Page last updated: 2024-12-08

Deoxycholic acid methyl ester

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID229346
CHEMBL ID1078051
CHEBI ID183913
SCHEMBL ID60803

Synonyms (40)

Synonym
cholan-24-oic acid, 3,12-dihydroxy-, methyl ester, (3.alpha.,5.beta.,12.alpha.)-
cholan-24-oic acid,12-dihydroxy-, methyl ester, (3.alpha.,5.beta.,12.alpha.)-
nsc-22957
nsc22957
mls002638913 ,
TIMTEC1_001899
methyl desoxycholate
3245-38-3
HMS1539G07
methyl 3,12-dihydroxycholan-24-oate
CHEMBL1078051
methyl deoxycholate
methyl (4r)-4-[(3r,5r,8r,9s,10s,12s,13r,14s,17r)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]pentanoate
CHEBI:183913
deoxycholic acid methyl ester
nsc 22957
einecs 221-819-1
methyl 7-deoxycholate
h1c2tvp7aq ,
unii-h1c2tvp7aq
cholan-24-oic acid, 3,12-dihydroxy-, methyl ester, (3alpha,5beta,12alpha)-
methyl 3-alpha,12-alpha-dihydroxy-5-beta-cholan-24-oate
methyl 4-((1s,2s,11s,16s,5r,7r,10r,14r,15r)-5,16-dihydroxy-2,15-dimethyltetrac yclo[8.7.0.0<2,7>.0<11,15>]heptadec-14-yl)pentanoate
ST024724
SCHEMBL60803
AKOS024278937
methyl 7-desoxycholate
methyl 3,12-dihydroxycholan-24-oate, (3.alpha.,5.beta.,12.alpha.)-
methyl 3.alpha.,12.alpha.-dihydroxy-5.beta.-cholanoate
methyl 3.alpha.,12.alpha.-dihydroxy-5.beta.-cholan-24-oate
deoxycholic acid, methyl ester
5.beta.-cholan-24-oic acid, 3.alpha.,12.alpha.-dihydroxy-, methyl ester
3alpha,12alpha-dihydroxy-5beta-cholan-24-oic acid methyl ester
cholan-24-oic acid, 3,12-dihydroxy-, methyl ester, (3a,5b,12a)-
J-018743
mfcd00046270
5beta-cholanic acid-3alpha,12alpha-diol methyl ester
Q63396505
F82321
DTXSID70954203

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" Finally, CDCA, DCA and LagoDCA were prominent outliers being more toxic than predicted by RMw."( Bile acid toxicity structure-activity relationships: correlations between cell viability and lipophilicity in a panel of new and known bile acids using an oesophageal cell line (HET-1A).
Gilmer, JF; Keaveney, R; Kelleher, D; Long, A; Majer, F; Peta, VK; Sharma, R; Wang, J, 2010
)
0.36
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
cholanoid
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (16)

Assay IDTitleYearJournalArticle
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID470601Antifungal activity against Candida parapsilosis ATCC 22019 after 48 hrs by microbroth dilution technique2009Bioorganic & medicinal chemistry letters, Sep-15, Volume: 19, Issue:18
Design and synthesis of bile acid-based amino sterols as antimicrobial agents.
AID470597Antifungal activity against Cryptococcus neoformans after 72 hrs by microbroth dilution technique2009Bioorganic & medicinal chemistry letters, Sep-15, Volume: 19, Issue:18
Design and synthesis of bile acid-based amino sterols as antimicrobial agents.
AID470593Antibacterial activity against Pseudomonas aeruginosa ATCC BAA-427 after 24 hrs by NCCLS method2009Bioorganic & medicinal chemistry letters, Sep-15, Volume: 19, Issue:18
Design and synthesis of bile acid-based amino sterols as antimicrobial agents.
AID470599Antifungal activity against Trichophyton mentagrophytes after 96 hrs by microbroth dilution technique2009Bioorganic & medicinal chemistry letters, Sep-15, Volume: 19, Issue:18
Design and synthesis of bile acid-based amino sterols as antimicrobial agents.
AID515398Cytotoxicity against human HET-1A cells assessed as cell viability after 24 hrs by MTT assay2010Bioorganic & medicinal chemistry, Sep-15, Volume: 18, Issue:18
Bile acid toxicity structure-activity relationships: correlations between cell viability and lipophilicity in a panel of new and known bile acids using an oesophageal cell line (HET-1A).
AID470295Antibacterial activity against Escherichia coli ATCC 9637 after 24 hrs by NCCLS method2009Bioorganic & medicinal chemistry letters, Sep-15, Volume: 19, Issue:18
Design and synthesis of bile acid-based amino sterols as antimicrobial agents.
AID515399Cytotoxicity against human HuH7 cells assessed as cell viability at 500 uM after 24 hrs by MTT assay relative to control2010Bioorganic & medicinal chemistry, Sep-15, Volume: 18, Issue:18
Bile acid toxicity structure-activity relationships: correlations between cell viability and lipophilicity in a panel of new and known bile acids using an oesophageal cell line (HET-1A).
AID515400Cytotoxicity against human HET-1A cells assessed as cell viability at 500 uM after 24 hrs by MTT assay relative to control2010Bioorganic & medicinal chemistry, Sep-15, Volume: 18, Issue:18
Bile acid toxicity structure-activity relationships: correlations between cell viability and lipophilicity in a panel of new and known bile acids using an oesophageal cell line (HET-1A).
AID977599Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM2013Molecular pharmacology, Jun, Volume: 83, Issue:6
Structure-based identification of OATP1B1/3 inhibitors.
AID470600Antifungal activity against Aspergillus fumigatus AF-27 after 72 hrs by microbroth dilution technique2009Bioorganic & medicinal chemistry letters, Sep-15, Volume: 19, Issue:18
Design and synthesis of bile acid-based amino sterols as antimicrobial agents.
AID470596Antifungal activity against Candida albicans after 48 hrs by microbroth dilution technique2009Bioorganic & medicinal chemistry letters, Sep-15, Volume: 19, Issue:18
Design and synthesis of bile acid-based amino sterols as antimicrobial agents.
AID977602Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM2013Molecular pharmacology, Jun, Volume: 83, Issue:6
Structure-based identification of OATP1B1/3 inhibitors.
AID470594Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by NCCLS method2009Bioorganic & medicinal chemistry letters, Sep-15, Volume: 19, Issue:18
Design and synthesis of bile acid-based amino sterols as antimicrobial agents.
AID470598Antifungal activity against Sporothrix schenckii after 72 hrs by microbroth dilution technique2009Bioorganic & medicinal chemistry letters, Sep-15, Volume: 19, Issue:18
Design and synthesis of bile acid-based amino sterols as antimicrobial agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's4 (80.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.63

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.63 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.42 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.63)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]