Page last updated: 2024-11-13

mefway

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

mefway: a 5-HT(1A) receptor radioligand for PET imaging [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID24860642
CHEMBL ID5222145
CHEMBL ID5222456
CHEMBL ID5222183
SCHEMBL ID15709829
SCHEMBL ID12677607
SCHEMBL ID12677606
MeSH IDM0504963

Synonyms (11)

Synonym
SCHEMBL15709829
SCHEMBL12677607
SCHEMBL12677606
CHEMBL5222145
v3a7fm6pbm ,
946530-09-2
mefway
trans-4-(fluoromethyl)-n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-2-pyridinylcyclohexanecarboxamide
cyclohexanecarboxamide, 4-(fluoromethyl)-n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-2-pyridinyl-, trans-
CHEMBL5222456
CHEMBL5222183

Research Excerpts

Overview

Mefway was found to be a poor substrate for the multidrug resistance 1 protein. This suggests low likelihood of brain uptake being affected by P-glycoprotein.

ExcerptReferenceRelevance
"Mefway was found to be a poor substrate (>30 μM) for the multidrug resistance 1 protein, suggesting low likelihood of brain uptake being affected by P-glycoprotein."( Comparative assessment of (18) F-Mefway as a serotonin 5-HT1A receptor PET imaging agent across species: Rodents, nonhuman primates, and humans.
Bajwa, AK; Christian, BT; Hillmer, AT; Mukherjee, J; Pan, ML; Pandey, SK; Saigal, N; Wooten, DW, 2016
)
1.44
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (19)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (5.26)29.6817
2010's17 (89.47)24.3611
2020's1 (5.26)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 22.43

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index22.43 (24.57)
Research Supply Index3.04 (2.92)
Research Growth Index6.18 (4.65)
Search Engine Demand Index18.60 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (22.43)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (5.26%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other18 (94.74%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]