Page last updated: 2024-11-13
retigeric acid b
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
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Protein Interactions
Research Growth
Market Indicators
Description
retigeric acid B: from a lichen, Lobaria kurokawae Yoshim; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
ID Source | ID |
---|---|
PubMed CID | 53319374 |
CHEMBL ID | 1629725 |
MeSH ID | M0535649 |
Synonyms (15)
Synonym |
---|
retigeric acid b |
CHEMBL1629725 |
38327-77-4 |
Q15424781 |
DTXSID001336062 |
(2.alpha.,3.beta.,4.alpha.,8.alpha.,13.alpha.,14.beta.,17.alpha.,18.beta.)-2,3-dihydroxy-13,17-dimethyl-a-neo-26,28-dinorgammacer-9(11)-ene-23,25-dioic acid |
(3r,3ar,5ar,5br,7ar,8s,9r,10r,11ar,13as,13br)-9,10-dihydroxy-3a,5a,8,13a-tetramethyl-3-(propan-2-yl)-1,2,3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,13,13a,13b-octadecahydro-11ah-cyclopenta[a]chrysene-8,11a-dicarboxylic acid |
a-neo-26,28-dinorgammacer-9(11)-ene-23,25-dioic acid, 2,3-dihydroxy-13,17-dimethyl-, (2.alpha.,3.beta.,4.alpha.,8.alpha.,13.alpha.,14.beta.,17.alpha.,18.beta.)- |
d:c-friedo-b:a-neogammacer-9(11)-ene-23,25-dioic acid, 2,3-dihydroxy-, (2.alpha.,3.beta.,4.alpha.)- |
unii-5m66ara2br |
5m66ara2br , |
a-neo-26,28-dinorgammacer-9(11)-ene-23,25-dioic acid, 2,3-dihydroxy-13,17-dimethyl-, (2alpha,3beta,4alpha,8alpha,13alpha,14beta,17alpha,18beta)- |
d:c-friedo-b:a-neogammacer-9(11)-ene-23,25-dioic acid, 2,3-dihydroxy-, (2alpha,3beta,4alpha)- |
(3r,3ar,5ar,5br,7ar,8s,9r,10r,11ar,13as,13br)-9,10-dihydroxy-3a,5a,8,13a-tetramethyl-3-(propan-2-yl)-1,2,3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,13,13a,13b-octadecahydro-11ah-cyclopenta(a)chrysene-8,11a-dicarboxylic acid |
(2alpha,3beta,4alpha,8alpha,13alpha,14beta,17alpha,18beta)-2,3-dihydroxy-13,17-dimethyl-a-neo-26,28-dinorgammacer-9(11)-ene-23,25-dioic acid |
Research Excerpts
Effects
Excerpt | Reference | Relevance |
---|---|---|
"Retigeric acid B (RB) has been reported to exhibit its anti-tumor activity in vitro and in vivo. " | ( Induction of DNA damage and ATF3 by retigeric acid B, a novel topoisomerase II inhibitor, promotes apoptosis in prostate cancer cells. Bi, Y; Gao, F; Jiang, H; Liu, Y; Lou, H; Niu, L; Young, CY; Yuan, H, 2013) | 2.11 |
Compound-Compound Interactions
Excerpt | Reference | Relevance |
---|---|---|
"The vitro antifungal activity of retigeric acid B (RAB), a pentacyclic triterpenoid from the lichen species Lobaria kurokawae, was evaluated alone and in combination with fluconazole, ketoconazole, and itraconazole against Candida albicans using checkerboard microdilution and time-killing tests." | ( In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. Cheng, A; Lou, H; Sun, L; Sun, S; Wu, X; Zhang, Y, 2009) | 0.94 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (46)
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID549046 | Antifungal activity against Candida albicans CA3 after 48 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549045 | Antifungal activity against Candida albicans CA2 after 48 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549290 | Antifungal activity against Candida albicans CA135 after 48 hrs by broth microdilution method in presence of ketoconazole | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549287 | Antifungal activity against Candida albicans CA127 after 48 hrs by broth microdilution method in presence of ketoconazole | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549308 | Antifungal activity against Candida albicans CA10 assessed as cell viability after 2 hrs by XTT reduction assay in presence of itraconazole | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549064 | Antifungal activity against Candida albicans CA1 after 48 hrs by broth microdilution method in presence of ketoconazole | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549288 | Antifungal activity against Candida albicans CA132 after 48 hrs by broth microdilution method in presence of ketoconazole | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549292 | Antifungal activity against Candida albicans CA138 after 48 hrs by broth microdilution method in presence of ketoconazole | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549296 | Antifungal activity against Candida albicans CA4 after 48 hrs by broth microdilution method in presence of itraconazole | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549291 | Antifungal activity against Candida albicans CA137 after 48 hrs by broth microdilution method in presence of ketoconazole | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549063 | Antifungal activity against Candida albicans CA138 after 48 hrs by broth microdilution method in presence of fluconazole | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549056 | Antifungal activity against Candida albicans CA3 after 48 hrs by broth microdilution method in presence of fluconazole | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549306 | Antifungal activity against Candida albicans CA10 assessed as cell viability after 2 hrs by XTT reduction assay in presence of fluconazole | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549303 | Antifungal activity against Candida albicans CA10 assessed as log reduction in fungal burden at 8 ug/ml after 48 hrs by time kill analysis in presence of fluconazole | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549301 | Antifungal activity against Candida albicans CA137 after 48 hrs by broth microdilution method in presence of itraconazole | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549060 | Antifungal activity against Candida albicans CA10 after 48 hrs by broth microdilution method in presence of fluconazole | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549051 | Antifungal activity against Candida albicans CA135 after 48 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549304 | Antifungal activity against Candida albicans CA10 assessed as log reduction in fungal burden at 8 ug/ml after 48 hrs by time kill analysis in presence of ketoconazole | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549066 | Antifungal activity against Candida albicans CA3 after 48 hrs by broth microdilution method in presence of ketoconazole | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549298 | Antifungal activity against Candida albicans CA132 after 48 hrs by broth microdilution method in presence of itraconazole | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549062 | Antifungal activity against Candida albicans CA137 after 48 hrs by broth microdilution method in presence of fluconazole | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549049 | Antifungal activity against Candida albicans CA132 after 48 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549293 | Antifungal activity against Candida albicans CA1 after 48 hrs by broth microdilution method in presence of itraconazole | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549058 | Antifungal activity against Candida albicans CA127 after 48 hrs by broth microdilution method in presence of fluconazole | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549059 | Antifungal activity against Candida albicans CA132 after 48 hrs by broth microdilution method in presence of fluconazole | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549052 | Antifungal activity against Candida albicans CA137 after 48 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549305 | Antifungal activity against Candida albicans CA10 assessed as log reduction in fungal burden at 8 ug/ml after 48 hrs by time kill analysis in presence of itraconazole | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549295 | Antifungal activity against Candida albicans CA3 after 48 hrs by broth microdilution method in presence of itraconazole | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549047 | Antifungal activity against Candida albicans CA4 after 48 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549048 | Antifungal activity against Candida albicans CA127 after 48 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549307 | Antifungal activity against Candida albicans CA10 assessed as cell viability after 2 hrs by XTT reduction assay in presence of ketoconazole | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549294 | Antifungal activity against Candida albicans CA2 after 48 hrs by broth microdilution method in presence of itraconazole | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549061 | Antifungal activity against Candida albicans CA135 after 48 hrs by broth microdilution method in presence of fluconazole | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549057 | Antifungal activity against Candida albicans CA4 after 48 hrs by broth microdilution method in presence of fluconazole | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549050 | Antifungal activity against Candida albicans CA10 after 48 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549300 | Antifungal activity against Candida albicans CA135 after 48 hrs by broth microdilution method in presence of itraconazole | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549054 | Antifungal activity against Candida albicans CA1 after 48 hrs by broth microdilution method in presence of fluconazole | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549055 | Antifungal activity against Candida albicans CA2 after 48 hrs by broth microdilution method in presence of fluconazole | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549289 | Antifungal activity against Candida albicans CA10 after 48 hrs by broth microdilution method in presence of ketoconazole | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549053 | Antifungal activity against Candida albicans CA138 after 48 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549065 | Antifungal activity against Candida albicans CA2 after 48 hrs by broth microdilution method in presence of ketoconazole | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549067 | Antifungal activity against Candida albicans CA4 after 48 hrs by broth microdilution method in presence of ketoconazole | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549297 | Antifungal activity against Candida albicans CA127 after 48 hrs by broth microdilution method in presence of itraconazole | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549299 | Antifungal activity against Candida albicans CA10 after 48 hrs by broth microdilution method in presence of itraconazole | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549044 | Antifungal activity against Candida albicans CA1 after 48 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
AID549302 | Antifungal activity against Candida albicans CA138 after 48 hrs by broth microdilution method in presence of itraconazole | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (10)
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (10.00) | 29.6817 |
2010's | 9 (90.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.40
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.40) All Compounds (24.57) |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 10 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |