fluconazole has been researched along with Sensitivity and Specificity in 81 studies
Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.
fluconazole : A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This investigation determined the ability of alfentanil miosis and single-point concentrations to detect various degrees of CYP3A inhibition." | 9.11 | Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimally invasive and noninvasive probes for hepatic and first-pass CYP3A activity. ( Hoffer, C; Kharasch, ED; Sheffels, P; Walker, A, 2005) |
| "To determine the cost-effectiveness of using empiric high-dose fluconazole in intensive care unit (ICU) with suspected invasive candidiasis." | 7.74 | High- versus low-dose fluconazole therapy for empiric treatment of suspected invasive candidiasis among high-risk patients in the intensive care unit: a cost-effectiveness analysis. ( Bearden, DT; Chen, H; Garey, KW; Pai, MP; Suda, KJ; Turpin, RS, 2007) |
| "Reported sensitivity of the galactomannan enzyme immunoassay as an early diagnostic test for invasive aspergillosis (IA) has been widely variable, ranging from 29% to 100% in earlier clinical studies." | 5.11 | Antifungal therapy decreases sensitivity of the Aspergillus galactomannan enzyme immunoassay. ( Gugel, A; Laverdiere, M; Leisenring, W; Marr, KA, 2005) |
| "This investigation determined the ability of alfentanil miosis and single-point concentrations to detect various degrees of CYP3A inhibition." | 5.11 | Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimally invasive and noninvasive probes for hepatic and first-pass CYP3A activity. ( Hoffer, C; Kharasch, ED; Sheffels, P; Walker, A, 2005) |
| "To examine the risk of congenital malformations associated with exposure to oral fluconazole at commonly used doses in the first trimester of pregnancy for the treatment of vulvovaginal candidiasis." | 3.96 | Oral fluconazole use in the first trimester and risk of congenital malformations: population based cohort study. ( Bateman, BT; Gray, KJ; Hernandez-Diaz, S; Huybrechts, KF; Mogun, H; Straub, L; Zhu, Y, 2020) |
| "To determine the cost-effectiveness of using empiric high-dose fluconazole in intensive care unit (ICU) with suspected invasive candidiasis." | 3.74 | High- versus low-dose fluconazole therapy for empiric treatment of suspected invasive candidiasis among high-risk patients in the intensive care unit: a cost-effectiveness analysis. ( Bearden, DT; Chen, H; Garey, KW; Pai, MP; Suda, KJ; Turpin, RS, 2007) |
| "Empirical fluconazole therapy is reasonable for likelihoods of invasive candidiasis greater than 2." | 3.73 | Empirical anti-Candida therapy among selected patients in the intensive care unit: a cost-effectiveness analysis. ( Golan, Y; Hadley, S; Pauker, SG; Wolf, MP; Wong, JB, 2005) |
| "Rapid and reliable exclusion of invasive fungal infections (IFI) by markers able to avoid unnecessary empirical antifungal treatment is still a critical unmet clinical need." | 1.56 | Quantification of 1,3-β-d-glucan by Wako β-glucan assay for rapid exclusion of invasive fungal infections in critical patients: A diagnostic test accuracy study. ( Alteri, C; Bielli, A; Brioschi, P; Cairoli, R; Cento, V; Colombo, J; De Gasperi, A; Gasparini, LE; Gatti, M; Lepera, V; Lombardi, G; Mancini, V; Mazza, E; Merli, M; Moioli, MC; Orcese, CA; Perno, CF; Puoti, M; Torri, S; Vismara, C, 2020) |
| "Posaconazole was associated with fewer IFIs (5." | 1.36 | Economic evaluation of posaconazole vs fluconazole in the prevention of invasive fungal infections in patients with GVHD following haematopoietic SCT. ( Carreras, E; Casado, MA; de la Cámara, R; Grau, S; Jarque, I; Sabater, FJ; Sanz, MA, 2010) |
| "Invasive candidiasis is associated with high morbidity and mortality." | 1.35 | Direct antifungal susceptibility testing of positive Candida blood cultures by sensititre YeastOne. ( Avolio, M; Bruschetta, G; Camporese, A; De Rosa, R; Grosso, S, 2009) |
| "Trifluoroacetic acid (TFA) is a commonly used additive in HPLC and LC-MS analysis of basic compounds." | 1.33 | Simple means to alleviate sensitivity loss by trifluoroacetic acid (TFA) mobile phases in the hydrophilic interaction chromatography-electrospray tandem mass spectrometric (HILIC-ESI/MS/MS) bioanalysis of basic compounds. ( Naidong, W; Shou, WZ, 2005) |
| "Fluconazole was administered intravenously at average multiple doses of 12." | 1.33 | Pharmacokinetics of fluconazole in the cerebrospinal fluid of children with hydrocephalus. ( Bafeltowska, JJ; Buszman, E, 2005) |
| "Fluconazole MICs were 16 (3 SDD strains) and 128 microg/ml (1 resistant strain), respectively." | 1.31 | Frequency and clinical significance of bloodstream infections caused by C albicans strains with reduced susceptibility to fluconazole. ( Alcalá, L; Bouza, E; Fernández-Turégano, CP; Muñoz, P; Peláez, T; Rodríguez-Créixems, M, 2002) |
| "The objective of this study was to evaluate the pharmacodynamic activity of fluconazole, itraconazole, and amphotericin B against Candida albicans." | 1.31 | Pharmacodynamics of fluconazole, itraconazole, and amphotericin B against Candida albicans. ( Burgess, DS; Hardin, TC; Hastings, RW; Rinaldi, MG; Summers, KK, 2000) |
| "Fluconazole was labelled with (99m)Tc and radiochemical analysis showed less than 5% impurities." | 1.31 | Technetium-99m labelled fluconazole and antimicrobial peptides for imaging of Candida albicans and Aspergillus fumigatus infections. ( Lupetti, A; Mazzi, U; Nibbering, PH; Pauwels, EK; Welling, MM, 2002) |
| " To determine whether the presence of an intracisternal needle alters pharmacokinetics in the CSF, we validated this model with uninfected rabbits by measuring pharmacokinetic constants following direct intracisternal and intravenous administration of fluconazole." | 1.29 | Pharmacokinetics of fluconazole in cerebrospinal fluid and serum of rabbits: validation of an animal model used to measure drug concentrations in cerebrospinal fluid. ( Burroughs, M; Cioffe, C; Madu, A; Mayers, M; Mian, U; Miller, M; Schwartz, E; Tuomanen, E, 1994) |
| "Patients with cryptococcal meningitis tend to have recurrences of infection." | 1.29 | Persistence of initial infection in recurrent Cryptococcus neoformans meningitis. ( Casadevall, A; Freundlich, LF; Spitzer, ED; Spitzer, SG, 1993) |
| "Fluconazole was extracted from diluted serum by adsorption on a small Bond-Elut C18 cartridge after the addition of UK48,134 as the internal standard and recovered by elution with methanol." | 1.28 | Determination of fluconazole in human serum by solid-phase extraction and reversed-phase high-performance liquid chromatography. ( Gill, MA; Inagaki, K; Lor, E; Okamoto, MP; Takagi, J, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 21 (25.93) | 18.2507 |
| 2000's | 47 (58.02) | 29.6817 |
| 2010's | 11 (13.58) | 24.3611 |
| 2020's | 2 (2.47) | 2.80 |
| Authors | Studies |
|---|---|
| Feng, BY | 1 |
| Toyama, BH | 1 |
| Wille, H | 1 |
| Colby, DW | 1 |
| Collins, SR | 1 |
| May, BC | 1 |
| Prusiner, SB | 1 |
| Weissman, J | 1 |
| Shoichet, BK | 1 |
| Gygax, SE | 1 |
| Vermitsky, JP | 1 |
| Chadwick, SG | 1 |
| Self, MJ | 1 |
| Zimmerman, JA | 1 |
| Mordechai, E | 1 |
| Adelson, ME | 1 |
| Trama, JP | 1 |
| Shrestha, JP | 1 |
| Baker, C | 1 |
| Kawasaki, Y | 1 |
| Subedi, YP | 1 |
| Vincent de Paul, NN | 1 |
| Takemoto, JY | 1 |
| Chang, CT | 1 |
| Zhu, Y | 1 |
| Bateman, BT | 1 |
| Gray, KJ | 1 |
| Hernandez-Diaz, S | 1 |
| Mogun, H | 1 |
| Straub, L | 1 |
| Huybrechts, KF | 1 |
| Cento, V | 1 |
| Alteri, C | 1 |
| Mancini, V | 1 |
| Gatti, M | 1 |
| Lepera, V | 1 |
| Mazza, E | 1 |
| Moioli, MC | 1 |
| Merli, M | 1 |
| Colombo, J | 1 |
| Orcese, CA | 1 |
| Bielli, A | 1 |
| Torri, S | 1 |
| Gasparini, LE | 1 |
| Vismara, C | 1 |
| De Gasperi, A | 1 |
| Brioschi, P | 1 |
| Puoti, M | 1 |
| Cairoli, R | 1 |
| Lombardi, G | 1 |
| Perno, CF | 1 |
| Darling, LA | 1 |
| Evans, AM | 1 |
| Stellrecht, KA | 1 |
| Nattanmai, SM | 1 |
| Montero, CI | 1 |
| Donders, GGG | 1 |
| Grinceviciene, S | 1 |
| Bellen, G | 1 |
| Jaeger, M | 1 |
| Ten Oever, J | 1 |
| Netea, MG | 1 |
| Altintop, YA | 1 |
| Ergul, AB | 1 |
| Koc, AN | 1 |
| Atalay, MA | 1 |
| Szweda, P | 1 |
| Gucwa, K | 1 |
| Naumiuk, L | 1 |
| Romanowska, E | 1 |
| Dzierzanowska-Fangrat, K | 1 |
| Brillowska-Dabrowska, A | 1 |
| Wojciechowska-Koszko, I | 1 |
| Milewski, S | 1 |
| Zhao, D | 1 |
| Qiu, G | 1 |
| Luo, Z | 1 |
| Zhang, Y | 1 |
| Liew, YX | 1 |
| Teo, J | 1 |
| Too, IA | 1 |
| Ngan, CC | 1 |
| Tan, AL | 1 |
| Chlebicki, MP | 1 |
| Kwa, AL | 1 |
| Lee, W | 1 |
| Sadeghi, G | 1 |
| Khaksar, AA | 1 |
| Bassiri Jahromi, S | 1 |
| Amirkhani, A | 1 |
| Eslamifar, A | 1 |
| Ajdary, S | 1 |
| Katiraee, F | 1 |
| Taeb, J | 1 |
| Paskiabi, FA | 1 |
| Sayyah, M | 1 |
| Lam, SW | 1 |
| Eschenauer, GA | 1 |
| Carver, PL | 1 |
| Posteraro, B | 1 |
| Martucci, R | 1 |
| La Sorda, M | 1 |
| Fiori, B | 1 |
| Sanglard, D | 1 |
| De Carolis, E | 1 |
| Florio, AR | 1 |
| Fadda, G | 1 |
| Sanguinetti, M | 1 |
| Avolio, M | 1 |
| Grosso, S | 1 |
| Bruschetta, G | 1 |
| De Rosa, R | 1 |
| Camporese, A | 1 |
| Pfaller, MA | 4 |
| Boyken, L | 2 |
| Hollis, RJ | 2 |
| Kroeger, J | 1 |
| Messer, SA | 3 |
| Tendolkar, S | 2 |
| Diekema, DJ | 2 |
| Wang, H | 1 |
| Kong, F | 1 |
| Sorrell, TC | 1 |
| Wang, B | 1 |
| McNicholas, P | 1 |
| Pantarat, N | 1 |
| Ellis, D | 1 |
| Xiao, M | 1 |
| Widmer, F | 1 |
| Chen, SC | 1 |
| de la Cámara, R | 1 |
| Jarque, I | 1 |
| Sanz, MA | 1 |
| Grau, S | 1 |
| Casado, MA | 1 |
| Sabater, FJ | 1 |
| Carreras, E | 1 |
| Kim, TH | 1 |
| Lee, MK | 1 |
| Lupetti, A | 2 |
| de Boer, MG | 1 |
| Erba, P | 1 |
| Campa, M | 1 |
| Nibbering, PH | 2 |
| Bicmen, C | 1 |
| Doluca, M | 1 |
| Gulat, S | 1 |
| Gunduz, AT | 1 |
| Tuksavul, F | 1 |
| Oon, LL | 1 |
| Yeo, MG | 1 |
| Bhoopathy, S | 1 |
| Sarkar, MA | 1 |
| Karnes, HT | 1 |
| Muñoz, P | 1 |
| Fernández-Turégano, CP | 1 |
| Alcalá, L | 1 |
| Rodríguez-Créixems, M | 1 |
| Peláez, T | 1 |
| Bouza, E | 1 |
| Mathy, FX | 1 |
| Vroman, B | 1 |
| Ntivunwa, D | 1 |
| De Winne, AJ | 1 |
| Verbeeck, RK | 1 |
| Préat, V | 1 |
| Eerkes, A | 1 |
| Shou, WZ | 2 |
| Naidong, W | 2 |
| Snydman, DR | 1 |
| Tullio, V | 1 |
| Cuffini, AM | 1 |
| Giacchino, F | 1 |
| Mandras, N | 1 |
| Roana, J | 1 |
| Comune, L | 1 |
| Merlino, C | 1 |
| Carlone, NA | 1 |
| Thompson, CM | 1 |
| Richards, DS | 1 |
| Fancy, SA | 1 |
| Perkins, GL | 1 |
| Pullen, FS | 1 |
| Thom, C | 1 |
| Cheng, MF | 1 |
| Yu, KW | 1 |
| Tang, RB | 1 |
| Fan, YH | 1 |
| Yang, YL | 1 |
| Hsieh, KS | 1 |
| Ho, M | 1 |
| Lo, HJ | 1 |
| Ozkütük, A | 1 |
| Ergon, C | 1 |
| Ozdemir, S | 1 |
| Yulug, N | 1 |
| Rice, C | 1 |
| Egle, H | 1 |
| Trittler, R | 1 |
| Kümmerer, K | 1 |
| Goldman, GH | 1 |
| da Silva Ferreira, ME | 1 |
| dos Reis Marques, E | 1 |
| Savoldi, M | 1 |
| Perlin, D | 1 |
| Park, S | 1 |
| Godoy Martinez, PC | 1 |
| Goldman, MH | 1 |
| Colombo, AL | 2 |
| Baddley, JW | 1 |
| Patel, M | 1 |
| Jones, M | 1 |
| Cloud, G | 1 |
| Smith, AC | 1 |
| Moser, SA | 1 |
| Rudensky, B | 1 |
| Broidie, E | 1 |
| Yinnon, AM | 1 |
| Weitzman, T | 1 |
| Paz, E | 1 |
| Keller, N | 1 |
| Raveh, D | 1 |
| Naidu, AS | 1 |
| Fowler, RS | 1 |
| Martinez, C | 1 |
| Chen, J | 1 |
| Tulpinski, J | 1 |
| Sun, S | 1 |
| Gao, Y | 1 |
| Ling, X | 1 |
| Lou, H | 1 |
| Wheat, LJ | 1 |
| Musial, CE | 1 |
| Jenny-Avital, E | 1 |
| Marr, KA | 1 |
| Laverdiere, M | 1 |
| Gugel, A | 1 |
| Leisenring, W | 1 |
| Kharasch, ED | 1 |
| Walker, A | 1 |
| Hoffer, C | 1 |
| Sheffels, P | 1 |
| Bafeltowska, JJ | 1 |
| Buszman, E | 1 |
| Golan, Y | 1 |
| Wolf, MP | 1 |
| Pauker, SG | 1 |
| Wong, JB | 1 |
| Hadley, S | 1 |
| Halliday, C | 1 |
| Hoile, R | 1 |
| Sorrell, T | 1 |
| James, G | 1 |
| Yadav, S | 1 |
| Shaw, P | 1 |
| Bleakley, M | 1 |
| Bradstock, K | 1 |
| Chen, S | 1 |
| Conrado, DJ | 1 |
| Palma, EC | 1 |
| Fraga, CA | 1 |
| Barreiro, EJ | 1 |
| Rates, SM | 1 |
| Dalla Costa, T | 1 |
| Stronati, M | 1 |
| Decembrino, L | 1 |
| Kim, SS | 1 |
| Im, HT | 1 |
| Kang, IM | 1 |
| Lee, HS | 1 |
| Lee, HW | 1 |
| Cho, SH | 1 |
| Kim, JB | 1 |
| Lee, KT | 1 |
| Pazos, C | 1 |
| Moragues, MD | 1 |
| Quindós, G | 1 |
| Pontón, J | 1 |
| del Palacio, A | 1 |
| Chen, H | 1 |
| Suda, KJ | 1 |
| Turpin, RS | 1 |
| Pai, MP | 1 |
| Bearden, DT | 1 |
| Garey, KW | 1 |
| Metwally, L | 1 |
| Hogg, G | 1 |
| Coyle, PV | 1 |
| Hay, RJ | 1 |
| Hedderwick, S | 1 |
| McCloskey, B | 1 |
| O'Neill, HJ | 1 |
| Ong, GM | 1 |
| Thompson, G | 1 |
| Webb, CH | 1 |
| McMullan, R | 1 |
| Matsumoto, FE | 1 |
| Dias, AL | 1 |
| Melhem, MS | 1 |
| Szeszs, MW | 1 |
| Auler, ME | 1 |
| Ruiz, LS | 1 |
| Gonçalves da Silva, E | 1 |
| Gandra, RF | 1 |
| Paula, CR | 1 |
| Benjamin, DK | 1 |
| Barchiesi, F | 2 |
| McGough, DA | 1 |
| Rinaldi, MG | 4 |
| Madu, A | 1 |
| Cioffe, C | 1 |
| Mian, U | 1 |
| Burroughs, M | 1 |
| Tuomanen, E | 1 |
| Mayers, M | 1 |
| Schwartz, E | 1 |
| Miller, M | 1 |
| Sewell, DL | 1 |
| Barry, AL | 1 |
| Spitzer, ED | 1 |
| Spitzer, SG | 1 |
| Freundlich, LF | 1 |
| Casadevall, A | 1 |
| Aoki, Y | 1 |
| Yoshihara, F | 1 |
| Kondoh, M | 1 |
| Nakamura, Y | 1 |
| Nakayama, N | 1 |
| Arisawa, M | 1 |
| Wu, AH | 1 |
| Ostheimer, D | 1 |
| Cremese, M | 1 |
| Forte, E | 1 |
| Hill, D | 1 |
| Galgiani, JN | 1 |
| Peng, T | 1 |
| Lewis, ML | 1 |
| Cloud, GA | 1 |
| Pappagianis, D | 1 |
| Patterson, TF | 2 |
| Revankar, SG | 1 |
| Kirkpatrick, WR | 2 |
| Dib, O | 1 |
| Fothergill, AW | 2 |
| Redding, SW | 2 |
| Sutton, DA | 1 |
| Kretschmar, M | 1 |
| Nichterlein, T | 1 |
| Kuntz, P | 1 |
| Hof, H | 1 |
| Cociglio, M | 1 |
| Brandissou, S | 1 |
| Alric, R | 1 |
| Bressolle, F | 1 |
| Cartledge, JD | 1 |
| Midgley, J | 1 |
| Gazzard, BG | 1 |
| Dannaoui, E | 1 |
| Colin, S | 1 |
| Pichot, J | 1 |
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| Einsele, H | 2 |
| Hebart, H | 2 |
| Roller, G | 1 |
| Löffler, J | 1 |
| Rothenhofer, I | 1 |
| Müller, CA | 1 |
| Bowden, RA | 1 |
| van Burik, J | 1 |
| Engelhard, D | 1 |
| Kanz, L | 1 |
| Schumacher, U | 2 |
| Ramani, R | 1 |
| Ramani, A | 1 |
| Wong, SJ | 1 |
| Di Francesco, LF | 1 |
| Compagnucci, P | 1 |
| Arzeni, D | 1 |
| Cirioni, O | 1 |
| Scalise, G | 1 |
| Turner, TM | 1 |
| McCarthy, DI | 1 |
| Marco, F | 1 |
| Jones, RN | 1 |
| Witthuhn, F | 1 |
| Toubas, D | 1 |
| Béguinot, I | 1 |
| Aubert, D | 1 |
| Rouger, C | 1 |
| Remy, G | 1 |
| Pinon, JM | 1 |
| Burgess, DS | 1 |
| Hastings, RW | 1 |
| Summers, KK | 1 |
| Hardin, TC | 1 |
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| Hagmeyer, L | 1 |
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| Crego, AL | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| PROCAS: Study Observational Prospective and Multicenter to Determine the Clinic Effectiveness and the Safety of Caspofungin Acetate (CANCIDAS®) in the Treatment of Invader Fungal Infection[NCT00388167] | 320 participants (Anticipated) | Observational | 2004-03-31 | Completed | |||
| ANTIVORIFUNGOL:Strategy of Antifungal Use in Oncohematological Neutropenic Patients. Use of Voriconazole as Early Treatment.[NCT00386802] | Phase 4 | 115 participants (Anticipated) | Interventional | 2006-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for fluconazole and Sensitivity and Specificity
| Article | Year |
|---|---|
Evolving role of early antifungals in the adult intensive care unit.
Topics: Adult; Antifungal Agents; Candidiasis; Cross Infection; Female; Fluconazole; Hospital Mortality; Hum | 2009 |
Radiotracers for fungal infection imaging.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Candida albicans; Candidiasis; Chi | 2011 |
Diagnosis and management of central nervous system histoplasmosis.
Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; Amphotericin B; Antifungal Agents; Female; Fluconaz | 2005 |
Neonatal invasive candidiasis.
Topics: Age Factors; Amphotericin B; Antifungal Agents; Candidiasis; Drug Therapy, Combination; Fluconazole; | 2006 |
3 trials available for fluconazole and Sensitivity and Specificity
| Article | Year |
|---|---|
Antifungal therapy decreases sensitivity of the Aspergillus galactomannan enzyme immunoassay.
Topics: Adolescent; Adult; Aged; Antifungal Agents; Aspergillosis; Aspergillus; Child; False Negative Reacti | 2005 |
Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimally invasive and noninvasive probes for hepatic and first-pass CYP3A activity.
Topics: Administration, Oral; Adult; Alfentanil; Analgesics, Opioid; Area Under Curve; Cross-Over Studies; C | 2005 |
Diagnostic potential of (1,3)-beta-D-glucan and anti-Candida albicans germ tube antibodies for the diagnosis and therapeutic monitoring of invasive candidiasis in neutropenic adult patients.
Topics: Adolescent; Adult; Aged; Amphotericin B; Anemia, Aplastic; Antibodies, Fungal; Antibody Specificity; | 2006 |
74 other studies available for fluconazole and Sensitivity and Specificity
| Article | Year |
|---|---|
Small-molecule aggregates inhibit amyloid polymerization.
Topics: Acetophenones; Animals; Benzopyrans; beta-Lactamase Inhibitors; beta-Lactamases; Clioquinol; Congo R | 2008 |
Antifungal resistance of Candida glabrata vaginal isolates and development of a quantitative reverse transcription-PCR-based azole susceptibility assay.
Topics: Antifungal Agents; Azoles; Candida glabrata; Candidiasis, Vulvovaginal; Drug Resistance, Fungal; Fem | 2008 |
Synthesis and bioactivity investigation of quinone-based dimeric cationic triazolium amphiphiles selective against resistant fungal and bacterial pathogens.
Topics: Anti-Bacterial Agents; Antifungal Agents; Azoles; Benzoquinones; Cell Line, Tumor; Drug Design; Drug | 2017 |
Oral fluconazole use in the first trimester and risk of congenital malformations: population based cohort study.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Adult; Antifungal Agents; Candidiasis, Vulvovagin | 2020 |
Quantification of 1,3-β-d-glucan by Wako β-glucan assay for rapid exclusion of invasive fungal infections in critical patients: A diagnostic test accuracy study.
Topics: Aged; Antifungal Agents; beta-Glucans; Caspofungin; Diagnostic Tests, Routine; Female; Fluconazole; | 2020 |
A Triple-Disk Enrichment Method for Carbapenem-Resistant Enterobacteriaceae (CRE) Screening.
Topics: Anti-Bacterial Agents; Bacterial Proteins; beta-Lactam Resistance; beta-Lactams; Carbapenem-Resistan | 2017 |
Is non-response to fluconazole maintenance therapy for recurrent Candida vaginitis related to sensitization to atopic reactions?
Topics: Adult; Candida albicans; Candidiasis, Vulvovaginal; Female; Fluconazole; Humans; Hypersensitivity, I | 2018 |
Evaluation of Candida colonization and use of the Candida Colonization Index in a paediatric Intensive Care Unit: a prospective observational study.
Topics: Adolescent; Amphotericin B; Antifungal Agents; Candida; Candidemia; Caspofungin; Child; Child, Presc | 2019 |
Evaluation of possibilities in identification and susceptibility testing for Candida glabrata clinical isolates with the Integral System Yeast Plus (ISYP).
Topics: Amphotericin B; Antifungal Agents; Candida glabrata; Candidiasis; Fluconazole; Flucytosine; Humans; | 2014 |
Platelet parameters and (1, 3)-β-D-glucan as a diagnostic and prognostic marker of invasive fungal disease in preterm infants.
Topics: beta-Glucans; Biomarkers; Blood Platelets; Case-Control Studies; Female; Fluconazole; Humans; Infant | 2015 |
Candida Surveillance in Surgical Intensive Care Unit (SICU) in a Tertiary Institution.
Topics: Adult; Aged; Aged, 80 and over; Amphotericin B; Anidulafungin; Antifungal Agents; beta-Glucans; Cand | 2015 |
Fungistatic effects of optical brightener 220 against Trichophyton tonsurans, Aspergillus fumigatus and Candida albicans.
Topics: Antifungal Agents; Aspergillus fumigatus; Candida albicans; Cells, Cultured; Culture Media; Fibrobla | 2009 |
Reliability of the Vitek 2 yeast susceptibility test for detection of in vitro resistance to fluconazole and voriconazole in clinical isolates of Candida albicans and Candida glabrata.
Topics: Antifungal Agents; Candida albicans; Candida glabrata; Candidiasis; Drug Resistance, Fungal; Flucona | 2009 |
Direct antifungal susceptibility testing of positive Candida blood cultures by sensititre YeastOne.
Topics: Amphotericin B; Antifungal Agents; Candida; Candidiasis; Drug Resistance, Fungal; Fluconazole; Flucy | 2009 |
Comparison of results of fluconazole and voriconazole disk diffusion testing for Candida spp. with results from a central reference laboratory in the ARTEMIS DISK Global Antifungal Surveillance Program.
Topics: Antifungal Agents; Candida; Diagnostic Errors; Fluconazole; Humans; Microbial Sensitivity Tests; Pyr | 2009 |
Rapid detection of ERG11 gene mutations in clinical Candida albicans isolates with reduced susceptibility to fluconazole by rolling circle amplification and DNA sequencing.
Topics: Amino Acid Substitution; Antifungal Agents; Base Sequence; Candida albicans; DNA Mutational Analysis | 2009 |
Economic evaluation of posaconazole vs fluconazole in the prevention of invasive fungal infections in patients with GVHD following haematopoietic SCT.
Topics: Antifungal Agents; Cost-Benefit Analysis; Fluconazole; Graft vs Host Disease; Hematopoietic Stem Cel | 2010 |
Comparison of the Vitek 2 system with the CLSI broth microdilution, disk diffusion, and sterol quantitation methods for determining fluconazole susceptibility against Candida spp.
Topics: Antifungal Agents; Candida; Candidiasis; Disk Diffusion Antimicrobial Tests; Fluconazole; Microbial | 2010 |
Species level identification and antifungal susceptibility of yeasts isolated from various clinical specimens and evaluation of Integral System Yeasts Plus.
Topics: Amphotericin B; Candida; Colorimetry; Drug Resistance, Multiple, Fungal; Fluconazole; Flucytosine; H | 2012 |
Fluconazole susceptibility of Candida species in Singapore by disc diffusion test.
Topics: Antifungal Agents; Candida; Candidiasis; Colony Count, Microbial; Dose-Response Relationship, Drug; | 2002 |
Characterization of quinidine 3-hydroxylation as a probe for the CYP 3A enzyme using a novel capillary electrophoresis technique.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biomarkers; Cytochrome P-450 CYP3A; Electrophoresis, Capilla | 2002 |
Frequency and clinical significance of bloodstream infections caused by C albicans strains with reduced susceptibility to fluconazole.
Topics: Antifungal Agents; Candidiasis; Drug Resistance, Microbial; Female; Fluconazole; Follow-Up Studies; | 2002 |
On-line determination of fluconazole in blood and dermal rat microdialysates by microbore high-performance liquid chromatography.
Topics: Animals; Antifungal Agents; Chromatography, High Pressure Liquid; Fluconazole; Male; Microdialysis; | 2003 |
Liquid/liquid extraction using 96-well plate format in conjunction with hydrophilic interaction liquid chromatography-tandem mass spectrometry method for the analysis of fluconazole in human plasma.
Topics: Calibration; Chromatography, Liquid; Cytochrome P-450 Enzyme Inhibitors; Fluconazole; Humans; Mass S | 2003 |
Shifting patterns in the epidemiology of nosocomial Candida infections.
Topics: Antifungal Agents; Candida glabrata; Candidiasis; Cross Infection; Fluconazole; Humans; Incidence; S | 2003 |
Combined action of fluconazole and PMNs from uremic patients in clearing intracellular Candida albicans.
Topics: Adult; Aged; Analysis of Variance; Candida albicans; Candidiasis; Case-Control Studies; Chemotaxis, | 2003 |
A comparison of accurate mass techniques for the structural elucidation of fluconazole.
Topics: Fluconazole; Mass Spectrometry; Molecular Structure; Molecular Weight; Quality Control; Reproducibil | 2003 |
Distribution and antifungal susceptibility of Candida species causing candidemia from 1996 to 1999.
Topics: Amphotericin B; Candida; Candidiasis; Drug Resistance, Fungal; Fluconazole; Fungemia; Humans; Microb | 2004 |
Is there any relationship between fluconazole resistance and some virulence factors in Candida albicans strains?
Topics: Antifungal Agents; Candida albicans; Candidiasis; Drug Resistance, Fungal; Fluconazole; Humans; Micr | 2003 |
In vitro activities of voriconazole, posaconazole, and fluconazole against 4,169 clinical isolates of Candida spp. and Cryptococcus neoformans collected during 2001 and 2002 in the ARTEMIS global antifungal surveillance program.
Topics: Candida; Cryptococcus neoformans; Drug Resistance, Fungal; Fluconazole; Global Health; Humans; Micro | 2004 |
A new, rapid, fully automated method for determination of fluconazole in serum by column-switching liquid chromatography.
Topics: Antifungal Agents; Autoanalysis; Chromatography, High Pressure Liquid; Fluconazole; Humans; Hydrogen | 2004 |
Evaluation of fluconazole resistance mechanisms in candida albicans clinical isolates from HIV-infected patients in Brazil.
Topics: Adult; AIDS-Related Opportunistic Infections; Antifungal Agents; Base Sequence; Brazil; Candida albi | 2004 |
Utility of real-time antifungal susceptibility testing for fluconazole in the treatment of candidemia.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Bacteriological Techniques; Candid | 2004 |
Rapid flow-cytometric susceptibility testing of Candida species.
Topics: Antifungal Agents; Candida; Candidiasis; Echinocandins; Flow Cytometry; Fluconazole; Fungal Proteins | 2005 |
Activated lactoferrin and fluconazole synergism against Candida albicans and Candida glabrata vaginal isolates.
Topics: Analysis of Variance; Antifungal Agents; Candida albicans; Candida glabrata; Drug Interactions; Fema | 2004 |
The combination effects of phenolic compounds and fluconazole on the formation of ergosterol in Candida albicans determined by high-performance liquid chromatography/tandem mass spectrometry.
Topics: Caffeic Acids; Candida albicans; Chromatography, High Pressure Liquid; Ergosterol; Fluconazole; Lano | 2005 |
Simple means to alleviate sensitivity loss by trifluoroacetic acid (TFA) mobile phases in the hydrophilic interaction chromatography-electrospray tandem mass spectrometric (HILIC-ESI/MS/MS) bioanalysis of basic compounds.
Topics: Acetic Acid; Chromatography, Liquid; Cotinine; Ethionamide; Fluconazole; Humans; Isoniazid; Nicotine | 2005 |
Pharmacokinetics of fluconazole in the cerebrospinal fluid of children with hydrocephalus.
Topics: Adolescent; Antifungal Agents; Chromatography, High Pressure Liquid; Drug Monitoring; Encephalitis; | 2005 |
Empirical anti-Candida therapy among selected patients in the intensive care unit: a cost-effectiveness analysis.
Topics: Amphotericin B; Anti-Bacterial Agents; Antifungal Agents; Candidiasis; Caspofungin; Cost-Benefit Ana | 2005 |
Role of prospective screening of blood for invasive aspergillosis by polymerase chain reaction in febrile neutropenic recipients of haematopoietic stem cell transplants and patients with acute leukaemia.
Topics: Acute Disease; Adolescent; Adult; Antifungal Agents; Aspergillosis; Aspergillus; DNA, Fungal; Female | 2006 |
Development and validation of a LC-MS/MS method with electrospray ionization for determination of LASSBio-579 in rat plasma.
Topics: Animals; Antipsychotic Agents; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; F | 2007 |
An optimized analytical method of fluconazole in human plasma by high-performance liquid chromatography with ultraviolet detection and its application to a bioequivalence study.
Topics: Adult; Antifungal Agents; Chromatography, High Pressure Liquid; Fluconazole; Humans; Male; Reference | 2007 |
High- versus low-dose fluconazole therapy for empiric treatment of suspected invasive candidiasis among high-risk patients in the intensive care unit: a cost-effectiveness analysis.
Topics: Adult; Aged; Aged, 80 and over; Antifungal Agents; Candidiasis; Cost-Benefit Analysis; Dose-Response | 2007 |
Rapid differentiation between fluconazole-sensitive and -resistant species of Candida directly from positive blood-culture bottles by real-time PCR.
Topics: Antifungal Agents; Blood; Candida; Candida albicans; Culture Media; DNA, Fungal; Drug Resistance, Fu | 2007 |
Antifungal susceptibility of bloodstream yeasts isolated at a public children's hospital in Brazil: comparison of the Etest and the AFST-EUCAST microdilution method.
Topics: Amphotericin B; Antifungal Agents; Blood; Brazil; Candida; Child; Child, Preschool; Fluconazole; Flu | 2007 |
First, do no harm.
Topics: Antifungal Agents; Candidiasis; Developmental Disabilities; Female; Fluconazole; Humans; Incidence; | 2008 |
Comparison of Etest and National Committee for Clinical Laboratory Standards broth macrodilution method for azole antifungal susceptibility testing.
Topics: Antifungal Agents; Candida; Cryptococcus neoformans; Double-Blind Method; Fluconazole; Itraconazole; | 1995 |
Pharmacokinetics of fluconazole in cerebrospinal fluid and serum of rabbits: validation of an animal model used to measure drug concentrations in cerebrospinal fluid.
Topics: Animals; Chromatography, High Pressure Liquid; Cisterna Magna; Erythrocyte Count; Fluconazole; Injec | 1994 |
Comparison of broth macrodilution, broth microdilution, and E test antifungal susceptibility tests for fluconazole.
Topics: Candida; Candidiasis; Culture Media; Evaluation Studies as Topic; Fluconazole; Humans; Indicator Dil | 1994 |
Persistence of initial infection in recurrent Cryptococcus neoformans meningitis.
Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; Blotting, Southern; Cerebrospinal Fluid; Diagnosis, | 1993 |
Ro 09-1470 is a selective inhibitor of P-450 lanosterol C-14 demethylase of fungi.
Topics: Animals; Antifungal Agents; Carbon Monoxide; Cholesterol; Cytochrome P-450 Enzyme Inhibitors; Cytoch | 1993 |
Characterization of drug interferences caused by coelution of substances in gas chromatography/mass spectrometry confirmation of targeted drugs in full-scan and selected-ion monitoring modes.
Topics: Cocaine; Fluconazole; Gas Chromatography-Mass Spectrometry; Humans; Immunoassay; Quality Control; Se | 1994 |
Cerebrospinal fluid antibodies detected by ELISA against a 33-kDa antigen from spherules of Coccidioides immitis in patients with coccidioidal meningitis. The National Institute of Allergy and Infectious Diseases Mycoses Study Group.
Topics: Antibodies, Fungal; Antifungal Agents; Antigens, Fungal; Coccidioides; Coccidioidomycosis; Complemen | 1996 |
Simple method for detecting fluconazole-resistant yeasts with chromogenic agar.
Topics: Agar; Antifungal Agents; Candida; Candida albicans; Candidiasis, Oral; Chromogenic Compounds; Cultur | 1996 |
Rapid detection of susceptibility to fluconazole in Candida species by a bioluminescence assay of intracellular ATP.
Topics: Adenosine Triphosphate; Antifungal Agents; Bacteria; Bacteriological Techniques; Candida; Candidiasi | 1996 |
High-performance liquid chromatographic determination of fluconazole in plasma.
Topics: Analysis of Variance; Antifungal Agents; Calibration; Chromatography, High Pressure Liquid; Fluconaz | 1996 |
Itraconazole cyclodextrin solution: the role of in vitro susceptibility testing in predicting successful treatment of HIV-related fluconazole-resistant and fluconazole-susceptible oral candidosis.
Topics: Antifungal Agents; Candida; Candidiasis, Oral; CD4 Lymphocyte Count; Drug Resistance, Microbial; Flu | 1997 |
Evaluation of the E test for fluconazole susceptibility testing of Candida albicans isolates from oropharyngeal candidiasis.
Topics: Amphotericin B; Antifungal Agents; Candida albicans; Candidiasis, Oral; CD4 Lymphocyte Count; Flucon | 1997 |
Detection and identification of fungal pathogens in blood by using molecular probes.
Topics: Amphotericin B; Antifungal Agents; Aspergillosis; Aspergillus; Candida; Candidiasis; DNA, Fungal; Fl | 1997 |
Rapid flow cytometric susceptibility testing of Candida albicans.
Topics: Amphotericin B; Antifungal Agents; Candida albicans; Cell Membrane Permeability; Flow Cytometry; Flu | 1997 |
Genotypic identification of sequential Candida albicans isolates from AIDS patients by polymerase chain reaction techniques.
Topics: AIDS-Related Opportunistic Infections; Antifungal Agents; Base Sequence; Candida albicans; Candidias | 1997 |
Fluconazole disk diffusion susceptibility testing of Candida species.
Topics: AIDS-Related Opportunistic Infections; Antifungal Agents; Candida; Candida albicans; Candidiasis; Dr | 1998 |
Activity of MK-0991 (L-743,872), a new echinocandin, compared with those of LY303366 and four other antifungal agents tested against blood stream isolates of Candida spp.
Topics: Amphotericin B; Anidulafungin; Anti-Bacterial Agents; Antifungal Agents; Blood; Candida; Caspofungin | 1998 |
Evaluation of the fungitest kit by using strains from human immunodeficiency virus-infected patients: study of azole drug susceptibility.
Topics: AIDS-Related Opportunistic Infections; Antifungal Agents; Candida; Candida albicans; Candidiasis; Fl | 1999 |
Pharmacodynamics of fluconazole, itraconazole, and amphotericin B against Candida albicans.
Topics: Amphotericin B; Antifungal Agents; Candida albicans; Colony Count, Microbial; Fluconazole; Humans; I | 2000 |
Rapid detection of point mutations by fluorescence resonance energy transfer and probe melting curves in Candida species.
Topics: Acquired Immunodeficiency Syndrome; Antifungal Agents; Candida; DNA, Fungal; Electrophoresis, Agar G | 2000 |
Abnormal cryptococcal serology in an asymptomatic patient.
Topics: Adult; AIDS-Related Opportunistic Infections; Antigens, Fungal; CD4 Lymphocyte Count; Cryptococcosis | 1995 |
Application of capillary zone electrophoresis with off-line solid-phase extraction to in vitro metabolism studies of antifungals.
Topics: Acetic Acid; Acetonitriles; Antifungal Agents; Clotrimazole; Drug Stability; Electrophoresis, Capill | 2001 |
Effect of fluconazole prophylaxis on fungal blood cultures: an autopsy-based study involving 720 patients with haematological malignancy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antifungal Agents; Aspergillosis; Autopsy; Candidiasis; | 2002 |
Technetium-99m labelled fluconazole and antimicrobial peptides for imaging of Candida albicans and Aspergillus fumigatus infections.
Topics: Animals; Aspergillosis; Aspergillus fumigatus; Candidiasis; Diagnosis, Differential; Fluconazole; Hu | 2002 |
Comparison of NCCLS microdilution method and Etest in antifungal susceptibility testing of clinical Trichosporon asahii isolates.
Topics: Amphotericin B; Antifungal Agents; Culture Media; Drug Resistance, Fungal; Fluconazole; Humans; Itra | 2002 |
Use of the sensititre colorimetric microdilution panel for antifungal susceptibility testing of dermatophytes.
Topics: Amphotericin B; Antifungal Agents; Arthrodermataceae; Colorimetry; Coloring Agents; Dermatomycoses; | 2002 |
Determination of fluconazole in human serum by solid-phase extraction and reversed-phase high-performance liquid chromatography.
Topics: Administration, Oral; Adult; Chemistry Techniques, Analytical; Chromatography, High Pressure Liquid; | 1992 |
Gas chromatographic analysis, with electron capture detection, of the antifungal drug fluconazole in microvolumes of human plasma.
Topics: Chromatography, Gas; Electrons; Fluconazole; HIV Infections; Humans; Molecular Structure; Reproducib | 1991 |