fluconazole has been researched along with Isochromosomes in 2 studies
Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.
fluconazole : A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.
Isochromosomes: Metacentric chromosomes produced during MEIOSIS or MITOSIS when the CENTROMERE splits transversely instead of longitudinally. The chromosomes produced by this abnormal division are one chromosome having the two long arms of the original chromosome, but no short arms, and the other chromosome consisting of the two short arms and no long arms. Each of these isochromosomes constitutes a simultaneous duplication and deletion.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We found that aneuploidy in general and a specific segmental aneuploidy, consisting of an isochromosome composed of the two left arms of chromosome 5, were associated with azole resistance." | 1.33 | Aneuploidy and isochromosome formation in drug-resistant Candida albicans. ( Berman, J; Forche, A; Selmecki, A, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Selmecki, A | 2 |
| Forche, A | 2 |
| Berman, J | 2 |
| Gerami-Nejad, M | 1 |
| Paulson, C | 1 |
2 other studies available for fluconazole and Isochromosomes
| Article | Year |
|---|---|
Aneuploidy and isochromosome formation in drug-resistant Candida albicans.
Topics: Aneuploidy; Antifungal Agents; Azoles; Candida albicans; Centromere; Chromosomes, Fungal; Cytochrome | 2006 |
An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1.
Topics: Antifungal Agents; Candida albicans; Candidiasis; Chromosomes, Fungal; Drug Resistance, Fungal; Fluc | 2008 |