Compounds > distamin
Page last updated: 2024-11-08

distamin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

distamin: distamycin A analog; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID194211
CHEMBL ID26468
MeSH IDM0144833

Synonyms (8)

Synonym
distamin
1h-pyrrole-2-carboxamide, n-[5-[[[5-[[[3-(dimethylamino)propyl]amino]carbonyl]-1-methyl-1h-pyrrol-3-yl]amino]carbonyl]-1-methyl-1h-pyrrol-3-yl]-4-(formylamino)-1-methyl-
n-[5-[[5-[3-(dimethylamino)propylcarbamoyl]-1-methyl-pyrrol-3-yl]carbamoyl]-1-methyl-pyrrol-3-yl]-4-formamido-1-methyl-pyrrole-2-carboxamide
CHEMBL26468
65361-29-7
1h-pyrrole-2-carboxamide, n-(5-(((3-(dimethylamino)propyl)amino)carbonyl)-1-methyl-1h-pyrrol-3-yl)-4-(((4-(formylamino)-1-methyl-1h-pyrrol-2-yl)carbonyl)amino)-1-methyl-
DTXSID70983977
[5-({5-[(5-{[3-(dimethylamino)propyl]carbamoyl}-1-methyl-1h-pyrrol-3-yl)carbamoyl]-1-methyl-1h-pyrrol-3-yl}carbamoyl)-1-methyl-1h-pyrrol-3-yl]methanimidic acid
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (25)

Assay IDTitleYearJournalArticle
AID754861Binding affinity to 5'-ATGCAT-3' of hairpin DNA (unknown origin) in cacodylic acid buffer at pH 6.5 assessed as change in melting temperature at 3 uM by thermal denaturation assay2013Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13
Design, synthesis, and DNA binding characteristics of a group of orthogonally positioned diamino, N-formamido, pyrrole- and imidazole-containing polyamides.
AID754862Binding affinity to 5'-ACGCGT-3' of hairpin DNA (unknown origin) in cacodylic acid buffer at pH 6.5 assessed as change in melting temperature at 3 uM by thermal denaturation assay2013Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13
Design, synthesis, and DNA binding characteristics of a group of orthogonally positioned diamino, N-formamido, pyrrole- and imidazole-containing polyamides.
AID37586Antifungal activity against Aspergillus niger IMI17454 strain; na = not active2004Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8
Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity.
AID55291Compound was evaluated for its binding activity to the DNA AT-rich sites2004Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5
DNA binding of a short lexitropsin.
AID69919Antibacterial activity against Escherichia coli NCTC 9001 strain.2004Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8
Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity.
AID144011Antibacterial activity against Mycobacterium fortuitum NCTC 10394 strain; na = not active2004Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8
Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity.
AID207184Antibacterial activity against Staphylococcus aureus NCTC 6571 strain.2004Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8
Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity.
AID754859Binding affinity to 5'-ATCGAT-3' of hairpin DNA (unknown origin) in cacodylic acid buffer at pH 6.5 assessed as change in melting temperature at 3 uM by thermal denaturation assay2013Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13
Design, synthesis, and DNA binding characteristics of a group of orthogonally positioned diamino, N-formamido, pyrrole- and imidazole-containing polyamides.
AID37565Antifungal activity against Aspergillus nidulans CABI 0160037 strain; na = not active2004Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8
Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity.
AID754881Binding affinity to 5'-AAATTT-3' of 11 bp hairpin DNA oligonucleotide (unknown origin) in cacodylic acid buffer at pH 6.5 at 25 degC by SPR analysis2013Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13
Design, synthesis, and DNA binding characteristics of a group of orthogonally positioned diamino, N-formamido, pyrrole- and imidazole-containing polyamides.
AID106701Antibacterial activity against MRSA PHLS M1 strain; na = not active2004Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8
Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity.
AID754858Binding affinity to 5'-ACGCGT-3' of hairpin DNA (unknown origin) in cacodylic acid buffer at pH 6.5 at 25 degC by SPR analysis2013Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13
Design, synthesis, and DNA binding characteristics of a group of orthogonally positioned diamino, N-formamido, pyrrole- and imidazole-containing polyamides.
AID754860Binding affinity to 5'-AAATTT-3' of hairpin DNA (unknown origin) in cacodylic acid buffer at pH 6.5 assessed as change in melting temperature at 3 uM by thermal denaturation assay2013Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13
Design, synthesis, and DNA binding characteristics of a group of orthogonally positioned diamino, N-formamido, pyrrole- and imidazole-containing polyamides.
AID754872Binding affinity to 5'-AAATTT-3' of DNA fragment (unknown origin) in Tris buffer at pH 7 at 20 uM by DNA footprinting2013Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13
Design, synthesis, and DNA binding characteristics of a group of orthogonally positioned diamino, N-formamido, pyrrole- and imidazole-containing polyamides.
AID754884Binding affinity to 5'-ATCGAT-3' of hairpin DNA (unknown origin) in cacodylic acid buffer at pH 6.5 at 25 degC by SPR analysis2013Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13
Design, synthesis, and DNA binding characteristics of a group of orthogonally positioned diamino, N-formamido, pyrrole- and imidazole-containing polyamides.
AID754866Binding affinity to 5'-AAATTT-3' DNA (unknown origin) at 80 uM at 25 degC by ITC method2013Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13
Design, synthesis, and DNA binding characteristics of a group of orthogonally positioned diamino, N-formamido, pyrrole- and imidazole-containing polyamides.
AID68024Antibacterial activity against Enterobacter cloacae NCTC 10005 strain.2004Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8
Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity.
AID44970Antifungal activity against Candida albicans NCPF 3179 strain; na = not active2004Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8
Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity.
AID163217Antibacterial activity against Proteus vulgaris NCTC 4175 strain.2004Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8
Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity.
AID209069Antibacterial activity against Streptococcus faecalis NCTC 775 strain.2004Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8
Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity.
AID28674Distribution coefficient of the compound at pH 7.4 (logD)2000Journal of medicinal chemistry, Aug-24, Volume: 43, Issue:17
DNA binding, solubility, and partitioning characteristics of extended lexitropsins.
AID55646The ionization constant (pKa) for the compound2000Journal of medicinal chemistry, Aug-24, Volume: 43, Issue:17
DNA binding, solubility, and partitioning characteristics of extended lexitropsins.
AID95731Antibacterial activity against Klebsiella aerogenes WRL CN 345 strain; na = not active2004Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8
Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity.
AID754857Binding affinity to 5'-ATGCAT-3' of hairpin DNA (unknown origin) in cacodylic acid buffer at pH 6.5 at 25 degC by SPR analysis2013Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13
Design, synthesis, and DNA binding characteristics of a group of orthogonally positioned diamino, N-formamido, pyrrole- and imidazole-containing polyamides.
AID23682Partition coefficient of the compound (logP)2000Journal of medicinal chemistry, Aug-24, Volume: 43, Issue:17
DNA binding, solubility, and partitioning characteristics of extended lexitropsins.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (4)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (75.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 38.86

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index38.86 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.55 (4.65)
Search Engine Demand Index48.15 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (38.86)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
stallimycin
[no description available]		210
fluconazole
Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.. fluconazole : A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.		2.0210conazole antifungal drug;
difluorobenzene;
tertiary alcohol;
triazole antifungal drug		environmental contaminant;
P450 inhibitor;
xenobiotic
itraconazole
[no description available]		2.0210piperazines
netropsin
Netropsin: A basic polypeptide isolated from Streptomyces netropsis. It is cytotoxic and its strong, specific binding to A-T areas of DNA is useful to genetics research.		210
streptomycin
[no description available]		2.0210antibiotic antifungal drug;
antibiotic fungicide;
streptomycins		antibacterial drug;
antifungal agrochemical;
antimicrobial agent;
antimicrobial drug;
bacterial metabolite;
protein synthesis inhibitor
amoxicillin
Amoxicillin: A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.. amoxicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-(4-hydroxyphenyl)acetamido group.		2.0210penicillin allergen;
penicillin		antibacterial drug
ConditionIndicatedRelationship StrengthStudiesTrials