Page last updated: 2024-11-09

n-(pyridin-4-ylmethyl)aniline

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

N-(pyridin-4-ylmethyl)aniline: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID1082703
CHEMBL ID406449
SCHEMBL ID522061
MeSH IDM0584731

Synonyms (20)

Synonym
HMS1684I18
phenyl-pyridin-4-ylmethyl-amine
BAS 06103407
MLS001212698
smr000523492
CHEMBL406449
n-(4-pyridylmethyl)phenylamine
AKOS000222556
n-(pyridin-4-ylmethyl)aniline
3034-32-0
phenyl-c-pyridin-4-yl-methylamine
HMS2830D15
FS-1909
SCHEMBL522061
n-[(pyridin-4-yl)methyl]aniline
F6790-0126
SB54178
DTXSID801306625
n-phenyl-4-pyridinemethanamine
CS-0323713
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, Ferritin light chainEquus caballus (horse)Potency31.62285.623417.292931.6228AID485281
Guanine nucleotide-binding protein GHomo sapiens (human)Potency3.54811.995325.532750.1187AID624287
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (5)

Processvia Protein(s)Taxonomy
negative regulation of inflammatory response to antigenic stimulusGuanine nucleotide-binding protein GHomo sapiens (human)
renal water homeostasisGuanine nucleotide-binding protein GHomo sapiens (human)
G protein-coupled receptor signaling pathwayGuanine nucleotide-binding protein GHomo sapiens (human)
regulation of insulin secretionGuanine nucleotide-binding protein GHomo sapiens (human)
cellular response to glucagon stimulusGuanine nucleotide-binding protein GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (2)

Processvia Protein(s)Taxonomy
G protein activityGuanine nucleotide-binding protein GHomo sapiens (human)
adenylate cyclase activator activityGuanine nucleotide-binding protein GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (1)

Processvia Protein(s)Taxonomy
plasma membraneGuanine nucleotide-binding protein GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (25)

Assay IDTitleYearJournalArticle
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID323064Antifungal activity against Microsporum gypseum C115 by microbroth dilution method2008Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2
Antifungal and cytotoxic activities of some N-substituted aniline derivatives bearing a hetaryl fragment.
AID323060Antifungal activity against Cryptococcus neoformans ATCC 32264 by microbroth dilution method2008Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2
Antifungal and cytotoxic activities of some N-substituted aniline derivatives bearing a hetaryl fragment.
AID323062Antifungal activity against Aspergillus flavus ATCC 9170 by micro-broth dilution method2008Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2
Antifungal and cytotoxic activities of some N-substituted aniline derivatives bearing a hetaryl fragment.
AID323066Antifungal activity against Trichophyton mentagrophytes ATCC 9972 by micro-broth dilution method2008Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2
Antifungal and cytotoxic activities of some N-substituted aniline derivatives bearing a hetaryl fragment.
AID323058Antifungal activity against Candida tropicalis C131 by micro-broth dilution method2008Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2
Antifungal and cytotoxic activities of some N-substituted aniline derivatives bearing a hetaryl fragment.
AID323057Antifungal activity against Candida albicans ATCC 10231 by micro-broth dilution method2008Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2
Antifungal and cytotoxic activities of some N-substituted aniline derivatives bearing a hetaryl fragment.
AID323065Antifungal activity against Trichophyton rubrum C113 by microbroth dilution method2008Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2
Antifungal and cytotoxic activities of some N-substituted aniline derivatives bearing a hetaryl fragment.
AID323063Antifungal activity against Aspergillus niger ATCC 9029 by micro-broth dilution method2008Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2
Antifungal and cytotoxic activities of some N-substituted aniline derivatives bearing a hetaryl fragment.
AID323061Antifungal activity against Aspergillus fumigatus ATCC 26934 by micro-broth dilution method2008Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2
Antifungal and cytotoxic activities of some N-substituted aniline derivatives bearing a hetaryl fragment.
AID323059Antifungal activity against Saccharomyces cerevisiae ATCC 9763 by microbroth dilution method2008Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2
Antifungal and cytotoxic activities of some N-substituted aniline derivatives bearing a hetaryl fragment.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (22.22)29.6817
2010's6 (66.67)24.3611
2020's1 (11.11)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.02

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.02 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.02)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]