Page last updated: 2024-12-08

tomentosin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

tomentosin: isolated from fresh Inula viscosa (Asteraceae) flowers; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
InulagenusA plant genus of the family ASTERACEAE. Members contain INULIN, alantol, helenin, alantic acid, and acrid resin.[MeSH]AsteraceaeA large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of daisy refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.[MeSH]

Cross-References

ID SourceID
PubMed CID155173
CHEMBL ID1164483
CHEBI ID9631
SCHEMBL ID12476412
MeSH IDM0424418

Synonyms (12)

Synonym
C09562
tomentosin
33649-15-9
CHEMBL1164483
chebi:9631 ,
2h-cyclohepta(b)furan-2-one, 3,3a,4,7,8,8a-hexahydro-7-methyl-3-methylene-6-(3-oxobutyl)-, (3ar,7s,8ar)-
SCHEMBL12476412
Q27108453
7-methyl-3-methylidene-6-(3-oxobutyl)-3,3a,4,7,8,8a-hexahydro-2h-cyclohepta[b]furan-2-one
DTXSID10955274
HY-N8284
CS-0142625

Research Excerpts

Overview

Tomentosin is a bioactive natural sesquiterpene lactone extracted by various plants with therapeutic properties, including anti‑neoplastic effects.

ExcerptReferenceRelevance
"Tomentosin is a bioactive natural sesquiterpene lactone extracted by various plants with therapeutic properties, including anti‑neoplastic effects."( Clarifying the molecular mechanism of tomentosin‑induced antiproliferative and proapoptotic effects in human multiple myeloma via gene expression profile and genetic interaction network analysis.
Bagella, L; Bordoni, V; De Miglio, MR; Fiorentino, FP; Fozza, C; Galleri, G; Marchesi, I; Migheli, R; Muroni, MR; Pintore, G; Podda, L; Sanna, L; Virdis, P, 2021
)
1.61
"Tomentosin is an active compound isolated from the I."( Tomentosin Reduces Behavior Deficits and Neuroinflammatory Response in MPTP-Induced Parkinson's Disease in Mice.
Alharbi, SA; Chinnathambi, A; Fan, Y; Hussain, S; Maghimaa, M; Mohan, SK; Rengarajan, T; Veeraraghavan, VP, 2021
)
2.79
"Tomentosin is a natural sesquiterpene lactone extracted from various plants and is widely used as a medicine because it exhibits essential therapeutic properties. "( Tomentosin Displays Anti-Carcinogenic Effect in Human Osteosarcoma MG-63 Cells via the Induction of Intracellular Reactive Oxygen Species.
Choi, YS; Lee, CM; Lee, J; Nam, MJ; Park, SH, 2019
)
3.4

Treatment

Tomentosin treatment decreased lung edema and reduced the levels of macrophages, lymphocytes, and neutrophils in the bronchoalveolar lavage fluid. Treatment with tomentosin (IC) prevented MPTP-stimulated impairments in motor function.

ExcerptReferenceRelevance
"Tomentosin treatment decreased lung edema and reduced the levels of macrophages, lymphocytes, and neutrophils in the bronchoalveolar lavage fluid."( Tomentosin Inhibits Lipopolysaccharide-Induced Acute Lung Injury and Inflammatory Response by Suppression of the NF-κB Pathway in a Mouse Model of Sepsis.
Fan, C; Sun, J; Wan, J; Wang, Y; Zhu, H, 2020
)
2.72
"Tomentosin treatment of the MPTP-intoxicated PD mice promoted appreciable regains in body weight and noticeably prevented MPTP-stimulated impairments in motor function."( Tomentosin Reduces Behavior Deficits and Neuroinflammatory Response in MPTP-Induced Parkinson's Disease in Mice.
Alharbi, SA; Chinnathambi, A; Fan, Y; Hussain, S; Maghimaa, M; Mohan, SK; Rengarajan, T; Veeraraghavan, VP, 2021
)
2.79
"Treatment with tomentosin (IC"( Tomentosin induces apoptotic pathway by blocking inflammatory mediators via modulation of cell proteins in AGS gastric cancer cell line.
Chang, W; Dong, X; Yang, H; Yang, Z; Zhao, H, 2020
)
2.34
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
sesquiterpene lactoneAny member of a diverse class of complex, multicyclic phytochemicals showing a variety of skeleton arrangements and bioactivities, and having in common a sesquiterpenoid structure including a lactone ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID487369Cytotoxicity against mouse RAW264.7 cells at concentration required inhibit NO synthesis by MTT assay2010Journal of natural products, Jun-25, Volume: 73, Issue:6
Sesquiterpenoids from Inula lineariifolia inhibit nitric oxide production.
AID1235873Cytostatic activity against human MCF7 cells incubated for 6 days by alamar blue reagent based resazurin metabolism assay2015Journal of natural products, Aug-28, Volume: 78, Issue:8
Guaianolides and a seco-Eudesmane from the Resinous Exudates of Cushion Bush (Leucophyta brownii) and Evaluation of Their Cytostatic and Anti-inflammatory Activity.
AID1235875Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced thromboxane B2 production incubated for 48 hrs by ELISA method2015Journal of natural products, Aug-28, Volume: 78, Issue:8
Guaianolides and a seco-Eudesmane from the Resinous Exudates of Cushion Bush (Leucophyta brownii) and Evaluation of Their Cytostatic and Anti-inflammatory Activity.
AID1235876Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced prostaglandin E2 production incubated for 48 hrs by ELISA method2015Journal of natural products, Aug-28, Volume: 78, Issue:8
Guaianolides and a seco-Eudesmane from the Resinous Exudates of Cushion Bush (Leucophyta brownii) and Evaluation of Their Cytostatic and Anti-inflammatory Activity.
AID1252949Antifungal activity against Candida albicans SC5314 assessed as inhibition of yeast cell to hyphae transition after 4 hrs by microscopic analysis2015Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22
Sesquiterpenes from Carpesium macrocephalum inhibit Candida albicans biofilm formation and dimorphism.
AID1712477Inhibition of LPS-induced NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based assay2016Journal of natural products, 06-24, Volume: 79, Issue:6
Sesquiterpenes from Inula japonica with Inhibitory Effects on Nitric Oxide Production in Murine Macrophage RAW 264.7 Cells.
AID625544Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins before LPS challenge measured 24 hrs after LPS challenge by Griess reaction method2011European journal of medicinal chemistry, Nov, Volume: 46, Issue:11
Sesquiterpene lactones from Inula falconeri, a plant endemic to the Himalayas, as potential anti-inflammatory agents.
AID625545Cytotoxicity against mouse RAW264.7 cells at antiinflammatory IC50 level by MTT assay2011European journal of medicinal chemistry, Nov, Volume: 46, Issue:11
Sesquiterpene lactones from Inula falconeri, a plant endemic to the Himalayas, as potential anti-inflammatory agents.
AID1252948Antifungal activity against Candida albicans SC5314 assessed as inhibition of biofilm formation by XTT assay2015Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22
Sesquiterpenes from Carpesium macrocephalum inhibit Candida albicans biofilm formation and dimorphism.
AID551550Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay2011Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1
Antiproliferative and apoptotic sesquiterpene lactones from Carpesium faberi.
AID1235874Cytostatic activity against human HT-29 cells incubated for 72 hrs by alamar blue reagent based resazurin metabolism assay2015Journal of natural products, Aug-28, Volume: 78, Issue:8
Guaianolides and a seco-Eudesmane from the Resinous Exudates of Cushion Bush (Leucophyta brownii) and Evaluation of Their Cytostatic and Anti-inflammatory Activity.
AID487368Inhibition of LPS-induced NO production in mouse RAW264.7 cells measured after 24 hrs2010Journal of natural products, Jun-25, Volume: 73, Issue:6
Sesquiterpenoids from Inula lineariifolia inhibit nitric oxide production.
AID1252947Antifungal activity against Candida albicans SC5314 by CLSI standard M27-A3 method2015Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22
Sesquiterpenes from Carpesium macrocephalum inhibit Candida albicans biofilm formation and dimorphism.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (23)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (8.70)29.6817
2010's11 (47.83)24.3611
2020's10 (43.48)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 22.62

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index22.62 (24.57)
Research Supply Index3.18 (2.92)
Research Growth Index5.22 (4.65)
Search Engine Demand Index21.17 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (22.62)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other23 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]