fluconazole has been researched along with Acute Liver Injury, Drug-Induced in 35 studies
Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.
fluconazole : A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We present a case of recovery from fulminant hepatic failure secondary to high serum levels of fluconazole precipitated by amphotericin B induced renal dysfunction." | 7.70 | Survival following fulminant hepatic failure from fluconazole induced hepatitis. ( Boots, R; Crerar-Gilbert, A; Fraenkel, D; MacDonald, GA, 1999) |
| "A patient with hepatitis experienced worsening of her liver function when treated with fluconazole for a Candida infection in her urine." | 4.79 | Worsening of liver function with fluconazole and review of azole antifungal hepatotoxicity. ( Gearhart, MO, 1994) |
| "A 73-year-old white man taking nitrofurantoin 50 mg/day for 5 years developed combined hepatic and pulmonary toxicity after taking fluconazole acutely for onychomycosis." | 3.72 | Pulmonary and hepatic toxicity due to nitrofurantoin and fluconazole treatment. ( Linnebur, SA; Parnes, BL, 2004) |
| "Four patients were identified with illnesses for which a drug-induced etiology could not be ruled out; one with an elevated liver function test while taking itraconazole, one with thrombocytopenia, one with neutropenia, and one with an abnormal liver function test just after receiving fluconazole." | 3.71 | Itraconazole and fluconazole and certain rare, serious adverse events. ( Bradbury, BD; Jick, SS, 2002) |
| "We present a case of recovery from fulminant hepatic failure secondary to high serum levels of fluconazole precipitated by amphotericin B induced renal dysfunction." | 3.70 | Survival following fulminant hepatic failure from fluconazole induced hepatitis. ( Boots, R; Crerar-Gilbert, A; Fraenkel, D; MacDonald, GA, 1999) |
| "Amphotericin B was significantly more toxic than Fluconazole especially in related allogeneic transplantation where 19% of patients developed toxicity vs 0% of Fluconazole recipients (p < 0." | 2.69 | Fluconazole vs low-dose amphotericin B for the prevention of fungal infections in patients undergoing bone marrow transplantation: a study of the North American Marrow Transplant Group. ( Bolwell, B; Collins, R; Dummer, S; Ericson, S; Fay, J; Freytes, CO; Goodman, SA; Greer, J; Herzig, RH; LeMaistre, F; Lynch, J; Pineiro, L; Pohlman, B; Stein, R; Stevens, D; Wolff, SN, 2000) |
| "When fluconazole was compared with placebo and other antifungals, the relative risk (RR) of hepatotoxicity was not statistically different [RR 1." | 2.49 | Safety of fluconazole in paediatrics: a systematic review. ( Adefurin, A; Choonara, I; Egunsola, O; Fakis, A; Jacqz-Aigrain, E; Sammons, H, 2013) |
| "The major adverse effect associated with systemic administration of Fluconazole (FLZ), is hepatic toxicity." | 1.51 | Vitamin B combination reduces fluconazole toxicity in Wistar rats. ( Al-Abbasi, FA; Anwar, F; Mushtaq, G; Sadath, S, 2019) |
| "Objective: Invasive fungal infections (IFI) in bone marrow transplant (BMT) recipients are common and lethal." | 1.48 | The Role of Fluconazole Prophylaxis Regimen and the Regimes Chosen by the Patient’s Risk of Fungal Infection in Reducing\ the Infection Rate after Bone Marrow Transplantation ( Habibzadeh, A; Hajfathali, A; Hosseini, MH; Mehdizadeh, M; Pourghasemian, M, 2018) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| "Anidulafungin was chosen when liver function test was abnormal in a setting of multiple causes of liver toxicity." | 1.37 | Anidulafungin treatment in a kidney transplant recipient with hepatic damage. ( De Rosa, FG; Di Perri, G; Manzione, NA; Messina, M; Ottobrelli, A; Ranghino, A; Raviolo, S; Segoloni, GP, 2011) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| " Rats were pretreated with PB (75 mg/kg for 4 days) prior to itraconazole or fluconazole dosing (20 and 200 mg/kg for 4 days)." | 1.33 | Involvement of phenobarbital and SKF 525A in the hepatotoxicity of antifungal drugs itraconazole and fluconazole in rats. ( Ahmad Bustamam, A; Hasiah, AH; Israf, DA; Khairi, HM; Somchit, N; Sulaiman, MR; Wong, CW; Zuraini, A, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.86) | 18.7374 |
| 1990's | 8 (22.86) | 18.2507 |
| 2000's | 12 (34.29) | 29.6817 |
| 2010's | 14 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Chen, M | 2 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 3 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Pourghasemian, M | 1 |
| Mehdizadeh, M | 1 |
| Hajfathali, A | 1 |
| Habibzadeh, A | 1 |
| Hosseini, MH | 1 |
| Al-Abbasi, FA | 1 |
| Sadath, S | 1 |
| Mushtaq, G | 1 |
| Anwar, F | 1 |
| Shi, D | 1 |
| Luo, Z | 1 |
| Yang, JJ | 1 |
| Huang, CH | 1 |
| Liu, CE | 1 |
| Tang, HJ | 1 |
| Yang, CJ | 1 |
| Lee, YC | 1 |
| Lee, KY | 1 |
| Tsai, MS | 1 |
| Lin, SW | 1 |
| Chen, YH | 1 |
| Lu, PL | 1 |
| Hung, CC | 1 |
| De Rosa, FG | 1 |
| Manzione, NA | 1 |
| Ranghino, A | 1 |
| Messina, M | 1 |
| Ottobrelli, A | 1 |
| Raviolo, S | 1 |
| Di Perri, G | 1 |
| Segoloni, GP | 1 |
| Egunsola, O | 1 |
| Adefurin, A | 1 |
| Fakis, A | 1 |
| Jacqz-Aigrain, E | 1 |
| Choonara, I | 1 |
| Sammons, H | 1 |
| Schöttker, B | 1 |
| Dösch, A | 1 |
| Kraemer, DM | 1 |
| WAJCHENBERG, BL | 1 |
| HOXTER, G | 1 |
| Su, FW | 1 |
| Perumalswami, P | 1 |
| Grammer, LC | 1 |
| Linnebur, SA | 1 |
| Parnes, BL | 1 |
| Kim, H | 1 |
| Bindslev-Jensen, C | 1 |
| Somchit, N | 2 |
| Norshahida, AR | 1 |
| Hasiah, AH | 2 |
| Zuraini, A | 2 |
| Sulaiman, MR | 2 |
| Noordin, MM | 1 |
| Fischer, MA | 1 |
| Winkelmayer, WC | 1 |
| Rubin, RH | 1 |
| Avorn, J | 1 |
| Wingard, JR | 1 |
| Leather, H | 1 |
| Wong, CW | 1 |
| Ahmad Bustamam, A | 1 |
| Khairi, HM | 1 |
| Israf, DA | 1 |
| Krause, DS | 1 |
| Upton, A | 1 |
| McCune, JS | 1 |
| Kirby, KA | 1 |
| Leisenring, W | 1 |
| McDonald, G | 1 |
| Batchelder, A | 1 |
| Marr, KA | 1 |
| Chmel, H | 1 |
| Jacobson, MA | 1 |
| Hanks, DK | 1 |
| Ferrell, LD | 1 |
| Gearhart, MO | 1 |
| Trujillo, MA | 1 |
| Galgiani, JN | 1 |
| Sampliner, RE | 1 |
| Guillaume, MP | 1 |
| De Prez, C | 1 |
| Cogan, E | 1 |
| Nozickova, M | 1 |
| Koudelkova, V | 1 |
| Kulikova, Z | 1 |
| Malina, L | 1 |
| Urbanowski, S | 1 |
| Silny, W | 1 |
| Crerar-Gilbert, A | 1 |
| Boots, R | 1 |
| Fraenkel, D | 1 |
| MacDonald, GA | 1 |
| Wolff, SN | 1 |
| Fay, J | 1 |
| Stevens, D | 1 |
| Herzig, RH | 1 |
| Pohlman, B | 1 |
| Bolwell, B | 1 |
| Lynch, J | 1 |
| Ericson, S | 1 |
| Freytes, CO | 1 |
| LeMaistre, F | 1 |
| Collins, R | 1 |
| Pineiro, L | 1 |
| Greer, J | 1 |
| Stein, R | 1 |
| Goodman, SA | 1 |
| Dummer, S | 1 |
| Bradbury, BD | 1 |
| Jick, SS | 1 |
| Wells, C | 1 |
| Lever, AM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| ANTIVORIFUNGOL:Strategy of Antifungal Use in Oncohematological Neutropenic Patients. Use of Voriconazole as Early Treatment.[NCT00386802] | Phase 4 | 115 participants (Anticipated) | Interventional | 2006-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for fluconazole and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
Safety of fluconazole in paediatrics: a systematic review.
Topics: Adolescent; Age Factors; Antifungal Agents; Chemical and Drug Induced Liver Injury; Child; Child, Pr | 2013 |
Worsening of liver function with fluconazole and review of azole antifungal hepatotoxicity.
Topics: Administration, Oral; Alanine Transaminase; Aspartate Aminotransferases; Candidiasis; Chemical and D | 1994 |
Subacute mitochondrial liver disease in a patient with AIDS: possible relationship to prolonged fluconazole administration.
Topics: Acquired Immunodeficiency Syndrome; Acute Disease; Adult; AIDS-Related Opportunistic Infections; Ant | 1996 |
3 trials available for fluconazole and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Fluconazole coadministration concurrent with cyclophosphamide conditioning may reduce regimen-related toxicity postmyeloablative hematopoietic cell transplantation.
Topics: Antifungal Agents; Aryl Hydrocarbon Hydroxylases; Chemical and Drug Induced Liver Injury; Cohort Stu | 2007 |
A comparison of the efficacy of oral fluconazole, 150 mg/week versus 50 mg/day, in the treatment of tinea corporis, tinea cruris, tinea pedis, and cutaneous candidosis.
Topics: Administration, Oral; Adult; Antifungal Agents; Candida; Candidiasis; Chemical and Drug Induced Live | 1998 |
Fluconazole vs low-dose amphotericin B for the prevention of fungal infections in patients undergoing bone marrow transplantation: a study of the North American Marrow Transplant Group.
Topics: Adult; Aged; Amphotericin B; Antifungal Agents; Bone Marrow Transplantation; Chemical and Drug Induc | 2000 |
28 other studies available for fluconazole and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
The Role of Fluconazole Prophylaxis Regimen and the Regimes Chosen by the Patient’s Risk of Fungal Infection in Reducing\
the Infection Rate after Bone Marrow Transplantation
Topics: Adolescent; Adult; Aged; Antifungal Agents; Bone Marrow Transplantation; Chemical and Drug Induced L | 2018 |
Vitamin B combination reduces fluconazole toxicity in Wistar rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; | 2019 |
[Clinical analysis of invasive laryngeal mycosis].
Topics: Administration, Oral; Amphotericin B; Antifungal Agents; Chemical and Drug Induced Liver Injury; Flu | 2013 |
Multicenter study of trimethoprim/sulfamethoxazole-related hepatotoxicity: incidence and associated factors among HIV-infected patients treated for Pneumocystis jirovecii pneumonia.
Topics: Adult; Aged; Aged, 80 and over; Anti-HIV Agents; Anti-Infective Agents; Arylamine N-Acetyltransferas | 2014 |
Anidulafungin treatment in a kidney transplant recipient with hepatic damage.
Topics: Anidulafungin; Antifungal Agents; Chemical and Drug Induced Liver Injury; Echinocandins; Female; Flu | 2011 |
Severe hepatotoxicity after application of desloratadine and fluconazole.
Topics: Adult; Antifungal Agents; Chemical and Drug Induced Liver Injury; Contraindications; Drug Interactio | 2003 |
Liver histochemistry (mucopolysaccharides) and plasma alpha3-globulin; studies in diffuse massive (fulminant viral hepatitis) and zonal liver necrosis (toxic hepatitis).
Topics: Chemical and Drug Induced Liver Injury; Fluconazole; Glycosaminoglycans; Hepatitis; Hepatitis A; Hum | 1955 |
Acute hepatitis and rash to fluconazole.
Topics: Adult; Antifungal Agents; Chemical and Drug Induced Liver Injury; Drug Eruptions; Drug Hypersensitiv | 2003 |
Pulmonary and hepatic toxicity due to nitrofurantoin and fluconazole treatment.
Topics: Aged; Antifungal Agents; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Fluconaz | 2004 |
Reported case of severe hepatotoxicity likely due to fluconazole and not desloratadine.
Topics: Antifungal Agents; Chemical and Drug Induced Liver Injury; Fluconazole; Histamine H1 Antagonists, No | 2004 |
Hepatotoxicity induced by antifungal drugs itraconazole and fluconazole in rats: a comparative in vivo study.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antifungal Agents; Body Weight; Chemical and Dr | 2004 |
The hepatotoxicity of antifungal medications in bone marrow transplant recipients.
Topics: Adult; Amphotericin B; Antifungal Agents; Bone Marrow Transplantation; Case-Control Studies; Chemica | 2005 |
Hepatotoxicity associated with antifungal therapy after bone marrow transplantation.
Topics: Amphotericin B; Antifungal Agents; Bone Marrow Transplantation; Chemical and Drug Induced Liver Inju | 2005 |
Involvement of phenobarbital and SKF 525A in the hepatotoxicity of antifungal drugs itraconazole and fluconazole in rats.
Topics: Animals; Antifungal Agents; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; | 2006 |
Posaconazole prophylaxis in hematologic cancer.
Topics: Antifungal Agents; Bilirubin; Chemical and Drug Induced Liver Injury; Fluconazole; Graft vs Host Dis | 2007 |
Fatal acute hepatic necrosis due to fluconazole.
Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Cimetidine; Fatal Outcome; Fluconazole; Human | 1995 |
Fatal acute hepatic necrosis due to fluconazole.
Topics: Acute Disease; Adult; AIDS-Related Opportunistic Infections; Chemical and Drug Induced Liver Injury; | 1994 |
Evaluation of hepatic injury arising during fluconazole therapy.
Topics: Adult; Chemical and Drug Induced Liver Injury; Fluconazole; Humans; Liver Diseases; Liver Function T | 1994 |
Survival following fulminant hepatic failure from fluconazole induced hepatitis.
Topics: Amphotericin B; Antifungal Agents; Chemical and Drug Induced Liver Injury; Cryptococcosis; Female; F | 1999 |
Itraconazole and fluconazole and certain rare, serious adverse events.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antifungal Agents; Chemical and Drug Induced Liver Injur | 2002 |
Dose-dependent fluconazole hepatotoxicity proven on biopsy and rechallenge.
Topics: Candidiasis, Oral; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug In | 1992 |