Page last updated: 2024-11-05

selenium disulfide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Selenium disulfide (SeS2) is a yellow solid compound with a pungent odor. It is used primarily as an antifungal and anti-dandruff agent in shampoos and topical medications. Its synthesis involves reacting elemental selenium with sulfur at high temperatures. Selenium disulfide works by inhibiting the growth of the Malassezia globosa fungus, which is a common cause of dandruff. It is studied for its potential to treat various skin conditions, including seborrheic dermatitis, psoriasis, and acne. While effective, it can cause skin irritation and sensitization in some individuals. '

Cross-References

ID SourceID
PubMed CID24087
CHEMBL ID1200680
CHEBI ID135934
MeSH IDM0085381

Synonyms (63)

Synonym
selenix
selen(iv) sulfid
einecs 231-303-8
zeran
un2657
seleen
sul-blue
sel-o-rinse
selenex
selukos
hsdb 6367
rcra waste no. u205
selsun blue
caswell no. 732a
selenium sulfide ses2
selenium sulfide (ses2)
epa pesticide chemical code 072003
selenium(iv) disulfide (1:2)
sebusan
lenium
exsel (tn)
D05815
7488-56-4
selenium sulfide (usp)
sulfur selenide
DB00971
selenium disulphide
selenium(iv) sulphide
selenium sulfide, micronized
selenium(iv) disulfide
selenium sulphide, micronized
selenium(iv) sulfide
selenium disulfide ,
selenium(iv) disulphide
CHEBI:135934
CHEMBL1200680
seledruff
selenium sulfide (ses(sub 2))
selenium sulphide (ses2)
selenii disulfidum
selendisulfid
tersi
selenium disulfide [un2657] [poison]
selenium sulfide [usp]
unii-z69d9e381q
z69d9e381q ,
DTXSID0042375
mfcd00011227
selenium sulfide [hsdb]
selenium sulfide [vandf]
selenium disulfide [hsdb]
selenium disulfide [ep monograph]
selenium sulfide [usp-rs]
selenium sulfide [usp monograph]
selenium sulfide [orange book]
selenium disulfide [mi]
selenium sulfide [mart.]
selenium disulfide [green book]
selenium sulfide [inci]
selenium disulfide [who-ip]
selenium sulfide [who-dd]
selenii disulfidum [who-ip latin]
Q56249646

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" The small but statistically significant increases in MN observed in the in vivo study are considered likely not to be biologically significant since no dose-response was observed and all the values obtained were within historical control range in our laboratory."( Genotoxicity evaluation of selenium sulfide in in vivo and in vivo/in vitro micronucleus and chromosome aberration assays.
Krishna, G; Moore, FR; Theiss, JC; Urda, GA, 1996
)
0.29
" Forty children aged 1-11 years with clinically diagnosed tinea capitis were randomized to receive selenium sulfide shampoo 1% or ciclopirox shampoo 1% twice a week as adjuncts to an 8-week course of ultramicronized griseofulvin dosed at 10-12 mg/kg/day."( A randomized, double-blind study comparing the efficacy of selenium sulfide shampoo 1% and ciclopirox shampoo 1% as adjunctive treatments for tinea capitis in children.
Barnes-Eley, ML; Chen, C; Dempsey, KK; Dice, JE; Hubbard, TW; Koch, LH; Moskowitz, AB; Williams, JV,
)
0.13
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
sulfide saltA salt in which the anionic species is sulfide (S(2-)).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (105)

TimeframeStudies, This Drug (%)All Drugs %
pre-199053 (50.48)18.7374
1990's15 (14.29)18.2507
2000's13 (12.38)29.6817
2010's16 (15.24)24.3611
2020's8 (7.62)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 28.62

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index28.62 (24.57)
Research Supply Index4.88 (2.92)
Research Growth Index4.57 (4.65)
Search Engine Demand Index69.38 (26.88)
Search Engine Supply Index3.98 (0.95)

This Compound (28.62)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials17 (15.04%)5.53%
Reviews10 (8.85%)6.00%
Case Studies21 (18.58%)4.05%
Observational1 (0.88%)0.25%
Other64 (56.64%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of the Antidandruff Effect of a Shampoo on Subjects With Dandruff and Slight Itching. Single-blind, Monocentric Study Realized Under Dermatological Control [NCT05503706]40 participants (Anticipated)Interventional2022-09-30Not yet recruiting
A Randomized, Double-Blinded, Placebo-Controlled Study Observing the Efficacy of Selenium Sulfide 1% Shampoo, Ketoconazole 2% Shampoo, and Ciclopirox 1% Shampoo as Adjunctive Treatments for Tinea Capitis in Children [NCT00127868]47 participants (Actual)Interventional2005-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]