| Assay ID | Title | Year | Journal | Article |
|---|
| AID1589606 | Mitochondrial toxicity in human 786-O cells measured after 6 hrs by MitoTracker Red chloromethyl-X-rosamine based assay | 2019 | Journal of medicinal chemistry, 04-25, Volume: 62, Issue:8
| Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections. |
| AID750285 | Antifungal activity against Candida krusei ATCC 6258 after 24 to 48 hrs by broth microdilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | 2-Aminobenzothiazole derivatives: search for new antifungal agents. |
| AID750286 | Antifungal activity against Candida tropicalis ATCC 750 after 24 to 48 hrs by broth microdilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | 2-Aminobenzothiazole derivatives: search for new antifungal agents. |
| AID179985 | Tested for the protection against glutamic acid-evoked convulsions in rats by intraperitoneal administration | 1999 | Journal of medicinal chemistry, Jul-29, Volume: 42, Issue:15
| Riluzole series. Synthesis and in vivo "antiglutamate" activity of 6-substituted-2-benzothiazolamines and 3-substituted-2-imino-benzothiazolines. |
| AID1589600 | Inhibition of human CYP2C19 expressed in baculovirus infected insect cells using beetle D-luciferin as substrate preincubated for 30 mins followed by NADPH addition and measured after 30 mins by CYP450-Glo assay | 2019 | Journal of medicinal chemistry, 04-25, Volume: 62, Issue:8
| Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections. |
| AID750289 | Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs by broth microdilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | 2-Aminobenzothiazole derivatives: search for new antifungal agents. |
| AID1589593 | Growth inhibition of Trypanosoma brucei bloodstream forms at 10 uM measured after 72 hrs by resazurin-based fluorescence assay relative to control | 2019 | Journal of medicinal chemistry, 04-25, Volume: 62, Issue:8
| Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections. |
| AID750287 | Antifungal activity against Candida parapsilosis ATCC 22019 after 24 to 48 hrs by broth microdilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | 2-Aminobenzothiazole derivatives: search for new antifungal agents. |
| AID1589601 | Inhibition of human CYP2D6 expressed in baculovirus infected insect cells using beetle D-luciferin as substrate preincubated for 30 mins followed by NADPH addition and measured after 30 mins by CYP450-Glo assay | 2019 | Journal of medicinal chemistry, 04-25, Volume: 62, Issue:8
| Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections. |
| AID1741933 | Antiproliferative activity against human HeLa cells assessed as growth inhibition at 20 uM viability after 72 hrs by SRB assay relative to control | 2020 | European journal of medicinal chemistry, Oct-15, Volume: 204 | Discovery of 2-(2-aminobenzo[d]thiazol-6-yl) benzo[d]oxazol-5-amine derivatives that regulated HPV relevant cellular pathway and prevented cervical cancer from abnormal proliferation. |
| AID1589598 | Inhibition of human CYP1A2 expressed in baculovirus infected insect cells using beetle D-luciferin as substrate preincubated for 30 mins followed by NADPH addition and measured after 30 mins by CYP450-Glo assay | 2019 | Journal of medicinal chemistry, 04-25, Volume: 62, Issue:8
| Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections. |
| AID1589602 | Inhibition of human CYP3A4 expressed in baculovirus infected insect cells using beetle D-luciferin as substrate preincubated for 30 mins followed by NADPH addition and measured after 30 mins by CYP450-Glo assay | 2019 | Journal of medicinal chemistry, 04-25, Volume: 62, Issue:8
| Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections. |
| AID1589604 | Cytotoxicity against human THP1 cells after 72 hrs by MTT assay | 2019 | Journal of medicinal chemistry, 04-25, Volume: 62, Issue:8
| Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections. |
| AID1589587 | Growth inhibition of luciferase expressing Leishmania infantum axenic amastigotes infected in human THP1 cells at 10 uM measured after 72 hrs by steady-glo luminescence assay relative to control | 2019 | Journal of medicinal chemistry, 04-25, Volume: 62, Issue:8
| Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections. |
| AID750290 | Antibacterial activity against Enterococcus faecalis ATCC 29212 after 24 hrs by broth microdilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | 2-Aminobenzothiazole derivatives: search for new antifungal agents. |
| AID1589592 | Inhibition of Leishmania major pteridine reductase 1 at 50 uM using di-hydrobiopterine as substrate in presence of NADPH relative to control | 2019 | Journal of medicinal chemistry, 04-25, Volume: 62, Issue:8
| Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections. |
| AID1589597 | Displacement of Tracer Red from human ERG by fluorescence polarization assay | 2019 | Journal of medicinal chemistry, 04-25, Volume: 62, Issue:8
| Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections. |
| AID750291 | Antibacterial activity against Staphylococcus aureus ATCC 29213 after 24 hrs by broth microdilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | 2-Aminobenzothiazole derivatives: search for new antifungal agents. |
| AID750288 | Antifungal activity against Candida albicans ATCC 10231 after 24 to 48 hrs by broth microdilution method | 2013 | European journal of medicinal chemistry, Jun, Volume: 64 | 2-Aminobenzothiazole derivatives: search for new antifungal agents. |
| AID1589586 | Growth inhibition of trypomastigote form of Trypanosoma cruzi Y infected in human U2OS cells at 50 uM measured after 72 hrs by DRAQ5 DNA dye based confocal microscopic analysis relative to control | 2019 | Journal of medicinal chemistry, 04-25, Volume: 62, Issue:8
| Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections. |
| AID1589605 | Cytotoxicity against human U2OS cells assessed as reduction in cell number | 2019 | Journal of medicinal chemistry, 04-25, Volume: 62, Issue:8
| Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections. |
| AID1589590 | Inhibition of N-terminal His-tagged Trypanosoma brucei pteridine reductase 1 at 50 uM using di-hydrobiopterine as substrate measured at 1 min interval for 50 mins in presence of NADPH relative to control | 2019 | Journal of medicinal chemistry, 04-25, Volume: 62, Issue:8
| Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections. |
| AID1589634 | Selectivity ratio of IC50 for Leishmania major pteridine reductase 1 to IC50 for N-terminal His-tagged Trypanosoma brucei pteridine reductase 1 | 2019 | Journal of medicinal chemistry, 04-25, Volume: 62, Issue:8
| Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections. |
| AID1589599 | Inhibition of human CYP2C9 expressed in baculovirus infected insect cells using beetle D-luciferin as substrate preincubated for 30 mins followed by NADPH addition and measured after 30 mins by CYP450-Glo assay | 2019 | Journal of medicinal chemistry, 04-25, Volume: 62, Issue:8
| Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections. |
| AID1589603 | Cytotoxicity against human A549 cells after 48 hrs by Celltiter-glo assay | 2019 | Journal of medicinal chemistry, 04-25, Volume: 62, Issue:8
| Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | | | |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | | | |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6
| A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| AID977611 | Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB | 2014 | ACS chemical biology, Dec-19, Volume: 9, Issue:12
| Competitive binding of a benzimidazole to the histone-binding pocket of the Pygo PHD finger. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |