| Assay ID | Title | Year | Journal | Article |
|---|
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3
| High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | | | |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | | | |
| AID1795561 | Kinase Inhibition Assay from Article 10.1021/jm9804681: \\Structure-activity relationships for 1-phenylbenzimidazoles as selective ATP site inhibitors of the platelet-derived growth factor receptor.\\ | 1998 | Journal of medicinal chemistry, Dec-31, Volume: 41, Issue:27
| Structure-activity relationships for 1-phenylbenzimidazoles as selective ATP site inhibitors of the platelet-derived growth factor receptor. |
| AID755672 | Antibacterial activity against Staphylococcus aureus after 24 hrs by agar dilution method | 2013 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 23, Issue:13
| Synthesis, antioxidant, and antimicrobial evaluation of some 2-arylbenzimidazole derivatives. |
| AID50436 | Compound tested for contractility in isolated cat papillary muscle at 10 e-5 M. | 1985 | Journal of medicinal chemistry, Jun, Volume: 28, Issue:6
| Structure-activity relationships of arylimidazopyridine cardiotonics: discovery and inotropic activity of 2-[2-methoxy-4-(methylsulfinyl)phenyl]-1H-imidazo[4,5-c]pyridine. |
| AID50434 | Compound tested for contractility in isolated cat papillary muscle at 10 e-4 M. | 1985 | Journal of medicinal chemistry, Jun, Volume: 28, Issue:6
| Structure-activity relationships of arylimidazopyridine cardiotonics: discovery and inotropic activity of 2-[2-methoxy-4-(methylsulfinyl)phenyl]-1H-imidazo[4,5-c]pyridine. |
| AID670504 | Growth inhibition of Chlamydia pneumoniae at 10 uM | 2012 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 22, Issue:14
| Conformation study of 2-arylbenzimidazoles as inhibitors of Chlamydia pneumoniae growth. |
| AID1130737 | Anthelmintic activity against Hymenolepis nana infected in CF1 mouse assessed as clearance of worm burden assessed as clearance of worm burden at 0.2% dosed through diet for 4 days dosed 16 days post infection by press-plate technique | 1979 | Journal of medicinal chemistry, Sep, Volume: 22, Issue:9
| Antiparasitic agents. 3. Synthesis and anthelmintic activities of novel 2-pyridinyl-5-isothiocyanatobenzimidazoles. |
| AID352317 | Antimicrobial activity against Staphylococcus aureus at 37 degC after 24 hrs by tube dilution method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3
| Synthesis and QSAR evaluation of 2-(substituted phenyl)-1H-benzimidazoles and [2-(substituted phenyl)-benzimidazol-1-yl]-pyridin-3-yl-methanones. |
| AID352318 | Antimicrobial activity against Bacillus subtilis at 37 degC after 24 hrs by tube dilution method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3
| Synthesis and QSAR evaluation of 2-(substituted phenyl)-1H-benzimidazoles and [2-(substituted phenyl)-benzimidazol-1-yl]-pyridin-3-yl-methanones. |
| AID1372212 | Induction of QR1 activity in mouse Hepa-1c1c7 cells assessed as induction ratio at 50 uM after 48 hrs by MTT assay relative to control | 2017 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 27, Issue:24
| Structure-activity relationships and docking studies of synthetic 2-arylindole derivatives determined with aromatase and quinone reductase 1. |
| AID755670 | Antibacterial activity against Bacillus cereus after 24 hrs by agar dilution method | 2013 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 23, Issue:13
| Synthesis, antioxidant, and antimicrobial evaluation of some 2-arylbenzimidazole derivatives. |
| AID755671 | Antibacterial activity against Staphylococcus albus after 24 hrs by agar dilution method | 2013 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 23, Issue:13
| Synthesis, antioxidant, and antimicrobial evaluation of some 2-arylbenzimidazole derivatives. |
| AID755683 | Antioxidant activity assessed as superoxide radical anion scavenging activity by spectrophotometric analysis | 2013 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 23, Issue:13
| Synthesis, antioxidant, and antimicrobial evaluation of some 2-arylbenzimidazole derivatives. |
| AID38394 | Inhibitory potency to aminopyrine N-demethylase activity (P450) in hepatic microsomes from phenobarbitone-induced rats. | 1982 | Journal of medicinal chemistry, Aug, Volume: 25, Issue:8
| Inhibition of rat hepatic microsomal aminopyrine N-demethylase activity by benzimidazole derivatives. Quantitative structure-activity relationships. |
| AID1359153 | Cytotoxicity against human HeLa cells assessed as reduction in cell viability at 50 uM after 48 hrs by MTT assay relative to control | 2018 | European journal of medicinal chemistry, May-25, Volume: 152 | Synthesis, anionophoric activity and apoptosis-inducing bioactivity of benzimidazolyl-based transmembrane anion transporters. |
| AID1359155 | Cytotoxicity against human MCF7 cells assessed as reduction in cell viability at 50 uM after 48 hrs by MTT assay relative to control | 2018 | European journal of medicinal chemistry, May-25, Volume: 152 | Synthesis, anionophoric activity and apoptosis-inducing bioactivity of benzimidazolyl-based transmembrane anion transporters. |
| AID1130739 | Anthelmintic activity against Hymenolepis nana infected in sheep assessed as reduction of fecal egg count at 50 mg/kg, po measured up to 7 days relative to control | 1979 | Journal of medicinal chemistry, Sep, Volume: 22, Issue:9
| Antiparasitic agents. 3. Synthesis and anthelmintic activities of novel 2-pyridinyl-5-isothiocyanatobenzimidazoles. |
| AID755682 | Antioxidant activity assessed as hydroxyl radical scavenging activity after 1 hr by spectrophotometric analysis | 2013 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 23, Issue:13
| Synthesis, antioxidant, and antimicrobial evaluation of some 2-arylbenzimidazole derivatives. |
| AID352322 | Octanol-water partition coefficient, log P of the compound | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3
| Synthesis and QSAR evaluation of 2-(substituted phenyl)-1H-benzimidazoles and [2-(substituted phenyl)-benzimidazol-1-yl]-pyridin-3-yl-methanones. |
| AID24235 | Partition coefficient (logP) | 1982 | Journal of medicinal chemistry, Aug, Volume: 25, Issue:8
| Inhibition of rat hepatic microsomal aminopyrine N-demethylase activity by benzimidazole derivatives. Quantitative structure-activity relationships. |
| AID49060 | Response ratio = (percent increase to drug)/(percent increase to 10 E-5 M isoproterenol) | 1985 | Journal of medicinal chemistry, Jun, Volume: 28, Issue:6
| Structure-activity relationships of arylimidazopyridine cardiotonics: discovery and inotropic activity of 2-[2-methoxy-4-(methylsulfinyl)phenyl]-1H-imidazo[4,5-c]pyridine. |
| AID161099 | Inhibition of phosphorylation of a random glutamate/tyrosine copolymer in lysates of transfected Sf9 insect cells overexpressing mouse platelet-derived growth factor receptor beta | 1998 | Journal of medicinal chemistry, Dec-31, Volume: 41, Issue:27
| Structure-activity relationships for 1-phenylbenzimidazoles as selective ATP site inhibitors of the platelet-derived growth factor receptor. |
| AID1130735 | Nematocidal activity against Nematospiroides dubius infected in CF1 mouse assessed as clearance of worm burden at 0.2% dosed through diet for 4 days dosed 16 days post infection by press-plate technique | 1979 | Journal of medicinal chemistry, Sep, Volume: 22, Issue:9
| Antiparasitic agents. 3. Synthesis and anthelmintic activities of novel 2-pyridinyl-5-isothiocyanatobenzimidazoles. |
| AID352320 | Antifungal activity against Candida albicans at 37 degC after 48 hrs by tube dilution method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3
| Synthesis and QSAR evaluation of 2-(substituted phenyl)-1H-benzimidazoles and [2-(substituted phenyl)-benzimidazol-1-yl]-pyridin-3-yl-methanones. |
| AID73439 | Inhibition of phosphorylation of a random glutamate/tyrosine copolymer in lysates of transfected Sf9 insect cells overexpressing human fibroblast growth factor receptor 1 | 1998 | Journal of medicinal chemistry, Dec-31, Volume: 41, Issue:27
| Structure-activity relationships for 1-phenylbenzimidazoles as selective ATP site inhibitors of the platelet-derived growth factor receptor. |
| AID1359156 | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability at 50 uM after 48 hrs by MTT assay relative to control | 2018 | European journal of medicinal chemistry, May-25, Volume: 152 | Synthesis, anionophoric activity and apoptosis-inducing bioactivity of benzimidazolyl-based transmembrane anion transporters. |
| AID755674 | Antibacterial activity against Escherichia coli after 24 hrs by agar dilution method | 2013 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 23, Issue:13
| Synthesis, antioxidant, and antimicrobial evaluation of some 2-arylbenzimidazole derivatives. |
| AID1282094 | Inhibition of LPS induced NF-kappa-B transcriptional activity in mouse RAW264.7 cells after 20 hrs by SEAP reporter assay | 2016 | Bioorganic & medicinal chemistry, Apr-15, Volume: 24, Issue:8
| Exploration of 2-benzylbenzimidazole scaffold as novel inhibitor of NF-κB. |
| AID352319 | Antimicrobial activity against Escherichia coli at 37 degC after 24 hrs by tube dilution method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3
| Synthesis and QSAR evaluation of 2-(substituted phenyl)-1H-benzimidazoles and [2-(substituted phenyl)-benzimidazol-1-yl]-pyridin-3-yl-methanones. |
| AID1282093 | Inhibition of LPS induced NF-kappa-B transcriptional activity in mouse RAW264.7 cells at 30 uM after 20 hrs by SEAP reporter assay | 2016 | Bioorganic & medicinal chemistry, Apr-15, Volume: 24, Issue:8
| Exploration of 2-benzylbenzimidazole scaffold as novel inhibitor of NF-κB. |
| AID59489 | Compound tested for contractility in anesthetized dog when administered intravenously; NT=Not tested | 1985 | Journal of medicinal chemistry, Jun, Volume: 28, Issue:6
| Structure-activity relationships of arylimidazopyridine cardiotonics: discovery and inotropic activity of 2-[2-methoxy-4-(methylsulfinyl)phenyl]-1H-imidazo[4,5-c]pyridine. |
| AID49059 | Response ratio = (percent increase to drug)/(percent increase to 10 E-4 M isoproterenol) | 1985 | Journal of medicinal chemistry, Jun, Volume: 28, Issue:6
| Structure-activity relationships of arylimidazopyridine cardiotonics: discovery and inotropic activity of 2-[2-methoxy-4-(methylsulfinyl)phenyl]-1H-imidazo[4,5-c]pyridine. |
| AID1359154 | Cytotoxicity against human A549 cells assessed as reduction in cell viability at 50 uM after 48 hrs by MTT assay relative to control | 2018 | European journal of medicinal chemistry, May-25, Volume: 152 | Synthesis, anionophoric activity and apoptosis-inducing bioactivity of benzimidazolyl-based transmembrane anion transporters. |
| AID755673 | Antibacterial activity against Pseudomonas aeruginosa after 24 hrs by agar dilution method | 2013 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 23, Issue:13
| Synthesis, antioxidant, and antimicrobial evaluation of some 2-arylbenzimidazole derivatives. |
| AID1372210 | Inhibition of CYP19A1 (unknown origin) at 50 uM preincubated with NADPH followed by DBF substrate addition after 30 mins by fluorescence based assay relative to control | 2017 | Bioorganic & medicinal chemistry letters, 12-15, Volume: 27, Issue:24
| Structure-activity relationships and docking studies of synthetic 2-arylindole derivatives determined with aromatase and quinone reductase 1. |
| AID755681 | Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by spectrophotometric analysis | 2013 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 23, Issue:13
| Synthesis, antioxidant, and antimicrobial evaluation of some 2-arylbenzimidazole derivatives. |
| AID352321 | Antifungal activity against Aspergillus niger at 25 degC after 7 days by tube dilution method | 2009 | European journal of medicinal chemistry, Mar, Volume: 44, Issue:3
| Synthesis and QSAR evaluation of 2-(substituted phenyl)-1H-benzimidazoles and [2-(substituted phenyl)-benzimidazol-1-yl]-pyridin-3-yl-methanones. |
| AID755669 | Cytotoxicity against mouse NIH/3T3 cells after 48 hrs by SRB assay | 2013 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 23, Issue:13
| Synthesis, antioxidant, and antimicrobial evaluation of some 2-arylbenzimidazole derivatives. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |