Compounds > 6-nonadecynoic acid
Page last updated: 2024-11-12

6-nonadecynoic acid

Description

6-nonadecynoic acid: from the roots of Pentagonia gigantifolia; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10424556
CHEMBL ID454322
SCHEMBL ID270054
MeSH IDM0457880

Synonyms (6)

Synonym
6-nonadecynoic acid
nonadec-6-ynoic acid
CHEMBL454322
600175-30-2
SCHEMBL270054
DTXSID90439744
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (57)

Assay IDTitleYearJournalArticle
AID531196Cytotoxicity against human SK-MEL cells up to 32 uM by neutral red method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID530451Antifungal activity against Candida albicans ATCC 90028 at 169.8 uM after 48 hrs by CLSI method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID356360Antifungal activity against fluconazole-resistant Candida albicans isolate 2 after 24 to 48 hrs by NCCLS method2003Journal of natural products, Aug, Volume: 66, Issue:8
Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia.
AID530957Antifungal activity against Aspergillus fumigatus ATCC 204305 after 5 days by CLSI method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID530470Antifungal activity against Fluconazole resistant Candida albicans isolate 17 at 169.8 uM after 48 hrs by CLSI method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID530953Antifungal activity against Trichophyton mentagrophytes ATCC MYA-4439 by CLSI method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID530956Antifungal activity against Aspergillus fumigatus ATCC 90906 after 5 days by CLSI method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID356361Antifungal activity against fluconazole-resistant Candida albicans isolate 5 after 24 to 48 hrs by NCCLS method2003Journal of natural products, Aug, Volume: 66, Issue:8
Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia.
AID531183Antifungal activity against Candida albicans ATCC 32354 after 48 hrs by CLSI method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID356362Antifungal activity against fluconazole-resistant Candida albicans isolate 8 after 24 to 48 hrs by NCCLS method2003Journal of natural products, Aug, Volume: 66, Issue:8
Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia.
AID530705Antifungal activity against Aspergillus flavus ATCC 204304 at 169.8 uM after 48 hrs by CLSI method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID531205Antifungal activity against Candida albicans ATCC 14053 after 48 hrs by CLSI method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID530988Antifungal activity against Candida albicans ATCC 90028 after 48 hrs by CLSI method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID356365Antifungal activity against Candida albicans ATCC 90028 by sphingolipid reversal assay in presence of 1.25 ug/mL dihydrosphingosine2003Journal of natural products, Aug, Volume: 66, Issue:8
Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia.
AID356354Cytotoxicity against human KB cells at 10 ug/mL2003Journal of natural products, Aug, Volume: 66, Issue:8
Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia.
AID531201Cytotoxicity against pig LLC-PK1 cells up to 32 uM by neutral red method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID356363Antifungal activity against fluconazole-resistant Candida albicans isolate 17 after 24 to 48 hrs by NCCLS method2003Journal of natural products, Aug, Volume: 66, Issue:8
Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia.
AID530724Antifungal activity against Trichophyton rubrum ATCC MYA-4438 at 169.8 uM after 5 days by CLSI method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID530964Antifungal activity against Fluconazole resistant Candida albicans clinical isolate 17 after 48 hrs by CLSI method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID530981Antifungal activity against Candida albicans ATCC 200955 after 48 hrs by CLSI method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID356356Cytotoxicity against human BT549 cells at 10 ug/mL2003Journal of natural products, Aug, Volume: 66, Issue:8
Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia.
AID530712Antifungal activity against Aspergillus niger ATCC 16404 at 169.8 uM after 48 hrs by CLSI method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID530947Antifungal activity against Trichophyton rubrum ATCC MYA-4438 by CLSI method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID530490Antifungal activity against Candida parapsilosis ATCC 22019 at 169.8 uM after 48 hrs by CLSI method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID356442Antifungal activity against Candida albicans ATCC 90028 after 24 to 48 hrs by NCCLS method2003Journal of natural products, Aug, Volume: 66, Issue:8
Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia.
AID530962Antifungal activity against Candida krusei ATCC 6258 after 48 hrs by CLSI method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID356355Cytotoxicity against human SK-MEL cells at 10 ug/mL2003Journal of natural products, Aug, Volume: 66, Issue:8
Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia.
AID356359Antifungal activity against fluconazole-susceptible Candida albicans isolate 1 after 24 to 48 hrs by NCCLS method2003Journal of natural products, Aug, Volume: 66, Issue:8
Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia.
AID531202Toxicity in mouse up to 34 umol/kg/day, ip for 3 days2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID530445Antifungal activity against Candida albicans ATCC 32354 at 169.8 uM after 48 hrs by CLSI method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID356367Antifungal activity against Candida albicans ATCC 90028 by sphingolipid reversal assay in presence of 5.0 ug/mL dihydrosphingosine2003Journal of natural products, Aug, Volume: 66, Issue:8
Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia.
AID531206Antifungal activity against Candida albicans ATCC 60193 after 48 hrs by CLSI method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID530960Antifungal activity against Candida tropicalis ATCC 750 after 48 hrs by CLSI method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID531200Cytotoxicity against African green monkey Vero cells up to 32 uM by neutral red method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID530680Antifungal activity against Cryptococcus neoformans ATCC 90113 at 169.8 uM after 72 hrs by CLSI method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID530941Antifungal activity against Trichophyton rubrum ATCC 10218 by CLSI method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID356357Cytotoxicity against human SKOV3 cells at 10 ug/mL2003Journal of natural products, Aug, Volume: 66, Issue:8
Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia.
AID356358Cytotoxicity against african green monkey Vero cells at 10 ug/mL2003Journal of natural products, Aug, Volume: 66, Issue:8
Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia.
AID530950Antifungal activity against Trichophyton mentagrophytes ATCC 9533 by CLSI method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID356370Antifungal activity against Candida albicans ATCC 90028 by sphingolipid reversal assay in presence of 30 ug/mL stearylamine2003Journal of natural products, Aug, Volume: 66, Issue:8
Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia.
AID356366Antifungal activity against Candida albicans ATCC 90028 by sphingolipid reversal assay in presence of 2.5 ug/mL dihydrosphingosine2003Journal of natural products, Aug, Volume: 66, Issue:8
Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia.
AID531198Cytotoxicity against human BT549 cells up to 32 uM by neutral red method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID530464Antifungal activity against Fluconazole resistant Candida albicans isolate 1 at 169.8 uM after 48 hrs by CLSI method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID356368Antifungal activity against Candida albicans ATCC 90028 by sphingolipid reversal assay in presence of 5 ug/mL stearylamine2003Journal of natural products, Aug, Volume: 66, Issue:8
Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia.
AID356369Antifungal activity against Candida albicans ATCC 90028 by sphingolipid reversal assay in presence of 15 ug/mL stearylamine2003Journal of natural products, Aug, Volume: 66, Issue:8
Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia.
AID530692Antifungal activity against Aspergillus fumigatus ATCC 204305 at 169.8 uM after 48 hrs by CLSI method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID530686Antifungal activity against Cryptococcus neoformans ATCC 66031 at 169.8 uM after 72 hrs by CLSI method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID530438Antifungal activity against Candida albicans ATCC 60193 at 169.8 uM after 48 hrs by CLSI method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID530496Antifungal activity against Candida tropicalis ATCC 750 at 169.8 uM after 48 hrs by CLSI method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID530477Antifungal activity against Candida glabrata ATCC 90030 at 169.8 uM after 48 hrs by CLSI method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID531199Cytotoxicity against human SKOV3 cells up to 32 uM by neutral red method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID530458Antifungal activity against Candida albicans ATCC 200955 at 169.8 uM after 48 hrs by CLSI method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID530970Antifungal activity against Fluconazole resistant Candida albicans clinical isolate 1 after 48 hrs by CLSI method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID530483Antifungal activity against Candida krusei ATCC 6258 at 169.8 uM after 48 hrs by CLSI method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID531197Cytotoxicity against human KB cells up to 32 uM by neutral red method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID530699Antifungal activity against Aspergillus fumigatus ATCC 90906 at 169.8 uM after 48 hrs by CLSI method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
AID530958Antifungal activity against Cryptococcus neoformans ATCC 66031 after 72 hrs by CLSI method2008Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
Potent in vitro antifungal activities of naturally occurring acetylenic acids.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.63

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.63 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.42 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.63)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
dimethyl sulfoxide
Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.. dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.		2.1510sulfoxide;
volatile organic compound		alkylating agent;
antidote;
Escherichia coli metabolite;
geroprotector;
MRI contrast agent;
non-narcotic analgesic;
polar aprotic solvent;
radical scavenger
5,8,11,14-eicosatetraynoic acid
5,8,11,14-Eicosatetraynoic Acid: A 20-carbon unsaturated fatty acid containing 4 alkyne bonds. It inhibits the enzymatic conversion of arachidonic acid to prostaglandins E(2) and F(2a).		2.0410long-chain fatty acid
fluconazole
Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.. fluconazole : A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.		2.7330conazole antifungal drug;
difluorobenzene;
tertiary alcohol;
triazole antifungal drug		environmental contaminant;
P450 inhibitor;
xenobiotic
flucytosine
Flucytosine: A fluorinated cytosine analog that is used as an antifungal agent.. flucytosine : An organofluorine compound that is cytosine that is substituted at position 5 by a fluorine. A prodrug for the antifungal 5-fluorouracil, it is used for the treatment of systemic fungal infections.		2.0110aminopyrimidine;
nucleoside analogue;
organofluorine compound;
pyrimidine antifungal drug;
pyrimidone		prodrug
ketoconazole
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.		2.0410dichlorobenzene;
dioxolane;
ether;
imidazoles;
N-acylpiperazine;
N-arylpiperazine
undecylenic acid
undecylenic acid: a fatty acid with a terminal double bond. 10-undecenoic acid : An undecenoic acid having its double bond in the 10-position. It is derived from castor oil and is used for the treatment of skin problems.. undecenoic acid : A C11, straight-chain fatty acid carrying a C=C double bond at any position.		2.0410undecenoic acidantifungal drug;
plant metabolite
cyclopentane
Cyclopentanes: A group of alicyclic hydrocarbons with the general formula R-C5H9.. cyclopentanes : Cyclopentane and its derivatives formed by substitution.		2.1510cycloalkane;
cyclopentanes;
volatile organic compound		non-polar solvent
9-stearolic acid
9-stearolic acid: structure given in first source. stearolic acid : An octadecynoic acid having its triple bond at position 9.		2.0410octadecynoic acid
2-hexadecynoic acid
2-hexadecynoic acid: RN given refers to parent cpd		2.0710long-chain fatty acid
6-octadecynoic acid
6-octadecynoic acid: from the roots of Pentagonia gigantifolia; structure in first source. tariric acid : An octadecynoic acid having its triple bond at position 6.		2.4320octadecynoic acid
sampangine
sampangine: a plant-derived copyrine alkaloid extracted from the stem bark of Cananga odorata. sampangine : A copyrine alkaloid with formula C15H8N2O, extracted from several plants including the stem bark of Cananga odorata. It is a heme biosynthesis inhibitor and exhibits antifungal and anticancer properties.		2.1510alkaloid;
organic heterotetracyclic compound		antifungal agent;
plant metabolite
terbinafine
[no description available]		2.0410acetylenic compound;
allylamine antifungal drug;
enyne;
naphthalenes;
tertiary amine		EC 1.14.13.132 (squalene monooxygenase) inhibitor;
P450 inhibitor;
sterol biosynthesis inhibitor
cancidas
[no description available]		2.0410
amphotericin b
Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.		2.4320antibiotic antifungal drug;
macrolide antibiotic;
polyene antibiotic		antiamoebic agent;
antiprotozoal drug;
bacterial metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
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