Central Nervous System Lyme Disease

Nervous system infections caused by tick-borne spirochetes of the BORRELIA BURGDORFERI GROUP. The disease may affect elements of the central or peripheral nervous system in isolation or in combination. Common clinical manifestations include a lymphocytic meningitis, cranial neuropathy (most often a facial neuropathy), POLYRADICULOPATHY, and a mild loss of memory and other cognitive functions. Less often more extensive inflammation involving the central nervous system (encephalomyelitis) may occur. In the peripheral nervous system, B. burgdorferi infection is associated with mononeuritis multiplex and polyradiculoneuritis. (From J Neurol Sci 1998 Jan 8;153(2):182-91)

Synonym
Lyme Borreliosis, Nervous System
Neuroborreliosis, Borrelia burgdorferi
Lyme Polyradiculopathy
Meningoencephalitis, Lyme
Lyme Polyradiculitis
Lyme Neuroborreliosis
Lyme Meningoradiculitis
Lyme Meningoencephalitis
Lyme Disease Encephalopathy
Lyme Disease, Nervous System
Nervous System Lyme Disease
Encephalopathy, Lyme Disease
Lyme Disease, Central Nervous System
Lyme Disease Mononeuritis Multiplex
Nervous System Lyme Borreliosis
Central Nervous System Lyme Disease
Mononeuritis Multiplex, Lyme Disease
Peripheral Nervous System Lyme Disease

Excerpt	Reference
"Lyme neuroborreliosis is diagnostically challenging because of its diverse manifestations."	( Bonner, FJ; Lafontant, G; Zhang, Y, 2000)
"Lyme neuroborreliosis is a frequent cause of facial nerve palsy in children, isolated oculomotor nerve palsy due to Borrelia-associated nervous system infection however is rarely seen."	( Drenckhahn, A; Knierim, E; Spors, B, 2016)
"Lyme neuroborreliosis is a rare disease in Japan."	( Haratani, K; Kakehi, Y; Katanami, Y; Kawabata, H; Miyazaki, M; Nagami, S; Shimizu, H; Takahashi, N, 2016)
"Lyme neuroborreliosis is a tick-borne infectious disease caused by the spirochete bacterium Borrelia burgdorferi sensu lato."	( Dersch, R; Rauer, S, 2017)
"Lyme neuroborreliosis is a bacterial infection caused by the dissemination and proliferation of a Borrelia species in the central nervous system."	( Cohen, R; Dommergues, MA; Ferroni, A; Guet-Revillet, H; Hentgen, V; Laugel, V; Levy, C; Maghraoui-Slim, V; Paget, C; Vallet, C, 2019)

Excerpt	Reference
"This is the first report on Lyme neuroborreliosis in a patient treated with TNF-alpha inhibitor."	( Merkac, MI; Strle, F; Tomazic, J, 2015)
"Cases associated with Lyme neuroborreliosis are treated with antibiotics in addition to the study treatment."	( Arnason, S; Hadziosmanovic, N; Hultcrantz, M; Karlsson, S; Laestadius, Å; Marsk, E; Skogman, BH, 2021)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	2 (1.11)	12.5806
2000's	81 (45.00)	18.1394
2010's	84 (46.67)	28.8240
2020's	13 (7.22)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	medium	2	1
lactic acid	low	2	0
thioctic acid	low	1	0
niacinamide	low	1	0
cefuroxime	low	4	0
chlorambucil	low	1	0
citalopram	low	1	0
diazepam	low	1	0
valproic acid	low	1	0
fluconazole	low	1	0
gabapentin	medium	2	1
nimodipine	low	1	0
probenecid	low	1	0
prednisolone	low	4	0
prednisone	low	3	0
penicillin g	low	2	0
lysine	low	2	0
carbostyril	low	1	0
methylprednisolone	low	6	0
quinuclidines	low	1	0
thiazoles	low	2	0
malondialdehyde	low	2	0
congo red	low	1	0
vancomycin	low	1	0
thioflavin t	low	1	0
gadolinium	low	3	0
trolamine salicylate	low	1	0
fludrocortisone	low	1	0
amoxicillin	medium	11	1
aripiprazole	low	1	0
cephalosporin c	low	10	0
fluorodeoxyglucose f18	low	3	0
cyanates	low	1	0
n-(4-carboxycyclohexylmethyl)maleimide n-hydroxysuccinimide ester	low	1	0
l 703606	low	1	0
beta-lactams	low	4	0
cortisone	medium	1	1
zithromax	low	1	0
myelin basic protein	low	2	0
bilirubin	low	1	0
dinoprostone	low	1	0
luteolin	low	1	0
4-hydroxy-2-hexenal	low	1	0
4-hydroxy-2-nonenal	low	1	0
lysophosphatidylcholines	low	1	0
cefotaxime	low	12	0
gadolinium dtpa	low	2	0
cosyntropin	low	1	0
adrenocorticotropin zinc	low	1	0
ro13-9904	medium	108	9
glycolipids	low	1	0
interleukin-8	low	1	0
minocycline	low	3	0
mobic	low	1	0
calca protein, human	low	1	0
transforming growth factor beta	low	2	0
cefuroxime axetil	low	2	0
flavin mononucleotide	low	1	0
acyclovir	low	1	0
inosine diphosphate	low	1	0
neopterin	low	3	0
aprepitant	low	1	0

Protein Targets (819)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Microtubule-associated protein tau	5	0	0	5
vitamin D3 receptor isoform VDRA	6	0	0	6
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	6	0	0	6
Chain B, HADH2 protein	6	0	0	6
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
Chain A, Ferritin light chain	4	0	0	4
Thymidine kinase	0	1	0	1
thioredoxin reductase	6	0	0	6
phosphopantetheinyl transferase	3	0	0	3
GLS protein	7	0	0	7
TDP1 protein	17	0	0	17
Smad3	2	0	0	2
thyroid stimulating hormone receptor	8	0	0	8
EWS/FLI fusion protein	8	0	0	8
arylsulfatase A	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	11	0	0	11
activating transcription factor 6	5	0	0	5
Histone H2A.x	5	0	0	5
Bloom syndrome protein isoform 1	7	0	0	7
hemoglobin subunit beta	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
lamin isoform A-delta10	11	0	0	11
Solute carrier family 22 member 1	0	1	0	3
ATP-binding cassette sub-family C member 3	0	14	0	14
Multidrug resistance-associated protein 4	0	14	0	15
Solute carrier family 22 member 6	0	3	0	4
Bile salt export pump	0	5	0	5
Bile salt export pump	0	20	0	20
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	1
POU domain, class 2, transcription factor 2	0	0	0	1
Cytochrome P450 2C9	0	7	0	7
Cytochrome P450 2J2	0	6	0	6
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	3	0	5
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	4	0	6
Canalicular multispecific organic anion transporter 1	0	13	0	13
Thymidine kinase	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	8	0	0	8
Chain A, Beta-lactamase	4	0	0	4
Chain A, 2-oxoglutarate Oxygenase	3	0	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	3
AR protein	18	0	0	18
apical membrane antigen 1, AMA1	2	0	0	2
estrogen nuclear receptor alpha	23	0	0	23
Beta-lactamase	0	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
DNA polymerase eta isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	5	0	0	5
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
DNA polymerase kappa isoform 1	6	0	0	6
Beta-lactamase SHV-1	0	0	0	3
Beta-lactamase SHV-1	0	0	0	3
Beta-lactamase	0	0	0	3
Kappa-type opioid receptor	0	1	0	4
Solute carrier family 15 member 1	0	4	0	4
Solute carrier family 15 member 1	0	1	0	1
B2 metallo-beta-lactamase	0	0	0	3
Solute carrier family 15 member 2	0	3	0	3
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	3
Solute carrier family 15 member 2	0	3	0	3
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	3
hypoxia-inducible factor 1 alpha subunit	6	0	0	6
RAR-related orphan receptor gamma	12	0	0	12
GALC protein	3	0	0	3
GLI family zinc finger 3	15	0	0	15
caspase 7, apoptosis-related cysteine protease	2	0	0	2
estrogen receptor 2 (ER beta)	7	0	0	7
nuclear receptor subfamily 1, group I, member 3	10	0	0	10
progesterone receptor	12	0	0	12
cytochrome P450 family 3 subfamily A polypeptide 4	10	0	0	10
glucocorticoid receptor [Homo sapiens]	18	0	0	18
retinoic acid nuclear receptor alpha variant 1	15	0	0	15
retinoid X nuclear receptor alpha	10	0	0	10
estrogen-related nuclear receptor alpha	16	0	0	16
farnesoid X nuclear receptor	7	0	0	7
pregnane X nuclear receptor	13	0	0	13
G	8	0	0	8
cytochrome P450 2D6	6	0	0	6
peroxisome proliferator-activated receptor delta	7	0	0	7
peroxisome proliferator activated receptor gamma	8	0	0	8
vitamin D (1,25- dihydroxyvitamin D3) receptor	11	0	0	11
caspase-3	2	0	0	2
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	11	0	0	11
thyroid stimulating hormone receptor	7	0	0	7
v-jun sarcoma virus 17 oncogene homolog (avian)	11	0	0	11
thyroid hormone receptor beta isoform 2	11	0	0	11
heat shock protein beta-1	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 1	12	0	0	12
Voltage-dependent calcium channel gamma-2 subunit	7	0	0	7
Interferon beta	12	0	0	12
HLA class I histocompatibility antigen, B alpha chain	8	0	0	8
Cellular tumor antigen p53	11	0	0	11
Cytochrome P450 3A4	0	4	1	5
Glutamate receptor 2	8	0	0	8
Substance-P receptor	0	3	2	5
Neuromedin-K receptor	0	1	0	1
Spike glycoprotein	5	0	1	6
cGMP-dependent protein kinase 1	0	0	1	1
Substance-P receptor	0	1	0	1
Inositol hexakisphosphate kinase 1	8	0	0	8
cytochrome P450 2C9, partial	8	0	0	8
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	6	0	0	6
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
5-hydroxytryptamine receptor 3E	0	1	0	1
acetylcholinesterase	7	0	0	7
SMAD family member 2	4	0	0	4
Fumarate hydratase	1	0	0	1
USP1 protein, partial	6	0	0	6
PPM1D protein	4	0	0	4
SMAD family member 3	4	0	0	4
polyprotein	1	0	0	1
67.9K protein	2	0	0	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	3	0	0	3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
lysosomal alpha-glucosidase preproprotein	2	0	0	2
mu-type opioid receptor isoform MOR-1	0	0	1	1
nuclear factor erythroid 2-related factor 2 isoform 2	6	0	0	6
potassium voltage-gated channel subfamily H member 2 isoform d	6	0	0	6
transcriptional regulator ERG isoform 3	3	0	0	3
nuclear receptor ROR-gamma isoform 1	7	0	0	7
geminin	14	0	0	14
peripheral myelin protein 22	5	0	0	5
histone acetyltransferase KAT2A isoform 1	4	0	0	4
5-hydroxytryptamine receptor 2A	0	0	1	1
neuropeptide S receptor isoform A	3	0	0	3
Solute carrier family 22 member 2	0	1	0	2
5-hydroxytryptamine receptor 3A	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
ATP-dependent translocase ABCB1	0	3	0	4
5-hydroxytryptamine receptor 1A	0	1	1	2
5-hydroxytryptamine receptor 2C	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
D(2) dopamine receptor	0	2	1	3
5-hydroxytryptamine receptor 2A	0	1	0	2
Alpha-1B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	3	0	3
D	0	1	0	1
5-hydroxytryptamine receptor 1A	0	5	1	6
Muscarinic acetylcholine receptor M3	0	1	0	1
D(1A) dopamine receptor	0	1	0	1
D(4) dopamine receptor	0	1	0	1
D(1B) dopamine receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	3	0	3
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	4	0	4
D(4) dopamine receptor	0	1	0	1
Histamine H1 receptor	0	1	1	2
Sodium-dependent serotonin transporter	0	3	1	4
5-hydroxytryptamine receptor 7	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Alpha-1A adrenergic receptor	0	2	0	2
Histamine H1 receptor	0	4	0	4
Alpha-1B adrenergic receptor	0	1	0	1
D(3) dopamine receptor	0	1	1	2
5-hydroxytryptamine receptor 2B	0	3	0	3
Alpha-1A adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 3A	0	1	0	1
5-hydroxytryptamine receptor 6	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Inositol monophosphatase 1	2	0	0	2
Potassium voltage-gated channel subfamily H member 2	0	4	0	4
5-hydroxytryptamine receptor 3D	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
Multidrug and toxin extrusion protein 1	0	2	0	2
Histamine H3 receptor	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
Chain A, Cruzipain	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	9	0	0	9
caspase-1 isoform alpha precursor	1	0	0	1
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1B3	0	4	0	5
Solute carrier organic anion transporter family member 1B1	0	2	0	3
Chain A, serum paraoxonase	0	1	0	1
Carbonic anhydrase 12	0	4	0	4
Carbonic anhydrase 1	0	5	0	5
Carbonic anhydrase 2	0	5	0	5
Carbonic anhydrase 3	0	1	0	1
Neutrophil cytosol factor 1	0	1	0	1
Carbonic anhydrase 4	0	3	0	3
Carbonic anhydrase 6	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase 7	0	2	0	2
Carbonic anhydrase 9	0	3	0	3
Carbonic anhydrase 13	0	1	0	1
Poly [ADP-ribose] polymerase tankyrase-2	0	2	0	2
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase type 2	0	0	0	2
Metallo-beta-lactamase VIM-11	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase VIM-19	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	2
Albumin	0	0	4	5
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-13	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase Toho-1	0	0	0	2
Solute carrier family 22 member 7	0	2	0	3
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	2
BlaVIM-1	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	2
Histamine H3 receptor	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	2
Solute carrier family 22 member 11	0	3	0	4
Solute carrier family 22 member 8	0	4	0	5
Beta-lactamase VIM-1	0	0	0	2
Solute carrier family 22 member 7	0	3	0	4
Luciferase	6	0	0	6
interleukin 8	2	0	0	2
NFKB1 protein, partial	1	0	0	1
Thrombopoietin	1	0	0	1
thioredoxin glutathione reductase	3	0	0	3
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	4	0	0	4
bromodomain adjacent to zinc finger domain 2B	6	0	0	6
peripheral myelin protein 22 isoform 1	3	0	0	3
chromobox protein homolog 1	7	0	0	7
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
survival motor neuron protein isoform d	6	0	0	6
muscleblind-like protein 1 isoform 1	3	0	0	3
muscarinic acetylcholine receptor M1	3	0	0	3
Cytochrome P450 2D6	0	2	0	2
Nuclear receptor ROR-gamma	5	0	0	5
ATPase family AAA domain-containing protein 5	7	0	0	7
Ataxin-2	8	0	0	8
ATP-dependent phosphofructokinase	6	0	0	6
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
D(1A) dopamine receptor	2	0	0	2
Sodium-dependent noradrenaline transporter	0	1	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Aldo-keto reductase family 1 member B1	0	4	0	4
Tryptophan 5-hydroxylase 1	0	1	0	1
Angiotensin-converting enzyme	0	3	0	3
Aldo-keto reductase family 1 member B1	0	2	0	2
Acetylcholinesterase	0	3	0	3
Aromatase	0	1	0	1
Sodium-dependent noradrenaline transporter	0	2	1	3
Sodium-dependent dopamine transporter	0	1	1	2
Sodium-dependent serotonin transporter	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	4	0	4
Sigma non-opioid intracellular receptor 1	0	1	0	1
Transporter	0	3	0	3
aryl hydrocarbon receptor	6	0	0	6
B2 bradykinin receptor	0	1	0	1
Dihydrofolate reductase	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Chymotrypsinogen A	0	1	0	2
Beta-lactamase	0	2	0	2
Amyloid-beta precursor protein	0	4	0	4
Beta-lactamase	0	0	0	2
Beta-galactosidase	0	1	0	2
Choline O-acetyltransferase	0	1	0	1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	0	2	0	2
PH domain leucine-rich repeat-containing protein phosphatase 2	0	1	0	1
Chymotrypsin-C	0	1	0	1
endonuclease IV	2	0	0	2
dopamine D1 receptor	1	0	0	1
pregnane X receptor	3	0	0	3
regulator of G-protein signaling 4	5	0	0	5
flap endonuclease 1	2	0	0	2
cytochrome P450 3A4 isoform 1	5	0	0	5
M-phase phosphoprotein 8	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	5	4	1	10
Glucocorticoid receptor	0	8	2	16
Sex hormone-binding globulin	0	0	1	1
Glycine receptor subunit alpha-1	0	8	0	8
Corticosteroid-binding globulin	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	5	4	1	10
Gamma-aminobutyric acid receptor subunit delta	5	4	1	10
Gamma-aminobutyric acid receptor subunit gamma-2	5	4	2	11
Gamma-aminobutyric acid receptor subunit alpha-5	5	4	1	10
Gamma-aminobutyric acid receptor subunit alpha-3	5	4	1	10
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Gamma-aminobutyric acid receptor subunit gamma-1	5	4	1	10
Gamma-aminobutyric acid receptor subunit alpha-2	5	4	1	10
Glycine receptor subunit alpha-3	0	8	0	8
Gamma-aminobutyric acid receptor subunit alpha-4	5	4	1	10
Gamma-aminobutyric acid receptor subunit gamma-3	5	4	1	10
Gamma-aminobutyric acid receptor subunit alpha-6	5	4	1	10
Gamma-aminobutyric acid receptor subunit alpha-1	5	4	2	11
Gamma-aminobutyric acid receptor subunit beta-3	5	4	1	10
Gamma-aminobutyric acid receptor subunit beta-2	5	4	2	11
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
TAR DNA-binding protein 43	7	0	0	7
GABA theta subunit	5	4	1	10
Gamma-aminobutyric acid receptor subunit epsilon	5	4	1	10
Carbonic anhydrase 15	0	1	0	1
Gamma-aminobutyric acid	0	1	1	2
glp-1 receptor, partial	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	0	3	0	3
Gamma-aminobutyric acid receptor subunit delta	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Fatty acid-binding protein, liver	0	2	0	2
Alpha-1-acid glycoprotein 1	0	0	0	1
Albumin	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	3	6
Translocator protein	0	1	1	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	3	1	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	2	5
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit delta	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	3	2	5
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	3	3	6
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	2	5
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	2	5
Gamma-aminobutyric acid receptor subunit beta-2	0	3	2	5
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	1	4
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit epsilon	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit pi	0	1	1	2
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Gamma-aminobutyric acid receptor subunit theta	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit theta	0	3	0	3
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
prostaglandin E2 receptor EP2 subtype	1	0	0	1
mitogen-activated protein kinase 1	1	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Prostacyclin receptor	0	2	1	3
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
unnamed protein product	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
bcl-2-like protein 11 isoform 1	0	0	1	1
Histone deacetylase 3	0	4	0	4
Rap guanine nucleotide exchange factor 3	2	0	0	2
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Heme oxygenase 1	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	1	2
Aromatase	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Heme oxygenase 2	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Histone deacetylase 4	0	4	0	4
Cytochrome P450 144	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Mycocyclosin synthase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Histone deacetylase 1	0	4	0	4
Lanosterol 14-alpha demethylase	0	1	1	2
Sterol 14-alpha demethylase	0	0	1	1
Sterol 14-alpha demethylase	0	1	1	2
Histone deacetylase 7	0	4	0	4
Histone deacetylase 2	0	4	0	4
Polyamine deacetylase HDAC10	0	4	0	4
Histone deacetylase 11	0	4	0	4
14-alpha sterol demethylase	0	0	1	1
Histone deacetylase 8	0	4	0	4
Histone deacetylase 6	0	4	0	4
Histone deacetylase 9	0	4	0	4
Histone deacetylase 5	0	4	0	4
heat shock protein 90, putative	0	0	0	1
likely tRNA 2'-phosphotransferase	0	1	0	1
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
ATAD5 protein, partial	4	0	0	4
Hsf1 protein	0	0	1	1
thyroid hormone receptor beta isoform a	4	0	0	4
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Sterol O-acyltransferase 1	0	0	1	1
Proton-coupled amino acid transporter 1	0	1	0	1
Platelet glycoprotein VI	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
cellular tumor antigen p53 isoform a	2	0	0	2
Integrin beta-3	2	0	0	2
Integrin alpha-IIb	2	0	0	2
Chain A, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
Chain B, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
Chain B, Transthyretin	0	0	1	1
Chain A, Casein kinase II subunit alpha	0	1	0	1
Chain A, Casein kinase II subunit alpha	0	1	0	1
Chain A, Casein Kinase Ii Subunit Alpha	0	1	0	1
Genome polyprotein	0	1	0	1
histidine kinase	0	1	0	1
BRCA1	1	0	0	1
15-lipoxygenase, partial	1	0	0	1
WRN	1	0	0	1
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7	0	0	0	1
Neuraminidase	0	2	0	2
glucocerebrosidase	1	0	0	1
P53	1	0	0	1
alpha-galactosidase	3	0	0	3
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
cytochrome P450 2D6 isoform 1	2	0	0	2
galactokinase	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
cytochrome P450 2C19 precursor	2	0	0	2
cytochrome P450 2C9 precursor	1	0	0	1
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
importin subunit beta-1 isoform 1	1	0	0	1
DNA polymerase beta	2	0	0	2
snurportin-1	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
POsterior Segregation	0	0	1	1
lethal factor (plasmid)	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Transmembrane protease serine 2	0	0	1	1
Aldo-keto reductase family 1 member B10	0	1	0	1
G2/mitotic-specific cyclin-B2	0	1	0	1
Poly [ADP-ribose] polymerase tankyrase-1	0	1	0	1
Cationic trypsin	0	1	0	1
Transthyretin	0	1	1	2
Interstitial collagenase	0	1	0	1
Cytochrome P450 1A1	0	2	0	2
Cytochrome P450 1A2	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Cyclin-dependent kinase 1	0	1	0	1
Chemotaxis protein CheA	0	1	0	1
Procathepsin L	0	0	1	1
Tyrosine-protein kinase Yes	0	1	0	1
Seed linoleate 13S-lipoxygenase-1	0	2	0	4
Neutrophil elastase	0	2	0	2
72 kDa type IV collagenase	0	1	0	1
Stromelysin-1	0	2	0	2
Poly [ADP-ribose] polymerase 1	0	2	0	2
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	2	1	3
Alpha-amylase 1A	0	1	0	1
Androgen receptor	0	2	0	3
Sialidase	0	1	0	1
Serine/threonine-protein kinase pim-1	0	1	0	1
Fatty acid synthase	0	1	0	1
G2/mitotic-specific cyclin-B1	0	1	0	1
Tyrosinase	0	1	0	1
Matrix metalloproteinase-9	0	2	0	2
Urease subunit alpha	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
G2/mitotic-specific cyclin-B	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	0	1
Casein kinase II subunit alpha'	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Cyclin-dependent kinase 2	0	1	0	1
Cruzipain	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Proteasome subunit beta type-5	0	1	0	1
Cytosol aminopeptidase	0	1	0	1
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	0	1	0	1
Substance-P receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	3	0	3
Receptor-type tyrosine-protein kinase FLT3	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Alpha-synuclein	0	1	0	1
Macrophage metalloelastase	0	1	0	1
Homeobox protein Nkx-2.5	0	1	0	1
Tyrosine-protein kinase SYK	0	1	1	2
Collagenase 3	0	1	0	1
1-deoxy-D-xylulose 5-phosphate reductoisomerase	0	1	0	1
Histamine H2 receptor	1	0	0	1
Xanthine dehydrogenase/oxidase	0	2	0	2
Fatty acid synthase	0	1	0	1
Glycogen synthase kinase-3 alpha	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	0	1
Death-associated protein kinase 1	0	1	0	1
Mitogen-activated protein kinase 10	0	1	0	1
Casein kinase II subunit beta	0	1	0	1
Casein kinase II subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	0	3
Cyclin-dependent kinase 6	0	1	0	1
Cyclin-dependent-like kinase 5	0	1	0	1
Cyclin homolog	0	1	0	1
Lactoylglutathione lyase	0	1	0	1
Transcription factor GATA-4	0	1	0	1
Cyclin-dependent kinase 5 activator 1	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Cytochrome P450 1B1	0	2	0	2
Carbonic anhydrase 3	0	1	0	1
Substance-K receptor	0	1	0	1
Integrase	0	1	0	1
Protein polybromo-1	0	0	1	1
Casein kinase II subunit alpha 3	0	1	0	1
Inositol polyphosphate multikinase	0	1	0	1
Histone-lysine N-methyltransferase SETD7	0	1	0	1
G2/mitotic-specific cyclin-B3	0	1	0	1
Enoyl-acyl-carrier protein reductase	0	2	0	2
3-oxoacyl-acyl-carrier protein reductase	0	2	0	2
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)	0	2	0	2
Aurora kinase B	0	1	0	1
MAP kinase-interacting serine/threonine-protein kinase 1	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
Cyclin-dependent kinase 1	0	1	0	1
MAP kinase-interacting serine/threonine-protein kinase 2	0	1	0	1
G-protein coupled receptor 35	0	1	1	2
NADPH oxidase 4	0	1	0	1
Dipeptidyl peptidase 3	0	1	0	1
Inositol hexakisphosphate kinase 2	0	1	0	1
Short transient receptor potential channel 5	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	2
DNA topoisomerase 1	0	1	0	1
Zinc finger protein mex-5	0	0	1	1
Sialidase-2	0	1	0	1
phosphoglycerate kinase	1	0	0	1
M1-family alanyl aminopeptidase	0	1	0	1
large T antigen	0	1	1	2
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Glutathione reductase, mitochondrial	0	3	0	3
Cationic amino acid transporter 3	0	1	0	1
nonstructural protein 1	2	0	0	2
IDH1	2	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Androgen receptor	0	3	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	2	0	2
Protein-arginine deiminase type-4	0	3	0	3
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Chain A, NAD-dependent deacetylase	0	1	0	1
Caspase-7	1	0	0	1
caspase-3	1	0	0	1
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Coagulation factor VII	0	1	0	1
Tissue factor	0	2	0	2
Cytochrome P450 3A5	0	1	0	1
NAD-dependent protein deacetylase HST2	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	2	0	2
NAD-dependent protein deacetylase	0	1	0	1
Parkin	1	0	0	1
Voltage-dependent L-type calcium channel subunit beta-4	0	1	0	1
Voltage-dependent P/Q-type calcium channel subunit alpha-1A	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1G	0	1	0	1
Voltage-dependent calcium channel gamma-3 subunit	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1H	0	1	0	1
Adenosine receptor A3	0	1	0	1
Cannabinoid receptor 1	0	2	0	2
Adenosine receptor A2a	0	1	0	1
Cytochrome P450 2C19	0	3	0	3
Voltage-dependent L-type calcium channel subunit beta-3	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Voltage-dependent calcium channel gamma-7 subunit	0	1	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Voltage-dependent L-type calcium channel subunit beta-1	0	1	0	1
Voltage-dependent calcium channel gamma-1 subunit	0	1	0	1
Voltage-dependent L-type calcium channel subunit beta-2	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Voltage-dependent R-type calcium channel subunit alpha-1E	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-4	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Voltage-dependent calcium channel subunit alpha-2/delta-3	0	1	0	1
Voltage-dependent calcium channel gamma-8 subunit	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Bile acid receptor	0	1	0	1
Voltage-dependent calcium channel gamma-6 subunit	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1I	0	1	0	1
Voltage-dependent calcium channel gamma-4 subunit	0	1	0	1
Voltage-dependent calcium channel gamma-5 subunit	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	0	1	0	1
Beta-lactamase	0	0	0	1
streptokinase A precursor	0	0	2	2
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	3	0	4
Beta-lactamase	0	0	0	1
Beta-lactamase 1	0	0	0	1
Beta-lactamase OXA-10	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase TEM	0	1	0	2
Guanine nucleotide-binding protein G	1	0	0	1
Beta-lactamase	0	0	0	1
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase OXA-7	0	0	0	1
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
ras-related protein Rab-9A	1	0	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	1	0	2
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
UDP-glucuronosyltransferase 1-6	0	1	0	2
UDP-glucuronosyltransferase 1A1	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	1
Pannexin-1	0	1	0	1
Solute carrier family 22 member 12	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
UDP-glucuronosyltransferase 1A7	0	1	0	1
UDP-glucuronosyltransferase 1A10	0	1	0	1
Pannexin-1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Ubiquitin-like modifier activating enzyme 2	0	1	0	1
SUMO1 activating enzyme subunit 1	0	1	0	1
hexokinase	0	1	0	1
SUMO-conjugating enzyme UBC9	0	1	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
Vif	0	1	0	1
Tat	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	0	1	0	1
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase	0	1	0	1
Cholinesterase	0	2	0	2
Glutamate receptor 1	1	0	0	1
Glutamate receptor 3	1	0	0	1
Glutamate receptor 4	1	0	0	1
Alpha-2A adrenergic receptor	0	3	0	3
Cytochrome P450 2C8	0	1	0	1
Alpha-2B adrenergic receptor	0	2	0	2
Cytochrome P450 2B6	0	2	0	2
Cocaine esterase	0	1	0	1
Cytochrome P450 2A6	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	2
Liver carboxylesterase 1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
twin arginine protein translocation system - TatA protein	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Central Nervous System Lyme Disease

Synonyms(18)

Research Excerpts

Overview

Treatment

Research

Studies (180)

Protein Targets (819)

Central Nervous System Lyme Disease

Synonyms(18)

Research Excerpts

Overview

Treatment

Research

Studies (180)

Drugs Studied (73)

Protein Targets (819)