fluconazole has been researched along with Leishmaniasis, Cutaneous in 37 studies
Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.
fluconazole : A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.
Leishmaniasis, Cutaneous: An endemic disease that is characterized by the development of single or multiple localized lesions on exposed areas of skin that typically ulcerate. The disease has been divided into Old and New World forms. Old World leishmaniasis is separated into three distinct types according to epidemiology and clinical manifestations and is caused by species of the L. tropica and L. aethiopica complexes as well as by species of the L. major genus. New World leishmaniasis, also called American leishmaniasis, occurs in South and Central America and is caused by species of the L. mexicana or L. braziliensis complexes.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Oral fluconazole at a dosage of 6." | 2.84 | Fluconazole in the Treatment of Cutaneous Leishmaniasis Caused by Leishmania braziliensis: A Randomized Controlled Trial. ( Almeida, J; Brito, MD; Carvalho, EM; Dourado, ME; Guimarães, LH; Machado, PR; Prates, FV; Schriefer, A; Silva, SC, 2017) |
| "Fluconazole was well tolerated." | 2.76 | High-dose oral fluconazole therapy effective for cutaneous leishmaniasis due to Leishmania (Vianna) braziliensis. ( Frutuoso, MS; Moraes, EA; Pearson, RD; Pompeu, MM; Sousa, AQ, 2011) |
| "Cutaneous leishmaniasis was not considered as an initial diagnosis because of the atypical appearance of the lesion as well as his residence in the hilly region of Nepal." | 1.62 | Case Report: An Atypical Erysipeloid Presentation of Cutaneous Leishmaniasis from the Hilly Region of Nepal. ( Nepal, S, 2021) |
| "Treatment with meglumine antimoniate (Glucantime) was ineffective." | 1.56 | [Cutaneous leishmaniasis of the vermilion border of the upper lip extending to the oral mucosa]. ( Boumezzourh, A; Chiheb, S; Dessay, M; Elfatoiki, FZ; Elkhalfaoui, N; Maksouri, H; Riyad, M, 2020) |
| "Cutaneous leishmaniasis has an incidence of 0." | 1.48 | Pediatric Old World cutaneous leishmaniasis treated with oral fluconazole: A case series. ( Barruscotti, S; Bossi, G; Brazzelli, V; Michelerio, A, 2018) |
| "Oral fluconazole was started and the lesion resolved completely." | 1.42 | Cutaneous leishmaniasis mimicking granulomatous cheilitis and treated successfully with oral fluconazole in a boy. ( Aksakal, M; Serarslan, G, 2015) |
| "American cutaneous leishmaniasis is an endemic anthropozoonosis that exhibits a broad spectrum of clinical presentations." | 1.40 | Intermediate cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis successfully treated with fluconazole. ( Convit, J; Daly, K; De Lima, H; Kato, H; Paniz-Mondolfi, AE; Reyes-Jaimes, O; Sordillo, EM; Zerpa, O, 2014) |
| "The optimal treatment of cutaneous leishmaniasis is controversial." | 1.36 | Management of old world cutaneous leishmaniasis in refugee children. ( Crogan, J; Gunasekera, H; Isaacs, D; Sheikh, M; Wood, N, 2010) |
| " A pharmacokinetic study was conducted on Days 1 and 14 of treatment, representing single- and multiple-dose pharmacokinetics, respectively." | 1.34 | Effects of fluconazole on the pharmacokinetics and pharmacodynamics of antimony in cutaneous leishmaniasis-infected hamsters. ( Abou Alsoud, N; Al-Jaser, M; Alnaim, L; Zaghloul, I, 2007) |
| "Oral fluconazole treatment resulted in complete resolution." | 1.33 | Oral fluconazole treatment for extensive cutaneous leishmaniasis in an 11-year-old child. ( Armengaud, JB; Dupouy Camet, J; Gendrel, D; Toubiana, J, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.70) | 18.2507 |
| 2000's | 10 (27.03) | 29.6817 |
| 2010's | 20 (54.05) | 24.3611 |
| 2020's | 6 (16.22) | 2.80 |
| Authors | Studies |
|---|---|
| Hill, N | 1 |
| Irwin, A | 1 |
| Graham, N | 1 |
| Leung, C | 1 |
| Francis, JR | 1 |
| Wall, N | 1 |
| Nourse, C | 1 |
| Mitra, D | 1 |
| Bhatnagar, A | 1 |
| Patil, C | 1 |
| Kothari, R | 1 |
| Yadav, N | 1 |
| Madke, B | 1 |
| Elfatoiki, FZ | 1 |
| Boumezzourh, A | 1 |
| Maksouri, H | 1 |
| Elkhalfaoui, N | 1 |
| Dessay, M | 1 |
| Riyad, M | 1 |
| Chiheb, S | 1 |
| Nepal, S | 1 |
| Veraldi, S | 2 |
| Romagnuolo, M | 1 |
| Cusini, M | 1 |
| Maronese, CA | 1 |
| Laurent, K | 1 |
| Susong, J | 1 |
| Fillman, E | 1 |
| Ritchie, S | 1 |
| Elmehdi, E | 1 |
| Zerkly, B | 1 |
| Francesconi, VA | 1 |
| Francesconi, F | 1 |
| Ramasawmy, R | 1 |
| Romero, GAS | 1 |
| Alecrim, MDGC | 1 |
| Michelerio, A | 1 |
| Barruscotti, S | 1 |
| Bossi, G | 1 |
| Brazzelli, V | 1 |
| Benzaquen, M | 1 |
| Chambelland, A | 1 |
| Fongue, J | 1 |
| Melenotte, C | 1 |
| Christen, JR | 1 |
| Ranque, S | 1 |
| Buono, JP | 1 |
| Parola, P | 1 |
| Berbis, P | 1 |
| Hegg, RM | 1 |
| Alkousakis, TJ | 1 |
| Swick, BL | 1 |
| Daly, K | 1 |
| De Lima, H | 1 |
| Kato, H | 1 |
| Sordillo, EM | 1 |
| Convit, J | 1 |
| Reyes-Jaimes, O | 1 |
| Zerpa, O | 1 |
| Paniz-Mondolfi, AE | 1 |
| Oliveira, MB | 1 |
| Calixto, G | 1 |
| Graminha, M | 1 |
| Cerecetto, H | 1 |
| González, M | 1 |
| Chorilli, M | 1 |
| Nazzaro, G | 1 |
| Serarslan, G | 1 |
| Aksakal, M | 1 |
| Sousa, AQ | 2 |
| Lima Pompeu, MM | 1 |
| Pearson, RD | 2 |
| Ouadi, Z | 1 |
| Akhdari, N | 1 |
| Hocar, O | 1 |
| Amal, S | 1 |
| Tassi, N | 1 |
| Chacko, A | 1 |
| Joseph, M | 1 |
| Feltis, T | 1 |
| Morris, SK | 1 |
| Prates, FV | 1 |
| Dourado, ME | 1 |
| Silva, SC | 1 |
| Schriefer, A | 1 |
| Guimarães, LH | 1 |
| Brito, MD | 1 |
| Almeida, J | 1 |
| Carvalho, EM | 1 |
| Machado, PR | 1 |
| Caridha, D | 1 |
| Parriot, S | 1 |
| Hudson, TH | 1 |
| Lang, T | 1 |
| Ngundam, F | 1 |
| Leed, S | 1 |
| Sena, J | 1 |
| Harris, M | 1 |
| O'Neil, M | 1 |
| Sciotti, R | 1 |
| Read, L | 1 |
| Lecoeur, H | 1 |
| Hickman, M | 1 |
| Grogl, M | 2 |
| Crogan, J | 1 |
| Gunasekera, H | 1 |
| Wood, N | 1 |
| Sheikh, M | 1 |
| Isaacs, D | 1 |
| Fathy, FM | 1 |
| El-Kasah, F | 1 |
| El-Ahwal, AM | 1 |
| Sklavos, AV | 1 |
| Walls, T | 1 |
| Webber, MT | 1 |
| Watson, AB | 1 |
| Emad, M | 1 |
| Hayati, F | 1 |
| Fallahzadeh, MK | 1 |
| Namazi, MR | 1 |
| Frutuoso, MS | 1 |
| Moraes, EA | 1 |
| Pompeu, MM | 1 |
| Torres, JR | 1 |
| Suárez, JA | 1 |
| Zvulunov, A | 1 |
| Klaus, S | 1 |
| Vardy, D | 1 |
| Baron, S | 1 |
| Laube, S | 1 |
| Raafat, F | 1 |
| Moss, C | 1 |
| Laffitte, E | 2 |
| Genton, B | 1 |
| Panizzon, RG | 1 |
| Quante, G | 1 |
| Wittekindt, C | 1 |
| Beutner, D | 1 |
| Preuss, SF | 1 |
| Damm, M | 1 |
| Hüttenbrink, KB | 1 |
| Toubiana, J | 1 |
| Armengaud, JB | 1 |
| Dupouy Camet, J | 1 |
| Gendrel, D | 1 |
| Mussi, SV | 1 |
| Fernandes, AP | 1 |
| Ferreira, LA | 1 |
| Morizot, G | 1 |
| Delgiudice, P | 1 |
| Caumes, E | 1 |
| Marty, P | 1 |
| Dupuy, A | 1 |
| Sarfati, C | 1 |
| Hadj-Rabia, S | 1 |
| Darie, H | 1 |
| LE Guern, AS | 1 |
| Salah, AB | 1 |
| Pratlong, F | 1 |
| Dedet, JP | 1 |
| Buffet, PA | 1 |
| Alnaim, L | 1 |
| Abou Alsoud, N | 1 |
| Zaghloul, I | 1 |
| Al-Jaser, M | 1 |
| Al-Abdely, HM | 1 |
| Graybill, JR | 1 |
| Loebenberg, D | 1 |
| Melby, PC | 1 |
| Alrajhi, AA | 1 |
| Ibrahim, EA | 1 |
| De Vol, EB | 1 |
| Khairat, M | 1 |
| Faris, RM | 1 |
| Maguire, JH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase 3 Randomized Trial Comparing Fluconazole to Meglumine Antimoniate in the Treatment of Cutaneous Leishmaniasis Caused by L. Braziliensis and L. Guyanensis[NCT01953744] | Phase 3 | 53 participants (Actual) | Interventional | 2014-02-28 | Terminated (stopped due to Low cure rate in the study (fluconazole) group) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 trials available for fluconazole and Leishmaniasis, Cutaneous
| Article | Year |
|---|---|
Failure of fluconazole in treating cutaneous leishmaniasis caused by Leishmania guyanensis in the Brazilian Amazon: An open, nonrandomized phase 2 trial.
Topics: Administration, Oral; Adolescent; Adult; Antiprotozoal Agents; Brazil; Fluconazole; Hand; Humans; Le | 2018 |
Fluconazole in the Treatment of Cutaneous Leishmaniasis Caused by Leishmania braziliensis: A Randomized Controlled Trial.
Topics: Adolescent; Adult; Antimony; Antiprotozoal Agents; Brazil; Female; Fluconazole; Humans; Leishmania b | 2017 |
Superior efficacy of oral fluconazole 400 mg daily versus oral fluconazole 200 mg daily in the treatment of cutaneous leishmania major infection: a randomized clinical trial.
Topics: Adult; Female; Fluconazole; Humans; Leishmania major; Leishmaniasis, Cutaneous; Male; Middle Aged | 2011 |
High-dose oral fluconazole therapy effective for cutaneous leishmaniasis due to Leishmania (Vianna) braziliensis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antiprotozoal Agents; Child; Child, Preschool; Female; F | 2011 |
Healing of Old World cutaneous leishmaniasis in travelers treated with fluconazole: drug effect or spontaneous evolution?
Topics: Adult; Aged; Aged, 80 and over; Animals; Antiparasitic Agents; Biological Evolution; Child; Child, P | 2007 |
Fluconazole for the treatment of cutaneous leishmaniasis caused by Leishmania major.
Topics: Adult; Animals; Antifungal Agents; Double-Blind Method; Endemic Diseases; Female; Fluconazole; Follo | 2002 |
31 other studies available for fluconazole and Leishmaniasis, Cutaneous
| Article | Year |
|---|---|
Treatment of Cutaneous Leishmaniasis in a Nonendemic Country: A Case Series of Children in Australia.
Topics: Administration, Topical; Antiprotozoal Agents; Child; Fluconazole; Humans; Leishmaniasis, Cutaneous; | 2022 |
Successful management of pediatric cases of cutaneous leishmaniasis with oral fluconazole.
Topics: Administration, Oral; Antifungal Agents; Antiprotozoal Agents; Child; Fluconazole; Humans; Leishmani | 2023 |
Case Report: Diffuse Cutaneous Leishmaniasis Successfully Treated with a Combination of Oral Rifampicin and Fluconazole.
Topics: Female; Fluconazole; Humans; Leishmania; Leishmaniasis, Cutaneous; Leishmaniasis, Diffuse Cutaneous; | 2023 |
[Cutaneous leishmaniasis of the vermilion border of the upper lip extending to the oral mucosa].
Topics: Adolescent; Facial Dermatoses; Female; Fluconazole; Humans; Leishmaniasis, Cutaneous; Lip; Lip Disea | 2020 |
Case Report: An Atypical Erysipeloid Presentation of Cutaneous Leishmaniasis from the Hilly Region of Nepal.
Topics: Antifungal Agents; Antiprotozoal Agents; Fluconazole; Humans; Leishmaniasis, Cutaneous; Male; Middle | 2021 |
Therapy of cutaneous leishmaniasis caused by Leishmania braziliensis with fluconazole.
Topics: Fluconazole; Humans; Leishmania braziliensis; Leishmaniasis, Cutaneous | 2021 |
Cutaneous Leishmaniasis in a Saudi Arabian Soldier Stationed in the United States.
Topics: Adult; Emergency Service, Hospital; Fluconazole; Humans; Leishmaniasis, Cutaneous; Male; Military Pe | 2017 |
[Leg ulcer revealing cutaneous leishmaniasis].
Topics: Administration, Topical; Adolescent; Animals; Antiparasitic Agents; Biopsy; Fluconazole; Humans; Leg | 2017 |
Pediatric Old World cutaneous leishmaniasis treated with oral fluconazole: A case series.
Topics: Administration, Oral; Antifungal Agents; Child; Child, Preschool; Female; Fluconazole; Humans; Leish | 2018 |
Cutaneous sporotrichoid leishmaniasis treated with oral fluconazole.
Topics: Administration, Oral; Aged; Antifungal Agents; Fluconazole; Humans; Leishmania; Leishmaniasis, Cutan | 2019 |
What is your diagnosis? Old world Leishmaniasis.
Topics: Aminoquinolines; Anti-Infective Agents; Arm; Cryotherapy; Fluconazole; Humans; Imiquimod; Iraq; Leis | 2014 |
Intermediate cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis successfully treated with fluconazole.
Topics: Antifungal Agents; Child; Female; Fluconazole; Humans; Leishmania braziliensis; Leishmaniasis, Cutan | 2014 |
Development, characterization, and in vitro biological performance of fluconazole-loaded microemulsions for the topical treatment of cutaneous leishmaniasis.
Topics: Adhesiveness; Administration, Topical; Animals; Cell Line; Emulsions; Female; Fluconazole; Hardness; | 2015 |
Successful treatment of cutaneous leishmaniasis of the ear with oral fluconazole.
Topics: Administration, Oral; Antifungal Agents; Ear Diseases; Fluconazole; Humans; Leishmaniasis, Cutaneous | 2016 |
Cutaneous leishmaniasis mimicking granulomatous cheilitis and treated successfully with oral fluconazole in a boy.
Topics: Antiprotozoal Agents; Child; Diagnosis, Differential; Fluconazole; Humans; Leishmaniasis, Cutaneous; | 2015 |
Disseminated Cutaneous Leishmaniasis, a Patient with 178 Lesions Cured with Fluconazole.
Topics: Antifungal Agents; Fluconazole; Humans; Leishmaniasis, Cutaneous; Male; Middle Aged; Treatment Outco | 2016 |
[Polymorphic lesions of cutaneous leishmaniasis revealing human immunodeficiency virus infection].
Topics: AIDS-Related Opportunistic Infections; Anti-HIV Agents; Antiprotozoal Agents; Antiretroviral Therapy | 2016 |
Successful Treatment of Cutaneous Leishmaniasis with Topical Paramomycin in a Child After Treatment Failure with Systemic Fluconazole.
Topics: Administration, Oral; Administration, Topical; Antiprotozoal Agents; Child, Preschool; Fluconazole; | 2016 |
Use of Optical Imaging Technology in the Validation of a New, Rapid, Cost-Effective Drug Screen as Part of a Tiered
Topics: Amphotericin B; Animals; Antiprotozoal Agents; Cell Line; Cell Survival; Drug Evaluation, Preclinica | 2017 |
Management of old world cutaneous leishmaniasis in refugee children.
Topics: Amphotericin B; Animals; Antifungal Agents; Australia; Child; Female; Fluconazole; Humans; Infant; L | 2010 |
Emerging cutaneous leishmaniasis in Sirte-Libya: epidemiology, recognition and management.
Topics: Adolescent; Adult; Animals; Antimony Sodium Gluconate; Antiprotozoal Agents; Child; Cryotherapy; Dis | 2009 |
Cutaneous leishmaniasis in a child treated with oral fluconazole.
Topics: Administration, Oral; Cephalexin; Child, Preschool; Cicatrix; Female; Fluconazole; Humans; Leishmani | 2010 |
Fluconazole effectiveness against Leishmania (Viannia) braziliensis: is the evidence enough?
Topics: Antiprotozoal Agents; Female; Fluconazole; Humans; Leishmania braziliensis; Leishmaniasis, Cutaneous | 2012 |
Fluconazole for the treatment of cutaneous leishmaniasis.
Topics: Administration, Topical; Animals; Antifungal Agents; Antiprotozoal Agents; Fluconazole; Humans; Leis | 2002 |
Cutaneous leishmaniasis in a Kosovan child treated with oral fluconazole.
Topics: Administration, Oral; Antifungal Agents; Child, Preschool; Female; Fluconazole; Humans; Leishmaniasi | 2004 |
Cutaneous leishmaniasis caused by Leishmania tropica: treatment with oral fluconazole.
Topics: Administration, Oral; Adult; Animals; Antifungal Agents; Diagnosis, Differential; Female; Fluconazol | 2005 |
[Chronic-persistent infection of the auricle].
Topics: Animals; Antifungal Agents; Chronic Disease; Ear, External; Fluconazole; Humans; Leishmania tropica; | 2006 |
Oral fluconazole treatment for extensive cutaneous leishmaniasis in an 11-year-old child.
Topics: Administration, Oral; Animals; Antifungal Agents; Child; Female; Fluconazole; Humans; Leishmania maj | 2006 |
Comparative study of the efficacy of formulations containing fluconazole or paromomycin for topical treatment of infections by Leishmania (Leishmania) major and Leishmania (Leishmania) amazonensis.
Topics: Administration, Oral; Administration, Topical; Animals; Antiprotozoal Agents; Dose-Response Relation | 2007 |
Effects of fluconazole on the pharmacokinetics and pharmacodynamics of antimony in cutaneous leishmaniasis-infected hamsters.
Topics: Administration, Oral; Animals; Antifungal Agents; Antimony; Antiprotozoal Agents; Area Under Curve; | 2007 |
Efficacy of the triazole SCH 56592 against Leishmania amazonensis and Leishmania donovani in experimental murine cutaneous and visceral leishmaniases.
Topics: Amphotericin B; Animals; Fluconazole; Leishmania donovani; Leishmaniasis, Cutaneous; Leishmaniasis, | 1999 |