Page last updated: 2024-09-27

Ganglioneuroblastoma

A moderately malignant neoplasm composed of primitive neuroectodermal cells dispersed in myxomatous or fibrous stroma intermixed with mature ganglion cells. It may undergo transformation into a neuroblastoma. It arises from the sympathetic trunk or less frequently from the adrenal medulla, cerebral cortex, and other locations. Cervical ganglioneuroblastomas may be associated with HORNER SYNDROME and the tumor may occasionally secrete vasoactive intestinal peptide, resulting in chronic diarrhea.

Synonyms(1)

Synonym
Ganglioneuroblastoma

Research Excerpts

Overview

ExcerptReference
"Ganglioneuroblastoma is a rare tumor variant of neuroblastoma."( Kloet, A; Schipper, MH; Taphoorn, MJ; van Duinen, SG; Vecht, CJ; Walchenbach, R; Wiggenraad, RG, 2012)

Context

ExcerptReference
"To our knowledge, ganglioneuroblastoma has never been reported in association with vitamin D deficiency rickets."( Baroncelli, GI; Caruso-Nicoletti, M; Di Cataldo, A; La Rosa, C; Pavone, P; Praticò, AD, 2009)

Research

Studies (79)

TimeframeStudies, This Condition (%)All Conditions %
pre-19902 (2.53)23.3326
1990's23 (29.11)12.5806
2000's31 (39.24)18.1394
2010's19 (24.05)28.8240
2020's4 (5.06)9.53
DrugIndicatedRelationship StrengthStudiesTrials
formaldehyde0low10
vanilmandelic acid0low40
homovanillic acid0low40
pentetic acid0low10
doxazosin0low10
fluconazole0low10
ifosfamide0low20
mechlorethamine0low10
prednisolone0low10
carbachol0low10
bromodeoxyuridine0low10
azacitidine0low10
limestone0low10
hematoxylin0low10
copper gluconate0low10
eosine yellowish-(ys)0low10
ethylnitrosourea0low20
gadolinium0low10
camptothecin0low10
tetradecanoylphorbol acetate0low10
topotecan0low10
3-iodobenzylguanidine0low150
fluorodeoxyglucose f180low20
arginyl-glycyl-aspartic acid0low10
1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid0low10
clevidipine0low10
edotreotide0low10
lactogluconic acid0low10
carboplatin0low50
tretinoin0low30
bromochloroacetic acid0low10
isomethyleugenol0low10
ganglioside, gd20low10
alpha-synuclein0low10
pirarubicin0low20
pituitrin0low10
(dtpa-phe(1))-octreotide0low10
endothelin-10low10
cerebellin0low10
vasoactive intestinal peptide0low90
epidermal growth factor0low10
cyclin d10low20
adrenomedullin0low10
chondroitin sulfates0low10
dacarbazine0low10
metallothionein0low10
galanin-like peptide0low10

Protein Targets (475)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
ATAD5 protein, partial7007
apical membrane antigen 1, AMA13003
euchromatic histone-lysine N-methyltransferase 2120012
chromobox protein homolog 1120012
DNA polymerase iota isoform a (long)6006
geminin130013
lethal factor (plasmid)3014
botulinum neurotoxin type A0011
botulinum neurotoxin type F, BoNT/F0011
dopamine D1 receptor1001
thioredoxin reductase8008
GLS protein4004
Thrombopoietin3003
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
cytochrome P450 2D6 isoform 11001
cytochrome P450 2C19 precursor3003
ras-related protein Rab-9A3003
histone acetyltransferase KAT2A isoform 16006
POU domain, class 2, transcription factor 10001
Spike glycoprotein4004
ATP-dependent phosphofructokinase8008
DNA polymerase kappa isoform 16006
Integrin beta-33104
Integrin beta-10101
Integrin alpha-V 0101
Integrin alpha-IIb3104
Integrin alpha-50101
Integrin beta-50101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE5005
Chain A, Beta-lactamase5005
interleukin 84004
glp-1 receptor, partial2002
pregnane X receptor4004
RAR-related orphan receptor gamma120012
Fumarate hydratase7007
NFKB1 protein, partial3003
PPM1D protein5005
TDP1 protein150015
GLI family zinc finger 3100010
AR protein130013
Smad31001
aldehyde dehydrogenase 1 family, member A19009
estrogen receptor 2 (ER beta)6006
nuclear receptor subfamily 1, group I, member 38008
progesterone receptor7007
cytochrome P450 family 3 subfamily A polypeptide 48008
glucocorticoid receptor [Homo sapiens]100010
retinoic acid nuclear receptor alpha variant 1110011
retinoid X nuclear receptor alpha8008
estrogen-related nuclear receptor alpha110011
farnesoid X nuclear receptor4004
pregnane X nuclear receptor100010
estrogen nuclear receptor alpha130013
polyprotein7007
67.9K protein6006
Parkin3003
peroxisome proliferator-activated receptor delta6006
peroxisome proliferator activated receptor gamma7007
vitamin D (1,25- dihydroxyvitamin D3) receptor5005
arylsulfatase A4004
IDH14004
aryl hydrocarbon receptor4004
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a5005
thyroid stimulating hormone receptor7007
activating transcription factor 67007
Bloom syndrome protein isoform 17007
peripheral myelin protein 22 isoform 14004
hemoglobin subunit beta2002
cellular tumor antigen p53 isoform a4004
thyroid hormone receptor beta isoform 28008
huntingtin isoform 22002
serine/threonine-protein kinase mTOR isoform 15005
nuclear factor erythroid 2-related factor 2 isoform 19009
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
urokinase plasminogen activator surface receptor precursor3003
peripheral myelin protein 224004
muscarinic acetylcholine receptor M13003
lamin isoform A-delta106006
Interferon beta110011
Cellular tumor antigen p539009
Adenosine receptor A30505
DNA (cytosine-5)-methyltransferase 10101
Adenosine receptor A2a0101
Adenosine receptor A10101
D(1A) dopamine receptor3003
Nuclear receptor ROR-gamma3115
Multidrug and toxin extrusion protein 10303
Histone-lysine N-methyltransferase EHMT20101
ATPase family AAA domain-containing protein 57007
Ataxin-27007
Microtubule-associated protein tau6006
bromodomain adjacent to zinc finger domain 2B3003
nuclear receptor subfamily 1, group I, member 23003
Nuclear hormone receptor family member daf-120011
nuclear factor erythroid 2-related factor 2 isoform 26006
oxysterols receptor LXR-beta isoform 10011
survival motor neuron protein isoform d5005
Voltage-dependent calcium channel gamma-2 subunit6006
Thymidine kinase, cytosolic0101
Glutamate receptor 26006
Thymidine phosphorylase0001
Thymidylate kinase0101
Thymidine kinase0001
Thymidylate kinase0101
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, 2-oxoglutarate Oxygenase5005
Chain A, Ferritin light chain3003
Chain A, Cruzipain4004
DNA topoisomerase 0101
15-lipoxygenase, partial3003
thyroid stimulating hormone receptor4004
regulator of G-protein signaling 45005
EWS/FLI fusion protein6006
glucocerebrosidase2002
putative alpha-glucosidase1001
alpha-galactosidase1001
lysosomal alpha-glucosidase preproprotein3003
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor0011
nuclear receptor ROR-gamma isoform 15005
cytochrome P450 3A4 isoform 14004
M-phase phosphoprotein 84004
muscleblind-like protein 1 isoform 12002
relaxin receptor 1 isoform 11001
Gamma-aminobutyric acid receptor subunit pi4004
Telomerase reverse transcriptase0101
Serine/threonine-protein kinase Chk10011
Histone deacetylase 30202
ATP-binding cassette sub-family C member 30909
Multidrug resistance-associated protein 40909
Type-2 restriction enzyme ScaI0101
Deoxyribonuclease-2-alpha0101
Bile salt export pump010010
Tyrosyl-DNA phosphodiesterase 20101
Deoxyribonuclease-10101
Type-2 restriction enzyme PstI0101
Type-2 restriction enzyme EcoRI0101
Prothrombin0002
DNA ligase0101
Heterogeneous nuclear ribonucleoprotein A10011
DNA topoisomerase 103313
DNA topoisomerase 2-alpha0319
Gamma-aminobutyric acid receptor subunit beta-14004
Gamma-aminobutyric acid receptor subunit delta4004
Gamma-aminobutyric acid receptor subunit gamma-24004
Gamma-aminobutyric acid receptor subunit alpha-54004
Gamma-aminobutyric acid receptor subunit alpha-34004
Gamma-aminobutyric acid receptor subunit gamma-14004
Gamma-aminobutyric acid receptor subunit alpha-24004
Type-2 restriction enzyme BamHI0101
Gamma-aminobutyric acid receptor subunit alpha-44004
Gamma-aminobutyric acid receptor subunit gamma-34004
Gamma-aminobutyric acid receptor subunit alpha-64004
Somatostatin receptor type 10202
Somatostatin receptor type 20202
Somatostatin receptor type 40202
Somatostatin receptor type 30202
Somatostatin receptor type 50202
5-hydroxytryptamine receptor 2B0808
Type-2 restriction enzyme HindIII0101
Histone deacetylase 40202
Ribonuclease pancreatic0101
Gamma-aminobutyric acid receptor subunit alpha-14004
Gamma-aminobutyric acid receptor subunit beta-34004
Gamma-aminobutyric acid receptor subunit beta-24004
Inositol monophosphatase 13003
DNA topoisomerase 2-beta02110
DNA topoisomerase 10203
Histone deacetylase 10202
DNA topoisomerase 10101
Integrase 0202
Histone deacetylase 70202
GABA theta subunit4004
Histone deacetylase 20202
Canalicular multispecific organic anion transporter 1010011
DNA topoisomerase type IB small subunit 0011
Polyamine deacetylase HDAC100202
Histone deacetylase 11 0202
Histone deacetylase 80202
Gamma-aminobutyric acid receptor subunit epsilon4004
Tyrosyl-DNA phosphodiesterase 10101
Histone deacetylase 60202
Histone deacetylase 90202
Histone deacetylase 50202
acetylcholinesterase4004
GALC protein3003
thyrotropin-releasing hormone receptor2002
v-jun sarcoma virus 17 oncogene homolog (avian)4004
Neuronal acetylcholine receptor subunit alpha-30101
Muscarinic acetylcholine receptor M20225
Muscarinic acetylcholine receptor M40427
Muscarinic acetylcholine receptor M10215
Muscarinic acetylcholine receptor M30214
Muscarinic acetylcholine receptor M40203
Muscarinic acetylcholine receptor M50203
Muscarinic acetylcholine receptor M50225
Neuronal acetylcholine receptor subunit alpha-40101
Muscarinic acetylcholine receptor M20203
Muscarinic acetylcholine receptor M10225
Neuronal acetylcholine receptor subunit alpha-20101
Neuronal acetylcholine receptor subunit beta-20101
Neuronal acetylcholine receptor subunit beta-30101
Neuronal acetylcholine receptor subunit beta-40101
Muscarinic acetylcholine receptor M10112
Muscarinic acetylcholine receptor M30225
Neuronal acetylcholine receptor subunit alpha-50101
Delta-type opioid receptor0001
Neuronal acetylcholine receptor subunit alpha-60101
Neuronal acetylcholine receptor subunit alpha-90101
Neuronal acetylcholine receptor subunit alpha-70101
Sigma non-opioid intracellular receptor 10011
Muscarinic acetylcholine receptor0202
Muscarinic acetylcholine receptor M30013
Muscarinic acetylcholine receptor M20003
Neuronal acetylcholine receptor subunit alpha-100101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE5005
Chain A, Putative fructose-1,6-bisphosphate aldolase4004
phosphopantetheinyl transferase3003
G6006
cytochrome P450 2D64004
vitamin D3 receptor isoform VDRA4004
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
HLA class I histocompatibility antigen, B alpha chain 6006
Inositol hexakisphosphate kinase 16006
cytochrome P450 2C9, partial6006
hypoxia-inducible factor 1 alpha subunit6006
Matrix metalloproteinase-90101
Isocitrate lyase0101
Epidermal growth factor receptor0101
Vascular endothelial growth factor receptor 20101
Alpha-synuclein1203
Lactoylglutathione lyase0101
Histone acetyltransferase p3000101
CREB-binding protein0101
USP1 protein, partial4004
D(1A) dopamine receptor1001
Alpha-1A adrenergic receptor0101
5-hydroxytryptamine receptor 40202
Interstitial collagenase0202
Beta-2 adrenergic receptor0202
Alpha-2A adrenergic receptor0101
Angiotensin-converting enzyme0202
Alpha-1B adrenergic receptor0505
Alpha-2B adrenergic receptor0303
Alpha-1A adrenergic receptor0202
Alpha-2C adrenergic receptor0303
Alpha-2B adrenergic receptor0101
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Alpha-1D adrenergic receptor0202
Alpha-1D adrenergic receptor0203
5-hydroxytryptamine receptor 2C0202
Sodium-dependent serotonin transporter0202
Alpha-1A adrenergic receptor0102
Alpha-1B adrenergic receptor0102
Alpha-1A adrenergic receptor0617
Sodium-dependent dopamine transporter 0202
Potassium voltage-gated channel subfamily H member 20202
Nuclear receptor subfamily 3 group C member 3 0202
Endothelin-1 receptor0101
SMAD family member 21001
SMAD family member 31001
caspase 7, apoptosis-related cysteine protease2002
caspase-32002
LMP1 [Human herpesvirus 4]0001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
Histone H2A.x2002
heat shock protein beta-13003
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
transactivating tegument protein VP16 [Human herpesvirus 1]0101
nuclear receptor coactivator 3 isoform a0101
Regulatory protein E20011
ATP-dependent translocase ABCB10202
ATP-dependent translocase ABCB10304
Cytochrome P450 3A40415
Cytochrome P450 2C9 0314
Polyunsaturated fatty acid lipoxygenase ALOX150101
DNA topoisomerase 20001
ATP-dependent translocase ABCB10202
UDP-glucuronosyltransferase 1A1 0001
Serum paraoxonase/arylesterase 10202
Glutamate receptor ionotropic, NMDA 1 0001
Caspase-30101
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0001
Glutamate receptor ionotropic, NMDA 2C0001
DNA topoisomerase 2-alpha 0001
Glutamate receptor ionotropic, NMDA 2D0001
Tubulin beta-2B chain0101
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
Glutamate receptor ionotropic, NMDA 3B0001
Solute carrier organic anion transporter family member 1B30202
Glutamate receptor ionotropic, NMDA 3A0001
Chain A, BCL-2-RELATED PROTEIN A10011
unnamed protein product0101
transcriptional regulator ERG isoform 31001
heat shock protein HSP 90-alpha isoform 20001
bcl-2-like protein 11 isoform 10011
Rap guanine nucleotide exchange factor 32002
Chymotrypsinogen A0101
Beta-lactamase0101
Steroid 17-alpha-hydroxylase/17,20 lyase0101
Heme oxygenase 1 0101
Lanosterol 14-alpha demethylase0112
Aromatase0101
Cytochrome P450 11B1, mitochondrial0101
Cytochrome P450 11B2, mitochondrial0101
Heme oxygenase 20101
Malate dehydrogenase, cytoplasmic0101
Cytochrome P450 1440011
Steroid C26-monooxygenase0011
Steroid C26-monooxygenase0011
Mycocyclosin synthase0011
Lanosterol 14-alpha demethylase0011
Lanosterol 14-alpha demethylase0011
TAR DNA-binding protein 431001
Lanosterol 14-alpha demethylase0112
Sterol 14-alpha demethylase0011
Sterol 14-alpha demethylase0112
14-alpha sterol demethylase 0011
heat shock protein 90, putative0001
likely tRNA 2'-phosphotransferase0101
Chain E, Fibrin beta chain0101
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
Chain A, RNA-directed RNA polymerase NS50101
Luciferase5005
WRN1001
Mcl-10101
MPI protein0101
Cyclin-dependent kinase 5, regulatory subunit 1 (p35)0001
alkaline phosphatase, intestinal0011
thioredoxin glutathione reductase3003
hypothetical protein, conserved1001
luciferase1001
pyruvate kinase1001
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase0101
CDK50001
serine-protein kinase ATM isoform a1001
major prion protein preproprotein Prp precursor0101
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein0011
glucose-6-phosphate 1-dehydrogenase isoform b0101
intestinal alkaline phosphatase precursor0011
DNA polymerase beta1001
mitogen-activated protein kinase 11001
flap endonuclease 13003
serine/threonine-protein kinase PLK12002
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
DNA polymerase eta isoform 12002
lethal(3)malignant brain tumor-like protein 1 isoform I1001
Vif0101
Tat0101
DNA dC->dU-editing enzyme APOBEC-3G isoform 10101
alkaline phosphatase, germ cell type preproprotein0011
endoribonuclease toxin MazF0011
DNA dC->dU-editing enzyme APOBEC-3F isoform a1001
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Pyruvate kinase PKM0101
Endothelin receptor type B1001
Endothelin-1 receptor1001
Histamine H2 receptor2002
phosphoglycerate kinase1001
hypothetical protein CAALFM_CR05890CA0001
H3 histone acetyltransferase0001
large T antigen0101
ClpP1001
Solute carrier family 22 member 80001
Chain A, Acetylcholinesterase0101
interferon gamma precursor0001
Solute carrier family 22 member 20202
Solute carrier family 22 member 1 0101
Solute carrier family 22 member 30101
Acetylcholinesterase0101
Acetylcholinesterase0202
Liver carboxylesterase 10001
Multidrug and toxin extrusion protein 20202
Caspase-72002
thyroid hormone receptor beta isoform a2002
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
potassium voltage-gated channel subfamily H member 2 isoform d2002
caspase-32002
Ornithine decarboxylase0002
Retinoic acid receptor alpha0224
Retinoic acid receptor gamma0224
Retinoic acid receptor beta0224
Cellular retinoic acid-binding protein 20022
Mitogen-activated protein kinase 10202
Retinoic acid receptor RXR-alpha0224
Retinoic acid receptor RXR-beta0224
Retinoic acid receptor RXR-gamma0224
Cellular retinoic acid-binding protein 10203
Cellular retinoic acid-binding protein 10022
Mitogen-activated protein kinase 140101
Rap guanine nucleotide exchange factor 41001
Olfactory receptor 51E20101
endonuclease IV1001
nonstructural protein 12002
histone deacetylase 9 isoform 31001
luciferase0001
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Glucocorticoid receptor0218
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glycine receptor subunit alpha-10202
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Androgen receptor0101
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Histamine H1 receptor0011
Prostaglandin G/H synthase 20101
Nociceptin receptor0011
Cytochrome P450 2J20101
Estrogen receptor beta0202
polyadenylate-binding protein 10101
Carbonic anhydrase 120101
Tyrosine-protein kinase ABL10101
Carbonic anhydrase 10101
Carbonic anhydrase 20101
Tyrosine-protein kinase ABL20101
Carbonic anhydrase 90101
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
Serine/threonine-protein kinase D30011
Protein kinase C gamma type0112
Protein kinase C beta type0112
Luciferin 4-monooxygenase0011
Protein kinase C alpha type0112
Beta-1 adrenergic receptor0101
Protein kinase C eta type0011
Protein kinase C iota type0011
Protein kinase C epsilon type0112
Protein kinase C theta type0011
Protein kinase C zeta type0011
Protein kinase C delta type0112
Serine/threonine-protein kinase D10011
Ras guanyl-releasing protein 30011
NPYLR7B0011
tyrosine-protein kinase Yes1001
Hypoxia-inducible factor 1-alpha0112
Endothelial PAS domain-containing protein 10011
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Chain A, Nuclear Receptor ROR-beta0101
Amyloid-beta precursor protein0101
Cytochrome P450 1A20011
Ornithine decarboxylase0001
60 kDa chaperonin0101
Retinoic acid receptor alpha0227
Cytochrome P450 2D60011
60 kDa heat shock protein, mitochondrial0101
Retinoic acid receptor beta0227
Retinoic acid receptor gamma 0227
5-hydroxytryptamine receptor 1A0101
Retinoic acid receptor RXR-alpha0224
Retinoic acid receptor RXR-beta0224
Indoleamine 2,3-dioxygenase 10101
Cytochrome P450 2C190011
Nuclear receptor ROR-alpha0101
Retinoic acid receptor RXR-gamma0224
10 kDa heat shock protein, mitochondrial0101
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10213
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Indoleamine 2,3-dioxygenase 20101
Nuclear receptor ROR-beta0101
atrial natriuretic peptide receptor 1 precursor1001
neuropeptide S receptor isoform A1001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]