retigeric acid b profile

retigeric acid B: from a lichen, Lobaria kurokawae Yoshim; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	53319374
CHEMBL ID	1629725
MeSH ID	M0535649

Synonym
retigeric acid b
CHEMBL1629725
38327-77-4
Q15424781
DTXSID001336062
(2.alpha.,3.beta.,4.alpha.,8.alpha.,13.alpha.,14.beta.,17.alpha.,18.beta.)-2,3-dihydroxy-13,17-dimethyl-a-neo-26,28-dinorgammacer-9(11)-ene-23,25-dioic acid
(3r,3ar,5ar,5br,7ar,8s,9r,10r,11ar,13as,13br)-9,10-dihydroxy-3a,5a,8,13a-tetramethyl-3-(propan-2-yl)-1,2,3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,13,13a,13b-octadecahydro-11ah-cyclopenta[a]chrysene-8,11a-dicarboxylic acid
a-neo-26,28-dinorgammacer-9(11)-ene-23,25-dioic acid, 2,3-dihydroxy-13,17-dimethyl-, (2.alpha.,3.beta.,4.alpha.,8.alpha.,13.alpha.,14.beta.,17.alpha.,18.beta.)-
d:c-friedo-b:a-neogammacer-9(11)-ene-23,25-dioic acid, 2,3-dihydroxy-, (2.alpha.,3.beta.,4.alpha.)-
unii-5m66ara2br
5m66ara2br ,
a-neo-26,28-dinorgammacer-9(11)-ene-23,25-dioic acid, 2,3-dihydroxy-13,17-dimethyl-, (2alpha,3beta,4alpha,8alpha,13alpha,14beta,17alpha,18beta)-
d:c-friedo-b:a-neogammacer-9(11)-ene-23,25-dioic acid, 2,3-dihydroxy-, (2alpha,3beta,4alpha)-
(3r,3ar,5ar,5br,7ar,8s,9r,10r,11ar,13as,13br)-9,10-dihydroxy-3a,5a,8,13a-tetramethyl-3-(propan-2-yl)-1,2,3,3a,4,5,5a,5b,6,7,7a,8,9,10,11,13,13a,13b-octadecahydro-11ah-cyclopenta(a)chrysene-8,11a-dicarboxylic acid
(2alpha,3beta,4alpha,8alpha,13alpha,14beta,17alpha,18beta)-2,3-dihydroxy-13,17-dimethyl-a-neo-26,28-dinorgammacer-9(11)-ene-23,25-dioic acid

Excerpt	Reference	Relevance
"Retigeric acid B (RB) has been reported to exhibit its anti-tumor activity in vitro and in vivo. "	( Induction of DNA damage and ATF3 by retigeric acid B, a novel topoisomerase II inhibitor, promotes apoptosis in prostate cancer cells. Bi, Y; Gao, F; Jiang, H; Liu, Y; Lou, H; Niu, L; Young, CY; Yuan, H, 2013)	2.11

Excerpt	Reference	Relevance
"The vitro antifungal activity of retigeric acid B (RAB), a pentacyclic triterpenoid from the lichen species Lobaria kurokawae, was evaluated alone and in combination with fluconazole, ketoconazole, and itraconazole against Candida albicans using checkerboard microdilution and time-killing tests."	( In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. Cheng, A; Lou, H; Sun, L; Sun, S; Wu, X; Zhang, Y, 2009)	0.94

Bioassays (46)

Assay ID	Title	Year	Journal	Article
AID549046	Antifungal activity against Candida albicans CA3 after 48 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549045	Antifungal activity against Candida albicans CA2 after 48 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549290	Antifungal activity against Candida albicans CA135 after 48 hrs by broth microdilution method in presence of ketoconazole	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549287	Antifungal activity against Candida albicans CA127 after 48 hrs by broth microdilution method in presence of ketoconazole	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549308	Antifungal activity against Candida albicans CA10 assessed as cell viability after 2 hrs by XTT reduction assay in presence of itraconazole	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549064	Antifungal activity against Candida albicans CA1 after 48 hrs by broth microdilution method in presence of ketoconazole	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549288	Antifungal activity against Candida albicans CA132 after 48 hrs by broth microdilution method in presence of ketoconazole	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549292	Antifungal activity against Candida albicans CA138 after 48 hrs by broth microdilution method in presence of ketoconazole	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549296	Antifungal activity against Candida albicans CA4 after 48 hrs by broth microdilution method in presence of itraconazole	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549291	Antifungal activity against Candida albicans CA137 after 48 hrs by broth microdilution method in presence of ketoconazole	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549063	Antifungal activity against Candida albicans CA138 after 48 hrs by broth microdilution method in presence of fluconazole	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549056	Antifungal activity against Candida albicans CA3 after 48 hrs by broth microdilution method in presence of fluconazole	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549306	Antifungal activity against Candida albicans CA10 assessed as cell viability after 2 hrs by XTT reduction assay in presence of fluconazole	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549303	Antifungal activity against Candida albicans CA10 assessed as log reduction in fungal burden at 8 ug/ml after 48 hrs by time kill analysis in presence of fluconazole	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549301	Antifungal activity against Candida albicans CA137 after 48 hrs by broth microdilution method in presence of itraconazole	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549060	Antifungal activity against Candida albicans CA10 after 48 hrs by broth microdilution method in presence of fluconazole	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549051	Antifungal activity against Candida albicans CA135 after 48 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549304	Antifungal activity against Candida albicans CA10 assessed as log reduction in fungal burden at 8 ug/ml after 48 hrs by time kill analysis in presence of ketoconazole	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549066	Antifungal activity against Candida albicans CA3 after 48 hrs by broth microdilution method in presence of ketoconazole	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549298	Antifungal activity against Candida albicans CA132 after 48 hrs by broth microdilution method in presence of itraconazole	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549062	Antifungal activity against Candida albicans CA137 after 48 hrs by broth microdilution method in presence of fluconazole	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549049	Antifungal activity against Candida albicans CA132 after 48 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549293	Antifungal activity against Candida albicans CA1 after 48 hrs by broth microdilution method in presence of itraconazole	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549058	Antifungal activity against Candida albicans CA127 after 48 hrs by broth microdilution method in presence of fluconazole	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549059	Antifungal activity against Candida albicans CA132 after 48 hrs by broth microdilution method in presence of fluconazole	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549052	Antifungal activity against Candida albicans CA137 after 48 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549305	Antifungal activity against Candida albicans CA10 assessed as log reduction in fungal burden at 8 ug/ml after 48 hrs by time kill analysis in presence of itraconazole	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549295	Antifungal activity against Candida albicans CA3 after 48 hrs by broth microdilution method in presence of itraconazole	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549047	Antifungal activity against Candida albicans CA4 after 48 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549048	Antifungal activity against Candida albicans CA127 after 48 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549307	Antifungal activity against Candida albicans CA10 assessed as cell viability after 2 hrs by XTT reduction assay in presence of ketoconazole	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549294	Antifungal activity against Candida albicans CA2 after 48 hrs by broth microdilution method in presence of itraconazole	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549061	Antifungal activity against Candida albicans CA135 after 48 hrs by broth microdilution method in presence of fluconazole	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549057	Antifungal activity against Candida albicans CA4 after 48 hrs by broth microdilution method in presence of fluconazole	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549050	Antifungal activity against Candida albicans CA10 after 48 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549300	Antifungal activity against Candida albicans CA135 after 48 hrs by broth microdilution method in presence of itraconazole	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549054	Antifungal activity against Candida albicans CA1 after 48 hrs by broth microdilution method in presence of fluconazole	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549055	Antifungal activity against Candida albicans CA2 after 48 hrs by broth microdilution method in presence of fluconazole	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549289	Antifungal activity against Candida albicans CA10 after 48 hrs by broth microdilution method in presence of ketoconazole	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549053	Antifungal activity against Candida albicans CA138 after 48 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549065	Antifungal activity against Candida albicans CA2 after 48 hrs by broth microdilution method in presence of ketoconazole	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549067	Antifungal activity against Candida albicans CA4 after 48 hrs by broth microdilution method in presence of ketoconazole	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549297	Antifungal activity against Candida albicans CA127 after 48 hrs by broth microdilution method in presence of itraconazole	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549299	Antifungal activity against Candida albicans CA10 after 48 hrs by broth microdilution method in presence of itraconazole	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549044	Antifungal activity against Candida albicans CA1 after 48 hrs by broth microdilution method	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
AID549302	Antifungal activity against Candida albicans CA138 after 48 hrs by broth microdilution method in presence of itraconazole	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (10.00)	29.6817
2010's	9 (90.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	10 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
fluconazole Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.. fluconazole : A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.	2.46	2	conazole antifungal drug; difluorobenzene; tertiary alcohol; triazole antifungal drug	environmental contaminant; P450 inhibitor; xenobiotic
itraconazole [no description available]	2.05	1	piperazines
ketoconazole 1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.	2.46	2	dichlorobenzene; dioxolane; ether; imidazoles; N-acylpiperazine; N-arylpiperazine
itraconazole Itraconazole: A triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.. itraconazole : An N-arylpiperazine that is cis-ketoconazole in which the imidazol-1-yl group is replaced by a 1,2,4-triazol-1-yl group and in which the actyl group attached to the piperazine moiety is replaced by a p-[(+-)1-sec-butyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]phenyl group. A potent P-glycoprotein and CYP3A4 inhibitor, it is used as an antifungal drug for the treatment of various fungal infections, including aspergillosis, blastomycosis, candidiasis, chromoblastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, and sporotrichosis.	2.46	2	aromatic ether; conazole antifungal drug; cyclic ketal; dichlorobenzene; dioxolane; N-arylpiperazine; triazole antifungal drug; triazoles	EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor; Hedgehog signaling pathway inhibitor; P450 inhibitor
ergosterol [no description available]	2.51	2	3beta-hydroxy-Delta(5)-steroid; 3beta-sterol; ergostanoid; phytosterols	fungal metabolite; Saccharomyces cerevisiae metabolite
farnesol Farnesol: A colorless liquid extracted from oils of plants such as citronella, neroli, cyclamen, and tuberose. It is an intermediate step in the biological synthesis of cholesterol from mevalonic acid in vertebrates. It has a delicate odor and is used in perfumery. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed). (2-trans,6-trans)-farnesol : The (2-trans,6-trans)-stereoisomer of farnesol.. farnesol : A farnesane sesquiterpenoid that is dodeca-2,6,10-triene substituted by methyl groups at positions 3, 7 and 11 and a hydroxy group at position 1.	7.07	1	farnesol	plant metabolite
stilbenes Stilbenes: Organic compounds that contain 1,2-diphenylethylene as a functional group.. trans-stilbene : The trans-isomer of stilbene.	2.21	1	stilbene
riccardin d riccardin D: antifungal agent isolated from Dumortiera hirsute; structure in first source	2.21	1
bucladesine Bucladesine: A cyclic nucleotide derivative that mimics the action of endogenous CYCLIC AMP and is capable of permeating the cell membrane. It has vasodilator properties and is used as a cardiac stimulant. (From Merck Index, 11th ed). bucladesine : A 3',5'-cyclic purine nucleotide that is the 2'-butanoate ester and 6-N-butanoyl derivative of 3',5'-cyclic AMP.	2.06	1	3',5'-cyclic purine nucleotide

Condition	Relationship Strength	Studies
Cancer of Prostate [description not available]	2.99	4
Prostatic Neoplasms Tumors or cancer of the PROSTATE.	2.99	4
Candida Infection [description not available]	2.07	1
Candidiasis Infection with a fungus of the genus CANDIDA. It is usually a superficial infection of the moist areas of the body and is generally caused by CANDIDA ALBICANS. (Dorland, 27th ed)	2.07	1

retigeric acid b

Description

Cross-References

Synonyms (15)

Research Excerpts

Effects

Compound-Compound Interactions

Bioassays (46)

Research

Studies (10)

Market Indicators

Research Demand Index: 12.40

Study Types

retigeric acid b

Description

Cross-References

Synonyms (15)

Research Excerpts

Effects

Compound-Compound Interactions

Bioassays (46)

Research

Studies (10)

Market Indicators

Research Demand Index: 12.40

Study Types

Related Drugs (9)

Related Conditions (4)