AIDS, Murine

Acquired defect of cellular immunity that occurs in mice infected with mouse leukemia viruses (MuLV). The syndrome shows striking similarities with human AIDS and is characterized by lymphadenopathy, profound immunosuppression, enhanced susceptibility to opportunistic infections, and B-cell lymphomas.

Synonym
AIDS, Murine
Murine Acquired Immune Deficiency Syndrome
MAIDS
Murine Acquired Immuno-Deficiency Syndrome
Murine Acquired Immunodeficiency Syndrome
Murine AIDS

Excerpt	Reference
"Murine AIDS (MAIDS) is a disease that shows many similarities with human AIDS."	( Jolicoeur, P, 1991)
"Murine acquired immunodeficiency syndrome is induced by a defective retrovirus."	( Huang, M; Jolicoeur, P, 1990)
"MAIDS is a retrovirus-induced immunodeficiency syndrome in mice that has similarities to human AIDS."	( Hodes, RJ; June, CH; Morse, HC; Selvey, LA, 1995)
"Murine AIDS (MAIDS) is a disease that shows many similarities to human HIV infection."	( Cibull, ML; Gallicchio, VS; Hughes, NK; Tse, KF, 1993)
"MAIDS (murine AIDS) is caused by infection with the murine leukaemia retrovirus RadLV-Rs and is characterized by a severe immunodeficiency and T-cell anergy combined with a lymphoproliferative disease affecting both B- and T-cells."	( Aandahl, EM; Boniver, J; Giannini, S; Greimers, R; Moutschen, M; Nayjib, B; Rahmouni, S; Tasken, K; Verlaet, M; Zeddou, M, 2004)
"Immune pathology in MAIDs is similar to SIV and HIV-1 infection."	( Bellinger, DL; Lorton, D, 2022)

Excerpt	Reference
"Mice with MAIDS have been used to examine the efficacy of antiretroviral therapies for possible use in AIDS patients."	( Black, PL; Conover, J; Klinman, DM; Krieg, A; Ussery, MA, 1992)

Excerpt	Reference
"These results indicate that MAIDS can be used as a model for evaluating antivirals in an immunocompromised host, and suggest that both PMEA and HPMPC may be useful in the treatment of opportunistic CMV and HSV-1 infections."	( De Castro, LM; De Clercq, E; Gangemi, JD; Ghaffar, A; Kern, ER; Mayer, EP; Vogt, PE, 1991)
"This MAIDS retrovirus model was used to evaluate 3'azido-2,3'dideoxythymidine (AZT), using different doses, methods of administration and timing for initiation and continuation of therapy."	( Bilello, JA; Eiseman, JL; Fredrickson, TN; MacAuley, C; Shapiro, SG; Yetter, RA, 1991)
"SCF, administered to AZT-treated MAIDS mice, did not further enhance these increases."	( Chow, FP; Hamburger, AW; Zsebo, K, 1993)
"SCF administered to AZT-treated MAIDS mice did not further enhance these increases."	( Chow, FP; Hamburger, AW; Zsebo, K, 1993)
"In this study we treated groups of MAIDS-infected mice with combinations of pentoxifylline, an agent which increases cAMP and inhibits phosphodiesterases, and sodium meclofenamic acid, a PgE2 inhibitor."	( Ambrus, JL; Butsch, J; Chadha, KC; Mathur, N; Munschauer, F; Nakeeb, S; Satchidanand, SK; Stadler, I; Toumbis, C; Vladutiu, A, 1994)
"Thus, the bone marrow in murine AIDS may prove useful as a model for therapy of retroviral infections and for treating blood cytopenias."	( Brandi, G; Carnevali, A; Fraternale, A; Magnani, M; Rossi, L; Schiavano, GF, 1995)
"AZT-treated normal and MAIDS mice showed a significant decrease in hematocrit (64 and 78."	( Abraham, NG; Abu-Hijleh, MF; Lutton, JD; Moqattash, S; Rosenthal, G, 1997)
"neoformans in the brains and lungs of MAIDS mice, the pathogen grew in the brains of MAIDS mice treated with fluconazole."	( Furukawa, K; Pollard, RB; Sasaki, H; Suzuki, F, 2000)
"When MAIDS mice treated with Z-100 were compared with those of control mice, a decrease in splenomegaly and lymphadenopathy was observed."	( Kobayashi, M; Pollard, RB; Sasaki, H; Suzuki, F, 2001)
"Whereas 80% of untreated MAIDS mice were susceptible to MCMV retinitis, none (0%) of IL-2-treated MAIDS mice developed necrotizing retinitis."	( Cousins, SW; Dix, RD; Podack, ER, 2003)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	132 (74.58)	12.5806
2000's	30 (16.95)	18.1394
2010's	11 (6.21)	28.8240
2020's	4 (2.26)	9.53

Drug	Relationship Strength	Studies	Trials
dinitrochlorobenzene	low	1	0
adenine	low	3	0
cytosine	low	1	0
glycine	low	1	0
melatonin	low	1	0
nitrites	low	1	0
quinolinic acid	low	2	0
desipramine	low	1	0
amphetamine	low	1	0
3,4-dihydroxybenzohydroxamic acid	low	5	0
dipyridamole	low	1	0
fluconazole	low	1	0
fluorouracil	low	1	0
foscarnet	low	1	0
hydroxyurea	low	5	0
meclofenamic acid	low	1	0
oxidopamine	low	1	0
pentoxifylline	low	2	0
sulforaphane	low	2	0
corticosterone	low	1	0
floxuridine	low	1	0
dehydroepiandrosterone	low	2	0
bromodeoxyuridine	low	1	0
tyrosine	low	2	0
cysteamine	low	2	0
dimethylnitrosamine	low	2	0
phencyclidine	low	1	0
ditiocarb	medium	2	1
cyclopentane	low	1	0
azacitidine	low	1	0
myristic acid	low	1	0
acetylcysteine	low	3	0
dehydroepiandrosterone sulfate	low	3	0
nitrosobenzylmethylamine	low	2	0
deoxycytidine	low	2	0
glycyrrhizic acid	low	2	0
d-alpha tocopherol	low	18	0
dronabinol	low	1	0
phenethyl isothiocyanate	low	2	0
vidarabine	low	3	0
silver	low	1	0
zalcitabine	low	3	0
aluminum sulfate	low	1	0
clodronic acid	low	1	0
tetradecanoylphorbol acetate	low	5	0
fludarabine phosphate	low	1	0
phosphotyrosine	low	1	0
bromocriptine	low	1	0
glutamic acid	low	1	0
vidarabine phosphate	low	1	0
zidovudine	low	40	0
ribavirin	low	3	0
sq-11725	low	1	0
ng-nitroarginine methyl ester	low	1	0
enkephalin, methionine	low	1	0
eticlopride	low	1	0
adefovir	low	2	0
cidofovir anhydrous	low	1	0
gemcitabine	low	2	0
2',3'-dideoxythymidine triphosphate	low	1	0
8-((4-chlorophenyl)thio)cyclic-3',5'-amp	low	1	0
s-acetylglutathione	low	1	0
1-hexadecyl-2-acetyl-glycero-3-phosphocholine	low	2	0
2',3'-dideoxycytidine 5'-triphosphate	low	5	0
peroxynitrous acid	low	1	0
glycerophosphoinositol 4,5-bisphosphate	low	1	0
organophosphonates	low	3	0
3-nitrotyrosine	low	1	0
inositol 1,4,5-trisphosphate	low	1	0
abacavir	low	1	0
arachidonic acid	low	1	0
retinol	low	3	0
tacrolimus	low	1	0
cocaine	low	10	0
thapsigargin	low	1	0
decitabine	low	1	0
tenofovir	low	2	0
isomethyleugenol	low	1	0
cocaethylene	low	1	0
fludarabine	low	3	0
curcumin	low	1	0
latoconazole	low	1	0
lithium	low	2	0
ovalbumin	low	1	0
dinoprostone	low	3	0
calcitriol	low	1	0
leukotriene b4	low	1	0
canthaxanthin	low	1	0
brefeldin a	low	1	0
morphine	low	6	0
cytochalasin b	low	1	0
cysteine	low	1	0
selenium	low	3	0
dizocilpine maleate	low	2	0
lactacystin	low	1	0
sq-23377	low	3	0
losartan potassium	low	4	0
calcimycin	low	1	0
acid phosphatase	low	1	0
4,4-difluoro-4-bora-3a,4a-diaza-s-indacene	low	1	0
mannans	low	1	0
heme	low	1	0
transforming growth factor beta	low	3	0
sybr green i	low	1	0
thymic factor, circulating	low	1	0
cyclosporine	low	2	0
cytochalasin d	low	1	0
lactoferrin	low	1	0
orabase	low	1	0
folic acid	low	1	0
didanosine	low	7	0
ganciclovir	low	1	0
3,4,5-trihydroxybenzamidoxime	low	5	0
4-imino-1,3-diazabicyclo(3.1.0)hexan-2-one	low	1	0
eye	low	5	0
concanavalin a	low	9	0

Protein Targets (991)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	19	0	0	19
Chain A, Cruzipain	8	0	0	8
regulator of G-protein signaling 4	12	0	0	12
Platelet-activating factor receptor	0	2	0	2
Inositol monophosphatase 1	4	0	0	4
Reverse transcriptase/RNaseH	0	6	8	20
DNA polymerase beta	0	2	0	2
DNA polymerase beta	0	1	0	1
DNA polymerase lambda	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	6	0	0	6
Chain A, JmjC domain-containing histone demethylation protein 3A	6	0	0	6
phosphopantetheinyl transferase	11	0	0	11
bromodomain adjacent to zinc finger domain 2B	6	0	0	6
euchromatic histone-lysine N-methyltransferase 2	29	0	0	29
pyruvate kinase PKM isoform a	3	0	0	3
geminin	32	0	0	32
Glycoprotein hormones alpha chain	1	0	0	1
Guanine nucleotide-binding protein G	4	0	0	4
Tubulin--tyrosine ligase	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	4	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	4	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	4	0	4
Luciferase	6	0	0	6
cytochrome P450 family 3 subfamily A polypeptide 4	12	0	0	12
cytochrome P450 2D6	6	0	0	6
peripheral myelin protein 22	18	0	0	18
Albumin	0	0	5	5
ATP-dependent translocase ABCB1	0	5	0	5
Replicase polyprotein 1ab	0	4	3	7
Replicase polyprotein 1ab	0	4	3	7
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	4	0	4
Chain A, 2-oxoglutarate Oxygenase	8	0	0	8
Chain A, ATP-DEPENDENT DNA HELICASE Q1	5	0	0	5
acetylcholinesterase	8	0	0	8
dopamine D1 receptor	3	0	0	3
15-lipoxygenase, partial	6	0	0	6
pregnane X receptor	7	0	0	7
RAR-related orphan receptor gamma	18	0	0	18
USP1 protein, partial	16	0	0	16
NFKB1 protein, partial	9	0	0	9
Microtubule-associated protein tau	14	0	0	14
Thrombopoietin	7	0	0	7
AR protein	30	0	0	30
glucocorticoid receptor [Homo sapiens]	23	0	0	23
retinoic acid nuclear receptor alpha variant 1	22	0	0	22
retinoid X nuclear receptor alpha	18	0	0	18
farnesoid X nuclear receptor	16	0	0	16
estrogen nuclear receptor alpha	35	0	0	35
vitamin D (1,25- dihydroxyvitamin D3) receptor	13	0	0	13
arylsulfatase A	13	0	0	13
Bloom syndrome protein isoform 1	11	0	0	11
D(1A) dopamine receptor	7	0	0	7
thyroid hormone receptor beta isoform a	9	0	0	9
thyroid hormone receptor beta isoform 2	27	0	0	27
heat shock protein beta-1	11	0	0	11
flap endonuclease 1	8	0	0	8
survival motor neuron protein isoform d	11	0	0	11
muscarinic acetylcholine receptor M1	9	0	0	9
Histone deacetylase 3	0	3	0	3
Solute carrier family 22 member 6	0	1	0	4
Histone deacetylase 4	0	3	0	3
Histone deacetylase 1	0	4	0	4
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	4	0	4
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	3	0	3
Ataxin-2	18	0	0	18
Histone deacetylase 8	0	4	0	4
Histone deacetylase 6	0	3	0	3
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	3	0	3
ATP-dependent phosphofructokinase	10	0	0	10
potassium voltage-gated channel subfamily H member 2 isoform d	9	0	0	9
Phosphoribosyl pyrophosphate synthase-associated protein 2	0	1	0	2
Adenylate kinase isoenzyme 1	0	0	0	2
Adenylate kinase 2, mitochondrial	0	0	0	2
Adenosine deaminase	0	1	0	4
Capsid protein	0	0	2	2
Solute carrier family 22 member 6	0	2	0	8
Solute carrier family 22 member 8	0	0	0	4
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
TDP1 protein	32	0	0	32
nuclear receptor subfamily 1, group I, member 3	16	0	0	16
estrogen-related nuclear receptor alpha	25	0	0	25
pregnane X nuclear receptor	21	0	0	21
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	18	0	0	18
nuclear factor erythroid 2-related factor 2 isoform 2	15	0	0	16
importin subunit beta-1 isoform 1	5	0	0	5
snurportin-1	5	0	0	5
tumor susceptibility gene 101 protein	3	0	0	3
GTP-binding nuclear protein Ran isoform 1	5	0	0	5
lamin isoform A-delta10	21	0	0	21
Voltage-dependent calcium channel gamma-2 subunit	8	0	0	8
Bile salt export pump	0	26	0	26
Cyclin-dependent kinase 1	0	1	0	1
Heat shock protein HSP 90-beta	0	1	0	1
Glutamate receptor 2	9	3	2	14
Xanthine dehydrogenase/oxidase	0	1	0	1
TAR DNA-binding protein 43	9	0	0	9
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	0	2
ATPase family AAA domain-containing protein 5	13	0	0	13
Solute carrier family 22 member 3	0	3	0	3
5-hydroxytryptamine receptor 2C	0	4	1	5
Phenylethanolamine N-methyltransferase	0	2	0	2
Cytochrome P450 2A6	0	2	1	3
Substance-P receptor	0	1	0	1
5-hydroxytryptamine receptor 2A	0	4	1	5
5-hydroxytryptamine receptor 1A	0	5	1	6
Cytochrome P450 2A5	0	1	0	1
Sodium-dependent dopamine transporter	0	6	0	6
5-hydroxytryptamine receptor 1B	0	5	1	6
5-hydroxytryptamine receptor 1D	0	3	1	4
5-hydroxytryptamine receptor 1F	0	3	1	4
5-hydroxytryptamine receptor 2B	0	4	1	5
5-hydroxytryptamine receptor 6	0	2	1	3
5-hydroxytryptamine receptor 7	0	2	1	3
5-hydroxytryptamine receptor 5A	0	2	1	3
5-hydroxytryptamine receptor 5B	0	2	1	3
5-hydroxytryptamine receptor 3A	0	2	1	3
Sigma non-opioid intracellular receptor 1	0	1	0	1
5-hydroxytryptamine receptor 4	0	2	1	3
Beta-2 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 3B	0	2	1	3
Sigma non-opioid intracellular receptor 1	0	3	0	3
Chain A, ADIPOCYTE LIPID-BINDING PROTEIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	9	0	0	9
Chain A, Beta-lactamase	8	0	0	8
Chain A, HADH2 protein	6	0	0	6
Chain B, HADH2 protein	6	0	0	6
thioredoxin glutathione reductase	8	0	0	8
aldehyde dehydrogenase 1 family, member A1	17	0	0	17
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	5	0	0	5
cellular tumor antigen p53 isoform a	4	0	0	4
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	7	0	0	7
vitamin D3 receptor isoform VDRA	12	0	0	12
ubiquitin carboxyl-terminal hydrolase 2 isoform a	4	0	0	4
nuclear receptor ROR-gamma isoform 1	10	0	0	10
lethal(3)malignant brain tumor-like protein 1 isoform I	3	0	0	3
DNA polymerase kappa isoform 1	7	0	0	7
cytochrome P450 3A4 isoform 1	14	0	0	14
histone acetyltransferase KAT2A isoform 1	8	0	0	8
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	2	0	0	2
caspase-1 isoform alpha precursor	3	0	0	3
Fatty-acid amide hydrolase 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit pi	14	0	0	14
Polyunsaturated fatty acid lipoxygenase ALOX15B	6	0	0	6
Prostaglandin G/H synthase 1	0	1	0	2
Trypsin	0	2	0	2
Coagulation factor VII	0	2	0	2
60 kDa chaperonin	0	2	0	2
60 kDa heat shock protein, mitochondrial	0	2	0	2
Aromatase	0	4	0	4
Tissue factor	0	3	0	3
Fatty acid-binding protein, adipocyte	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	14	0	0	14
Gamma-aminobutyric acid receptor subunit delta	14	0	0	14
Gamma-aminobutyric acid receptor subunit gamma-2	14	0	0	14
Gamma-aminobutyric acid receptor subunit alpha-5	14	0	0	14
Gamma-aminobutyric acid receptor subunit alpha-3	14	0	0	14
Gamma-aminobutyric acid receptor subunit gamma-1	14	0	0	14
Gamma-aminobutyric acid receptor subunit alpha-2	14	0	0	14
Gamma-aminobutyric acid receptor subunit alpha-4	14	0	0	14
Gamma-aminobutyric acid receptor subunit gamma-3	14	0	0	14
Gamma-aminobutyric acid receptor subunit alpha-6	14	0	0	14
Prostaglandin G/H synthase 2	0	2	1	4
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Histamine H2 receptor	6	1	0	8
10 kDa heat shock protein, mitochondrial	0	2	0	2
Calmodulin	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	14	0	0	14
Gamma-aminobutyric acid receptor subunit beta-3	14	0	0	14
Gamma-aminobutyric acid receptor subunit beta-2	14	0	0	14
Disintegrin and metalloproteinase domain-containing protein 17	4	0	0	4
Prostaglandin G/H synthase 2	0	1	0	2
Solute carrier organic anion transporter family member 2A1	0	0	0	2
Fatty acid-binding protein 5	0	1	0	1
Fatty acid-binding protein 5	0	0	1	1
Thiosulfate sulfurtransferase	0	2	0	2
Lanosterol 14-alpha demethylase	0	2	1	3
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
GABA theta subunit	14	0	0	14
Gamma-aminobutyric acid receptor subunit epsilon	14	0	0	14
Solute carrier organic anion transporter family member 1B3	0	3	0	4
Cytosolic phospholipase A2 gamma	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	4	0	5
interleukin 8	7	0	0	7
glp-1 receptor, partial	10	0	0	10
ATAD5 protein, partial	14	0	0	14
Fumarate hydratase	8	0	0	8
PPM1D protein	3	0	0	3
GLI family zinc finger 3	17	0	0	17
Smad3	9	0	0	9
estrogen receptor 2 (ER beta)	9	0	0	9
progesterone receptor	10	0	0	10
polyprotein	8	0	0	8
67.9K protein	12	0	0	12
Parkin	5	0	0	5
peroxisome proliferator-activated receptor delta	9	0	0	9
peroxisome proliferator activated receptor gamma	14	0	0	14
IDH1	14	0	0	14
aryl hydrocarbon receptor	9	0	0	9
thyroid stimulating hormone receptor	8	0	0	8
activating transcription factor 6	10	0	0	10
peripheral myelin protein 22 isoform 1	8	0	0	8
hemoglobin subunit beta	3	0	0	3
chromobox protein homolog 1	23	0	0	23
huntingtin isoform 2	6	0	0	6
ras-related protein Rab-9A	6	0	0	6
serine/threonine-protein kinase mTOR isoform 1	9	0	0	9
nuclear factor erythroid 2-related factor 2 isoform 1	14	0	0	14
urokinase-type plasminogen activator precursor	13	0	0	13
plasminogen precursor	13	0	0	13
urokinase plasminogen activator surface receptor precursor	13	0	0	13
Interferon beta	7	0	0	7
Cellular tumor antigen p53	23	0	0	23
Integrin beta-3	2	0	1	3
Integrin alpha-IIb	2	0	1	3
Adenosine receptor A3	0	2	0	2
DNA (cytosine-5)-methyltransferase 1	0	2	0	2
Adenosine receptor A2a	0	2	0	2
Adenosine receptor A1	0	2	0	2
D(1A) dopamine receptor	4	0	0	4
Nuclear receptor ROR-gamma	7	0	0	7
Spike glycoprotein	11	0	2	13
Multidrug and toxin extrusion protein 1	0	2	0	2
Histone-lysine N-methyltransferase EHMT2	0	3	0	3
PAX8	0	0	0	1
thioredoxin reductase	24	0	0	24
NPC intracellular cholesterol transporter 1 precursor	4	0	0	4
major prion protein preproprotein Prp precursor	0	1	0	1
nuclear receptor subfamily 0 group B member 1	0	1	0	1
steroidogenic factor 1	0	1	0	1
Genome polyprotein	0	1	1	2
GLS protein	10	0	0	10
G	4	0	0	4
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	7	0	0	7
5-hydroxytryptamine receptor 4	0	2	0	2
HLA class I histocompatibility antigen, B alpha chain	4	0	0	4
ATP-dependent translocase ABCB1	0	3	0	3
Beta-1 adrenergic receptor	0	2	1	3
Cytochrome P450 3A4	0	7	2	10
5-hydroxytryptamine receptor 1A	0	1	0	1
Alpha-2A adrenergic receptor	0	3	1	4
D(2) dopamine receptor	0	4	1	5
Androgen receptor	0	3	0	3
Alpha-2B adrenergic receptor	0	3	0	3
Alpha-2C adrenergic receptor	0	3	0	3
D	0	2	0	2
D(3) dopamine receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	2	0	2
ATP-dependent translocase ABCB1	0	3	0	3
D(1A) dopamine receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
D(1B) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 2A	0	3	1	4
5-hydroxytryptamine receptor 2C	0	2	1	3
D(4) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	3	1	4
Alpha-synuclein	4	3	1	8
5-hydroxytryptamine receptor 2B	0	2	0	2
5-hydroxytryptamine receptor 6	0	2	0	2
D(2) dopamine receptor	0	4	1	5
Inositol hexakisphosphate kinase 1	4	0	0	4
cytochrome P450 2C9, partial	4	0	0	4
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
Nuclear hormone receptor family member daf-12	0	0	1	1
oxysterols receptor LXR-beta isoform 1	0	0	1	1
Thymidine kinase, cytosolic	0	3	0	5
Thymidine phosphorylase	0	0	0	2
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	0	0	3
Thymidylate kinase	0	2	0	2
Chain A, Ferritin light chain	7	0	0	7
acid sphingomyelinase	4	0	0	4
endonuclease IV	4	0	0	4
ClpP	3	0	0	3
electroneutral potassium-chloride cotransporter KCC2	0	0	1	1
TSHR protein	1	0	0	1
apical membrane antigen 1, AMA1	4	0	0	4
thyroid stimulating hormone receptor	13	0	0	13
nonstructural protein 1	4	0	0	4
glucocerebrosidase	4	0	0	4
LacZ protein (plasmid)	0	0	1	1
XBP1	0	1	0	1
serine-protein kinase ATM isoform a	2	0	0	2
lysosomal alpha-glucosidase preproprotein	4	0	0	4
hexokinase-4 isoform 1	1	0	0	1
type-1 angiotensin II receptor	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
glucokinase regulatory protein	1	0	0	1
mitogen-activated protein kinase 1	10	0	0	10
serine/threonine-protein kinase PLK1	5	0	0	5
apelin receptor	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	3
DNA polymerase iota isoform a (long)	13	0	0	13
DNA damage-inducible transcript 3 protein	0	1	0	1
Vpr	3	0	0	3
streptokinase A precursor	0	0	2	2
neuropeptide S receptor isoform A	4	0	0	4
Rap guanine nucleotide exchange factor 3	7	0	0	7
Amyloid-beta precursor protein	2	3	0	6
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	2
heat shock protein 90, putative	0	0	0	2
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Vitamin D3 receptor	0	0	1	1
ATP-binding cassette sub-family C member 3	0	19	0	19
Multidrug resistance-associated protein 4	0	20	0	23
Vitamin D-binding protein	0	0	1	1
Cytochrome P450 1A2	0	1	0	2
Androgen receptor	0	1	0	1
Cytochrome P450 2D6	0	3	0	3
Vitamin D3 receptor	0	1	2	4
Cytochrome P450 2C9	0	3	0	4
Vitamin D3 receptor	0	1	1	3
Retinoic acid receptor RXR-alpha	0	0	1	1
Cytochrome P450 2C19	0	1	0	1
Kappa-type opioid receptor	0	2	1	3
Vitamin D3 receptor	0	0	1	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Transporter	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	17	0	17
Vitamin D3 receptor A	0	0	2	2
Thymidine kinase	0	2	0	2
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Type IV secretion-like conjugative transfer relaxase protein TraI	0	1	0	1
72 kDa type IV collagenase	0	1	0	1
Stromelysin-1	0	1	1	2
Matrix metalloproteinase-9	0	1	0	1
Macrophage metalloelastase	0	1	0	1
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	1	3
Tryptophan 5-hydroxylase 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Liver carboxylesterase 1	0	0	0	1
Sodium-dependent noradrenaline transporter	0	4	1	5
Gamma-aminobutyric acid receptor subunit beta-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	0	2
Sodium-dependent serotonin transporter	0	4	0	4
Sodium-dependent serotonin transporter	0	6	0	7
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	9	2	12
Lysosomal Pro-X carboxypeptidase	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	9	2	12
Glutamate receptor ionotropic, NMDA 2B	0	9	2	12
Glutamate receptor ionotropic, NMDA 2C	0	9	2	13
Sodium-dependent dopamine transporter	0	4	0	4
Potassium voltage-gated channel subfamily H member 2	0	4	0	4
Leukotriene B4 receptor 1	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	0	2
Sodium-dependent dopamine transporter	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	9	2	12
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	9	2	12
Sigma non-opioid intracellular receptor 1	0	5	0	5
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Leukotriene B4 receptor 2	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	9	2	12
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
Transporter	0	5	0	5
GALC protein	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	6	0	0	6
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	6	0	0	6
Solute carrier family 22 member 2	0	3	0	4
Solute carrier family 22 member 1	0	6	0	8
Solute carrier family 22 member 3	0	2	0	2
Sex hormone-binding globulin	0	0	2	2
Corticosteroid-binding globulin	0	2	0	2
Mineralocorticoid receptor	0	0	1	1
C-8 sterol isomerase	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Solute carrier family 22 member 1	0	4	0	4
Solute carrier family 22 member 2	0	3	0	3
Chain A, Breast cancer type 1 susceptibility protein	2	0	0	2
Nrf2	1	0	0	1
hypoxia-inducible factor 1 alpha subunit	6	0	0	6
SMAD family member 2	7	0	0	7
SMAD family member 3	7	0	0	7
alkaline phosphatase, intestinal	0	1	0	1
caspase 7, apoptosis-related cysteine protease	4	0	0	4
PINK1	2	0	0	2
EWS/FLI fusion protein	12	0	0	13
toll-like receptor 9	0	1	0	1
caspase-3	4	0	0	4
TPA: protein transporter TIM10	0	1	0	1
thyrotropin-releasing hormone receptor	3	0	0	3
v-jun sarcoma virus 17 oncogene homolog (avian)	5	0	0	5
Histone H2A.x	8	0	0	8
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
perilipin-5	0	1	0	1
intestinal alkaline phosphatase precursor	0	1	0	1
perilipin-1	0	1	0	1
transcriptional regulator ERG isoform 3	3	0	0	3
DNA polymerase beta	2	0	0	2
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
muscleblind-like protein 1 isoform 1	3	0	0	3
alkaline phosphatase, germ cell type preproprotein	0	1	0	1
hypothetical protein SA1422	0	1	0	1
lethal factor (plasmid)	7	0	0	7
DNA dC->dU-editing enzyme APOBEC-3F isoform a	2	0	0	2
Prostaglandin E synthase	0	1	0	1
Acetylcholinesterase	0	2	0	2
Lysine-specific histone demethylase 1A	0	1	0	1
D-amino-acid oxidase	0	1	0	1
Phospholipase A2	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	3	1	4
Neuronal proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Cholinesterase	0	3	0	3
Heme oxygenase 1	0	2	0	2
Glutathione S-transferase P	0	2	0	2
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Microtubule-associated protein tau	0	1	0	2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	0	1	0	1
Tyrosinase	0	1	0	1
Aminopeptidase N	0	1	0	1
Aminopeptidase N	0	1	0	1
Alpha-1B adrenergic receptor	0	2	0	2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	0	2	0	2
Glycogen synthase kinase-3 beta	0	1	0	1
Amine oxidase [flavin-containing] A	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Acetylcholinesterase	0	3	0	3
Heme oxygenase 2	0	2	0	2
Alpha-1D adrenergic receptor	0	1	0	1
Amine oxidase [flavin-containing] B	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Proteasome subunit beta type-5	0	2	0	2
17-beta-hydroxysteroid dehydrogenase type 2	0	1	0	1
Alpha-1A adrenergic receptor	0	3	0	3
Glycogen synthase kinase-3 beta	0	2	1	3
Caspase-7	2	0	0	2
Beta-secretase 1	0	1	0	1
Cholinesterase	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Lactoylglutathione lyase	0	1	0	1
Histone acetyltransferase p300	0	1	0	1
Serine/threonine-protein kinase PAK 1	0	1	0	1
5-hydroxytryptamine receptor 4	0	0	1	1
Sodium/bile acid cotransporter	0	0	1	1
Nuclear factor erythroid 2-related factor 2	0	1	3	6
Thioredoxin reductase 1, cytoplasmic	0	1	0	1
Thioredoxin reductase 3	0	1	0	1
Sortase A	0	1	0	1
CREB-binding protein	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3	0	2	0	2
Cysteine protease	0	1	0	1
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Thioredoxin reductase 2, mitochondrial	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Lymphocyte antigen 96	0	0	1	1
Beta lactamase (plasmid)	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Histone-lysine N-methyltransferase EHMT1	0	1	0	1
neutrophil cytosol factor 1	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 1	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 3	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 4	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Alpha-tocopherol transfer protein	0	0	1	1
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
Beta-glucuronidase	0	2	0	2
Beta-glucuronidase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
G-protein coupled bile acid receptor 1	0	0	2	2
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
NPC1-like intracellular cholesterol transporter 1	0	0	1	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Steryl-sulfatase	0	0	0	1
Multidrug resistance-associated protein 1	0	0	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	3
ATP-binding cassette sub-family C member 11	0	0	0	1
Solute carrier family 22 member 11	0	0	0	3
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	1	0	3
Thymidine kinase 2	0	1	0	1
Deoxycytidine kinase	0	1	0	3
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	0	0	2
AAA family ATPase	0	0	0	2
cytochrome P450 2D6 isoform 1	4	0	0	4
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
Angiotensin-converting enzyme	0	2	0	2
Histamine H1 receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	2	0	2
Cytochrome P450 2J2	0	1	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Histamine H3 receptor	0	1	0	1
Solute carrier family 22 member 4	0	1	0	1
Histamine H3 receptor	0	2	0	2
ORF73	0	0	1	1
Glutathione S-transferase omega-1	0	1	0	1
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Prostacyclin receptor	0	2	1	3
Solute carrier family 22 member 7	0	0	0	3
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier family 22 member 7	0	0	0	2
RGS12	1	0	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
DNA polymerase III, partial	2	0	0	2
isocitrate dehydrogenase 1, partial	2	0	0	2
LANA	0	0	0	1
NPYLR7B	0	0	1	1
cytochrome P450 2C19 precursor	1	0	0	1
cytochrome P450 2C9 precursor	1	0	0	1
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
eyes absent homolog 2 isoform a	1	0	0	1
kelch-like ECH-associated protein 1	0	0	0	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	2	0	2
Multidrug resistance-associated protein 5	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	2	0	2
cGMP-specific 3',5'-cyclic phosphodiesterase	0	2	0	2
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	2	0	2
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	3	0	3
Exopolyphosphatase PRUNE1	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Equilibrative nucleoside transporter 1	0	3	0	3
Single-stranded DNA cytosine deaminase	1	0	0	1
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	0	1	0	1
Phosphodiesterase	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
Carbonic anhydrase 1	0	3	0	6
Carbonic anhydrase 2	0	5	0	8
Gasdermin-D	0	1	0	1
Gasdermin-D	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Transient receptor potential cation channel subfamily A member 1	0	0	1	2
L-lactate dehydrogenase A chain	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Glutamate receptor 1	1	3	2	6
Glutamate receptor 3	1	3	2	6
Glutamate receptor 4	1	3	2	6
Cannabinoid receptor 1	0	2	1	3
Cannabinoid receptor 1	0	2	1	4
Glycine receptor subunit alpha-1	0	0	2	2
Cannabinoid receptor 2	0	2	1	4
Cannabinoid receptor 1	0	1	0	1
Cannabinoid receptor 2	0	1	1	2
N-arachidonyl glycine receptor	0	0	1	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Lysophosphatidylserine lipase ABHD12	0	1	0	1
Monoglyceride lipase	0	1	0	1
Monoacylglycerol lipase ABHD6	0	1	0	1
Cannabinoid receptor 2	0	2	0	2
G-protein coupled receptor 55	0	1	1	2
D(4) dopamine receptor	0	1	0	1
D(2) dopamine receptor	0	1	0	1
interferon gamma precursor	0	0	0	1
Sodium/nucleoside cotransporter 2	0	1	0	1
Thymidylate synthase	0	3	0	3
Solute carrier family 15 member 1	0	1	0	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
unnamed protein product	0	1	0	1
bcl-2-like protein 11 isoform 1	0	0	1	1
Chymotrypsinogen A	0	1	0	1
Beta-lactamase	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	1	2
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Cytochrome P450 144	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Mycocyclosin synthase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Sterol 14-alpha demethylase	0	0	1	1
Sterol 14-alpha demethylase	0	1	1	2
14-alpha sterol demethylase	0	0	1	1
likely tRNA 2'-phosphotransferase	0	1	0	1
corticotropin-releasing hormone receptor 2	0	1	1	2
corticotropin releasing factor-binding protein	0	1	1	2
glycogen synthase kinase-3 beta isoform 1	0	0	3	3
5'-nucleotidase	0	1	0	1
Adenosine receptor A3	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	3	0	4
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Skn7p	0	0	0	1
Solute carrier family 22 member 8	0	0	0	1
Epidermal growth factor receptor	0	2	0	2
Chain A, Dihydrofolate reductase	0	0	1	1
alpha-galactosidase	2	0	0	2
Thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Multidrug resistance associated protein	0	0	0	1
Chain A, probable fosfomycin resistance protein	0	0	1	1
Chain B, probable fosfomycin resistance protein	0	0	1	1
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase alpha catalytic subunit	0	1	0	1
Carbonic anhydrase 4	0	3	0	4
DNA polymerase delta catalytic subunit	0	1	0	1
Carbonic anhydrase 9	0	2	0	4
WRN	1	0	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
Free fatty acid receptor 1	0	0	1	1
POU domain, class 2, transcription factor 2	0	0	0	1
Transitional endoplasmic reticulum ATPase	0	1	0	1
Purine nucleoside phosphorylase	0	0	1	1
Chain A, DEOXYNUCLEOSIDE KINASE	0	1	0	1
Spike glycoprotein	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Transmembrane protease serine 2	0	0	2	2
Procathepsin L	0	0	2	2
Replicase polyprotein 1a	0	0	3	3
Replicase polyprotein 1ab	0	0	2	2
Angiotensin-converting enzyme 2	0	0	2	2
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
Metabotropic glutamate receptor 8	0	2	0	2
Metabotropic glutamate receptor 6	0	1	1	3
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Excitatory amino acid transporter 4	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Glutathione reductase, mitochondrial	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	2	1	3
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Excitatory amino acid transporter 1	0	2	0	3
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	1	0	1
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	3	0	3
Glutamate receptor ionotropic, NMDA 2A	0	3	0	3
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	3	0	3
Metabotropic glutamate receptor 1	0	1	1	3
Metabotropic glutamate receptor 2	0	1	1	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	2
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	2	0	2
Proton-coupled amino acid transporter 1	0	1	0	1
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Pancreatic alpha-amylase	0	1	0	1
Beta-glucuronidase	0	1	0	1
High mobility group protein B1	0	0	1	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	1	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	1	2
High mobility group protein B1	0	0	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 2	0	1	1	2
Canalicular multispecific organic anion transporter 1	0	1	0	1
Urease subunit alpha	0	1	0	1
Ribonucleoside-diphosphate reductase large subunit	0	1	0	1
Urease subunit beta	0	1	0	1
Chain A, BETA-SPECTRIN	0	0	1	1
Chain A, Phospholipase C Delta-1	0	0	1	1
Chain A, Inositol 1,4,5-trisphosphate receptor type 1	0	0	1	1
Inositol-trisphosphate 3-kinase A	0	1	0	1
Inositol 1,4,5-trisphosphate receptor type 1	0	0	2	2
Inositol 1,4,5-trisphosphate receptor type 2	0	1	0	1
Inositol 1,4,5-trisphosphate receptor type 3	0	1	1	2
Inositol polyphosphate-5-phosphatase A	0	1	0	1
Inositol 1,4,5-trisphosphate receptor type 1	0	1	1	2
Proteasome subunit beta type-11	0	1	0	1
Proteasome subunit alpha type-7	0	1	0	1
Proteasome subunit beta type-1	0	1	0	1
Proteasome subunit alpha type-1	0	1	0	1
Proteasome subunit alpha type-2	0	1	0	1
Proteasome subunit alpha type-3	0	1	0	1
Proteasome subunit alpha type-4	0	1	0	1
Proteasome subunit beta type-8	0	1	0	1
Proteasome subunit beta type-9	0	1	0	1
Proteasome subunit alpha type-5	0	1	0	1
Proteasome subunit beta type-4	0	1	0	1
Proteasome subunit beta type-6	0	1	0	1
Proteasome subunit beta type-10	0	1	0	1
Proteasome subunit beta type-3	0	1	0	1
Proteasome subunit beta type-2	0	1	0	1
Proteasome subunit alpha type-6	0	1	0	1
Splicing factor 3B subunit 3	0	2	0	2
Proteasome subunit alpha-type 8	0	1	0	1
Proteasome subunit beta type-7	0	1	0	1
inositol monophosphatase 1	1	0	0	1
Cholecystokinin receptor type A	1	0	0	1
Gastrin/cholecystokinin type B receptor	1	0	0	1
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Fatty acid-binding protein, liver	0	2	0	2
Transthyretin	0	0	1	1
Fatty acid-binding protein, intestinal	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Mitogen-activated protein kinase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Aldo-keto reductase family 1 member C3	0	1	0	1
Transcription factor SOX-18	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
M-phase phosphoprotein 8	1	0	0	1
Cytochrome P450 1A1	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Myeloperoxidase	0	1	0	1
Cytochrome P450 2C11	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Acetylcholinesterase	0	1	0	1
Mu-type opioid receptor	0	3	1	7
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Cytochrome P450 1B1	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Opioid receptor, delta 1b	0	1	0	1
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	1	2
Muscarinic acetylcholine receptor M4	0	1	1	2
Muscarinic acetylcholine receptor M5	0	1	1	2
Muscarinic acetylcholine receptor M2	0	1	1	2
Translocator protein	0	0	1	1
Histidine decarboxylase	0	0	1	1
Proteinase-activated receptor 1	0	1	1	2
Delta-type opioid receptor	0	1	0	3
Delta-type opioid receptor	0	2	1	5
Kappa-type opioid receptor	0	2	1	5
Kappa-type opioid receptor	0	2	1	4
Mu-type opioid receptor	0	2	1	4
UDP-glucuronosyltransferase 1A3	0	0	0	1
Delta-type opioid receptor	0	2	1	4
Kappa-type opioid receptor	0	2	1	4
Mu-type opioid receptor	0	2	1	6
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Mas-related G-protein coupled receptor member X2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
Toll-like receptor 2	0	1	0	1
Peroxisome proliferator-activated receptor delta	0	0	0	1
Dynamin-1	0	1	0	1
Peroxisome proliferator-activated receptor alpha	1	0	1	2
G-protein coupled receptor 84	0	1	1	2
Neutrophil elastase	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Nitric oxide synthase, brain	0	1	0	1
Nitric oxide synthase, inducible	0	2	0	2
Nitric oxide synthase, inducible	0	1	0	1
Collagenase 3	0	1	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase 15	0	1	0	2
runt-related transcription factor 1 isoform AML1b	2	0	0	2
core-binding factor subunit beta isoform 2	2	0	0	2
Glyceraldehyde-3-phosphate dehydrogenase	0	1	0	1
DNA repair protein RAD52 homolog	0	1	0	1
vasopressin V1b receptor	1	0	0	1
relaxin receptor 1 isoform 1	1	0	0	1
Tumor necrosis factor	0	1	0	1
Adenosine receptor A2b	0	1	0	1
Chitotriosidase-1	0	2	1	3
Endochitinase B1	0	2	1	3
Chain A, Immunoglobulin	0	0	1	1
Chain B, Immunoglobulin	0	0	1	1
Muscarinic acetylcholine receptor M1	0	0	1	2
Cytochrome P450 2B6	0	1	0	1
Muscarinic acetylcholine receptor M4	0	0	1	2
Cholinesterase	0	1	0	1
Muscarinic acetylcholine receptor M5	0	0	1	2
Muscarinic acetylcholine receptor M3	0	0	1	2
Muscarinic acetylcholine receptor M2	0	0	1	2
Cytochrome P450 2E1	0	1	0	1
Macrophage migration inhibitory factor	0	2	0	2
Hypoxia-inducible factor 1-alpha	0	1	0	1
Cytochrome P450 2A13	0	1	1	2
Transient receptor potential cation channel subfamily V member 1	0	0	1	1
Endothelial PAS domain-containing protein 1	0	1	0	1
Tyrosine-protein kinase Lck	0	0	0	1
Proto-oncogene tyrosine-protein kinase Src	0	0	0	1
Growth factor receptor-bound protein 2	0	0	0	1
Tyrosine-protein phosphatase non-receptor type 11	0	0	0	1
Lysine-specific demethylase 4E	0	1	0	1
Advanced glycosylation end product-specific receptor	0	0	1	1
Beta-lactamase	0	1	0	1
Advanced glycosylation end product-specific receptor	0	0	1	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
NS5	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Polymerase basic protein 2	0	0	1	1
RNA-directed RNA polymerase catalytic subunit	0	0	1	1
Polymerase acidic protein	0	0	1	1
Adenosylhomocysteinase	0	0	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Adenosine receptor A1	0	1	0	1
Genome polyprotein	0	0	1	1
Beta-2 adrenergic receptor	0	0	1	1
Beta-3 adrenergic receptor	0	0	1	1
Transcription regulator protein BACH1	0	1	0	1
Transcription factor MafK	0	1	0	1
NAD	0	0	0	1
Quinone oxidoreductase	0	0	0	3
Kelch-like ECH-associated protein 1	0	1	2	3
Nuclear factor erythroid 2-related factor 2	0	0	0	1
NAD(P)H dehydrogenase [quinone] 1	0	0	0	1
Kelch-like ECH-associated protein 1	0	0	0	1
UDP-glucuronosyltransferase 2B7	0	0	0	2
Cytochrome P450 3A5	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Serine/threonine-protein kinase D3	0	0	1	1
Protein kinase C gamma type	0	1	1	2
Protein kinase C beta type	0	2	1	3
Luciferin 4-monooxygenase	0	0	1	1
Protein kinase C alpha type	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Protein kinase C eta type	0	0	1	1
Protein kinase C iota type	0	0	1	1
Protein kinase C epsilon type	0	2	1	3
Protein kinase C theta type	0	0	1	1
Protein kinase C zeta type	0	0	1	1
Protein kinase C delta type	0	1	1	2
Serine/threonine-protein kinase D1	0	0	1	1
Ras guanyl-releasing protein 3	0	0	1	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Polyphenol oxidase 2	0	0	0	1
Carbonic anhydrase 12	0	0	0	1
Plasma kallikrein	0	0	0	1
Carbonic anhydrase 3	0	0	0	1
Carbonic anhydrase 6	0	0	0	1
Adenosine receptor A1	0	0	0	1
Adenosine receptor A2a	0	0	0	1
Carbonic anhydrase 7	0	0	0	1
Carbonic anhydrase	0	0	0	1
SLC16A10 protein	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
Taste receptor type 2 member 14	0	0	0	1
Carbonic anhydrase 14	0	0	0	1
Carbonic anhydrase 5B, mitochondrial	0	0	0	1
Dipeptidyl peptidase 4	0	1	0	1
Histamine H1 receptor	0	0	1	1
Adenosylhomocysteinase	0	1	0	1
RNA-directed RNA polymerase	0	1	1	2
C-X-C chemokine receptor type 4	0	0	1	1
Caspase-7	1	0	0	1
caspase-3	1	0	0	1
tyrosine-protein kinase Yes	1	0	0	1
Ectonucleoside triphosphate diphosphohydrolase 1	0	0	0	1
Thymidine kinase, cytosolic	0	0	0	1
Thymidine kinase	0	1	0	2
Protease	0	1	1	2
Thymidine kinase	0	1	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(6)

Research Excerpts

Overview

Context

Treatment

Research

Studies (177)

Protein Targets (991)

AIDS, Murine

Synonyms(6)

Research Excerpts

Overview

Context

Treatment

Research

Studies (177)

Drugs Studied (134)

Protein Targets (991)