Page last updated: 2024-12-05

dichlone

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Description

dichlone: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID8342
CHEMBL ID318782
SCHEMBL ID45723
MeSH IDM0050479

Synonyms (107)

Synonym
2,3-dichloro-[1,4]naphthoquinone
DIVK1C_001315
2,3-dichlor-1,4-naftochinon [czech]
hsdb 313
2,3-dichloro-1,4-naphthalenedione
epa pesticide chemical code 029601
quintar 540f
dichlone [bsi:iso]
us rubber 604
phygon paste
latka 604 [czech]
2,3-dichloro-1,4-naphthaquinone
nsc 537
ccris 6667
2,3-dichlor-1,4-naphthochinon [german]
ai3-03776
quintar
einecs 204-210-5
caswell no. 298
CDS1_000275
1,4-naphthoquinone, 2,3-dichloro-
2,3-dichloro-1,4-naphthoquinone ,
2,3-dichloronaphthalene-1,4-dione
1,4-naphthalenedione, 2,3-dichloro-
inchi=1/c10h4cl2o2/c11-7-8(12)10(14)6-4-2-1-3-5(6)9(7)13/h1-4
AQ-390/13304011
usr 604
u.s. rubber 604
2,3-dichloro-.alpha.-naphthoquinone
cnq ,
uniroyal
phygon seed protectant
dichloronaphthoquinone
nsc-537
phygon
sanquinon
wln: l66 bv evj cg dg
2,3-dichloronaphthoquinone
2,4-naphthochinon
phygon xl
dichlone
ent 3,776
compound 604
2,4-naphthalenedione
117-80-6
algistat
diclone
nsc537
SR-01000634190-1
2,3-dichloro-1,4-naphthoquinone, 98%
NCGC00163987-01
MAYBRIDGE1_002563
chembl318782 ,
bdbm24774
2,3-dichloro-1,4-dihydronaphthalene-1,4-dione
2,3-dichloro-1,4-naphthoquinone, 1
D0384
HMS548M11
AKOS000121572
2,3-bis(chloranyl)naphthalene-1,4-dione
A803828
NCGC00163987-02
sr-01000634190
SR-01000634190-2
latka 604
2,3-dichlor-1,4-naphthochinon
unii-c28bkz2j9a
2,3-dichlor-1,4-naftochinon
c28bkz2j9a ,
NCGC00256618-01
dtxsid7020425 ,
tox21_303031
dtxcid30425
cas-117-80-6
NCGC00259201-01
tox21_201652
BBL013154
STL163952
c10h4cl2o2
CCG-44349
F1113-0043
dichlon
FT-0609535
dichlone [mi]
dichlone [hsdb]
usr-604
dichlone [iso]
SCHEMBL45723
AKOS025243278
2,3 -dichloro-1,4-naphthoquinone
2,3-dichloro(1,4)-naphthoquinone
2,3-dichloro-1,4-naphthquinone
2,3-dichloronaphthoquinone-1,4
2,3-dichloro-1,4naphthoquinone
2,3-dichloro-1,4-napthoquinone
2,3-dichloro-1,4-dihydro-1,4-dioxonaphthalene
W-108557
mfcd00001677
F0020-1851
dichlon, pestanal(r), analytical standard
2,3-dichloro-1,4-naphthoquinone, for spectrophotometric det. of hydrazides, >=98.0%
Q3026530
F21401
VS-03691
2,3-dichloro-1,4-napthalenedione
EN300-16587
dna methylation inhibitor, dichlone

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
"Three simple and sensitive spectrophotometric methods were developed and validated for determination of the hydrochloride salts of fluoxetine, sertraline, and paroxetine in their pharmaceutical dosage forms."( Development and validation of spectrophotometric methods for determination of fluoxetine, sertraline, and paroxetine in pharmaceutical dosage forms.
Darwish, IA,
)
0.13
" The proposed methods were successfully applied to the assay of sodium valproate in tablets and oral solution dosage forms with good accuracy and precision."( Validated spectrophotometric methods for determination of sodium valproate based on charge transfer complexation reactions.
Abdel-Khalek, MM; Abo-Gharam, AH; Belal, TS; El-Kafrawy, DS; Mahrous, MS, 2016
)
0.43
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (50)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
LuciferasePhotinus pyralis (common eastern firefly)Potency5.64730.007215.758889.3584AID1224835
acetylcholinesteraseHomo sapiens (human)Potency42.61580.002541.796015,848.9004AID1347395; AID1347397; AID1347398; AID1347399
pregnane X receptorRattus norvegicus (Norway rat)Potency31.62280.025127.9203501.1870AID651751
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency13.31223.189029.884159.4836AID1224846; AID1224894
RAR-related orphan receptor gammaMus musculus (house mouse)Potency7.68590.006038.004119,952.5996AID1159521; AID1159523
SMAD family member 2Homo sapiens (human)Potency20.18980.173734.304761.8120AID1346859; AID1346924
SMAD family member 3Homo sapiens (human)Potency20.18980.173734.304761.8120AID1346859; AID1346924
GLI family zinc finger 3Homo sapiens (human)Potency2.36540.000714.592883.7951AID1259369; AID1259392
AR proteinHomo sapiens (human)Potency14.92550.000221.22318,912.5098AID1259243; AID1259247; AID1259381; AID588515; AID588516; AID743035; AID743036; AID743042; AID743054; AID743063
caspase 7, apoptosis-related cysteine proteaseHomo sapiens (human)Potency68.79890.013326.981070.7614AID1346978
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency18.95500.000657.913322,387.1992AID1259377; AID1259378
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency70.92730.001022.650876.6163AID1224838; AID1224839; AID1224893
progesterone receptorHomo sapiens (human)Potency41.51940.000417.946075.1148AID1346795
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency43.46880.000214.376460.0339AID588533; AID720691; AID720692; AID720719
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency20.31500.003041.611522,387.1992AID1159552; AID1159553; AID1159555
retinoid X nuclear receptor alphaHomo sapiens (human)Potency11.12620.000817.505159.3239AID1159527; AID1159531; AID588544; AID588546
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency26.15720.001530.607315,848.9004AID1224841; AID1224842; AID1224848; AID1224849; AID1259401; AID1259403
farnesoid X nuclear receptorHomo sapiens (human)Potency35.93440.375827.485161.6524AID588526; AID743217; AID743220
pregnane X nuclear receptorHomo sapiens (human)Potency33.63120.005428.02631,258.9301AID1346982
estrogen nuclear receptor alphaHomo sapiens (human)Potency31.30110.000229.305416,493.5996AID1259244; AID1259248; AID1259383; AID588513; AID588514; AID743069; AID743075; AID743078; AID743079; AID743080; AID743091
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency16.17730.001024.504861.6448AID588534; AID588535; AID743212; AID743215
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency15.62130.001019.414170.9645AID588536; AID588537; AID743094; AID743191
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency5.87350.023723.228263.5986AID588541; AID743222; AID743223; AID743241
caspase-3Homo sapiens (human)Potency68.79890.013326.981070.7614AID1346978
aryl hydrocarbon receptorHomo sapiens (human)Potency17.56520.000723.06741,258.9301AID651777; AID743085; AID743122
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency3.01640.001723.839378.1014AID743083
thyroid stimulating hormone receptorHomo sapiens (human)Potency49.63560.001628.015177.1139AID1224843; AID1259385; AID1259395
activating transcription factor 6Homo sapiens (human)Potency54.26750.143427.612159.8106AID1159516; AID1159519
thyrotropin-releasing hormone receptorHomo sapiens (human)Potency21.38190.154917.870243.6557AID1346877
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency22.601019.739145.978464.9432AID1159509; AID1159518
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency7.08410.057821.109761.2679AID1159526; AID1159528
Histone H2A.xCricetulus griseus (Chinese hamster)Potency19.20950.039147.5451146.8240AID1224845; AID1224896
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency40.39730.010039.53711,122.0200AID588545; AID588547
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency4.27640.000323.4451159.6830AID743065; AID743066; AID743067
histone deacetylase 9 isoform 3Homo sapiens (human)Potency30.52430.037617.082361.1927AID1259364; AID1259388
heat shock protein beta-1Homo sapiens (human)Potency29.52460.042027.378961.6448AID743210; AID743228
nuclear factor NF-kappa-B p105 subunit isoform 1Homo sapiens (human)Potency39.81074.466824.832944.6684AID651749
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency32.58340.000627.21521,122.0200AID651741; AID720636; AID743202; AID743219
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency15.78280.001557.789015,848.9004AID1259244
Cellular tumor antigen p53Homo sapiens (human)Potency39.70470.002319.595674.0614AID651631; AID651743; AID720552
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency15.78280.001551.739315,848.9004AID1259244
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency68.79890.011917.942071.5630AID651632
Ataxin-2Homo sapiens (human)Potency68.79890.011912.222168.7989AID651632
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Indoleamine 2,3-dioxygenase 1Homo sapiens (human)IC50 (µMol)0.28000.05373.075710.0000AID1798473; AID326467
Amine oxidase [flavin-containing] AHomo sapiens (human)IC50 (µMol)2.30500.00002.37899.7700AID1801570
DNA (cytosine-5)-methyltransferase 1Homo sapiens (human)IC50 (µMol)1.60000.01861.64886.0000AID1199269
Carbonic anhydrase 2Mycobacterium tuberculosis H37RvIC50 (µMol)1.20001.20001.75002.3000AID1416033
Genome polyprotein Human rhinovirus sp.IC50 (µMol)4.60000.00052.98388.2000AID161699; AID161701
DNA (cytosine-5)-methyltransferase 3-likeHomo sapiens (human)IC50 (µMol)0.50000.50003.966710.0000AID1199272
DNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)IC50 (µMol)0.50000.50003.733310.0000AID1199272
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (199)

Processvia Protein(s)Taxonomy
negative regulation of cell population proliferationCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycleCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycle G2/M phase transitionCellular tumor antigen p53Homo sapiens (human)
DNA damage responseCellular tumor antigen p53Homo sapiens (human)
ER overload responseCellular tumor antigen p53Homo sapiens (human)
cellular response to glucose starvationCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
positive regulation of miRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
negative regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
mitophagyCellular tumor antigen p53Homo sapiens (human)
in utero embryonic developmentCellular tumor antigen p53Homo sapiens (human)
somitogenesisCellular tumor antigen p53Homo sapiens (human)
release of cytochrome c from mitochondriaCellular tumor antigen p53Homo sapiens (human)
hematopoietic progenitor cell differentiationCellular tumor antigen p53Homo sapiens (human)
T cell proliferation involved in immune responseCellular tumor antigen p53Homo sapiens (human)
B cell lineage commitmentCellular tumor antigen p53Homo sapiens (human)
T cell lineage commitmentCellular tumor antigen p53Homo sapiens (human)
response to ischemiaCellular tumor antigen p53Homo sapiens (human)
nucleotide-excision repairCellular tumor antigen p53Homo sapiens (human)
double-strand break repairCellular tumor antigen p53Homo sapiens (human)
regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
protein import into nucleusCellular tumor antigen p53Homo sapiens (human)
autophagyCellular tumor antigen p53Homo sapiens (human)
DNA damage responseCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorCellular tumor antigen p53Homo sapiens (human)
transforming growth factor beta receptor signaling pathwayCellular tumor antigen p53Homo sapiens (human)
Ras protein signal transductionCellular tumor antigen p53Homo sapiens (human)
gastrulationCellular tumor antigen p53Homo sapiens (human)
neuroblast proliferationCellular tumor antigen p53Homo sapiens (human)
negative regulation of neuroblast proliferationCellular tumor antigen p53Homo sapiens (human)
protein localizationCellular tumor antigen p53Homo sapiens (human)
negative regulation of DNA replicationCellular tumor antigen p53Homo sapiens (human)
negative regulation of cell population proliferationCellular tumor antigen p53Homo sapiens (human)
determination of adult lifespanCellular tumor antigen p53Homo sapiens (human)
mRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
rRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
response to salt stressCellular tumor antigen p53Homo sapiens (human)
response to inorganic substanceCellular tumor antigen p53Homo sapiens (human)
response to X-rayCellular tumor antigen p53Homo sapiens (human)
response to gamma radiationCellular tumor antigen p53Homo sapiens (human)
positive regulation of gene expressionCellular tumor antigen p53Homo sapiens (human)
cardiac muscle cell apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of cardiac muscle cell apoptotic processCellular tumor antigen p53Homo sapiens (human)
glial cell proliferationCellular tumor antigen p53Homo sapiens (human)
viral processCellular tumor antigen p53Homo sapiens (human)
glucose catabolic process to lactate via pyruvateCellular tumor antigen p53Homo sapiens (human)
cerebellum developmentCellular tumor antigen p53Homo sapiens (human)
negative regulation of cell growthCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
negative regulation of transforming growth factor beta receptor signaling pathwayCellular tumor antigen p53Homo sapiens (human)
mitotic G1 DNA damage checkpoint signalingCellular tumor antigen p53Homo sapiens (human)
negative regulation of telomere maintenance via telomeraseCellular tumor antigen p53Homo sapiens (human)
T cell differentiation in thymusCellular tumor antigen p53Homo sapiens (human)
tumor necrosis factor-mediated signaling pathwayCellular tumor antigen p53Homo sapiens (human)
regulation of tissue remodelingCellular tumor antigen p53Homo sapiens (human)
cellular response to UVCellular tumor antigen p53Homo sapiens (human)
multicellular organism growthCellular tumor antigen p53Homo sapiens (human)
positive regulation of mitochondrial membrane permeabilityCellular tumor antigen p53Homo sapiens (human)
cellular response to glucose starvationCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
entrainment of circadian clock by photoperiodCellular tumor antigen p53Homo sapiens (human)
mitochondrial DNA repairCellular tumor antigen p53Homo sapiens (human)
regulation of DNA damage response, signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of neuron apoptotic processCellular tumor antigen p53Homo sapiens (human)
transcription initiation-coupled chromatin remodelingCellular tumor antigen p53Homo sapiens (human)
negative regulation of proteolysisCellular tumor antigen p53Homo sapiens (human)
negative regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
positive regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
positive regulation of RNA polymerase II transcription preinitiation complex assemblyCellular tumor antigen p53Homo sapiens (human)
positive regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
response to antibioticCellular tumor antigen p53Homo sapiens (human)
fibroblast proliferationCellular tumor antigen p53Homo sapiens (human)
negative regulation of fibroblast proliferationCellular tumor antigen p53Homo sapiens (human)
circadian behaviorCellular tumor antigen p53Homo sapiens (human)
bone marrow developmentCellular tumor antigen p53Homo sapiens (human)
embryonic organ developmentCellular tumor antigen p53Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylationCellular tumor antigen p53Homo sapiens (human)
protein stabilizationCellular tumor antigen p53Homo sapiens (human)
negative regulation of helicase activityCellular tumor antigen p53Homo sapiens (human)
protein tetramerizationCellular tumor antigen p53Homo sapiens (human)
chromosome organizationCellular tumor antigen p53Homo sapiens (human)
neuron apoptotic processCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycleCellular tumor antigen p53Homo sapiens (human)
hematopoietic stem cell differentiationCellular tumor antigen p53Homo sapiens (human)
negative regulation of glial cell proliferationCellular tumor antigen p53Homo sapiens (human)
type II interferon-mediated signaling pathwayCellular tumor antigen p53Homo sapiens (human)
cardiac septum morphogenesisCellular tumor antigen p53Homo sapiens (human)
positive regulation of programmed necrotic cell deathCellular tumor antigen p53Homo sapiens (human)
protein-containing complex assemblyCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressCellular tumor antigen p53Homo sapiens (human)
thymocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of thymocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
necroptotic processCellular tumor antigen p53Homo sapiens (human)
cellular response to hypoxiaCellular tumor antigen p53Homo sapiens (human)
cellular response to xenobiotic stimulusCellular tumor antigen p53Homo sapiens (human)
cellular response to ionizing radiationCellular tumor antigen p53Homo sapiens (human)
cellular response to gamma radiationCellular tumor antigen p53Homo sapiens (human)
cellular response to UV-CCellular tumor antigen p53Homo sapiens (human)
stem cell proliferationCellular tumor antigen p53Homo sapiens (human)
signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
cellular response to actinomycin DCellular tumor antigen p53Homo sapiens (human)
positive regulation of release of cytochrome c from mitochondriaCellular tumor antigen p53Homo sapiens (human)
cellular senescenceCellular tumor antigen p53Homo sapiens (human)
replicative senescenceCellular tumor antigen p53Homo sapiens (human)
oxidative stress-induced premature senescenceCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathwayCellular tumor antigen p53Homo sapiens (human)
oligodendrocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of execution phase of apoptosisCellular tumor antigen p53Homo sapiens (human)
negative regulation of mitophagyCellular tumor antigen p53Homo sapiens (human)
regulation of mitochondrial membrane permeability involved in apoptotic processCellular tumor antigen p53Homo sapiens (human)
regulation of intrinsic apoptotic signaling pathway by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of miRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
negative regulation of G1 to G0 transitionCellular tumor antigen p53Homo sapiens (human)
negative regulation of miRNA processingCellular tumor antigen p53Homo sapiens (human)
negative regulation of glucose catabolic process to lactate via pyruvateCellular tumor antigen p53Homo sapiens (human)
negative regulation of pentose-phosphate shuntCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to hypoxiaCellular tumor antigen p53Homo sapiens (human)
regulation of fibroblast apoptotic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of stem cell proliferationCellular tumor antigen p53Homo sapiens (human)
positive regulation of cellular senescenceCellular tumor antigen p53Homo sapiens (human)
positive regulation of intrinsic apoptotic signaling pathwayCellular tumor antigen p53Homo sapiens (human)
regulation of activated T cell proliferationIndoleamine 2,3-dioxygenase 1Homo sapiens (human)
positive regulation of T cell tolerance inductionIndoleamine 2,3-dioxygenase 1Homo sapiens (human)
positive regulation of chronic inflammatory responseIndoleamine 2,3-dioxygenase 1Homo sapiens (human)
positive regulation of type 2 immune responseIndoleamine 2,3-dioxygenase 1Homo sapiens (human)
tryptophan catabolic processIndoleamine 2,3-dioxygenase 1Homo sapiens (human)
inflammatory responseIndoleamine 2,3-dioxygenase 1Homo sapiens (human)
female pregnancyIndoleamine 2,3-dioxygenase 1Homo sapiens (human)
tryptophan catabolic process to kynurenineIndoleamine 2,3-dioxygenase 1Homo sapiens (human)
response to lipopolysaccharideIndoleamine 2,3-dioxygenase 1Homo sapiens (human)
negative regulation of interleukin-10 productionIndoleamine 2,3-dioxygenase 1Homo sapiens (human)
positive regulation of interleukin-12 productionIndoleamine 2,3-dioxygenase 1Homo sapiens (human)
multicellular organismal response to stressIndoleamine 2,3-dioxygenase 1Homo sapiens (human)
kynurenic acid biosynthetic processIndoleamine 2,3-dioxygenase 1Homo sapiens (human)
swimming behaviorIndoleamine 2,3-dioxygenase 1Homo sapiens (human)
T cell proliferationIndoleamine 2,3-dioxygenase 1Homo sapiens (human)
negative regulation of T cell proliferationIndoleamine 2,3-dioxygenase 1Homo sapiens (human)
negative regulation of T cell apoptotic processIndoleamine 2,3-dioxygenase 1Homo sapiens (human)
positive regulation of T cell apoptotic processIndoleamine 2,3-dioxygenase 1Homo sapiens (human)
'de novo' NAD biosynthetic process from tryptophanIndoleamine 2,3-dioxygenase 1Homo sapiens (human)
biogenic amine metabolic processAmine oxidase [flavin-containing] AHomo sapiens (human)
positive regulation of signal transductionAmine oxidase [flavin-containing] AHomo sapiens (human)
dopamine catabolic processAmine oxidase [flavin-containing] AHomo sapiens (human)
negative regulation of transcription by RNA polymerase IIDNA (cytosine-5)-methyltransferase 1Homo sapiens (human)
DNA methylation-dependent heterochromatin formationDNA (cytosine-5)-methyltransferase 1Homo sapiens (human)
DNA-templated transcriptionDNA (cytosine-5)-methyltransferase 1Homo sapiens (human)
positive regulation of gene expressionDNA (cytosine-5)-methyltransferase 1Homo sapiens (human)
negative regulation of gene expressionDNA (cytosine-5)-methyltransferase 1Homo sapiens (human)
methylationDNA (cytosine-5)-methyltransferase 1Homo sapiens (human)
epigenetic programming of gene expressionDNA (cytosine-5)-methyltransferase 1Homo sapiens (human)
negative regulation of gene expression via chromosomal CpG island methylationDNA (cytosine-5)-methyltransferase 1Homo sapiens (human)
cellular response to amino acid stimulusDNA (cytosine-5)-methyltransferase 1Homo sapiens (human)
chromosomal DNA methylation maintenance following DNA replicationDNA (cytosine-5)-methyltransferase 1Homo sapiens (human)
cellular response to bisphenol ADNA (cytosine-5)-methyltransferase 1Homo sapiens (human)
positive regulation of vascular associated smooth muscle cell proliferationDNA (cytosine-5)-methyltransferase 1Homo sapiens (human)
negative regulation of vascular associated smooth muscle cell apoptotic processDNA (cytosine-5)-methyltransferase 1Homo sapiens (human)
negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switchingDNA (cytosine-5)-methyltransferase 1Homo sapiens (human)
cell population proliferationATPase family AAA domain-containing protein 5Homo sapiens (human)
positive regulation of B cell proliferationATPase family AAA domain-containing protein 5Homo sapiens (human)
nuclear DNA replicationATPase family AAA domain-containing protein 5Homo sapiens (human)
signal transduction in response to DNA damageATPase family AAA domain-containing protein 5Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorATPase family AAA domain-containing protein 5Homo sapiens (human)
isotype switchingATPase family AAA domain-containing protein 5Homo sapiens (human)
positive regulation of DNA replicationATPase family AAA domain-containing protein 5Homo sapiens (human)
positive regulation of isotype switching to IgG isotypesATPase family AAA domain-containing protein 5Homo sapiens (human)
DNA clamp unloadingATPase family AAA domain-containing protein 5Homo sapiens (human)
regulation of mitotic cell cycle phase transitionATPase family AAA domain-containing protein 5Homo sapiens (human)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorATPase family AAA domain-containing protein 5Homo sapiens (human)
positive regulation of cell cycle G2/M phase transitionATPase family AAA domain-containing protein 5Homo sapiens (human)
negative regulation of receptor internalizationAtaxin-2Homo sapiens (human)
regulation of translationAtaxin-2Homo sapiens (human)
RNA metabolic processAtaxin-2Homo sapiens (human)
P-body assemblyAtaxin-2Homo sapiens (human)
stress granule assemblyAtaxin-2Homo sapiens (human)
RNA transportAtaxin-2Homo sapiens (human)
placenta developmentDNA (cytosine-5)-methyltransferase 3-likeHomo sapiens (human)
DNA methylation-dependent heterochromatin formationDNA (cytosine-5)-methyltransferase 3-likeHomo sapiens (human)
male meiosis IDNA (cytosine-5)-methyltransferase 3-likeHomo sapiens (human)
spermatogenesisDNA (cytosine-5)-methyltransferase 3-likeHomo sapiens (human)
methylationDNA (cytosine-5)-methyltransferase 3-likeHomo sapiens (human)
epigenetic programing of female pronucleusDNA (cytosine-5)-methyltransferase 3-likeHomo sapiens (human)
negative regulation of gene expression, epigeneticDNA (cytosine-5)-methyltransferase 3-likeHomo sapiens (human)
stem cell differentiationDNA (cytosine-5)-methyltransferase 3-likeHomo sapiens (human)
chorionic trophoblast cell differentiationDNA (cytosine-5)-methyltransferase 3-likeHomo sapiens (human)
genomic imprintingDNA (cytosine-5)-methyltransferase 3-likeHomo sapiens (human)
negative regulation of DNA methylation-dependent heterochromatin formationDNA (cytosine-5)-methyltransferase 3-likeHomo sapiens (human)
retrotransposon silencing by heterochromatin formationDNA (cytosine-5)-methyltransferase 3-likeHomo sapiens (human)
autosome genomic imprintingDNA (cytosine-5)-methyltransferase 3-likeHomo sapiens (human)
negative regulation of transcription by RNA polymerase IIDNA (cytosine-5)-methyltransferase 3-likeHomo sapiens (human)
negative regulation of transcription by RNA polymerase IIDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
DNA methylation-dependent heterochromatin formationDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
spermatogenesisDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
response to xenobiotic stimulusDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
response to toxic substanceDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
response to ionizing radiationDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
response to lead ionDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
neuron differentiationDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
regulatory ncRNA-mediated heterochromatin formationDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
methylationDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
response to estradiolDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
response to vitamin ADNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
response to cocaineDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
negative regulation of gene expression via chromosomal CpG island methylationDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
S-adenosylmethionine metabolic processDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
cellular response to amino acid stimulusDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
cellular response to ethanolDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
cellular response to hypoxiaDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
hepatocyte apoptotic processDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
autosome genomic imprintingDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
positive regulation of cellular response to hypoxiaDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
cellular response to bisphenol ADNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
negative regulation of DNA-templated transcriptionDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (58)

Processvia Protein(s)Taxonomy
transcription cis-regulatory region bindingCellular tumor antigen p53Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
cis-regulatory region sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
core promoter sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
TFIID-class transcription factor complex bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription repressor activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
protease bindingCellular tumor antigen p53Homo sapiens (human)
p53 bindingCellular tumor antigen p53Homo sapiens (human)
DNA bindingCellular tumor antigen p53Homo sapiens (human)
chromatin bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription factor activityCellular tumor antigen p53Homo sapiens (human)
mRNA 3'-UTR bindingCellular tumor antigen p53Homo sapiens (human)
copper ion bindingCellular tumor antigen p53Homo sapiens (human)
protein bindingCellular tumor antigen p53Homo sapiens (human)
zinc ion bindingCellular tumor antigen p53Homo sapiens (human)
enzyme bindingCellular tumor antigen p53Homo sapiens (human)
receptor tyrosine kinase bindingCellular tumor antigen p53Homo sapiens (human)
ubiquitin protein ligase bindingCellular tumor antigen p53Homo sapiens (human)
histone deacetylase regulator activityCellular tumor antigen p53Homo sapiens (human)
ATP-dependent DNA/DNA annealing activityCellular tumor antigen p53Homo sapiens (human)
identical protein bindingCellular tumor antigen p53Homo sapiens (human)
histone deacetylase bindingCellular tumor antigen p53Homo sapiens (human)
protein heterodimerization activityCellular tumor antigen p53Homo sapiens (human)
protein-folding chaperone bindingCellular tumor antigen p53Homo sapiens (human)
protein phosphatase 2A bindingCellular tumor antigen p53Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor bindingCellular tumor antigen p53Homo sapiens (human)
14-3-3 protein bindingCellular tumor antigen p53Homo sapiens (human)
MDM2/MDM4 family protein bindingCellular tumor antigen p53Homo sapiens (human)
disordered domain specific bindingCellular tumor antigen p53Homo sapiens (human)
general transcription initiation factor bindingCellular tumor antigen p53Homo sapiens (human)
molecular function activator activityCellular tumor antigen p53Homo sapiens (human)
promoter-specific chromatin bindingCellular tumor antigen p53Homo sapiens (human)
electron transfer activityIndoleamine 2,3-dioxygenase 1Homo sapiens (human)
heme bindingIndoleamine 2,3-dioxygenase 1Homo sapiens (human)
indoleamine 2,3-dioxygenase activityIndoleamine 2,3-dioxygenase 1Homo sapiens (human)
metal ion bindingIndoleamine 2,3-dioxygenase 1Homo sapiens (human)
tryptophan 2,3-dioxygenase activityIndoleamine 2,3-dioxygenase 1Homo sapiens (human)
protein bindingAmine oxidase [flavin-containing] AHomo sapiens (human)
primary amine oxidase activityAmine oxidase [flavin-containing] AHomo sapiens (human)
aliphatic amine oxidase activityAmine oxidase [flavin-containing] AHomo sapiens (human)
monoamine oxidase activityAmine oxidase [flavin-containing] AHomo sapiens (human)
flavin adenine dinucleotide bindingAmine oxidase [flavin-containing] AHomo sapiens (human)
DNA bindingDNA (cytosine-5)-methyltransferase 1Homo sapiens (human)
RNA bindingDNA (cytosine-5)-methyltransferase 1Homo sapiens (human)
DNA (cytosine-5-)-methyltransferase activityDNA (cytosine-5)-methyltransferase 1Homo sapiens (human)
protein bindingDNA (cytosine-5)-methyltransferase 1Homo sapiens (human)
zinc ion bindingDNA (cytosine-5)-methyltransferase 1Homo sapiens (human)
methyl-CpG bindingDNA (cytosine-5)-methyltransferase 1Homo sapiens (human)
DNA-methyltransferase activityDNA (cytosine-5)-methyltransferase 1Homo sapiens (human)
promoter-specific chromatin bindingDNA (cytosine-5)-methyltransferase 1Homo sapiens (human)
protein bindingATPase family AAA domain-containing protein 5Homo sapiens (human)
ATP bindingATPase family AAA domain-containing protein 5Homo sapiens (human)
ATP hydrolysis activityATPase family AAA domain-containing protein 5Homo sapiens (human)
DNA clamp unloader activityATPase family AAA domain-containing protein 5Homo sapiens (human)
DNA bindingATPase family AAA domain-containing protein 5Homo sapiens (human)
RNA bindingAtaxin-2Homo sapiens (human)
epidermal growth factor receptor bindingAtaxin-2Homo sapiens (human)
protein bindingAtaxin-2Homo sapiens (human)
mRNA bindingAtaxin-2Homo sapiens (human)
protein bindingDNA (cytosine-5)-methyltransferase 3-likeHomo sapiens (human)
enzyme activator activityDNA (cytosine-5)-methyltransferase 3-likeHomo sapiens (human)
enzyme bindingDNA (cytosine-5)-methyltransferase 3-likeHomo sapiens (human)
metal ion bindingDNA (cytosine-5)-methyltransferase 3-likeHomo sapiens (human)
DNA (cytosine-5-)-methyltransferase activity, acting on CpG substratesDNA (cytosine-5)-methyltransferase 3-likeHomo sapiens (human)
DNA bindingDNA (cytosine-5)-methyltransferase 3-likeHomo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA bindingDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
DNA bindingDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
chromatin bindingDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
transcription corepressor activityDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
DNA (cytosine-5-)-methyltransferase activityDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
protein bindingDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
identical protein bindingDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
unmethylated CpG bindingDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
metal ion bindingDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor bindingDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
lncRNA bindingDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
protein-cysteine methyltransferase activityDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (39)

Processvia Protein(s)Taxonomy
nuclear bodyCellular tumor antigen p53Homo sapiens (human)
nucleusCellular tumor antigen p53Homo sapiens (human)
nucleoplasmCellular tumor antigen p53Homo sapiens (human)
replication forkCellular tumor antigen p53Homo sapiens (human)
nucleolusCellular tumor antigen p53Homo sapiens (human)
cytoplasmCellular tumor antigen p53Homo sapiens (human)
mitochondrionCellular tumor antigen p53Homo sapiens (human)
mitochondrial matrixCellular tumor antigen p53Homo sapiens (human)
endoplasmic reticulumCellular tumor antigen p53Homo sapiens (human)
centrosomeCellular tumor antigen p53Homo sapiens (human)
cytosolCellular tumor antigen p53Homo sapiens (human)
nuclear matrixCellular tumor antigen p53Homo sapiens (human)
PML bodyCellular tumor antigen p53Homo sapiens (human)
transcription repressor complexCellular tumor antigen p53Homo sapiens (human)
site of double-strand breakCellular tumor antigen p53Homo sapiens (human)
germ cell nucleusCellular tumor antigen p53Homo sapiens (human)
chromatinCellular tumor antigen p53Homo sapiens (human)
transcription regulator complexCellular tumor antigen p53Homo sapiens (human)
protein-containing complexCellular tumor antigen p53Homo sapiens (human)
cytosolIndoleamine 2,3-dioxygenase 1Homo sapiens (human)
smooth muscle contractile fiberIndoleamine 2,3-dioxygenase 1Homo sapiens (human)
stereocilium bundleIndoleamine 2,3-dioxygenase 1Homo sapiens (human)
cytoplasmIndoleamine 2,3-dioxygenase 1Homo sapiens (human)
plasma membraneGlutamate receptor 2Rattus norvegicus (Norway rat)
mitochondrionAmine oxidase [flavin-containing] AHomo sapiens (human)
mitochondrial outer membraneAmine oxidase [flavin-containing] AHomo sapiens (human)
cytosolAmine oxidase [flavin-containing] AHomo sapiens (human)
mitochondrionAmine oxidase [flavin-containing] AHomo sapiens (human)
female germ cell nucleusDNA (cytosine-5)-methyltransferase 1Homo sapiens (human)
nucleusDNA (cytosine-5)-methyltransferase 1Homo sapiens (human)
nucleoplasmDNA (cytosine-5)-methyltransferase 1Homo sapiens (human)
replication forkDNA (cytosine-5)-methyltransferase 1Homo sapiens (human)
pericentric heterochromatinDNA (cytosine-5)-methyltransferase 1Homo sapiens (human)
nucleusDNA (cytosine-5)-methyltransferase 1Homo sapiens (human)
Elg1 RFC-like complexATPase family AAA domain-containing protein 5Homo sapiens (human)
nucleusATPase family AAA domain-containing protein 5Homo sapiens (human)
cytoplasmAtaxin-2Homo sapiens (human)
Golgi apparatusAtaxin-2Homo sapiens (human)
trans-Golgi networkAtaxin-2Homo sapiens (human)
cytosolAtaxin-2Homo sapiens (human)
cytoplasmic stress granuleAtaxin-2Homo sapiens (human)
membraneAtaxin-2Homo sapiens (human)
perinuclear region of cytoplasmAtaxin-2Homo sapiens (human)
ribonucleoprotein complexAtaxin-2Homo sapiens (human)
cytoplasmic stress granuleAtaxin-2Homo sapiens (human)
ESC/E(Z) complexDNA (cytosine-5)-methyltransferase 3-likeHomo sapiens (human)
condensed nuclear chromosomeDNA (cytosine-5)-methyltransferase 3-likeHomo sapiens (human)
nucleusDNA (cytosine-5)-methyltransferase 3-likeHomo sapiens (human)
cytosolDNA (cytosine-5)-methyltransferase 3-likeHomo sapiens (human)
catalytic complexDNA (cytosine-5)-methyltransferase 3-likeHomo sapiens (human)
heterochromatinDNA (cytosine-5)-methyltransferase 3-likeHomo sapiens (human)
nucleusDNA (cytosine-5)-methyltransferase 3-likeHomo sapiens (human)
chromosome, centromeric regionDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
XY bodyDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
nucleusDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
nucleoplasmDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
cytoplasmDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
nuclear matrixDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
catalytic complexDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
euchromatinDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
heterochromatinDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
nucleusDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
cytoplasmDNA (cytosine-5)-methyltransferase 3AHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (57)

Assay IDTitleYearJournalArticle
AID1183569Selectivity index, ratio of IC50 for human MRC5 cells to IC50 for human HuCCa1 cells2014European journal of medicinal chemistry, Sep-12, Volume: 84Synthesis, anticancer activity and QSAR study of 1,4-naphthoquinone derivatives.
AID672965Antitrypanosomal activity against Trypanosoma cruzi Y epimastigotes assessed as cell death at 50 uM after 72 hrs by propidium iodide staining-based flow cytometric analysis2012Bioorganic & medicinal chemistry, Aug-15, Volume: 20, Issue:16
New oxirane derivatives of 1,4-naphthoquinones and their evaluation against T. cruzi epimastigote forms.
AID672967Cytotoxicity against african green monkey Vero cells after 72 hrs by spectrophotometric analysis2012Bioorganic & medicinal chemistry, Aug-15, Volume: 20, Issue:16
New oxirane derivatives of 1,4-naphthoquinones and their evaluation against T. cruzi epimastigote forms.
AID161699Inhibitory activity against HCMV protease by HPLC assay1999Bioorganic & medicinal chemistry letters, Oct-04, Volume: 9, Issue:19
2-chloro-3-substituted-1,4-naphthoquinone inactivators of human cytomegalovirus protease.
AID672966Antitrypanosomal activity against Trypanosoma cruzi Y epimastigotes after 72 hrs by Neubauer counter-based microscopic analysis2012Bioorganic & medicinal chemistry, Aug-15, Volume: 20, Issue:16
New oxirane derivatives of 1,4-naphthoquinones and their evaluation against T. cruzi epimastigote forms.
AID1183565Cytotoxicity against human A549 cells after 48 hrs by MTT assay2014European journal of medicinal chemistry, Sep-12, Volume: 84Synthesis, anticancer activity and QSAR study of 1,4-naphthoquinone derivatives.
AID1416036Inhibition of recombinant Mycobacterium tuberculosis N-terminal Hi-tagged Rv3588c expressed in Escherichia coli BL21-Al cells assessed as enzyme residual activity at 25 uM measured for 10 secs by m-cresol purple staining based stopped-flow CO2 hydration a2017MedChemComm, Jun-01, Volume: 8, Issue:6
Dichloro-naphthoquinone as a non-classical inhibitor of the mycobacterial carbonic anhydrase Rv3588c.
AID352613Antifungal activity against Aspergillus fumigatus after 72 hrs by micro broth dilution method2009European journal of medicinal chemistry, Mar, Volume: 44, Issue:3
2,3-Disubstituted-1,4-naphthoquinones, 12H-benzo[b]phenothiazine-6,11-diones and related compounds: synthesis and biological evaluation as potential antiproliferative and antifungal agents.
AID1199269Inhibition of His6-tagged human recombinant DNMT1 expressed in insect Sf9 cells assessed as reduction in DNA methyltransferase activity using 5'-biotinylated 45-bp unmethylated or hemimethylated oligonucleotide substrates and [3H]-AdoMet by liquid scintil2015Journal of medicinal chemistry, Mar-26, Volume: 58, Issue:6
Targeting DNA methylation with small molecules: what's next?
AID352598Antiproliferative activity against human HeLa cells at 5 uM after 24 hrs by sulforhodamine B assay2009European journal of medicinal chemistry, Mar, Volume: 44, Issue:3
2,3-Disubstituted-1,4-naphthoquinones, 12H-benzo[b]phenothiazine-6,11-diones and related compounds: synthesis and biological evaluation as potential antiproliferative and antifungal agents.
AID326467Inhibition of purified human recombinant IDO2008Journal of medicinal chemistry, Mar-27, Volume: 51, Issue:6
Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors.
AID117492Maximum survival by an optimum dose at 6 mg/kg in treated to that of untreated mice1983Journal of medicinal chemistry, Apr, Volume: 26, Issue:4
Substituted 1,4-naphthoquinones vs. the ascitic sarcoma 180 of mice.
AID1416037Inhibition of recombinant human carbonic anhydrase 2 expressed in Escherichia coli BL21 (DE3) assessed as enzyme residual activity at 25 uM measured for 10 secs by m-cresol purple staining based stopped-flow CO2 hydration assay relative to control2017MedChemComm, Jun-01, Volume: 8, Issue:6
Dichloro-naphthoquinone as a non-classical inhibitor of the mycobacterial carbonic anhydrase Rv3588c.
AID1597610Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by WST1 assay2019European journal of medicinal chemistry, Sep-01, Volume: 177Betulin-1,4-quinone hybrids: Synthesis, anticancer activity and molecular docking study with NQO1 enzyme.
AID352610Antifungal activity against Cryptococcus neoformans after 72 hrs by micro broth dilution method2009European journal of medicinal chemistry, Mar, Volume: 44, Issue:3
2,3-Disubstituted-1,4-naphthoquinones, 12H-benzo[b]phenothiazine-6,11-diones and related compounds: synthesis and biological evaluation as potential antiproliferative and antifungal agents.
AID23482Partition coefficient (logP)1983Journal of medicinal chemistry, Apr, Volume: 26, Issue:4
Substituted 1,4-naphthoquinones vs. the ascitic sarcoma 180 of mice.
AID352597Antiproliferative activity against human HeLa cells at 20 uM after 24 hrs by sulforhodamine B assay2009European journal of medicinal chemistry, Mar, Volume: 44, Issue:3
2,3-Disubstituted-1,4-naphthoquinones, 12H-benzo[b]phenothiazine-6,11-diones and related compounds: synthesis and biological evaluation as potential antiproliferative and antifungal agents.
AID1631041Induction of MLV PrGag C>S mutant cross linking transfected in HEK293T cells assessed as formation of protein dimer at 1 mM after 1 hr by immunoblot analysis2016Bioorganic & medicinal chemistry, 11-01, Volume: 24, Issue:21
Analysis of quinolinequinone reactivity, cytotoxicity, and anti-HIV-1 properties.
AID1183568Selectivity index, ratio of IC50 for human MRC5 cells to IC50 for human HepG2 cells2014European journal of medicinal chemistry, Sep-12, Volume: 84Synthesis, anticancer activity and QSAR study of 1,4-naphthoquinone derivatives.
AID660266Trypanocidal activity against bloodstream form of Trypanosoma cruzi Y isolated from albino mouse blood after 24 hrs by neubauer chamber analysis2012European journal of medicinal chemistry, Jun, Volume: 52On the search for potential anti-Trypanosoma cruzi drugs: synthesis and biological evaluation of 2-hydroxy-3-methylamino and 1,2,3-triazolic naphthoquinoidal compounds obtained by click chemistry reactions.
AID1183571Selectivity index, ratio of IC50 for human MRC5 cells to IC50 for human MOLT3 cells2014European journal of medicinal chemistry, Sep-12, Volume: 84Synthesis, anticancer activity and QSAR study of 1,4-naphthoquinone derivatives.
AID1416033Inhibition of recombinant Mycobacterium tuberculosis N-terminal Hi-tagged Rv3588c expressed in Escherichia coli BL21-Al cells measured for 10 secs by m-cresol purple staining based stopped-flow CO2 hydration assay2017MedChemComm, Jun-01, Volume: 8, Issue:6
Dichloro-naphthoquinone as a non-classical inhibitor of the mycobacterial carbonic anhydrase Rv3588c.
AID1199272Inhibition of His6-tagged human recombinant DNMT3A/DNMT3L expressed in insect Sf9 cells assessed as reduction in DNA methyltransferase activity using 5'-biotinylated 45-bp unmethylated or hemimethylated oligonucleotide substrates and [3H]-AdoMet by liquid2015Journal of medicinal chemistry, Mar-26, Volume: 58, Issue:6
Targeting DNA methylation with small molecules: what's next?
AID308238Inhibition of pig pancreatic elastase2007Bioorganic & medicinal chemistry, Aug-01, Volume: 15, Issue:15
The 1,4-naphthoquinone scaffold in the design of cysteine protease inhibitors.
AID1183567Cytotoxicity against human MRC5 cells after 48 hrs by MTT assay2014European journal of medicinal chemistry, Sep-12, Volume: 84Synthesis, anticancer activity and QSAR study of 1,4-naphthoquinone derivatives.
AID39233Effective dose that would give a 25% increase in the survival time against the ascitic sarcoma 180 in mice1983Journal of medicinal chemistry, Apr, Volume: 26, Issue:4
Substituted 1,4-naphthoquinones vs. the ascitic sarcoma 180 of mice.
AID1631039Induction of immature HIV1 PrGag cross linking transfected in HEK293T cells assessed as formation of protein dimer at 1 mM after 1 hr by immunoblot analysis2016Bioorganic & medicinal chemistry, 11-01, Volume: 24, Issue:21
Analysis of quinolinequinone reactivity, cytotoxicity, and anti-HIV-1 properties.
AID1274027Antimalarial activity against chloroquine-sensitive NF54 isolated Plasmodium falciparum 3D7 infected in erythrocytes assessed as inhibition of parasitic growth after 48 hrs by optical microscopy2016European journal of medicinal chemistry, Jan-27, Volume: 108Synthesis and antimalarial activity of quinones and structurally-related oxirane derivatives.
AID1597607Antiproliferative activity against human C32 cells assessed as reduction in cell viability incubated for 72 hrs by WST1 assay2019European journal of medicinal chemistry, Sep-01, Volume: 177Betulin-1,4-quinone hybrids: Synthesis, anticancer activity and molecular docking study with NQO1 enzyme.
AID1597608Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by WST1 assay2019European journal of medicinal chemistry, Sep-01, Volume: 177Betulin-1,4-quinone hybrids: Synthesis, anticancer activity and molecular docking study with NQO1 enzyme.
AID117228Tested for acute toxicity which is the single dose given intraperitoneally that will kill one-half of the mice within 5 days1983Journal of medicinal chemistry, Apr, Volume: 26, Issue:4
Substituted 1,4-naphthoquinones vs. the ascitic sarcoma 180 of mice.
AID1597609Antiproliferative activity against human T47D cells assessed as reduction in cell viability incubated for 72 hrs by WST1 assay2019European journal of medicinal chemistry, Sep-01, Volume: 177Betulin-1,4-quinone hybrids: Synthesis, anticancer activity and molecular docking study with NQO1 enzyme.
AID21140Solubility in water was determined1983Journal of medicinal chemistry, Apr, Volume: 26, Issue:4
Substituted 1,4-naphthoquinones vs. the ascitic sarcoma 180 of mice.
AID1597605Antiproliferative activity against human SNB19 cells assessed as reduction in cell viability incubated for 72 hrs by WST1 assay2019European journal of medicinal chemistry, Sep-01, Volume: 177Betulin-1,4-quinone hybrids: Synthesis, anticancer activity and molecular docking study with NQO1 enzyme.
AID1274029Selectivity index, ratio of IC50 for MRC5 cells to IC50 for chloroquine-sensitive NF54 isolated Plasmodium falciparum 3D72016European journal of medicinal chemistry, Jan-27, Volume: 108Synthesis and antimalarial activity of quinones and structurally-related oxirane derivatives.
AID1274028Cytotoxicity against human MRC5 cells assessed as cell growth inhibition after 48 hrs by alamar blue assay2016European journal of medicinal chemistry, Jan-27, Volume: 108Synthesis and antimalarial activity of quinones and structurally-related oxirane derivatives.
AID352599Antiproliferative activity against human HeLa cells at 1 uM after 24 hrs by sulforhodamine B assay2009European journal of medicinal chemistry, Mar, Volume: 44, Issue:3
2,3-Disubstituted-1,4-naphthoquinones, 12H-benzo[b]phenothiazine-6,11-diones and related compounds: synthesis and biological evaluation as potential antiproliferative and antifungal agents.
AID352611Antifungal activity against Sporothrix schenckii after 72 hrs by micro broth dilution method2009European journal of medicinal chemistry, Mar, Volume: 44, Issue:3
2,3-Disubstituted-1,4-naphthoquinones, 12H-benzo[b]phenothiazine-6,11-diones and related compounds: synthesis and biological evaluation as potential antiproliferative and antifungal agents.
AID1183570Selectivity index, ratio of IC50 for human MRC5 cells to IC50 for human A549 cells2014European journal of medicinal chemistry, Sep-12, Volume: 84Synthesis, anticancer activity and QSAR study of 1,4-naphthoquinone derivatives.
AID1597611Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by WST1 assay2019European journal of medicinal chemistry, Sep-01, Volume: 177Betulin-1,4-quinone hybrids: Synthesis, anticancer activity and molecular docking study with NQO1 enzyme.
AID352614Antifungal activity against Candida parapsilosis ATCC 22019 after 48 hrs by micro broth dilution method2009European journal of medicinal chemistry, Mar, Volume: 44, Issue:3
2,3-Disubstituted-1,4-naphthoquinones, 12H-benzo[b]phenothiazine-6,11-diones and related compounds: synthesis and biological evaluation as potential antiproliferative and antifungal agents.
AID1416034Binding affinity to recombinant Mycobacterium tuberculosis Rv1284 expressed in Escherichia coli BL21-Al cells assessed as change in melting temperature by SYPRO Orange dye based differential scanning fluorimetric method2017MedChemComm, Jun-01, Volume: 8, Issue:6
Dichloro-naphthoquinone as a non-classical inhibitor of the mycobacterial carbonic anhydrase Rv3588c.
AID1183564Cytotoxicity against human HuCCa1 cells after 48 hrs by MTT assay2014European journal of medicinal chemistry, Sep-12, Volume: 84Synthesis, anticancer activity and QSAR study of 1,4-naphthoquinone derivatives.
AID1597606Antiproliferative activity against human COLO829 cells assessed as reduction in cell viability incubated for 72 hrs by WST1 assay2019European journal of medicinal chemistry, Sep-01, Volume: 177Betulin-1,4-quinone hybrids: Synthesis, anticancer activity and molecular docking study with NQO1 enzyme.
AID1631035Induction of CSILD IRQGP KEPFR DYVDR FYKTL RAEQA S peptide cross linking assessed as formation of dimer bands at 50 uM after 2 hrs by coomassie blue staining based electrophoresis2016Bioorganic & medicinal chemistry, 11-01, Volume: 24, Issue:21
Analysis of quinolinequinone reactivity, cytotoxicity, and anti-HIV-1 properties.
AID1183566Cytotoxicity against human MOLT3 cells after 48 hrs by MTT assay2014European journal of medicinal chemistry, Sep-12, Volume: 84Synthesis, anticancer activity and QSAR study of 1,4-naphthoquinone derivatives.
AID1754246Inhibition of recombinant Trypanosoma cruzi cruzain at 100 uM using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition measured for 5 mins by fluorimetric analysis relative to control
AID352609Antifungal activity against Candida albicans after 48 hrs by micro broth dilution method2009European journal of medicinal chemistry, Mar, Volume: 44, Issue:3
2,3-Disubstituted-1,4-naphthoquinones, 12H-benzo[b]phenothiazine-6,11-diones and related compounds: synthesis and biological evaluation as potential antiproliferative and antifungal agents.
AID1631040Induction of MLV PrGag cross linking transfected in HEK293T cells assessed as formation of protein dimer at 1mM after 1 hr by immunoblot analysis2016Bioorganic & medicinal chemistry, 11-01, Volume: 24, Issue:21
Analysis of quinolinequinone reactivity, cytotoxicity, and anti-HIV-1 properties.
AID1416035Inhibition of recombinant Mycobacterium tuberculosis Rv1284 expressed in Escherichia coli BL21-Al cells assessed as enzyme residual activity at 25 uM measured for 10 secs by m-cresol purple staining based stopped-flow CO2 hydration assay relative to contr2017MedChemComm, Jun-01, Volume: 8, Issue:6
Dichloro-naphthoquinone as a non-classical inhibitor of the mycobacterial carbonic anhydrase Rv3588c.
AID1183563Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay2014European journal of medicinal chemistry, Sep-12, Volume: 84Synthesis, anticancer activity and QSAR study of 1,4-naphthoquinone derivatives.
AID352612Antifungal activity against Trichophyton mentagrophytes after 96 hrs by micro broth dilution method2009European journal of medicinal chemistry, Mar, Volume: 44, Issue:3
2,3-Disubstituted-1,4-naphthoquinones, 12H-benzo[b]phenothiazine-6,11-diones and related compounds: synthesis and biological evaluation as potential antiproliferative and antifungal agents.
AID161701Inhibitory activity against HCMV protease by SPA assay1999Bioorganic & medicinal chemistry letters, Oct-04, Volume: 9, Issue:19
2-chloro-3-substituted-1,4-naphthoquinone inactivators of human cytomegalovirus protease.
AID1754248Inhibition of recombinant Trypanosoma brucei rhodesain at 100 uM using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition measured for 5 mins by fluorimetric analysis relative to control
AID1798473Enzyme Inhibition Assay from Article 10.1021/jm7014155: \\Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors.\\2008Journal of medicinal chemistry, Mar-27, Volume: 51, Issue:6
Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors.
AID1801570MAO Inhibition Assay from Article 10.1111/cbdd.12708: \\Evaluation of Natural and Synthetic 1,4-naphthoquinones as Inhibitors of Monoamine Oxidase.\\2016Chemical biology & drug design, May, Volume: 87, Issue:5
Evaluation of Natural and Synthetic 1,4-naphthoquinones as Inhibitors of Monoamine Oxidase.
AID1159607Screen for inhibitors of RMI FANCM (MM2) intereaction2016Journal of biomolecular screening, Jul, Volume: 21, Issue:6
A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (42)

TimeframeStudies, This Drug (%)All Drugs %
pre-199011 (26.19)18.7374
1990's3 (7.14)18.2507
2000's11 (26.19)29.6817
2010's15 (35.71)24.3611
2020's2 (4.76)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 50.63

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index50.63 (24.57)
Research Supply Index3.81 (2.92)
Research Growth Index4.88 (4.65)
Search Engine Demand Index76.22 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (50.63)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (2.27%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other43 (97.73%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]