebrospinal fluid at 2 weeks (NCT01802385)
Timeframe: 14 days

InterventionParticipants (Count of Participants)
Placebo90
Sertraline 400mg101

Event Free Survival

Event free survival of composite events of: death,central nervous system (CNS) cryptococcal-related paradoxical immune reconstitution inflammatory syndrome (IRIS) or culture-positive relapse. (NCT01802385)
Timeframe: 18 weeks

InterventionParticipants (Count of Participants)
Placebo116
Sertraline 400mg103

Number of Participants Experiencing IRIS OR Relapse

Cumulative incidence of central nervous system (CNS) cryptococcal-related paradoxical immune reconstitution inflammatory syndrome (IRIS) or culture-positive relapse (NCT01802385)
Timeframe: 18 weeks

InterventionParticipants (Count of Participants)
Placebo9
Sertraline 400mg5

Quantitative Neurocognitive Performance Score (QNPZ-8)

Quantitative neurocognitive performance Z-score (QNPZ-8) at 14 weeks. The QNPZ-8 is a mean score of testing of 8 neurocognitive domains. Eqach domain is scaled based on a Z-score where the mean = 0 for the HIV-negative Ugandan population, accounting for age and educational status. Each +1 unit is one standard deviation better than the population norm. Each -1 unit is one standard deviation worse than the population norm. (NCT01802385)
Timeframe: 14 weeks

Interventionscore (Mean)
Placebo-1.4
Sertraline 400mg-1.3

Safety (Occurence of Adverse Events)

Safety and tolerability of adjunctive sertraline (grade 4-5) adverse reactions (NCT01802385)
Timeframe: 18 weeks

Interventionevents (Number)
Placebo121
Sertraline 400mg141

Survival

18-week survival. The comparison will be between sertraline 400mg group and placebo (NCT01802385)
Timeframe: 18 weeks

InterventionParticipants (Count of Participants)
Placebo125
Sertraline 400mg109

Fungal Clearance as Determined by Early Fungicidal Activity of CDF

To determine whether adjunctive sertraline will lead to a faster rate of fungal clearance from cerebrospinal fluid (CSF), as measured by early fungicidal activity (EFA) of clearance of the Cryptococcus colony forming units (cfu) per mL of CSF per day, compared to standard therapy alone. (NCT01802385)
Timeframe: 14 days

,
Intervention-log10 CFU/ml/day (Mean)
General Linear RegressionMixed-Effects Regression
Placebo0.470.33
Sertraline 400mg.43.33

Reviews

4 reviews available for fluconazole and Co-infection

ArticleYear
Antifungal therapy in the management of fungal secondary infections in COVID-19 patients: A systematic review and meta-analysis.
    PloS one, 2022, Volume: 17, Issue:7

    Topics: Antifungal Agents; Coinfection; COVID-19; Fluconazole; Humans; Mycoses; Prospective Studies; Retrosp

2022
Prosthetic joint infection due to Candida species: Case series and review of literature.
    Medicine, 2020, Volume: 99, Issue:15

    Topics: Aged; Aged, 80 and over; Antifungal Agents; Bacterial Infections; Candida albicans; Coinfection; Com

2020
Leave no one behind: response to new evidence and guidelines for the management of cryptococcal meningitis in low-income and middle-income countries.
    The Lancet. Infectious diseases, 2019, Volume: 19, Issue:4

    Topics: Africa; Amphotericin B; Antifungal Agents; Coinfection; Cryptococcus neoformans; Developing Countrie

2019
Comparison of flucytosine and fluconazole combined with amphotericin B for the treatment of HIV-associated cryptococcal meningitis: a systematic review and meta-analysis.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2014, Volume: 33, Issue:8

    Topics: Amphotericin B; Antifungal Agents; Coinfection; Drug Therapy, Combination; Fluconazole; Flucytosine;

2014

Trials

3 trials available for fluconazole and Co-infection

ArticleYear
Effects of fluconazole on the clinical outcome and immune response in fungal co-infected tuberculosis patients.
    Microbial pathogenesis, 2018, Volume: 117

    Topics: Aged; Aged, 80 and over; Body Mass Index; Chemokine CXCL10; Chemokine CXCL11; Chemokine CXCL9; Chemo

2018
AMBITION-cm: intermittent high dose AmBisome on a high dose fluconazole backbone for cryptococcal meningitis induction therapy in sub-Saharan Africa: study protocol for a randomized controlled trial.
    Trials, 2015, Jun-17, Volume: 16

    Topics: AIDS-Related Opportunistic Infections; Amphotericin B; Antifungal Agents; Botswana; Clinical Protoco

2015
Increased Antifungal Drug Resistance in Clinical Isolates of Cryptococcus neoformans in Uganda.
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:12

    Topics: Amphotericin B; Antifungal Agents; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Coinfection; Cr

2015

Other Studies

20 other studies available for fluconazole and Co-infection

ArticleYear
Pseudomonas Synergizes with Fluconazole against
    Infection and immunity, 2022, 04-21, Volume: 90, Issue:4

    Topics: Animals; Antifungal Agents; Candida; Candida albicans; Coinfection; Drug Resistance, Fungal; Flucona

2022
Competition for Iron during Polymicrobial Infections May Increase Antifungal Drug Susceptibility-How Will It Impact Treatment Options?
    Infection and immunity, 2022, 04-21, Volume: 90, Issue:4

    Topics: Antifungal Agents; Candida albicans; Candidiasis; Coinfection; Drug Resistance, Fungal; Fluconazole;

2022
Synergistic Effects of Fluconazole Combined with Doxycycline Against Dual-Species Cultures of
    Microbial drug resistance (Larchmont, N.Y.), 2022, Volume: 28, Issue:5

    Topics: Anti-Bacterial Agents; Antifungal Agents; Biofilms; Candida albicans; Coinfection; Doxycycline; Drug

2022
Assessment of Risk Factors and Clinical Outcomes in Hospitalized COVID-19 Patients with Candida spp. Co-infections: Species Distribution and Antifungal Susceptibility Patterns of Isolates.
    Mycopathologia, 2023, Volume: 188, Issue:1-2

    Topics: Antifungal Agents; Candida; Candida albicans; Candidiasis; Coinfection; COVID-19; Drug Resistance, F

2023
Assessment of Risk Factors and Clinical Outcomes in Hospitalized COVID-19 Patients with Candida spp. Co-infections: Species Distribution and Antifungal Susceptibility Patterns of Isolates.
    Mycopathologia, 2023, Volume: 188, Issue:1-2

    Topics: Antifungal Agents; Candida; Candida albicans; Candidiasis; Coinfection; COVID-19; Drug Resistance, F

2023
Assessment of Risk Factors and Clinical Outcomes in Hospitalized COVID-19 Patients with Candida spp. Co-infections: Species Distribution and Antifungal Susceptibility Patterns of Isolates.
    Mycopathologia, 2023, Volume: 188, Issue:1-2

    Topics: Antifungal Agents; Candida; Candida albicans; Candidiasis; Coinfection; COVID-19; Drug Resistance, F

2023
Assessment of Risk Factors and Clinical Outcomes in Hospitalized COVID-19 Patients with Candida spp. Co-infections: Species Distribution and Antifungal Susceptibility Patterns of Isolates.
    Mycopathologia, 2023, Volume: 188, Issue:1-2

    Topics: Antifungal Agents; Candida; Candida albicans; Candidiasis; Coinfection; COVID-19; Drug Resistance, F

2023
Cryptococcus genetic diversity and mixed infections in Ivorian HIV patients: A follow up study.
    PLoS neglected tropical diseases, 2019, Volume: 13, Issue:11

    Topics: Adult; Amphotericin B; Antifungal Agents; Coinfection; Cryptococcosis; Cryptococcus; Cryptococcus ne

2019
Triple infection with Cryptococcus, varicella-zoster virus, and Mycobacterium abscessus in a patient with anti-interferon-gamma autoantibodies: a case report.
    BMC infectious diseases, 2020, Mar-19, Volume: 20, Issue:1

    Topics: Acyclovir; Amphotericin B; Autoantibodies; Coinfection; Cryptococcosis; Fluconazole; Herpesvirus 3,

2020
A rare case of Trichosporon mycotoxinivorans and Cryptococcus neoformans co-infection in lung.
    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2020, Volume: 26, Issue:8

    Topics: Aged; Antifungal Agents; Biopsy; Bronchoalveolar Lavage Fluid; Coinfection; Cryptococcosis; Cryptoco

2020
Candida duobushaemulonii sepsis and Candida auris co-isolation following hospitalisation in Vietnam.
    Pathology, 2020, Volume: 52, Issue:5

    Topics: Aged, 80 and over; Amphotericin B; Antifungal Agents; Candida; Candidemia; Candidiasis, Cutaneous; C

2020
Dynamics of Mixed- Candida Species Biofilms in Response to Antifungals.
    Journal of dental research, 2018, Volume: 97, Issue:1

    Topics: Amphotericin B; Antifungal Agents; Biofilms; Candida; Candida glabrata; Candida tropicalis; Candidia

2018
Mixed yeast infections in Taiwan.
    Medical mycology, 2018, Aug-01, Volume: 56, Issue:6

    Topics: Antifungal Agents; Candida; Candidiasis; Coinfection; Drug Resistance, Fungal; Epidemiological Monit

2018
Cryptococcoma of a transplanted kidney in a patient presenting with recurrent urinary tract infection: a case report.
    BMC nephrology, 2018, 04-23, Volume: 19, Issue:1

    Topics: Adult; Antifungal Agents; Bacterial Infections; Biopsy; Coinfection; Cryptococcosis; Cryptococcus ne

2018
Nodulo-ulcerative and erythrodermic secondary syphilis in human immunodeficiency virus-infected individuals.
    International journal of STD & AIDS, 2019, Volume: 30, Issue:5

    Topics: Administration, Oral; Adult; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Chancre;

2019
Successful Treatment of Cutaneous Blastomycosis in a Renal Transplant Patient With BK Virus Infection: A Case Report.
    Transplantation proceedings, 2019, Volume: 51, Issue:2

    Topics: Amphotericin B; Antifungal Agents; BK Virus; Blastomycosis; Coinfection; Fluconazole; Humans; Immuno

2019
Endocarditis due to a co-infection of Candida albicans and Candida tropicalis in a drug abuser.
    Journal of medical microbiology, 2013, Volume: 62, Issue:Pt 11

    Topics: Adult; Amphotericin B; Antifungal Agents; Candida albicans; Candida tropicalis; Candidiasis; Coinfec

2013
Frequency of clinically isolated strains of oral Candida species at Kagoshima University Hospital, Japan, and their susceptibility to antifungal drugs in 2006-2007 and 2012-2013.
    BMC oral health, 2014, Feb-20, Volume: 14

    Topics: Adult; Aged; Aged, 80 and over; Amphotericin B; Antifungal Agents; Autoimmune Diseases; Bacterial Lo

2014
In vitro interactions between fluconazole and minocycline against mixed cultures of Candida albicans and Staphylococcus aureus.
    Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi, 2015, Volume: 48, Issue:6

    Topics: Anti-Bacterial Agents; Antifungal Agents; Biofilms; Calcium; Candida albicans; Candidiasis; Coinfect

2015
Clinical implications of oral candidiasis: host tissue damage and disseminated bacterial disease.
    Infection and immunity, 2015, Volume: 83, Issue:2

    Topics: Animals; Candida albicans; Candidiasis, Oral; Coinfection; Disease Models, Animal; Female; Fluconazo

2015
Positive peritoneal fluid fungal cultures in postoperative peritonitis after bariatric surgery.
    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2015, Volume: 21, Issue:9

    Topics: Adult; Ascitic Fluid; Bacteria; Bariatric Surgery; Candida; Candidiasis; Coinfection; Drug Resistanc

2015
Candida glabrata Binding to Candida albicans Hyphae Enables Its Development in Oropharyngeal Candidiasis.
    PLoS pathogens, 2016, Volume: 12, Issue:3

    Topics: Animals; Candida albicans; Candida glabrata; Candidiasis, Oral; Cell Wall; Coinfection; Female; Fluc

2016
Antibiotic exposure as a risk factor for fluconazole-resistant Candida bloodstream infection.
    Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Antifungal Agents; Bacteria; Bacterial Infect

2012