Compounds > retigeric acid b
Page last updated: 2024-11-13

retigeric acid b

Description

retigeric acid B: from a lichen, Lobaria kurokawae Yoshim; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID53319374
CHEMBL ID1629725
MeSH IDM0535649

Synonyms (15)

Synonym
retigeric acid b
CHEMBL1629725
38327-77-4
Q15424781
DTXSID001336062
(2.alpha.,3.beta.,4.alpha.,8.alpha.,13.alpha.,14.beta.,17.alpha.,18.beta.)-2,3-dihydroxy-13,17-dimethyl-a-neo-26,28-dinorgammacer-9(11)-ene-23,25-dioic acid
(3r,3ar,5ar,5br,7ar,8s,9r,10r,11ar,13as,13br)-9,10-dihydroxy-3a,5a,8,13a-tetramethyl-3-(propan-2-yl)-1,2,3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,13,13a,13b-octadecahydro-11ah-cyclopenta[a]chrysene-8,11a-dicarboxylic acid
a-neo-26,28-dinorgammacer-9(11)-ene-23,25-dioic acid, 2,3-dihydroxy-13,17-dimethyl-, (2.alpha.,3.beta.,4.alpha.,8.alpha.,13.alpha.,14.beta.,17.alpha.,18.beta.)-
d:c-friedo-b:a-neogammacer-9(11)-ene-23,25-dioic acid, 2,3-dihydroxy-, (2.alpha.,3.beta.,4.alpha.)-
unii-5m66ara2br
5m66ara2br ,
a-neo-26,28-dinorgammacer-9(11)-ene-23,25-dioic acid, 2,3-dihydroxy-13,17-dimethyl-, (2alpha,3beta,4alpha,8alpha,13alpha,14beta,17alpha,18beta)-
d:c-friedo-b:a-neogammacer-9(11)-ene-23,25-dioic acid, 2,3-dihydroxy-, (2alpha,3beta,4alpha)-
(3r,3ar,5ar,5br,7ar,8s,9r,10r,11ar,13as,13br)-9,10-dihydroxy-3a,5a,8,13a-tetramethyl-3-(propan-2-yl)-1,2,3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,13,13a,13b-octadecahydro-11ah-cyclopenta(a)chrysene-8,11a-dicarboxylic acid
(2alpha,3beta,4alpha,8alpha,13alpha,14beta,17alpha,18beta)-2,3-dihydroxy-13,17-dimethyl-a-neo-26,28-dinorgammacer-9(11)-ene-23,25-dioic acid

Research Excerpts

Effects

ExcerptReferenceRelevance
"Retigeric acid B (RB) has been reported to exhibit its anti-tumor activity in vitro and in vivo. "( Induction of DNA damage and ATF3 by retigeric acid B, a novel topoisomerase II inhibitor, promotes apoptosis in prostate cancer cells.
Bi, Y; Gao, F; Jiang, H; Liu, Y; Lou, H; Niu, L; Young, CY; Yuan, H, 2013)		2.11

Compound-Compound Interactions

ExcerptReferenceRelevance
"The vitro antifungal activity of retigeric acid B (RAB), a pentacyclic triterpenoid from the lichen species Lobaria kurokawae, was evaluated alone and in combination with fluconazole, ketoconazole, and itraconazole against Candida albicans using checkerboard microdilution and time-killing tests."( In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
Cheng, A; Lou, H; Sun, L; Sun, S; Wu, X; Zhang, Y, 2009)		0.94
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (46)

Assay IDTitleYearJournalArticle
AID549046Antifungal activity against Candida albicans CA3 after 48 hrs by broth microdilution method2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549045Antifungal activity against Candida albicans CA2 after 48 hrs by broth microdilution method2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549290Antifungal activity against Candida albicans CA135 after 48 hrs by broth microdilution method in presence of ketoconazole2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549287Antifungal activity against Candida albicans CA127 after 48 hrs by broth microdilution method in presence of ketoconazole2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549308Antifungal activity against Candida albicans CA10 assessed as cell viability after 2 hrs by XTT reduction assay in presence of itraconazole2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549064Antifungal activity against Candida albicans CA1 after 48 hrs by broth microdilution method in presence of ketoconazole2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549288Antifungal activity against Candida albicans CA132 after 48 hrs by broth microdilution method in presence of ketoconazole2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549292Antifungal activity against Candida albicans CA138 after 48 hrs by broth microdilution method in presence of ketoconazole2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549296Antifungal activity against Candida albicans CA4 after 48 hrs by broth microdilution method in presence of itraconazole2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549291Antifungal activity against Candida albicans CA137 after 48 hrs by broth microdilution method in presence of ketoconazole2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549063Antifungal activity against Candida albicans CA138 after 48 hrs by broth microdilution method in presence of fluconazole2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549056Antifungal activity against Candida albicans CA3 after 48 hrs by broth microdilution method in presence of fluconazole2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549306Antifungal activity against Candida albicans CA10 assessed as cell viability after 2 hrs by XTT reduction assay in presence of fluconazole2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549303Antifungal activity against Candida albicans CA10 assessed as log reduction in fungal burden at 8 ug/ml after 48 hrs by time kill analysis in presence of fluconazole2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549301Antifungal activity against Candida albicans CA137 after 48 hrs by broth microdilution method in presence of itraconazole2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549060Antifungal activity against Candida albicans CA10 after 48 hrs by broth microdilution method in presence of fluconazole2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549051Antifungal activity against Candida albicans CA135 after 48 hrs by broth microdilution method2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549304Antifungal activity against Candida albicans CA10 assessed as log reduction in fungal burden at 8 ug/ml after 48 hrs by time kill analysis in presence of ketoconazole2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549066Antifungal activity against Candida albicans CA3 after 48 hrs by broth microdilution method in presence of ketoconazole2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549298Antifungal activity against Candida albicans CA132 after 48 hrs by broth microdilution method in presence of itraconazole2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549062Antifungal activity against Candida albicans CA137 after 48 hrs by broth microdilution method in presence of fluconazole2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549049Antifungal activity against Candida albicans CA132 after 48 hrs by broth microdilution method2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549293Antifungal activity against Candida albicans CA1 after 48 hrs by broth microdilution method in presence of itraconazole2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549058Antifungal activity against Candida albicans CA127 after 48 hrs by broth microdilution method in presence of fluconazole2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549059Antifungal activity against Candida albicans CA132 after 48 hrs by broth microdilution method in presence of fluconazole2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549052Antifungal activity against Candida albicans CA137 after 48 hrs by broth microdilution method2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549305Antifungal activity against Candida albicans CA10 assessed as log reduction in fungal burden at 8 ug/ml after 48 hrs by time kill analysis in presence of itraconazole2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549295Antifungal activity against Candida albicans CA3 after 48 hrs by broth microdilution method in presence of itraconazole2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549047Antifungal activity against Candida albicans CA4 after 48 hrs by broth microdilution method2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549048Antifungal activity against Candida albicans CA127 after 48 hrs by broth microdilution method2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549307Antifungal activity against Candida albicans CA10 assessed as cell viability after 2 hrs by XTT reduction assay in presence of ketoconazole2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549294Antifungal activity against Candida albicans CA2 after 48 hrs by broth microdilution method in presence of itraconazole2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549061Antifungal activity against Candida albicans CA135 after 48 hrs by broth microdilution method in presence of fluconazole2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549057Antifungal activity against Candida albicans CA4 after 48 hrs by broth microdilution method in presence of fluconazole2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549050Antifungal activity against Candida albicans CA10 after 48 hrs by broth microdilution method2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549300Antifungal activity against Candida albicans CA135 after 48 hrs by broth microdilution method in presence of itraconazole2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549054Antifungal activity against Candida albicans CA1 after 48 hrs by broth microdilution method in presence of fluconazole2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549055Antifungal activity against Candida albicans CA2 after 48 hrs by broth microdilution method in presence of fluconazole2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549289Antifungal activity against Candida albicans CA10 after 48 hrs by broth microdilution method in presence of ketoconazole2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549053Antifungal activity against Candida albicans CA138 after 48 hrs by broth microdilution method2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549065Antifungal activity against Candida albicans CA2 after 48 hrs by broth microdilution method in presence of ketoconazole2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549067Antifungal activity against Candida albicans CA4 after 48 hrs by broth microdilution method in presence of ketoconazole2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549297Antifungal activity against Candida albicans CA127 after 48 hrs by broth microdilution method in presence of itraconazole2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549299Antifungal activity against Candida albicans CA10 after 48 hrs by broth microdilution method in presence of itraconazole2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549044Antifungal activity against Candida albicans CA1 after 48 hrs by broth microdilution method2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549302Antifungal activity against Candida albicans CA138 after 48 hrs by broth microdilution method in presence of itraconazole2009Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (10.00)29.6817
2010's9 (90.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.40

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.40 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.80 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.40)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
fluconazole
Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.. fluconazole : A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.		2.4620conazole antifungal drug;
difluorobenzene;
tertiary alcohol;
triazole antifungal drug		environmental contaminant;
P450 inhibitor;
xenobiotic
itraconazole
[no description available]		2.0510piperazines
ketoconazole
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.		2.4620dichlorobenzene;
dioxolane;
ether;
imidazoles;
N-acylpiperazine;
N-arylpiperazine
itraconazole
Itraconazole: A triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.. itraconazole : An N-arylpiperazine that is cis-ketoconazole in which the imidazol-1-yl group is replaced by a 1,2,4-triazol-1-yl group and in which the actyl group attached to the piperazine moiety is replaced by a p-[(+-)1-sec-butyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]phenyl group. A potent P-glycoprotein and CYP3A4 inhibitor, it is used as an antifungal drug for the treatment of various fungal infections, including aspergillosis, blastomycosis, candidiasis, chromoblastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, and sporotrichosis.		2.4620aromatic ether;
conazole antifungal drug;
cyclic ketal;
dichlorobenzene;
dioxolane;
N-arylpiperazine;
triazole antifungal drug;
triazoles		EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor;
Hedgehog signaling pathway inhibitor;
P450 inhibitor
ergosterol
[no description available]		2.51203beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
ergostanoid;
phytosterols		fungal metabolite;
Saccharomyces cerevisiae metabolite
farnesol
Farnesol: A colorless liquid extracted from oils of plants such as citronella, neroli, cyclamen, and tuberose. It is an intermediate step in the biological synthesis of cholesterol from mevalonic acid in vertebrates. It has a delicate odor and is used in perfumery. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed). (2-trans,6-trans)-farnesol : The (2-trans,6-trans)-stereoisomer of farnesol.. farnesol : A farnesane sesquiterpenoid that is dodeca-2,6,10-triene substituted by methyl groups at positions 3, 7 and 11 and a hydroxy group at position 1.		7.0710farnesolplant metabolite
stilbenes
Stilbenes: Organic compounds that contain 1,2-diphenylethylene as a functional group.. trans-stilbene : The trans-isomer of stilbene.		2.2110stilbene
riccardin d
riccardin D: antifungal agent isolated from Dumortiera hirsute; structure in first source		2.2110
bucladesine
Bucladesine: A cyclic nucleotide derivative that mimics the action of endogenous CYCLIC AMP and is capable of permeating the cell membrane. It has vasodilator properties and is used as a cardiac stimulant. (From Merck Index, 11th ed). bucladesine : A 3',5'-cyclic purine nucleotide that is the 2'-butanoate ester and 6-N-butanoyl derivative of 3',5'-cyclic AMP.		2.06103',5'-cyclic purine nucleotide
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Prostate
[description not available]		02.9940
Prostatic Neoplasms
Tumors or cancer of the PROSTATE.		02.9940
Candida Infection
[description not available]		02.0710
Candidiasis
Infection with a fungus of the genus CANDIDA. It is usually a superficial infection of the moist areas of the body and is generally caused by CANDIDA ALBICANS. (Dorland, 27th ed)		02.0710
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