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fluconazole and Delayed Effects, Prenatal Exposure

fluconazole has been researched along with Delayed Effects, Prenatal Exposure in 9 studies

Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.
fluconazole : A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.

Research Excerpts

ExcerptRelevanceReference
" She took a 150-mg dose of fluconazole 2 weeks ago for the treatment of vaginal candidiasis and she is worried about the effect on her child and pregnancy."7.81Fluconazole exposure during pregnancy. ( Bozzo, P; Kaplan, YC; Koren, G, 2015)
"We evaluated pregnancy outcomes in 234 women exposed to fluconazole, 492 exposed to a topically administered azole preparation, 88 exposed to an oral azole preparation other than fluconazole, and 1629 not exposed to any of these agents during the first trimester of pregnancy Relative risks of having a baby with a congenital disorder for women exposed to fluconazole, oral azoles, and topical azoles in the first trimester of pregnancy compared with those who were unexposed were 1."7.70Pregnancy outcomes after maternal exposure to fluconazole. ( Jick, SS, 1999)
" The oral antifungal agents used during pregnancy were fluconazole and itraconazole."5.05Fetal outcomes after maternal exposure to oral antifungal agents during pregnancy: A systematic review and meta-analysis. ( Liu, D; Wu, L; Zhang, C; Zhang, L, 2020)
" She took a 150-mg dose of fluconazole 2 weeks ago for the treatment of vaginal candidiasis and she is worried about the effect on her child and pregnancy."3.81Fluconazole exposure during pregnancy. ( Bozzo, P; Kaplan, YC; Koren, G, 2015)
"We evaluated pregnancy outcomes in 234 women exposed to fluconazole, 492 exposed to a topically administered azole preparation, 88 exposed to an oral azole preparation other than fluconazole, and 1629 not exposed to any of these agents during the first trimester of pregnancy Relative risks of having a baby with a congenital disorder for women exposed to fluconazole, oral azoles, and topical azoles in the first trimester of pregnancy compared with those who were unexposed were 1."3.70Pregnancy outcomes after maternal exposure to fluconazole. ( Jick, SS, 1999)
" However, patients with this phenotype have been reported with a new dominant mutation at the FGFR2 locus as well as in the offspring of mothers taking the antifungal agent fluconazole during early pregnancy."3.70Evidence for digenic inheritance in some cases of Antley-Bixler syndrome? ( Adès, L; Baraitser, M; Das, D; DeLozier-Blanchet, C; Hindmarsh, P; Honour, JW; Kelly, T; Kumar, D; Malcolm, S; McKee, S; McKeehan, WL; Nelson, I; Reardon, W; Rumsby, G; Sillence, D; Smith, A; Winter, RM, 2000)
"Fluconazole is a triazole antifungal used to treat mycotic infections."1.33Prenatal exposure to fluconazole: an identifiable dysmorphic phenotype. ( Lopez-Rangel, E; Van Allen, MI, 2005)
"Fluconazole (FCZ) is a potent inhibitor of the cytochrome P450 (CYP)-mediated metabolism of the anti-epileptic agent phenytoin (PHT), a well-known human and animal teratogen."1.32Additional investigation on the potentiation of phenytoin teratogenicity by fluconazole. ( Angelucci, S; Bellati, U; Di Ilio, C; Giampietro, F; Moio, P; Tiboni, GM, 2003)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (22.22)18.2507
2000's3 (33.33)29.6817
2010's3 (33.33)24.3611
2020's1 (11.11)2.80

Authors

AuthorsStudies
Liu, D1
Zhang, C1
Wu, L1
Zhang, L2
Mogensen, DM1
Pihl, MB1
Skakkebæk, NE1
Andersen, HR1
Juul, A1
Kyhl, HB1
Swan, S1
Kristensen, DM1
Andersen, MS1
Lind, DV1
Jensen, TK1
Kaplan, YC1
Koren, G1
Bozzo, P1
Barzin, A1
Mounsey, A1
Tiboni, GM1
Giampietro, F1
Angelucci, S1
Moio, P1
Bellati, U1
Di Ilio, C1
Lopez-Rangel, E1
Van Allen, MI1
Wray, CM1
Jick, SS1
Reardon, W1
Smith, A1
Honour, JW1
Hindmarsh, P1
Das, D1
Rumsby, G1
Nelson, I1
Malcolm, S1
Adès, L1
Sillence, D1
Kumar, D1
DeLozier-Blanchet, C1
McKee, S1
Kelly, T1
McKeehan, WL1
Baraitser, M1
Winter, RM1

Reviews

1 review available for fluconazole and Delayed Effects, Prenatal Exposure

ArticleYear
Fetal outcomes after maternal exposure to oral antifungal agents during pregnancy: A systematic review and meta-analysis.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2020, Volume: 148, Issue:1

    Topics: Abortion, Spontaneous; Antifungal Agents; Case-Control Studies; Cohort Studies; Congenital Abnormali

2020

Other Studies

8 other studies available for fluconazole and Delayed Effects, Prenatal Exposure

ArticleYear
Prenatal exposure to antifungal medication may change anogenital distance in male offspring: a preliminary study.
    Environmental health : a global access science source, 2017, 06-21, Volume: 16, Issue:1

    Topics: Adult; Androgen Antagonists; Antifungal Agents; Denmark; Female; Fluconazole; Genitalia, Male; Human

2017
Fluconazole exposure during pregnancy.
    Canadian family physician Medecin de famille canadien, 2015, Volume: 61, Issue:8

    Topics: Abnormalities, Drug-Induced; Antifungal Agents; Candidiasis, Vulvovaginal; Female; Fluconazole; Huma

2015
PURLs: Yeast infection in pregnancy? Think twice about fluconazole.
    The Journal of family practice, 2016, Volume: 65, Issue:9

    Topics: Abortion, Spontaneous; Administration, Oral; Administration, Topical; Antifungal Agents; Azoles; Fem

2016
Additional investigation on the potentiation of phenytoin teratogenicity by fluconazole.
    Toxicology letters, 2003, Dec-10, Volume: 145, Issue:3

    Topics: Animals; Chromatography, High Pressure Liquid; Cleft Palate; Dose-Response Relationship, Drug; Drug

2003
Prenatal exposure to fluconazole: an identifiable dysmorphic phenotype.
    Birth defects research. Part A, Clinical and molecular teratology, 2005, Volume: 73, Issue:11

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Antifungal Agents; Female; Fluconazole; HIV In

2005
Congenital anomalies and fluconazole.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1997, Jan-01, Volume: 156, Issue:1

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Antifungal Agents; Candidiasis, Vulvo

1997
Pregnancy outcomes after maternal exposure to fluconazole.
    Pharmacotherapy, 1999, Volume: 19, Issue:2

    Topics: Abnormalities, Drug-Induced; Antifungal Agents; Female; Fluconazole; Humans; Limb Deformities, Conge

1999
Evidence for digenic inheritance in some cases of Antley-Bixler syndrome?
    Journal of medical genetics, 2000, Volume: 37, Issue:1

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Ankle Joint; Ankylosis; Craniosynostoses; Eye

2000