Page last updated: 2024-11-13

sinistrin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

sinistrin: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID92024375
MeSH IDM0178035

Synonyms (1)

Synonym
sinistrin

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" The results obtained by fitting a pharmacokinetic model to all the plasma and urine data served as the standard against which the performance of the respective calculation methods were examined."( Sinistrin clearance for determination of glomerular filtration rate: a reappraisal of various approaches using a new analytical method.
Biollaz, J; Buclin, T; Burnier, M; Décosterd, LA; Munafo, A; Pechère-Bertschi, A; Séchaud, R, 1997
)
1.74
" Data are simulated by running a bicompartmental pharmacokinetic model with renal elimination, and contaminating the values with an array of random errors."( Estimation of glomerular filtration rate by sinistrin clearance using various approaches.
Appenzeller, M; Belaz, N; Bertschi, AP; Biollaz, J; Buclin, T; Burnier, M; Decosterd, LA; Sechaud, R, 1998
)
0.56
" The potential interaction between these markers was investigated in a pharmacokinetic study where markers (M) or fluconazole (F) were administered alone or together (M + F)."( Simultaneous administration of a cocktail of markers to measure renal drug elimination pathways: absence of a pharmacokinetic interaction between fluconazole and sinistrin, p-aminohippuric acid and pindolol.
Beal, JB; Gross, AS; McLachlan, AJ; Minns, I; Tett, SE, 2001
)
0.51
"This prospective, observational pharmacokinetic (PK) study was performed in a university-affiliated, tertiary-level, adult intensive care unit (ICU)."( Determining the mechanisms underlying augmented renal drug clearance in the critically ill: use of exogenous marker compounds.
Dunlop, R; Jarrett, P; Lassig-Smith, M; Lipman, J; Roberts, JA; Starr, T; Stuart, J; Udy, AA; Wallis, SC, 2014
)
0.4
" Pharmacokinetic modeling using adequate software is necessary to calculate disappearance rate and half-life of sinistrin."( Use of a Microsoft Excel based add-in program to calculate plasma sinistrin clearance by a two-compartment model analysis in dogs.
Dunning, MD; Neiger, R; Steinbach, SM; Sturgess, CP, 2015
)
0.87

Dosage Studied

ExcerptRelevanceReference
" This has implications for accurate dosing of renally eliminated drugs."( Determining the mechanisms underlying augmented renal drug clearance in the critically ill: use of exogenous marker compounds.
Dunlop, R; Jarrett, P; Lassig-Smith, M; Lipman, J; Roberts, JA; Starr, T; Stuart, J; Udy, AA; Wallis, SC, 2014
)
0.4
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (35)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (2.86)18.7374
1990's9 (25.71)18.2507
2000's13 (37.14)29.6817
2010's10 (28.57)24.3611
2020's2 (5.71)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 28.94

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index28.94 (24.57)
Research Supply Index3.76 (2.92)
Research Growth Index5.51 (4.65)
Search Engine Demand Index34.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (28.94)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials6 (16.67%)5.53%
Reviews0 (0.00%)6.00%
Case Studies2 (5.56%)4.05%
Observational1 (2.78%)0.25%
Other27 (75.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]