Page last updated: 2024-10-27

fluconazole and Esophageal Diseases

fluconazole has been researched along with Esophageal Diseases in 50 studies

Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.
fluconazole : A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.

Esophageal Diseases: Pathological processes in the ESOPHAGUS.

Research Excerpts

ExcerptRelevanceReference
"We evaluated the efficacy and safety of oral posaconazole for human immunodeficiency virus (HIV)-infected subjects with oropharyngeal candidiasis (OPC) and/or esophageal candidiasis (EC) who were clinically refractory to treatment with oral fluconazole or itraconazole."9.12Posaconazole for the treatment of azole-refractory oropharyngeal and esophageal candidiasis in subjects with HIV infection. ( Anstead, GM; Boparai, N; Graybill, JR; Hare, R; Isaacs, R; Reynes, J; Skiest, DJ; Vazquez, JA; Ward, D, 2007)
" This randomized, double-blind, double-dummy study compared the efficacy and safety of intravenous anidulafungin to that of oral fluconazole in 601 patients with endoscopically and microbiologically documented esophageal candidiasis."9.11A randomized, double-blind trial of anidulafungin versus fluconazole for the treatment of esophageal candidiasis. ( Goldstein, BP; Henkel, T; Krause, DS; Simjee, AE; van Rensburg, C; Viljoen, J; Walsh, TJ; Wible, M, 2004)
"A total of 245 patients (age, > or =18 years) with a prior diagnosis of acquired immunodeficiency syndrome/human immunodeficiency virus (HIV) infection and esophageal candidiasis, confirmed by endoscopy and culture, were randomized to receive micafungin (50, 100, or 150 mg per day) or fluconazole (200 mg per day)."9.11A randomized, double-blind, parallel-group, dose-response study of micafungin compared with fluconazole for the treatment of esophageal candidiasis in HIV-positive patients. ( Baraldi, E; de Wet, N; Della Negra, M; Diekmann-Berndt, H; Krantz, EF; Llanos-Cuentas, A; Suleiman, J, 2004)
"Intravenous micafungin (150 mg daily) is well tolerated and as efficacious as intravenous fluconazole (200 mg daily) in the primary treatment of oesophageal candidiasis, achieving high rates of clinical and endoscopic cure."9.11A randomized, double blind, comparative trial of micafungin (FK463) vs. fluconazole for the treatment of oesophageal candidiasis. ( Bester, AJ; Buell, D; de Wet, NT; Filho, F; Fisco, C; Lau, W; Llanos, EA; Suleiman, JM; Ticona, E; Viljoen, JJ, 2005)
"Caspofungin is a new echinocandin drug with comparable in vitro activity against azole-susceptible and -resistant isolates of that could provide a less toxic alternative to amphotericin B for the management of esophageal candidiasis with clinical or laboratory evidence of decreased susceptibility to fluconazole."9.10Efficacy of caspofungin in the treatment of esophageal candidiasis resistant to fluconazole. ( Bartizal, K; DiNubile, MJ; Hicks, PS; Kartsonis, N; Ryan, D; Sable, CA, 2002)
"The efficacy, safety, and tolerability of voriconazole and fluconazole were compared in 391 immunocompromised patients with mycology- and biopsy-proven esophageal candidiasis."9.09A randomized, double-blind, double-dummy, multicenter trial of voriconazole and fluconazole in the treatment of esophageal candidiasis in immunocompromised patients. ( Aguirrebengoa, K; Ally, R; Carosi, G; Dupont, B; Hodges, M; Kreisel, W; Romero, AJ; Schürmann, D; Troke, P, 2001)
"This multicenter, randomized, double-blind study compared the efficacy and safety of itraconazole oral solution and fluconazole tablets in the treatment of esophageal candidiasis."9.08A randomized, double-blind comparison of itraconazole oral solution and fluconazole tablets in the treatment of esophageal candidiasis. ( Darouiche, RO; Laine, L; Mallegol, I; Moskovitz, BL; Wilcox, CM; Wu, J, 1997)
"Symptoms resolved in 100% of patients with AIDS and oesophageal candidiasis receiving an oral suspension of fluconazole, and 90% of patients had symptom resolution within 2 weeks."9.08Prospective study of fluconazole suspension for the treatment of oesophageal candidiasis in patients with AIDS. ( Laine, L; Rabeneck, L, 1995)
"In order to evaluate the efficacy of 200 mg single weekly dose of fluconazole in the secondary prophylaxis of esophageal candidiasis in AIDS, 18 patients who had an endoscopic confirmation of cure after an esophageal candidiasis, were studied."9.07[Secondary prevention of esophageal candidiasis with fluconazole in acquired immunodeficiency syndrome]. ( García Puig, J; Gil, A; Khamashta, M; Lavilla Uriol, P; López Dupla, M; Ortiz Vázquez, J; Pintado, V; Valencia, E, 1992)
"A prospective, multicenter, open study of fluconazole prophylaxis was performed in AIDS patients to evaluate the efficacy and toxicity of the drug in preventing relapses of esophageal candidiasis."9.07Clinical and mycological evaluation of fluconazole in the secondary prophylaxis of esophageal candidiasis in AIDS patients. An open, multicenter study. ( Agresti, MG; Bellocco, R; Caputo, RM; Carosi, GP; Chiodo, F; de Bernardis, F; Giannini, V; Milazzo, F; Minoli, L; Mondello, F, 1994)
"We studied the prevalence of fluconazole resistance in esophageal candidiasis."7.80Is empiric therapy with fluconazole appropriate for esophageal candidiasis? ( Chacko, A; Dutta, AK; Esakimuthu, S; Sahni, RD; Sajith, KG, 2014)
" We studied the activity of PLD-118 in escalating dosages against experimental oropharyngeal and esophageal candidiasis (OPEC) caused by fluconazole (FLC)-resistant Candida albicans in immunocompromised rabbits."7.72Efficacy of PLD-118, a novel inhibitor of candida isoleucyl-tRNA synthetase, against experimental oropharyngeal and esophageal candidiasis caused by fluconazole-resistant C. albicans. ( Bacher, J; Groll, AH; Kelaher, AM; Mickiene, D; Petraitiene, R; Petraitis, V; Sarafandi, AA; Sein, T; Walsh, TJ, 2004)
" We studied the antifungal efficacy, the concentrations in saliva and tissue, and the safety of VER-002 at escalating dosages against experimental oropharyngeal and esophageal candidiasis caused by fluconazole-resistant Candida albicans in immunocompromised rabbits."7.71Dosage-dependent antifungal efficacy of V-echinocandin (LY303366) against experimental fluconazole-resistant oropharyngeal and esophageal candidiasis. ( Bacher, J; Francesconi, A; Groll, AH; Lyman, CA; Petraitiene, R; Petraitis, V; Piscitelli, SC; Schaufele, RL; Sein, T; Walsh, TJ, 2001)
"In our study 77 AIDS patients suffering from oral and/or esophageal candidiasis were evaluated: 38 received fluconazole, 39 ketoconazole."7.68Fluconazole and ketoconazole in the treatment of oral and esophageal candidiasis in AIDS patients. ( Ancarani, F; Arzeni, D; Barchiesi, F; Branchesi, P; Crescenzi, G; Giacometti, A; Scalise, G, 1992)
"Isavuconazole is a novel, broad-spectrum antifungal developed for the treatment of opportunistic fungal infections."6.80A phase 2, randomized, double-blind, multicenter trial to evaluate the safety and efficacy of three dosing regimens of isavuconazole compared with fluconazole in patients with uncomplicated esophageal candidiasis. ( Azie, N; Ghannoum, M; Schmitt-Hoffmann, AH; Viljoen, J, 2015)
"Fluconazole is a new triazole antifungal agent with good activity against Candida and cryptococcal meningitis."6.38Fluconazole: a new option in the treatment of Candida mucositis and esophageal candidiasis. ( Garber, GE, 1992)
" The concentrations of fluconazole in plasma were maintained above the MICs for FS isolates throughout the dosing interval."5.31Correlation between in vitro and in vivo antifungal activities in experimental fluconazole-resistant oropharyngeal and esophageal candidiasis. ( Bacher, JD; Gonzalez, CE; Katsov, V; Kligys, K; Lyman, CA; Peter, J; Piscitelli, S; Shetti, D; Torres, R; Walsh, TJ, 2000)
"Fluconazole was well tolerated in all the patients."5.28[Treatment of esophageal candidiasis with fluconazole in acquired immunodeficiency syndrome. Comparative study of 2 therapeutic schemes]. ( García Puig, J; Gil, A; Khamashta, M; Lavilla, P; López Dupla, M; Ortiz-Vázquez, J; Pintado, V; Valencia, E, 1992)
"We evaluated the efficacy and safety of oral posaconazole for human immunodeficiency virus (HIV)-infected subjects with oropharyngeal candidiasis (OPC) and/or esophageal candidiasis (EC) who were clinically refractory to treatment with oral fluconazole or itraconazole."5.12Posaconazole for the treatment of azole-refractory oropharyngeal and esophageal candidiasis in subjects with HIV infection. ( Anstead, GM; Boparai, N; Graybill, JR; Hare, R; Isaacs, R; Reynes, J; Skiest, DJ; Vazquez, JA; Ward, D, 2007)
" This randomized, double-blind, double-dummy study compared the efficacy and safety of intravenous anidulafungin to that of oral fluconazole in 601 patients with endoscopically and microbiologically documented esophageal candidiasis."5.11A randomized, double-blind trial of anidulafungin versus fluconazole for the treatment of esophageal candidiasis. ( Goldstein, BP; Henkel, T; Krause, DS; Simjee, AE; van Rensburg, C; Viljoen, J; Walsh, TJ; Wible, M, 2004)
"A total of 245 patients (age, > or =18 years) with a prior diagnosis of acquired immunodeficiency syndrome/human immunodeficiency virus (HIV) infection and esophageal candidiasis, confirmed by endoscopy and culture, were randomized to receive micafungin (50, 100, or 150 mg per day) or fluconazole (200 mg per day)."5.11A randomized, double-blind, parallel-group, dose-response study of micafungin compared with fluconazole for the treatment of esophageal candidiasis in HIV-positive patients. ( Baraldi, E; de Wet, N; Della Negra, M; Diekmann-Berndt, H; Krantz, EF; Llanos-Cuentas, A; Suleiman, J, 2004)
"Intravenous micafungin (150 mg daily) is well tolerated and as efficacious as intravenous fluconazole (200 mg daily) in the primary treatment of oesophageal candidiasis, achieving high rates of clinical and endoscopic cure."5.11A randomized, double blind, comparative trial of micafungin (FK463) vs. fluconazole for the treatment of oesophageal candidiasis. ( Bester, AJ; Buell, D; de Wet, NT; Filho, F; Fisco, C; Lau, W; Llanos, EA; Suleiman, JM; Ticona, E; Viljoen, JJ, 2005)
"Caspofungin is a new echinocandin drug with comparable in vitro activity against azole-susceptible and -resistant isolates of that could provide a less toxic alternative to amphotericin B for the management of esophageal candidiasis with clinical or laboratory evidence of decreased susceptibility to fluconazole."5.10Efficacy of caspofungin in the treatment of esophageal candidiasis resistant to fluconazole. ( Bartizal, K; DiNubile, MJ; Hicks, PS; Kartsonis, N; Ryan, D; Sable, CA, 2002)
"The efficacy, safety, and tolerability of voriconazole and fluconazole were compared in 391 immunocompromised patients with mycology- and biopsy-proven esophageal candidiasis."5.09A randomized, double-blind, double-dummy, multicenter trial of voriconazole and fluconazole in the treatment of esophageal candidiasis in immunocompromised patients. ( Aguirrebengoa, K; Ally, R; Carosi, G; Dupont, B; Hodges, M; Kreisel, W; Romero, AJ; Schürmann, D; Troke, P, 2001)
"This multicenter, randomized, double-blind study compared the efficacy and safety of itraconazole oral solution and fluconazole tablets in the treatment of esophageal candidiasis."5.08A randomized, double-blind comparison of itraconazole oral solution and fluconazole tablets in the treatment of esophageal candidiasis. ( Darouiche, RO; Laine, L; Mallegol, I; Moskovitz, BL; Wilcox, CM; Wu, J, 1997)
"Symptoms resolved in 100% of patients with AIDS and oesophageal candidiasis receiving an oral suspension of fluconazole, and 90% of patients had symptom resolution within 2 weeks."5.08Prospective study of fluconazole suspension for the treatment of oesophageal candidiasis in patients with AIDS. ( Laine, L; Rabeneck, L, 1995)
"A prospective, multicenter, open study of fluconazole prophylaxis was performed in AIDS patients to evaluate the efficacy and toxicity of the drug in preventing relapses of esophageal candidiasis."5.07Clinical and mycological evaluation of fluconazole in the secondary prophylaxis of esophageal candidiasis in AIDS patients. An open, multicenter study. ( Agresti, MG; Bellocco, R; Caputo, RM; Carosi, GP; Chiodo, F; de Bernardis, F; Giannini, V; Milazzo, F; Minoli, L; Mondello, F, 1994)
"In order to evaluate the efficacy of 200 mg single weekly dose of fluconazole in the secondary prophylaxis of esophageal candidiasis in AIDS, 18 patients who had an endoscopic confirmation of cure after an esophageal candidiasis, were studied."5.07[Secondary prevention of esophageal candidiasis with fluconazole in acquired immunodeficiency syndrome]. ( García Puig, J; Gil, A; Khamashta, M; Lavilla Uriol, P; López Dupla, M; Ortiz Vázquez, J; Pintado, V; Valencia, E, 1992)
"We studied the prevalence of fluconazole resistance in esophageal candidiasis."3.80Is empiric therapy with fluconazole appropriate for esophageal candidiasis? ( Chacko, A; Dutta, AK; Esakimuthu, S; Sahni, RD; Sajith, KG, 2014)
" We studied the activity of PLD-118 in escalating dosages against experimental oropharyngeal and esophageal candidiasis (OPEC) caused by fluconazole (FLC)-resistant Candida albicans in immunocompromised rabbits."3.72Efficacy of PLD-118, a novel inhibitor of candida isoleucyl-tRNA synthetase, against experimental oropharyngeal and esophageal candidiasis caused by fluconazole-resistant C. albicans. ( Bacher, J; Groll, AH; Kelaher, AM; Mickiene, D; Petraitiene, R; Petraitis, V; Sarafandi, AA; Sein, T; Walsh, TJ, 2004)
" We studied the antifungal efficacy, the concentrations in saliva and tissue, and the safety of VER-002 at escalating dosages against experimental oropharyngeal and esophageal candidiasis caused by fluconazole-resistant Candida albicans in immunocompromised rabbits."3.71Dosage-dependent antifungal efficacy of V-echinocandin (LY303366) against experimental fluconazole-resistant oropharyngeal and esophageal candidiasis. ( Bacher, J; Francesconi, A; Groll, AH; Lyman, CA; Petraitiene, R; Petraitis, V; Piscitelli, SC; Schaufele, RL; Sein, T; Walsh, TJ, 2001)
"In our study 77 AIDS patients suffering from oral and/or esophageal candidiasis were evaluated: 38 received fluconazole, 39 ketoconazole."3.68Fluconazole and ketoconazole in the treatment of oral and esophageal candidiasis in AIDS patients. ( Ancarani, F; Arzeni, D; Barchiesi, F; Branchesi, P; Crescenzi, G; Giacometti, A; Scalise, G, 1992)
"We describe a patient with the acquired immunodeficiency syndrome who had persistent oral esophageal pseudomembranous candidiasis clinically refractory to nystatin, clotrimazole, and ketoconazole."3.68Treatment of refractory oral candidiasis with fluconazole. A case report. ( Chafey, S; Franker, C; Hardy, WD; Lucatorto, FM, 1991)
"Isavuconazole is a novel, broad-spectrum antifungal developed for the treatment of opportunistic fungal infections."2.80A phase 2, randomized, double-blind, multicenter trial to evaluate the safety and efficacy of three dosing regimens of isavuconazole compared with fluconazole in patients with uncomplicated esophageal candidiasis. ( Azie, N; Ghannoum, M; Schmitt-Hoffmann, AH; Viljoen, J, 2015)
"Fluconazole has proved to be effective in treating oropharyngeal and esophageal candidiasis in immunocompromised patients."2.67Efficacy of fluconazole in the treatment of upper gastrointestinal candidiasis in neutropenic patients with cancer: factors influencing the outcome. ( Akalin, HE; Akova, M; Aslan, S; Hayran, M; Kansu, E; Tekuzman, G; Telatar, H; Uzun, O, 1994)
"Fluconazole is a new triazole antifungal agent with good activity against Candida and cryptococcal meningitis."2.38Fluconazole: a new option in the treatment of Candida mucositis and esophageal candidiasis. ( Garber, GE, 1992)
"Fluconazole was commenced within 72 h of blood culture positivity in 96."1.40Support for the EUCAST and revised CLSI fluconazole clinical breakpoints by Sensititre® YeastOne® for Candida albicans: a prospective observational cohort study. ( Chen, SC; Ellis, DH; Marriott, DM; Slavin, M; Sorrell, TC; van Hal, SJ, 2014)
"Azoles are safe, effective agents to treat esophageal candidiasis."1.33Caspofungin in the treatment of azole-refractory esophageal candidiasis in kidney transplant recipients. ( Cappello, D; Di Mare, M; Fiamingo, P; Gagliano, M; Giuffrida, G; Macarone, M; Severino, V; Sorbello, M; Spataro, M; Veroux, M; Veroux, P; Vizcarra, D, 2006)
" The concentrations of fluconazole in plasma were maintained above the MICs for FS isolates throughout the dosing interval."1.31Correlation between in vitro and in vivo antifungal activities in experimental fluconazole-resistant oropharyngeal and esophageal candidiasis. ( Bacher, JD; Gonzalez, CE; Katsov, V; Kligys, K; Lyman, CA; Peter, J; Piscitelli, S; Shetti, D; Torres, R; Walsh, TJ, 2000)
"Recurrences were also responsive to diflucan."1.29[Use of Diflucan in the treatment of chronic and recurrent candidosis with involvement of the esophagus]. ( Antonov, VV; Barantsevich, EP; Nizamutdinova, AS, 1996)
"Almost all patients with acquired immunodeficiency syndrome and successfully treated esophageal candidiasis develop a recurrence, usually within 2-3 months."1.29The natural history of esophageal candidiasis after successful treatment in patients with AIDS. ( Laine, L, 1994)
"Fluconazole was well tolerated in all the patients."1.28[Treatment of esophageal candidiasis with fluconazole in acquired immunodeficiency syndrome. Comparative study of 2 therapeutic schemes]. ( García Puig, J; Gil, A; Khamashta, M; Lavilla, P; López Dupla, M; Ortiz-Vázquez, J; Pintado, V; Valencia, E, 1992)

Research

Studies (50)

TimeframeStudies, this research(%)All Research%
pre-19901 (2.00)18.7374
1990's28 (56.00)18.2507
2000's12 (24.00)29.6817
2010's8 (16.00)24.3611
2020's1 (2.00)2.80

Authors

AuthorsStudies
López Peña, C1
Barrientos Delgado, A1
Soler Góngora, M1
Bamidele, OF1
Olokoba, AB1
Bojuwoye, MO1
Barde, AA1
Köklü, S1
Köklü, H1
Morare, NMT1
Rose, DM1
Appels, O1
Armstrong, MJ1
Ahmed, R1
Boulton, R1
Khan, AT1
Dhorajiya, P1
Lung, E1
Sajith, KG1
Dutta, AK1
Sahni, RD1
Esakimuthu, S1
Chacko, A1
van Hal, SJ1
Chen, SC1
Sorrell, TC1
Ellis, DH1
Slavin, M1
Marriott, DM1
Viljoen, J2
Azie, N1
Schmitt-Hoffmann, AH1
Ghannoum, M1
Kartsonis, N1
DiNubile, MJ1
Bartizal, K1
Hicks, PS1
Ryan, D1
Sable, CA1
Tapia, C1
González, P1
Pereira, A1
Pérez, J1
Noriega, LM1
Palavecino, E1
Petraitis, V2
Petraitiene, R2
Kelaher, AM1
Sarafandi, AA1
Sein, T2
Mickiene, D1
Bacher, J2
Groll, AH2
Walsh, TJ4
Krause, DS1
Simjee, AE1
van Rensburg, C1
Goldstein, BP1
Wible, M1
Henkel, T1
de Wet, N1
Llanos-Cuentas, A1
Suleiman, J1
Baraldi, E1
Krantz, EF1
Della Negra, M1
Diekmann-Berndt, H1
Kamai, Y1
Kakuta, M1
Shibayama, T1
Fukuoka, T1
Kuwahara, S1
de Wet, NT1
Bester, AJ1
Viljoen, JJ1
Filho, F1
Suleiman, JM1
Ticona, E1
Llanos, EA1
Fisco, C1
Lau, W1
Buell, D1
Veroux, M1
Macarone, M1
Fiamingo, P1
Cappello, D1
Gagliano, M1
Di Mare, M1
Vizcarra, D1
Spataro, M1
Giuffrida, G1
Sorbello, M1
Severino, V1
Veroux, P1
Skiest, DJ1
Vazquez, JA1
Anstead, GM1
Graybill, JR1
Reynes, J1
Ward, D1
Hare, R1
Boparai, N1
Isaacs, R1
Force, RW1
Nahata, MC1
Prignet, JM1
Galzin, M1
Demarquay, JF1
Raynard, B1
Louvety, S1
Künkel, D1
Agresti, MG1
de Bernardis, F1
Mondello, F1
Bellocco, R1
Carosi, GP1
Caputo, RM1
Milazzo, F1
Chiodo, F1
Giannini, V1
Minoli, L1
Akova, M1
Akalin, HE1
Uzun, O1
Hayran, M1
Tekuzman, G1
Kansu, E1
Aslan, S1
Telatar, H1
Laine, L3
Lesur, G1
Paupard, T1
Turner, L1
Bergemer, AM1
Parlier, H1
Dupuy, P1
Háber, J1
Kolesková, E1
Kostelková, A1
Klener, P1
Slavícek, A1
Palecek, A1
Másová, I1
Sanguineti, A1
Carmichael, JK1
Campbell, K1
Rabeneck, L1
Cartledge, JD2
Midgley, J2
Gazzard, BG2
Eichel, M1
Just-Nübling, G1
Helm, EB1
Stille, W1
Wildfeuer, A1
Laufen, H1
Yeates, RA1
Zimmermann, T1
Taylor, CB1
Finlay, R1
Richardson, C1
Bunting, P1
Welch, J1
Wilcox, CM2
Alexander, LN1
Clark, WS1
Thompson, SE1
Barantsevich, EP1
Antonov, VV1
Nizamutdinova, AS1
Darouiche, RO2
Moskovitz, BL1
Mallegol, I1
Wu, J1
Petrou, M1
Shanson, D1
Fortun Abete, J1
Laing, RB1
Brettle, RP1
Leen, CL1
Hood, SV1
Hollis, S1
Percy, M1
Atkinson, G1
Williams, K1
Denning, DW1
Gonzalez, CE1
Piscitelli, S1
Bacher, JD1
Peter, J1
Torres, R1
Shetti, D1
Katsov, V1
Kligys, K1
Lyman, CA2
Schaufele, RL1
Francesconi, A1
Piscitelli, SC1
Ally, R1
Schürmann, D1
Kreisel, W1
Carosi, G1
Aguirrebengoa, K1
Dupont, B1
Hodges, M1
Troke, P1
Romero, AJ1
Barchiesi, F1
Giacometti, A1
Arzeni, D1
Branchesi, P1
Crescenzi, G1
Ancarani, F1
Scalise, G1
Lavilla Uriol, P1
Gil, A2
Valencia, E2
Pintado, V2
López Dupla, M2
Khamashta, M2
García Puig, J2
Ortiz Vázquez, J1
Garber, GE1
Lavilla, P1
Ortiz-Vázquez, J1
Lucatorto, FM1
Franker, C1
Hardy, WD1
Chafey, S1
Kitchen, VS1
Savage, M1
Harris, JR1
Chave, JP1
Francioli, P1
Hirschel, B1
Glauser, MP1
Hendel, L1
Svejgaard, E1
Walsøe, I1
Kieffer, M1
Stenderup, A1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase 3, Randomized, Double-Blind, Comparative Trial of Micafungin Versus Fluconazole for the Treatment of Esophageal Candidiasis[NCT00666185]Phase 3523 participants (Actual)Interventional2003-08-31Completed
An Open Multicenter Trial of Fluconazole Oral Suspension in the Treatment of Esophageal Candidiasis in Immunocompromised Patients[NCT00002339]Phase 3100 participants InterventionalCompleted
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for fluconazole and Esophageal Diseases

ArticleYear
[Diagnosis, treatment and prevention of infections caused by fungi in HIV-positive patients].
    Revista clinica espanola, 1995, Volume: 195 Suppl 3

    Topics: Adult; AIDS-Related Opportunistic Infections; Amphotericin B; Antifungal Agents; Aspergillosis; Cand

1995
Oropharyngeal and esophageal candidiasis in immunocompromised patients: treatment issues.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1998, Volume: 26, Issue:2

    Topics: Antifungal Agents; Candidiasis, Oral; Drug Resistance, Microbial; Esophageal Diseases; Fluconazole;

1998
Fluconazole: a new option in the treatment of Candida mucositis and esophageal candidiasis.
    The Journal of otolaryngology, 1992, Volume: 21, Issue:2

    Topics: Candidiasis; Candidiasis, Oral; Esophageal Diseases; Fluconazole; HIV Infections; Humans; Mouth Muco

1992

Trials

15 trials available for fluconazole and Esophageal Diseases

ArticleYear
A phase 2, randomized, double-blind, multicenter trial to evaluate the safety and efficacy of three dosing regimens of isavuconazole compared with fluconazole in patients with uncomplicated esophageal candidiasis.
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:3

    Topics: Administration, Oral; Adult; Antifungal Agents; Candidiasis; Double-Blind Method; Esophageal Disease

2015
Efficacy of caspofungin in the treatment of esophageal candidiasis resistant to fluconazole.
    Journal of acquired immune deficiency syndromes (1999), 2002, Oct-01, Volume: 31, Issue:2

    Topics: Adult; Anti-Bacterial Agents; Antifungal Agents; Candida; Candidiasis; Caspofungin; Cohort Studies;

2002
A randomized, double-blind trial of anidulafungin versus fluconazole for the treatment of esophageal candidiasis.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2004, Sep-15, Volume: 39, Issue:6

    Topics: Administration, Oral; Adult; Aged; Anidulafungin; Antifungal Agents; Candidiasis; Double-Blind Metho

2004
A randomized, double-blind, parallel-group, dose-response study of micafungin compared with fluconazole for the treatment of esophageal candidiasis in HIV-positive patients.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2004, Sep-15, Volume: 39, Issue:6

    Topics: Adolescent; Adult; Aged; AIDS-Related Opportunistic Infections; Antifungal Agents; Candidiasis; Doub

2004
A randomized, double blind, comparative trial of micafungin (FK463) vs. fluconazole for the treatment of oesophageal candidiasis.
    Alimentary pharmacology & therapeutics, 2005, Apr-01, Volume: 21, Issue:7

    Topics: Adolescent; Adult; Aged; Antifungal Agents; Candidiasis; Double-Blind Method; Echinocandins; Esophag

2005
Posaconazole for the treatment of azole-refractory oropharyngeal and esophageal candidiasis in subjects with HIV infection.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2007, Feb-15, Volume: 44, Issue:4

    Topics: Administration, Oral; Adult; AIDS-Related Opportunistic Infections; Candidiasis; Candidiasis, Oral;

2007
Salivary concentrations of ketoconazole and fluconazole: implications for drug efficacy in oropharyngeal and esophageal candidiasis.
    The Annals of pharmacotherapy, 1995, Volume: 29, Issue:1

    Topics: Administration, Oral; Adult; Candida albicans; Candidiasis; Chromatography, High Pressure Liquid; Cr

1995
Clinical and mycological evaluation of fluconazole in the secondary prophylaxis of esophageal candidiasis in AIDS patients. An open, multicenter study.
    European journal of epidemiology, 1994, Volume: 10, Issue:1

    Topics: Adult; AIDS-Related Opportunistic Infections; Antigens, Fungal; Candida albicans; Candidiasis; Esoph

1994
Efficacy of fluconazole in the treatment of upper gastrointestinal candidiasis in neutropenic patients with cancer: factors influencing the outcome.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1994, Volume: 18, Issue:3

    Topics: Adult; Candida; Candidiasis, Oral; Esophageal Diseases; Female; Fluconazole; Humans; Male; Middle Ag

1994
Prospective study of fluconazole suspension for the treatment of oesophageal candidiasis in patients with AIDS.
    Alimentary pharmacology & therapeutics, 1995, Volume: 9, Issue:5

    Topics: Administration, Oral; Adult; AIDS-Related Opportunistic Infections; Antifungal Agents; Candidiasis;

1995
Fluconazole compared with endoscopy for human immunodeficiency virus-infected patients with esophageal symptoms.
    Gastroenterology, 1996, Volume: 110, Issue:6

    Topics: Adult; Antifungal Agents; Candidiasis; Cost-Benefit Analysis; Esophageal Diseases; Esophagitis; Esop

1996
A randomized, double-blind comparison of itraconazole oral solution and fluconazole tablets in the treatment of esophageal candidiasis.
    The Journal of infectious diseases, 1997, Volume: 176, Issue:1

    Topics: Administration, Oral; Adult; Antifungal Agents; Candidiasis; Double-Blind Method; Esophageal Disease

1997
Assessment of therapeutic response of oropharyngeal and esophageal candidiasis in AIDS with use of a new clinical scoring system: studies with D0870.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1999, Volume: 28, Issue:3

    Topics: AIDS-Related Opportunistic Infections; Antifungal Agents; Candida albicans; Candidiasis, Oral; Colon

1999
A randomized, double-blind, double-dummy, multicenter trial of voriconazole and fluconazole in the treatment of esophageal candidiasis in immunocompromised patients.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2001, Nov-01, Volume: 33, Issue:9

    Topics: Adolescent; Adult; Aged; Antifungal Agents; Candidiasis; Consumer Product Safety; Double-Blind Metho

2001
[Secondary prevention of esophageal candidiasis with fluconazole in acquired immunodeficiency syndrome].
    Revista clinica espanola, 1992, Volume: 190, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Adult; Candidiasis; Esophageal Diseases; Female; Fluconazole; Fo

1992

Other Studies

32 other studies available for fluconazole and Esophageal Diseases

ArticleYear
Recidivant odynophagia secondary to persistent esophageal candidiasis in an immunocompetent patient: the importance of brush cytology.
    Revista espanola de enfermedades digestivas, 2022, Volume: 114, Issue:6

    Topics: Candidiasis; Deglutition Disorders; Esophageal Diseases; Esophagitis; Female; Fluconazole; Humans; M

2022
Oesophageal intramural pseudodiverticulosis: a rare endoscopic finding.
    Ghana medical journal, 2019, Volume: 53, Issue:2

    Topics: Adult; Anti-Bacterial Agents; Antifungal Agents; Candidiasis; Deglutition Disorders; Endoscopy, Dige

2019
Rectal Candidiasis Mimicking Ulcerative Colitis in an Immunocompetent Patient.
    Inflammatory bowel diseases, 2019, 10-18, Volume: 25, Issue:11

    Topics: Aged; Candida; Candidiasis; Colitis, Ulcerative; Diagnosis, Differential; Endoscopy, Gastrointestina

2019
Oesophageal tuberculosis with concomitant candidiasis: a rare cause of dysphagia.
    BMJ case reports, 2019, Nov-02, Volume: 12, Issue:11

    Topics: Antifungal Agents; Antitubercular Agents; Candidiasis; Deglutition Disorders; Esophageal Diseases; F

2019
Dysphagia: More Than Meets the Eye?
    Gastroenterology, 2018, Volume: 154, Issue:8

    Topics: Aged; Antifungal Agents; Candida; Candidiasis; Deglutition Disorders; Diagnosis, Differential; Endos

2018
A rapidly regressive esophageal squamous papilloma.
    Gastrointestinal endoscopy, 2019, Volume: 90, Issue:4

    Topics: Anti-HIV Agents; Antifungal Agents; Candidiasis; Esophageal Diseases; Esophageal Neoplasms; Fluconaz

2019
Is empiric therapy with fluconazole appropriate for esophageal candidiasis?
    Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2014, Volume: 33, Issue:2

    Topics: Adult; Candida albicans; Candida glabrata; Candidiasis; Drug Resistance, Fungal; Esophageal Diseases

2014
Support for the EUCAST and revised CLSI fluconazole clinical breakpoints by Sensititre® YeastOne® for Candida albicans: a prospective observational cohort study.
    The Journal of antimicrobial chemotherapy, 2014, Volume: 69, Issue:8

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antifungal Agents; Candida albicans; Candidemia; Child;

2014
[Antifungal susceptibility for Candida albicans isolated from AIDS patients with oropharyngeal and esophageal candidiasis: experience with Etest].
    Revista medica de Chile, 2003, Volume: 131, Issue:5

    Topics: AIDS-Related Opportunistic Infections; Amphotericin B; Antifungal Agents; Candida albicans; Candidia

2003
Efficacy of PLD-118, a novel inhibitor of candida isoleucyl-tRNA synthetase, against experimental oropharyngeal and esophageal candidiasis caused by fluconazole-resistant C. albicans.
    Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:10

    Topics: Animals; Antifungal Agents; Area Under Curve; Candida albicans; Candidiasis; Candidiasis, Oral; Cycl

2004
Antifungal activities of R-135853, a sordarin derivative, in experimental candidiasis in mice.
    Antimicrobial agents and chemotherapy, 2005, Volume: 49, Issue:1

    Topics: Animals; Antifungal Agents; Azepines; Bridged-Ring Compounds; Candida; Candida albicans; Candidiasis

2005
Caspofungin in the treatment of azole-refractory esophageal candidiasis in kidney transplant recipients.
    Transplantation proceedings, 2006, Volume: 38, Issue:4

    Topics: Adult; Aged; Antifungal Agents; Candidiasis; Candidiasis, Vulvovaginal; Caspofungin; Cyclosporine; E

2006
[Esophageal candidiasis during interferon therapy for chronic viral hepatitis C].
    Gastroenterologie clinique et biologique, 1994, Volume: 18, Issue:8-9

    Topics: Candidiasis; Esophageal Diseases; Female; Fluconazole; Hepatitis C; Hepatitis, Chronic; Humans; Inte

1994
The natural history of esophageal candidiasis after successful treatment in patients with AIDS.
    Gastroenterology, 1994, Volume: 107, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antifungal Agents; Candidiasis; Esophageal Diseases; Fluc

1994
[Esophageal mycosis during treatment with omeprazole].
    Gastroenterologie clinique et biologique, 1993, Volume: 17, Issue:8-9

    Topics: Esophageal Diseases; Fluconazole; Humans; Male; Middle Aged; Mycoses; Omeprazole; Stomach Ulcer

1993
[Treatment of oropharyngeal and esophageal mycoses in immunodeficient patients with fluconazole (Diflucan, Pfizer)].
    Casopis lekaru ceskych, 1993, Dec-20, Volume: 132, Issue:24

    Topics: Adult; Aged; Esophageal Diseases; Female; Fluconazole; Humans; Immunocompromised Host; Male; Middle

1993
Fluconazole-resistant Candida albicans after long-term suppressive therapy.
    Archives of internal medicine, 1993, May-10, Volume: 153, Issue:9

    Topics: Adult; AIDS-Related Opportunistic Infections; Candida albicans; Candidiasis; Candidiasis, Oral; Drug

1993
Relative growth measurement of Candida species in a single concentration of fluconazole predicts the clinical response to fluconazole in HIV infected patients with oral candidosis.
    The Journal of antimicrobial chemotherapy, 1996, Volume: 37, Issue:2

    Topics: AIDS-Related Opportunistic Infections; Antifungal Agents; Candida; Candidiasis, Oral; Drug Resistanc

1996
[Itraconazole suspension in the treatment of HIV-infected patients with fluconazole-resistant oropharyngeal candidiasis and esophagitis].
    Mycoses, 1996, Volume: 39 Suppl 1

    Topics: AIDS-Related Opportunistic Infections; Antifungal Agents; Candida; Candida albicans; Candidiasis; Ca

1996
[A new pharmaceutical concept for the therapy of oropharyngeal and esophageal candidiasis with fluconazole].
    Mycoses, 1996, Volume: 39 Suppl 1

    Topics: Administration, Oral; Aged; Antifungal Agents; Candidiasis; Candidiasis, Oral; Cross-Over Studies; E

1996
Rationalizing prescribing for oral and oesophageal candidiasis.
    International journal of STD & AIDS, 1996, Volume: 7, Issue:6

    Topics: AIDS-Related Opportunistic Infections; Antifungal Agents; Candidiasis; Candidiasis, Oral; Drug Costs

1996
[Use of Diflucan in the treatment of chronic and recurrent candidosis with involvement of the esophagus].
    Klinicheskaia meditsina, 1996, Volume: 74, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antifungal Agents; Candidiasis; Child; Chronic Disease;

1996
Unresponsive HIV-related oro-oesophageal candidosis--an evaluation of two new in-vitro azole susceptibility tests.
    The Journal of antimicrobial chemotherapy, 1997, Volume: 40, Issue:4

    Topics: AIDS-Related Opportunistic Infections; Antifungal Agents; Candida; Candidiasis, Oral; Drug Resistanc

1997
Clinical predictors of azole resistance, outcome and survival from oesophageal candidiasis in AIDS patients.
    International journal of STD & AIDS, 1998, Volume: 9, Issue:1

    Topics: AIDS-Related Opportunistic Infections; Antifungal Agents; Body Weight; Candidiasis; CD4 Lymphocyte C

1998
Correlation between in vitro and in vivo antifungal activities in experimental fluconazole-resistant oropharyngeal and esophageal candidiasis.
    Journal of clinical microbiology, 2000, Volume: 38, Issue:6

    Topics: Animals; Candidiasis; Candidiasis, Oral; Child; Colony Count, Microbial; Disease Models, Animal; Dru

2000
Dosage-dependent antifungal efficacy of V-echinocandin (LY303366) against experimental fluconazole-resistant oropharyngeal and esophageal candidiasis.
    Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:2

    Topics: Amphotericin B; Anidulafungin; Animals; Antifungal Agents; Candidiasis; Candidiasis, Oral; Drug Resi

2001
Fluconazole and ketoconazole in the treatment of oral and esophageal candidiasis in AIDS patients.
    Journal of chemotherapy (Florence, Italy), 1992, Volume: 4, Issue:6

    Topics: Adult; Aged; AIDS-Related Opportunistic Infections; Candidiasis; Candidiasis, Oral; Esophageal Disea

1992
[Treatment of esophageal candidiasis with fluconazole in acquired immunodeficiency syndrome. Comparative study of 2 therapeutic schemes].
    Medicina clinica, 1992, Apr-25, Volume: 98, Issue:16

    Topics: Acquired Immunodeficiency Syndrome; Adult; Candidiasis; Drug Administration Schedule; Esophageal Dis

1992
Treatment of refractory oral candidiasis with fluconazole. A case report.
    Oral surgery, oral medicine, and oral pathology, 1991, Volume: 71, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Adult; Amphotericin B; Candida albicans; Candidiasis, Oral; Clot

1991
Candida albicans resistance in AIDS.
    The Journal of infection, 1991, Volume: 22, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Adult; Candidiasis, Oral; Drug Resistance, Microbial; Esophageal

1991
Single-dose therapy for esophageal candidiasis with fluconazole.
    AIDS (London, England), 1990, Volume: 4, Issue:10

    Topics: Administration, Oral; Adult; Candidiasis; Esophageal Diseases; Female; Fluconazole; HIV Infections;

1990
Esophageal candidosis in progressive systemic sclerosis: occurrence, significance, and treatment with fluconazole.
    Scandinavian journal of gastroenterology, 1988, Volume: 23, Issue:10

    Topics: Adult; Aged; Antifungal Agents; Candidiasis; Esophageal Diseases; Esophagoscopy; Female; Fluconazole

1988