Page last updated: 2024-12-08
distamin
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
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Protein Interactions
Research Growth
Market Indicators
Description
distamin: distamycin A analog; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 194211 |
| CHEMBL ID | 26468 |
| MeSH ID | M0144833 |
Synonyms (8)
| Synonym |
|---|
| distamin |
| 1h-pyrrole-2-carboxamide, n-[5-[[[5-[[[3-(dimethylamino)propyl]amino]carbonyl]-1-methyl-1h-pyrrol-3-yl]amino]carbonyl]-1-methyl-1h-pyrrol-3-yl]-4-(formylamino)-1-methyl- |
| n-[5-[[5-[3-(dimethylamino)propylcarbamoyl]-1-methyl-pyrrol-3-yl]carbamoyl]-1-methyl-pyrrol-3-yl]-4-formamido-1-methyl-pyrrole-2-carboxamide |
| CHEMBL26468 |
| 65361-29-7 |
| 1h-pyrrole-2-carboxamide, n-(5-(((3-(dimethylamino)propyl)amino)carbonyl)-1-methyl-1h-pyrrol-3-yl)-4-(((4-(formylamino)-1-methyl-1h-pyrrol-2-yl)carbonyl)amino)-1-methyl- |
| DTXSID70983977 |
| [5-({5-[(5-{[3-(dimethylamino)propyl]carbamoyl}-1-methyl-1h-pyrrol-3-yl)carbamoyl]-1-methyl-1h-pyrrol-3-yl}carbamoyl)-1-methyl-1h-pyrrol-3-yl]methanimidic acid |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (25)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID754861 | Binding affinity to 5'-ATGCAT-3' of hairpin DNA (unknown origin) in cacodylic acid buffer at pH 6.5 assessed as change in melting temperature at 3 uM by thermal denaturation assay | 2013 | Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13 | Design, synthesis, and DNA binding characteristics of a group of orthogonally positioned diamino, N-formamido, pyrrole- and imidazole-containing polyamides. |
| AID754862 | Binding affinity to 5'-ACGCGT-3' of hairpin DNA (unknown origin) in cacodylic acid buffer at pH 6.5 assessed as change in melting temperature at 3 uM by thermal denaturation assay | 2013 | Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13 | Design, synthesis, and DNA binding characteristics of a group of orthogonally positioned diamino, N-formamido, pyrrole- and imidazole-containing polyamides. |
| AID37586 | Antifungal activity against Aspergillus niger IMI17454 strain; na = not active | 2004 | Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8 | Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity. |
| AID55291 | Compound was evaluated for its binding activity to the DNA AT-rich sites | 2004 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 14, Issue:5 | DNA binding of a short lexitropsin. |
| AID69919 | Antibacterial activity against Escherichia coli NCTC 9001 strain. | 2004 | Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8 | Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity. |
| AID144011 | Antibacterial activity against Mycobacterium fortuitum NCTC 10394 strain; na = not active | 2004 | Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8 | Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity. |
| AID207184 | Antibacterial activity against Staphylococcus aureus NCTC 6571 strain. | 2004 | Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8 | Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity. |
| AID754859 | Binding affinity to 5'-ATCGAT-3' of hairpin DNA (unknown origin) in cacodylic acid buffer at pH 6.5 assessed as change in melting temperature at 3 uM by thermal denaturation assay | 2013 | Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13 | Design, synthesis, and DNA binding characteristics of a group of orthogonally positioned diamino, N-formamido, pyrrole- and imidazole-containing polyamides. |
| AID37565 | Antifungal activity against Aspergillus nidulans CABI 0160037 strain; na = not active | 2004 | Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8 | Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity. |
| AID754881 | Binding affinity to 5'-AAATTT-3' of 11 bp hairpin DNA oligonucleotide (unknown origin) in cacodylic acid buffer at pH 6.5 at 25 degC by SPR analysis | 2013 | Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13 | Design, synthesis, and DNA binding characteristics of a group of orthogonally positioned diamino, N-formamido, pyrrole- and imidazole-containing polyamides. |
| AID106701 | Antibacterial activity against MRSA PHLS M1 strain; na = not active | 2004 | Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8 | Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity. |
| AID754858 | Binding affinity to 5'-ACGCGT-3' of hairpin DNA (unknown origin) in cacodylic acid buffer at pH 6.5 at 25 degC by SPR analysis | 2013 | Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13 | Design, synthesis, and DNA binding characteristics of a group of orthogonally positioned diamino, N-formamido, pyrrole- and imidazole-containing polyamides. |
| AID754860 | Binding affinity to 5'-AAATTT-3' of hairpin DNA (unknown origin) in cacodylic acid buffer at pH 6.5 assessed as change in melting temperature at 3 uM by thermal denaturation assay | 2013 | Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13 | Design, synthesis, and DNA binding characteristics of a group of orthogonally positioned diamino, N-formamido, pyrrole- and imidazole-containing polyamides. |
| AID754872 | Binding affinity to 5'-AAATTT-3' of DNA fragment (unknown origin) in Tris buffer at pH 7 at 20 uM by DNA footprinting | 2013 | Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13 | Design, synthesis, and DNA binding characteristics of a group of orthogonally positioned diamino, N-formamido, pyrrole- and imidazole-containing polyamides. |
| AID754884 | Binding affinity to 5'-ATCGAT-3' of hairpin DNA (unknown origin) in cacodylic acid buffer at pH 6.5 at 25 degC by SPR analysis | 2013 | Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13 | Design, synthesis, and DNA binding characteristics of a group of orthogonally positioned diamino, N-formamido, pyrrole- and imidazole-containing polyamides. |
| AID754866 | Binding affinity to 5'-AAATTT-3' DNA (unknown origin) at 80 uM at 25 degC by ITC method | 2013 | Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13 | Design, synthesis, and DNA binding characteristics of a group of orthogonally positioned diamino, N-formamido, pyrrole- and imidazole-containing polyamides. |
| AID68024 | Antibacterial activity against Enterobacter cloacae NCTC 10005 strain. | 2004 | Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8 | Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity. |
| AID44970 | Antifungal activity against Candida albicans NCPF 3179 strain; na = not active | 2004 | Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8 | Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity. |
| AID163217 | Antibacterial activity against Proteus vulgaris NCTC 4175 strain. | 2004 | Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8 | Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity. |
| AID209069 | Antibacterial activity against Streptococcus faecalis NCTC 775 strain. | 2004 | Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8 | Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity. |
| AID28674 | Distribution coefficient of the compound at pH 7.4 (logD) | 2000 | Journal of medicinal chemistry, Aug-24, Volume: 43, Issue:17 | DNA binding, solubility, and partitioning characteristics of extended lexitropsins. |
| AID55646 | The ionization constant (pKa) for the compound | 2000 | Journal of medicinal chemistry, Aug-24, Volume: 43, Issue:17 | DNA binding, solubility, and partitioning characteristics of extended lexitropsins. |
| AID95731 | Antibacterial activity against Klebsiella aerogenes WRL CN 345 strain; na = not active | 2004 | Journal of medicinal chemistry, Apr-08, Volume: 47, Issue:8 | Distamycin analogues with enhanced lipophilicity: synthesis and antimicrobial activity. |
| AID754857 | Binding affinity to 5'-ATGCAT-3' of hairpin DNA (unknown origin) in cacodylic acid buffer at pH 6.5 at 25 degC by SPR analysis | 2013 | Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13 | Design, synthesis, and DNA binding characteristics of a group of orthogonally positioned diamino, N-formamido, pyrrole- and imidazole-containing polyamides. |
| AID23682 | Partition coefficient of the compound (logP) | 2000 | Journal of medicinal chemistry, Aug-24, Volume: 43, Issue:17 | DNA binding, solubility, and partitioning characteristics of extended lexitropsins. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (4)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 38.86
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.
| This Compound (38.86) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||