Page last updated: 2024-10-15

lanthiopeptin

Description

lanthiopeptin: Isolated from Streptoverticillium griseoverticillatum; contains 15 amino acids; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

cinnamycin : A type B lantibiotic consisting of a 19 amino acid tetracyclic polypeptide produced by Streptomyces cinnamoneus. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID131801649
CHEBI ID141991
MeSH IDM0157307

Synonyms (11)

Synonym
nsc 71936
ro-09-0198
nsc-71936
cinnamycin
lanthiopeptin
CHEBI:141991
l-cysteinyl-l-arginyl-l-glutaminyl-d-cysteinyl-l-cysteinyl-3-aminoalanyl-l-phenylalanylglycyl-l-prolyl-l-phenylalanyl-(2s,3s)-2-amino-3-mercaptobutanoyl-l-phenylalanyl-l-valyl-l-cysteinyl-(3r)-3-hydroxy-l-a-aspartylglycyl-l-asparaginyl-(2s,3s)-2-amino-3-m
110655-58-8
unii-um32raq8sc
um32raq8sc ,
cys-arg-gln-cys-cys-3-nh2-ala-phe-gly-pro-phe-(2s,3s)-2-amino-3-mercaptobutanoyl-phe-val-cys-3-oh-.alpha.-asp-gly-asn-(2s,3s)-2-amino-3-mercaptobutanoyl-lys disulfide bridges 1-18, 4-14, 5-11, lysinoalanine bridge 6-19

Dosage Studied

ExcerptReference
" Cinnamycin B showed an antibacterial activity against Streptomyces antibioticus with dosage of 5 μg (0."( Isolation and structure determination of a new lantibiotic cinnamycin B from Actinomadura atramentaria based on genome mining.
Hemmi, H; Ishimura, S; Kodani, S; Komaki, H; Ohnishi-Kameyama, M, 2016
)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (4)

ClassDescription
heterodetic cyclic peptideA heterodetic cyclic peptide is a peptide consisting only of amino-acid residues, but in which the linkages forming the ring are not solely peptide bonds; one or more is an isopeptide, disulfide, ester, or other bond.
macrocycleA cyclic compound containing nine or more atoms as part of the cyclic system.
type B lantibioticAny lantibiotic which has which has a rigid, globular structure. The globular shape and its restricted flexibility confers stability against degradation by proteases.
L-cysteine thioetherAny L-cysteine derivative obtained by conversion of the thiol group into a sulfide.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (46)

TimeframeStudies, This Drug (%)All Drugs %
pre-19907 (15.22)18.7374
1990's13 (28.26)18.2507
2000's10 (21.74)29.6817
2010's10 (21.74)24.3611
2020's6 (13.04)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (4.26%)6.00%
Case Studies1 (2.13%)4.05%
Observational0 (0.00%)0.25%
Other44 (93.62%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]