fluconazole and heme

fluconazole has been researched along with heme in 8 studies

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (37.50)18.2507
2000's4 (50.00)29.6817
2010's1 (12.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Aoki, Y; Arisawa, M; Kondoh, M; Nakamura, Y; Nakayama, N; Yoshihara, F1
Einsele, H; Kelly, DE; Kelly, SL; Lamb, DC; Loeffler, J1
Kelly, DE; Kelly, SL; Lamb, DC1
Aoyama, Y; Chung, SK; Kudo, M; Nitahara, Y; Ohi, M; Yoshida, Y1
Leys, D; McLean, KJ; Munro, AW; Roujeinikova, A; Seward, HE1
Hutzler, JM; Locuson, CW; Tracy, TS1
Balding, PR; de Visser, SP; Maréchal, JD; McLean, KJ; Munro, AW; Porro, CS; Sutcliffe, MJ1
Bakkeren, E; Cadieux, B; Caza, M; Do, E; Hu, G; Jung, WH; Kronstad, JW1

Other Studies

8 other study(ies) available for fluconazole and heme

ArticleYear
Ro 09-1470 is a selective inhibitor of P-450 lanosterol C-14 demethylase of fungi.
    Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:12

    Topics: Animals; Antifungal Agents; Carbon Monoxide; Cholesterol; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Fluconazole; Fungal Proteins; Glycine; Heme; Ketoconazole; Liver; Male; Microsomes, Liver; Oxidoreductases; Pyrans; Rats; Rats, Sprague-Dawley; Saccharomyces cerevisiae; Sensitivity and Specificity; Sterol 14-Demethylase

1993
The G464S amino acid substitution in Candida albicans sterol 14alpha-demethylase causes fluconazole resistance in the clinic through reduced affinity.
    Biochemical and biophysical research communications, 1999, Aug-19, Volume: 262, Issue:1

    Topics: Amino Acid Sequence; Amino Acid Substitution; Antifungal Agents; Candida albicans; Carbon Monoxide; Catalysis; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Resistance, Microbial; Ergosterol; Fluconazole; Heme; Inhibitory Concentration 50; Kinetics; Mutagenesis, Site-Directed; Oxidation-Reduction; Oxidoreductases; Protein Binding; Saccharomyces cerevisiae; Spectrum Analysis; Sterol 14-Demethylase

1999
Y132H substitution in Candida albicans sterol 14alpha-demethylase confers fluconazole resistance by preventing binding to haem.
    FEMS microbiology letters, 1999, Nov-15, Volume: 180, Issue:2

    Topics: Amino Acid Substitution; Antifungal Agents; Candida albicans; Cytochrome P-450 Enzyme System; Drug Resistance, Microbial; Fluconazole; Heme; Humans; Mutagenesis, Site-Directed; Oxidoreductases; Recombinant Proteins; Saccharomyces cerevisiae; Spectrophotometry; Sterol 14-Demethylase

1999
Effects of Y132H and F145L substitutions on the activity, azole resistance and spectral properties of Candida albicans sterol 14-demethylase P450 (CYP51): a live example showing the selection of altered P450 through interaction with environmental compound
    Journal of biochemistry, 2005, Volume: 137, Issue:5

    Topics: Amino Acid Sequence; Amino Acid Substitution; Antifungal Agents; Azoles; Candida albicans; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dithionite; Drug Resistance, Microbial; Escherichia coli; Fluconazole; Fungal Proteins; Heme; Oxidoreductases; Spectrum Analysis; Sterol 14-Demethylase

2005
Crystal structure of the Mycobacterium tuberculosis P450 CYP121-fluconazole complex reveals new azole drug-P450 binding mode.
    The Journal of biological chemistry, 2006, Dec-22, Volume: 281, Issue:51

    Topics: Antifungal Agents; Azoles; Binding Sites; Circular Dichroism; Cytochrome P-450 Enzyme System; Fluconazole; Heme; Ligands; Models, Molecular; Mycobacterium tuberculosis; Protein Binding; Protein Conformation; Spectrophotometry; Thermodynamics; X-Ray Diffraction

2006
Visible spectra of type II cytochrome P450-drug complexes: evidence that "incomplete" heme coordination is common.
    Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:4

    Topics: Aniline Compounds; Aryl Hydrocarbon Hydroxylases; Benzodioxoles; Binding Sites; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Fluconazole; Heme; Humans; Imidazoles; Itraconazole; Kinetics; Ligands; Light; Models, Chemical; Molecular Structure; NADP; Nonlinear Dynamics; Protein Binding; Pyrimidines; Recombinant Proteins; Reference Standards; Regression Analysis; Spectrum Analysis; Sulfaphenazole; Triazoles

2007
How do azoles inhibit cytochrome P450 enzymes? A density functional study.
    The journal of physical chemistry. A, 2008, Dec-18, Volume: 112, Issue:50

    Topics: Azoles; Binding Sites; Camphor; Catalytic Domain; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Fluconazole; Heme; Humans; Kinetics; Liver; Metyrapone; Models, Molecular; Protein Conformation; Water

2008
The endosomal sorting complex required for transport machinery influences haem uptake and capsule elaboration in Cryptococcus neoformans.
    Molecular microbiology, 2015, Volume: 96, Issue:5

    Topics: Animals; Antifungal Agents; Cryptococcosis; Cryptococcus neoformans; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Endosomal Sorting Complexes Required for Transport; Fluconazole; Fungal Capsules; Heme; Macrophages; Mice; Mutation; Phenotype; Proteolysis

2015