hymexazol profile

hymexazol: a chemical used to sterilize soil; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

hymexazol : A member of the class of isoxazoles carrying hydroxy and methyl substituents at positions 3 and 5 respectively. It is used worldwide as a systemic soil and seed fungicide for the control of diseases caused by Fusarium, Aphanomyces, Pythium, and Corticium spp. in rice, sugarbeet, fodderbeet, vegetables, cucurbits, and ornamentals. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	24781
CHEMBL ID	244877
CHEBI ID	5827
MeSH ID	M0524569

Synonym
BB 0218281
STL313888
hymexazole
NSC217971 ,
isoxazole, 3-hydroxy-5-methyl-
3(2h)-isoxazolone, 5-methyl-
hydroxyisoxazole (pesticide)
itachigarden
nsc-217971
sf-6505
wln: t5noj c1 eq
3-isoxazolol, 5-methyl-
tachigaren
5-methyl-3(2h)-isoxazolone
f 319
3-hydroxy-5-methylisoxazole
5-methyl-3-hydroxyisoxazole
hydroxyisoxazole
NCI60_001815
5-methylisoxazol-3-ol
bucide
f-319
bucid
hymexazol [bsi:iso]
butsid
nsc 217971
einecs 233-000-6
UPCMLD00X10004-44-1:001
hymexazol
10004-44-1
inchi=1/c4h5no2/c1-3-2-4(6)5-7-3/h2h,1h3,(h,5,6
3-hydroxy-5-methylisoxazole, >=90%
chebi:5827 ,
CHEMBL244877
5-methyl-1,2-oxazol-3-one
AKOS001021985
5-methylisoxazol-3(2h)-one
A800021
AKOS003620478
NCGC00248192-01
5-methyl-isoxazol-3-one
5-methyl-isoxazol-3-ol
unii-20t2m875lo
20t2m875lo ,
cas-10004-44-1
tox21_300856
dtxcid1012622
dtxsid3032622 ,
NCGC00254759-01
EN300-07726
5-methyl-1,2-oxazol-3-ol
H1348
FT-0636609
S10286
hymexazol [iso]
rty-319
hymexazol [mi]
BP-21478
BBL033480
5-methylisoxazole-3-ol
KGVPNLBXJKTABS-UHFFFAOYSA-N
5-methyl-1,2-oxazol-3(2h)-one
W-108979
5-methyl-2,3-dihydro-1,2-oxazol-3-one
PS-9334
5-methylisoxazol-3-one
mfcd00144468
Z56761467
4 inverted exclamation mark(r)-methylbiphenyl-2-carbaldehyde
hymexazol 100 microg/ml in acetonitrile
CS-W011330
Q16512783
AMY22453

Role	Description
antifungal agrochemical	Any substance used in acriculture, horticulture, forestry, etc. for its fungicidal properties.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
isoxazoles	Oxazoles in which the N and O atoms are adjacent.
heteroaryl hydroxy compound	Any organic aromatic compound having one or more hydroxy groups attached to a heteroarene ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	0.6740	0.0002	29.3054	16,493.5996	AID743075
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (98)

Assay ID	Title	Year	Journal	Article
AID295741	Antifungal activity Phytophthora infestans	2007	Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11	Synthesis and antifungal activity of novel s-substituted 6-fluoro-4-alkyl(aryl)thioquinazoline derivatives.
AID288318	Growth inhibition of Rhizoctonia solani	2007	Bioorganic & medicinal chemistry, Jun-15, Volume: 15, Issue:12	Synthesis and antifungal activities of 5-(3,4,5-trimethoxyphenyl)-2-sulfonyl-1,3,4-thiadiazole and 5-(3,4,5-trimethoxyphenyl)-2-sulfonyl-1,3,4-oxadiazole derivatives.
AID1103641	Growth inhibition of Alternaria brassicae at 500 ug/ml after 4 days by poisoned food technique	2007	Chemical & pharmaceutical bulletin, Dec, Volume: 55, Issue:12	Antifungal activity of some diaryl ethers.
AID1108112	Antifungal activity against Colletotrichum gloeosporioides assessed as inhibition of mycelium growth after 1 week	2013	Journal of agricultural and food chemistry, Mar-20, Volume: 61, Issue:11	Synthesis and antifungal activity of 2-chloromethyl-1H-benzimidazole derivatives against phytopathogenic fungi in vitro.
AID1103642	Growth inhibition of Fusarium oxysporum f. sp. cucumerinum at 50 ug/ml after 4 days by poisoned food technique	2007	Chemical & pharmaceutical bulletin, Dec, Volume: 55, Issue:12	Antifungal activity of some diaryl ethers.
AID327812	Antifungal activity against Fusarium oxysporum by poison plate technique	2008	Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7	Synthesis and antifungal activity of novel sulfoxide derivatives containing trimethoxyphenyl substituted 1,3,4-thiadiazole and 1,3,4-oxadiazole moiety.
AID1092104	Antifungal activity against Fusarium oxysporum assessed as mycelial growth inhibition	2011	Molecules (Basel, Switzerland), Nov-01, Volume: 16, Issue:11	Synthesis and antifungal activity of novel sulfone derivatives containing 1,3,4-oxadiazole moieties.
AID1108109	Antifungal activity against Fusarium solani assessed as inhibition of mycelium growth after 1 week	2013	Journal of agricultural and food chemistry, Mar-20, Volume: 61, Issue:11	Synthesis and antifungal activity of 2-chloromethyl-1H-benzimidazole derivatives against phytopathogenic fungi in vitro.
AID295735	Antifungal activity against Cytospora mandshurica at 500 ug/mL	2007	Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11	Synthesis and antifungal activity of novel s-substituted 6-fluoro-4-alkyl(aryl)thioquinazoline derivatives.
AID288313	Antifungal activity against Gibberella zeae at 50 ug/mL	2007	Bioorganic & medicinal chemistry, Jun-15, Volume: 15, Issue:12	Synthesis and antifungal activities of 5-(3,4,5-trimethoxyphenyl)-2-sulfonyl-1,3,4-thiadiazole and 5-(3,4,5-trimethoxyphenyl)-2-sulfonyl-1,3,4-oxadiazole derivatives.
AID295748	Increase in membrane permeability of Fusarium oxysporum at 100 ug/mL after 5 mins	2007	Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11	Synthesis and antifungal activity of novel s-substituted 6-fluoro-4-alkyl(aryl)thioquinazoline derivatives.
AID1082815	Antifungal activity against Botryotinia fuckeliana at 28 degC after 48 hr microbroth dilution method	2012	Journal of agricultural and food chemistry, Apr-04, Volume: 60, Issue:13	Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activities.
AID1092109	Antifungal activity against Botryotinia fuckeliana assessed as mycelial growth inhibition	2011	Molecules (Basel, Switzerland), Nov-01, Volume: 16, Issue:11	Synthesis and antifungal activity of novel sulfone derivatives containing 1,3,4-oxadiazole moieties.
AID1082818	Antifungal activity against Colletotrichum gloeosporioides at 28 degC after 48 hr microbroth dilution method	2012	Journal of agricultural and food chemistry, Apr-04, Volume: 60, Issue:13	Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activities.
AID1103649	Growth inhibition of Fusarium graminearum at 500 ug/ml after 4 days by poisoned food technique	2007	Chemical & pharmaceutical bulletin, Dec, Volume: 55, Issue:12	Antifungal activity of some diaryl ethers.
AID327822	Effect on membrane permeability of Sclerotinia sclerotiorum at 100 ug/ml after 240 mins relative to control	2008	Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7	Synthesis and antifungal activity of novel sulfoxide derivatives containing trimethoxyphenyl substituted 1,3,4-thiadiazole and 1,3,4-oxadiazole moiety.
AID1103648	Growth inhibition of Alternaria alternata at 50 ug/ml after 4 days by poisoned food technique	2007	Chemical & pharmaceutical bulletin, Dec, Volume: 55, Issue:12	Antifungal activity of some diaryl ethers.
AID1082822	Antifungal activity against Fusarium graminearum at 28 degC after 48 hr microbroth dilution method	2012	Journal of agricultural and food chemistry, Apr-04, Volume: 60, Issue:13	Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activities.
AID539686	Antifungal activity against Alternaria brassicae assessed as percent inhibition at 100 ug/ml	2010	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24	Antifungal agents. Part 5: synthesis and antifungal activities of aminoguanidine derivatives of N-arylsulfonyl-3-acylindoles.
AID1108117	Antifungal activity against Cytospora sp. assessed as inhibition of mycelium growth at 100 ug/ml after 1 week	2013	Journal of agricultural and food chemistry, Mar-20, Volume: 61, Issue:11	Synthesis and antifungal activity of 2-chloromethyl-1H-benzimidazole derivatives against phytopathogenic fungi in vitro.
AID1092103	Antifungal activity against Cytospora mandshurica assessed as mycelial growth inhibition	2011	Molecules (Basel, Switzerland), Nov-01, Volume: 16, Issue:11	Synthesis and antifungal activity of novel sulfone derivatives containing 1,3,4-oxadiazole moieties.
AID1662932	Antifungal activity against Alternaria alternata assessed as fungal growth inhibition by micro-dilution method	2020	Bioorganic & medicinal chemistry letters, 07-01, Volume: 30, Issue:13	Design, synthesis and evaluation of hydrazine and acyl hydrazone derivatives of 5-pyrrolidin-2-one as antifungal agents.
AID327818	Antifungal activity against Sclerotinia sclerotiorum by poison plate technique	2008	Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7	Synthesis and antifungal activity of novel sulfoxide derivatives containing trimethoxyphenyl substituted 1,3,4-thiadiazole and 1,3,4-oxadiazole moiety.
AID594410	Antimicrobial activity against Pyricularia oryzae at 50 ug/ml after 5 days by poisoned food technique	2011	European journal of medicinal chemistry, May, Volume: 46, Issue:5	Synthesis and antifungal activities of novel 5,6-dihydro-indolo[1,2-a]quinoxaline derivatives.
AID539683	Antifungal activity against Fusarium oxysporum f. sp. vasinfectum assessed as percent inhibition at 100 ug/ml	2010	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24	Antifungal agents. Part 5: synthesis and antifungal activities of aminoguanidine derivatives of N-arylsulfonyl-3-acylindoles.
AID327815	Antifungal activity against Thanatephorus cucumeris by poison plate technique	2008	Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7	Synthesis and antifungal activity of novel sulfoxide derivatives containing trimethoxyphenyl substituted 1,3,4-thiadiazole and 1,3,4-oxadiazole moiety.
AID1103644	Growth inhibition of Fusarium oxysporum f. sp. vasinfectum at 50 ug/ml after 4 days by poisoned food technique	2007	Chemical & pharmaceutical bulletin, Dec, Volume: 55, Issue:12	Antifungal activity of some diaryl ethers.
AID1103637	Growth inhibition of Bipolaris sorokiniana at 50 ug/ml after 4 days by poisoned food technique	2007	Chemical & pharmaceutical bulletin, Dec, Volume: 55, Issue:12	Antifungal activity of some diaryl ethers.
AID295739	Antifungal activity against Rhizoctonia solani	2007	Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11	Synthesis and antifungal activity of novel s-substituted 6-fluoro-4-alkyl(aryl)thioquinazoline derivatives.
AID1108116	Antifungal activity against Alternaria solani assessed as inhibition of mycelium growth at 100 ug/ml after 1 week	2013	Journal of agricultural and food chemistry, Mar-20, Volume: 61, Issue:11	Synthesis and antifungal activity of 2-chloromethyl-1H-benzimidazole derivatives against phytopathogenic fungi in vitro.
AID327828	Change in mycelial chitinase activity in Sclerotinia sclerotiorum assessed as N-acetyl-glucosamine level after 24 hrs	2008	Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7	Synthesis and antifungal activity of novel sulfoxide derivatives containing trimethoxyphenyl substituted 1,3,4-thiadiazole and 1,3,4-oxadiazole moiety.
AID327819	Antifungal activity against Colletotrichum gloeosporioides by poison plate technique	2008	Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7	Synthesis and antifungal activity of novel sulfoxide derivatives containing trimethoxyphenyl substituted 1,3,4-thiadiazole and 1,3,4-oxadiazole moiety.
AID1092112	Antifungal activity against Fusarium oxysporum at 50 ug/ml after 5 days by poison plate technique	2011	Molecules (Basel, Switzerland), Nov-01, Volume: 16, Issue:11	Synthesis and antifungal activity of novel sulfone derivatives containing 1,3,4-oxadiazole moieties.
AID539689	Antifungal activity against Fusarium oxysporum f. sp. cucumerinum assessed as percent inhibition at 100 ug/ml	2010	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24	Antifungal agents. Part 5: synthesis and antifungal activities of aminoguanidine derivatives of N-arylsulfonyl-3-acylindoles.
AID295733	Antifungal activity against Gibberella zeae at 500 ug/mL	2007	Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11	Synthesis and antifungal activity of novel s-substituted 6-fluoro-4-alkyl(aryl)thioquinazoline derivatives.
AID295744	Antifungal activity against Colletotrichum gloeosporioides	2007	Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11	Synthesis and antifungal activity of novel s-substituted 6-fluoro-4-alkyl(aryl)thioquinazoline derivatives.
AID327816	Antifungal activity against Phytophthora infestans by poison plate technique	2008	Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7	Synthesis and antifungal activity of novel sulfoxide derivatives containing trimethoxyphenyl substituted 1,3,4-thiadiazole and 1,3,4-oxadiazole moiety.
AID327811	Antifungal activity against Gibberella zeae by poison plate technique	2008	Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7	Synthesis and antifungal activity of novel sulfoxide derivatives containing trimethoxyphenyl substituted 1,3,4-thiadiazole and 1,3,4-oxadiazole moiety.
AID1662935	Antifungal activity against Geotrichum candidum assessed as fungal growth inhibition by micro-dilution method	2020	Bioorganic & medicinal chemistry letters, 07-01, Volume: 30, Issue:13	Design, synthesis and evaluation of hydrazine and acyl hydrazone derivatives of 5-pyrrolidin-2-one as antifungal agents.
AID1662933	Antifungal activity against Cladosporium cladosporioides assessed as fungal growth inhibition by micro-dilution method	2020	Bioorganic & medicinal chemistry letters, 07-01, Volume: 30, Issue:13	Design, synthesis and evaluation of hydrazine and acyl hydrazone derivatives of 5-pyrrolidin-2-one as antifungal agents.
AID288314	Antifungal activity against Botrytis cinerea at 50 ug/mL	2007	Bioorganic & medicinal chemistry, Jun-15, Volume: 15, Issue:12	Synthesis and antifungal activities of 5-(3,4,5-trimethoxyphenyl)-2-sulfonyl-1,3,4-thiadiazole and 5-(3,4,5-trimethoxyphenyl)-2-sulfonyl-1,3,4-oxadiazole derivatives.
AID327817	Antifungal activity against Botrytis cinerea by poison plate technique	2008	Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7	Synthesis and antifungal activity of novel sulfoxide derivatives containing trimethoxyphenyl substituted 1,3,4-thiadiazole and 1,3,4-oxadiazole moiety.
AID1092106	Antifungal activity against Sclerotinia sclerotiorum assessed as mycelial growth inhibition	2011	Molecules (Basel, Switzerland), Nov-01, Volume: 16, Issue:11	Synthesis and antifungal activity of novel sulfone derivatives containing 1,3,4-oxadiazole moieties.
AID1103645	Growth inhibition of Fusarium oxysporum f. sp. vasinfectum at 500 ug/ml after 4 days by poisoned food technique	2007	Chemical & pharmaceutical bulletin, Dec, Volume: 55, Issue:12	Antifungal activity of some diaryl ethers.
AID539687	Antifungal activity against Fusarium graminearum assessed as percent inhibition at 100 ug/ml	2010	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24	Antifungal agents. Part 5: synthesis and antifungal activities of aminoguanidine derivatives of N-arylsulfonyl-3-acylindoles.
AID295753	Decrease in mycelial chitinase activity assessed as D-GlcNAc content in Fusarium oxysporum after 1 hrs	2007	Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11	Synthesis and antifungal activity of novel s-substituted 6-fluoro-4-alkyl(aryl)thioquinazoline derivatives.
AID1092108	Antifungal activity against Phytophthora infestans assessed as mycelial growth inhibition	2011	Molecules (Basel, Switzerland), Nov-01, Volume: 16, Issue:11	Synthesis and antifungal activity of novel sulfone derivatives containing 1,3,4-oxadiazole moieties.
AID295737	Antifungal activity against Fusarium oxysporum	2007	Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11	Synthesis and antifungal activity of novel s-substituted 6-fluoro-4-alkyl(aryl)thioquinazoline derivatives.
AID1103650	Growth inhibition of Alternaria alternata at 500 ug/ml after 4 days by poisoned food technique	2007	Chemical & pharmaceutical bulletin, Dec, Volume: 55, Issue:12	Antifungal activity of some diaryl ethers.
AID594409	Antimicrobial activity against Fusarium graminearum at 50 ug/ml after 5 days by poisoned food technique	2011	European journal of medicinal chemistry, May, Volume: 46, Issue:5	Synthesis and antifungal activities of novel 5,6-dihydro-indolo[1,2-a]quinoxaline derivatives.
AID295734	Antifungal activity against Fusarium oxysporum at 500 ug/mL	2007	Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11	Synthesis and antifungal activity of novel s-substituted 6-fluoro-4-alkyl(aryl)thioquinazoline derivatives.
AID327813	Antifungal activity against Cytospora mandshurica by poison plate technique	2008	Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7	Synthesis and antifungal activity of novel sulfoxide derivatives containing trimethoxyphenyl substituted 1,3,4-thiadiazole and 1,3,4-oxadiazole moiety.
AID327827	Change in mycelial N-acetyl-glucosamine content in Sclerotinia sclerotiorum after 24 hrs	2008	Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7	Synthesis and antifungal activity of novel sulfoxide derivatives containing trimethoxyphenyl substituted 1,3,4-thiadiazole and 1,3,4-oxadiazole moiety.
AID1662929	Antifungal activity against Paecilomyces variotii assessed as fungal growth inhibition by micro-dilution method	2020	Bioorganic & medicinal chemistry letters, 07-01, Volume: 30, Issue:13	Design, synthesis and evaluation of hydrazine and acyl hydrazone derivatives of 5-pyrrolidin-2-one as antifungal agents.
AID1103647	Growth inhibition of Magnaporthe oryzae at 500 ug/ml after 4 days by poisoned food technique	2007	Chemical & pharmaceutical bulletin, Dec, Volume: 55, Issue:12	Antifungal activity of some diaryl ethers.
AID288315	Antifungal activity against Sclerotinia sclerotiorum at 50 ug/mL	2007	Bioorganic & medicinal chemistry, Jun-15, Volume: 15, Issue:12	Synthesis and antifungal activities of 5-(3,4,5-trimethoxyphenyl)-2-sulfonyl-1,3,4-thiadiazole and 5-(3,4,5-trimethoxyphenyl)-2-sulfonyl-1,3,4-oxadiazole derivatives.
AID539688	Antifungal activity against Bipolaris sorokiniana assessed as percent inhibition at 100 ug/ml	2010	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24	Antifungal agents. Part 5: synthesis and antifungal activities of aminoguanidine derivatives of N-arylsulfonyl-3-acylindoles.
AID1108110	Antifungal activity against Alternaria solani assessed as inhibition of mycelium growth after 1 week	2013	Journal of agricultural and food chemistry, Mar-20, Volume: 61, Issue:11	Synthesis and antifungal activity of 2-chloromethyl-1H-benzimidazole derivatives against phytopathogenic fungi in vitro.
AID1103651	Growth inhibition of Fusarium graminearum at 50 ug/ml after 4 days by poisoned food technique	2007	Chemical & pharmaceutical bulletin, Dec, Volume: 55, Issue:12	Antifungal activity of some diaryl ethers.
AID1082816	Antifungal activity against Alternaria solani at 28 degC after 48 hr microbroth dilution method	2012	Journal of agricultural and food chemistry, Apr-04, Volume: 60, Issue:13	Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activities.
AID327808	Antifungal activity against Gibberella zeae at 50 ug/ml by poison plate technique	2008	Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7	Synthesis and antifungal activity of novel sulfoxide derivatives containing trimethoxyphenyl substituted 1,3,4-thiadiazole and 1,3,4-oxadiazole moiety.
AID295736	Antifungal activity against Gibberella zeae	2007	Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11	Synthesis and antifungal activity of novel s-substituted 6-fluoro-4-alkyl(aryl)thioquinazoline derivatives.
AID594413	Antimicrobial activity against Alternaria brassicae at 50 ug/ml after 5 days by poisoned food technique	2011	European journal of medicinal chemistry, May, Volume: 46, Issue:5	Synthesis and antifungal activities of novel 5,6-dihydro-indolo[1,2-a]quinoxaline derivatives.
AID295743	Antifungal activity against Botrytis cinerea	2007	Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11	Synthesis and antifungal activity of novel s-substituted 6-fluoro-4-alkyl(aryl)thioquinazoline derivatives.
AID1108111	Antifungal activity against Botryotinia fuckeliana assessed as inhibition of mycelium growth after 1 week	2013	Journal of agricultural and food chemistry, Mar-20, Volume: 61, Issue:11	Synthesis and antifungal activity of 2-chloromethyl-1H-benzimidazole derivatives against phytopathogenic fungi in vitro.
AID1082821	Antifungal activity against Fusarium oxysporum f. sp. vasinfectum at 28 degC after 48 hr microbroth dilution method	2012	Journal of agricultural and food chemistry, Apr-04, Volume: 60, Issue:13	Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activities.
AID1092111	Antifungal activity against Cytospora mandshurica at 50 ug/ml after 5 days by poison plate technique	2011	Molecules (Basel, Switzerland), Nov-01, Volume: 16, Issue:11	Synthesis and antifungal activity of novel sulfone derivatives containing 1,3,4-oxadiazole moieties.
AID1108114	Antifungal activity against Fusarium solani assessed as inhibition of mycelium growth at 100 ug/ml after 1 week	2013	Journal of agricultural and food chemistry, Mar-20, Volume: 61, Issue:11	Synthesis and antifungal activity of 2-chloromethyl-1H-benzimidazole derivatives against phytopathogenic fungi in vitro.
AID1082817	Antifungal activity against Alternaria alternata at 28 degC after 48 hr microbroth dilution method	2012	Journal of agricultural and food chemistry, Apr-04, Volume: 60, Issue:13	Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activities.
AID295738	Antifungal activity against Cytospora mandshurica	2007	Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11	Synthesis and antifungal activity of novel s-substituted 6-fluoro-4-alkyl(aryl)thioquinazoline derivatives.
AID594411	Antimicrobial activity against Fusarium oxysporum f. sp. vasinfectum at 50 ug/ml after 5 days by poisoned food technique	2011	European journal of medicinal chemistry, May, Volume: 46, Issue:5	Synthesis and antifungal activities of novel 5,6-dihydro-indolo[1,2-a]quinoxaline derivatives.
AID539685	Antifungal activity against Alternaria alternata assessed as percent inhibition at 100 ug/ml	2010	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24	Antifungal agents. Part 5: synthesis and antifungal activities of aminoguanidine derivatives of N-arylsulfonyl-3-acylindoles.
AID594412	Antimicrobial activity against Alternaria alternata at 50 ug/ml after 5 days by poisoned food technique	2011	European journal of medicinal chemistry, May, Volume: 46, Issue:5	Synthesis and antifungal activities of novel 5,6-dihydro-indolo[1,2-a]quinoxaline derivatives.
AID295740	Antifungal activity against Thanatephorus cucumeris	2007	Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11	Synthesis and antifungal activity of novel s-substituted 6-fluoro-4-alkyl(aryl)thioquinazoline derivatives.
AID1662930	Antifungal activity against Penicillium ochrochloron assessed as fungal growth inhibition by micro-dilution method	2020	Bioorganic & medicinal chemistry letters, 07-01, Volume: 30, Issue:13	Design, synthesis and evaluation of hydrazine and acyl hydrazone derivatives of 5-pyrrolidin-2-one as antifungal agents.
AID295742	Antifungal activity against Sclerotinia sclerotiorum	2007	Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11	Synthesis and antifungal activity of novel s-substituted 6-fluoro-4-alkyl(aryl)thioquinazoline derivatives.
AID1662931	Antifungal activity against Aspergillus oryzae assessed as fungal growth inhibition by micro-dilution method	2020	Bioorganic & medicinal chemistry letters, 07-01, Volume: 30, Issue:13	Design, synthesis and evaluation of hydrazine and acyl hydrazone derivatives of 5-pyrrolidin-2-one as antifungal agents.
AID539684	Antifungal activity against Pyricularia oryzae assessed as percent inhibition at 100 ug/ml	2010	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24	Antifungal agents. Part 5: synthesis and antifungal activities of aminoguanidine derivatives of N-arylsulfonyl-3-acylindoles.
AID1103640	Growth inhibition of Alternaria brassicae at 50 ug/ml after 4 days by poisoned food technique	2007	Chemical & pharmaceutical bulletin, Dec, Volume: 55, Issue:12	Antifungal activity of some diaryl ethers.
AID327810	Antifungal activity against Cytospora mandshurica at 50 ug/ml by poison plate technique	2008	Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7	Synthesis and antifungal activity of novel sulfoxide derivatives containing trimethoxyphenyl substituted 1,3,4-thiadiazole and 1,3,4-oxadiazole moiety.
AID327830	Change in mycelial soluble protein content in Sclerotinia sclerotiorum after 24 hrs	2008	Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7	Synthesis and antifungal activity of novel sulfoxide derivatives containing trimethoxyphenyl substituted 1,3,4-thiadiazole and 1,3,4-oxadiazole moiety.
AID1092107	Antifungal activity against Colletotrichum gloeosporioides assessed as mycelial growth inhibition	2011	Molecules (Basel, Switzerland), Nov-01, Volume: 16, Issue:11	Synthesis and antifungal activity of novel sulfone derivatives containing 1,3,4-oxadiazole moieties.
AID1108118	Antifungal activity against Colletotrichum gloeosporioides assessed as inhibition of mycelium growth at 100 ug/ml after 1 week	2013	Journal of agricultural and food chemistry, Mar-20, Volume: 61, Issue:11	Synthesis and antifungal activity of 2-chloromethyl-1H-benzimidazole derivatives against phytopathogenic fungi in vitro.
AID327809	Antifungal activity against Fusarium oxysporum at 50 ug/ml by poison plate technique	2008	Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7	Synthesis and antifungal activity of novel sulfoxide derivatives containing trimethoxyphenyl substituted 1,3,4-thiadiazole and 1,3,4-oxadiazole moiety.
AID1082819	Antifungal activity against Fusarium solani at 28 degC after 48 hr microbroth dilution method	2012	Journal of agricultural and food chemistry, Apr-04, Volume: 60, Issue:13	Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activities.
AID1662934	Antifungal activity against Sclerotinia sclerotiorum assessed as fungal growth inhibition by micro-dilution method	2020	Bioorganic & medicinal chemistry letters, 07-01, Volume: 30, Issue:13	Design, synthesis and evaluation of hydrazine and acyl hydrazone derivatives of 5-pyrrolidin-2-one as antifungal agents.
AID1103643	Growth inhibition of Fusarium oxysporum f. sp. cucumerinum at 500 ug/ml after 4 days by poisoned food technique	2007	Chemical & pharmaceutical bulletin, Dec, Volume: 55, Issue:12	Antifungal activity of some diaryl ethers.
AID1103638	Growth inhibition of Bipolaris sorokiniana at 500 ug/ml after 4 days by poisoned food technique	2007	Chemical & pharmaceutical bulletin, Dec, Volume: 55, Issue:12	Antifungal activity of some diaryl ethers.
AID1662928	Antifungal activity against Fusarium solani assessed as fungal growth inhibition by micro-dilution method	2020	Bioorganic & medicinal chemistry letters, 07-01, Volume: 30, Issue:13	Design, synthesis and evaluation of hydrazine and acyl hydrazone derivatives of 5-pyrrolidin-2-one as antifungal agents.
AID1108113	Antifungal activity against Cytospora sp. assessed as inhibition of mycelium growth after 1 week	2013	Journal of agricultural and food chemistry, Mar-20, Volume: 61, Issue:11	Synthesis and antifungal activity of 2-chloromethyl-1H-benzimidazole derivatives against phytopathogenic fungi in vitro.
AID1103646	Growth inhibition of Magnaporthe oryzae at 50 ug/ml after 4 days by poisoned food technique	2007	Chemical & pharmaceutical bulletin, Dec, Volume: 55, Issue:12	Antifungal activity of some diaryl ethers.
AID288322	Growth inhibition of Fusarium oxysporum	2007	Bioorganic & medicinal chemistry, Jun-15, Volume: 15, Issue:12	Synthesis and antifungal activities of 5-(3,4,5-trimethoxyphenyl)-2-sulfonyl-1,3,4-thiadiazole and 5-(3,4,5-trimethoxyphenyl)-2-sulfonyl-1,3,4-oxadiazole derivatives.
AID327814	Antifungal activity against Rhizoctonia solani by poison plate technique	2008	Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7	Synthesis and antifungal activity of novel sulfoxide derivatives containing trimethoxyphenyl substituted 1,3,4-thiadiazole and 1,3,4-oxadiazole moiety.
AID295751	Effect on mycelial reducing sugar content in Fusarium oxysporum after 12 hrs	2007	Bioorganic & medicinal chemistry, Jun-01, Volume: 15, Issue:11	Synthesis and antifungal activity of novel s-substituted 6-fluoro-4-alkyl(aryl)thioquinazoline derivatives.
AID1082820	Antifungal activity against Fusarium oxysporum f. sp. niveum at 28 degC after 48 hr microbroth dilution method	2012	Journal of agricultural and food chemistry, Apr-04, Volume: 60, Issue:13	Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activities.
AID1092110	Antifungal activity against Rhizoctonia solani assessed as mycelial growth inhibition	2011	Molecules (Basel, Switzerland), Nov-01, Volume: 16, Issue:11	Synthesis and antifungal activity of novel sulfone derivatives containing 1,3,4-oxadiazole moieties.
AID1108115	Antifungal activity against Botryotinia fuckeliana assessed as inhibition of mycelium growth at 100 ug/ml after 1 week	2013	Journal of agricultural and food chemistry, Mar-20, Volume: 61, Issue:11	Synthesis and antifungal activity of 2-chloromethyl-1H-benzimidazole derivatives against phytopathogenic fungi in vitro.
AID1092105	Antifungal activity against Thanatephorus cucumeris assessed as mycelial growth inhibition	2011	Molecules (Basel, Switzerland), Nov-01, Volume: 16, Issue:11	Synthesis and antifungal activity of novel sulfone derivatives containing 1,3,4-oxadiazole moieties.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (3.70)	18.2507
2000's	5 (18.52)	29.6817
2010's	16 (59.26)	24.3611
2020's	5 (18.52)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	27 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
uracil 2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder	2.07	1	pyrimidine nucleobase; pyrimidone	allergen; Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; prodrug; Saccharomyces cerevisiae metabolite
eucalyptol [no description available]	2.17	1
fluconazole Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.. fluconazole : A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.	2.25	1	conazole antifungal drug; difluorobenzene; tertiary alcohol; triazole antifungal drug	environmental contaminant; P450 inhibitor; xenobiotic
linalool linalool: RN given refers to parent cpd without isomeric designation; structure. linalool : A monoterpenoid that is octa-1,6-diene substituted by methyl groups at positions 3 and 7 and a hydroxy group at position 3. It has been isolated from plants like Ocimum canum.	2.17	1	monoterpenoid; tertiary alcohol	antimicrobial agent; fragrance; plant metabolite; volatile oil component
acetophenone acetophenone : A methyl ketone that is acetone in which one of the methyl groups has been replaced by a phenyl group.	2.08	1	acetophenones	animal metabolite; photosensitizing agent; xenobiotic
cyclohexanol Cyclohexanols: Monohydroxy derivatives of cyclohexanes that contain the general formula R-C6H11O. They have a camphorlike odor and are used in making soaps, insecticides, germicides, dry cleaning, and plasticizers.. cyclohexanols : An alcohol in which one or more hydroxy groups are attached to a cyclohexane skeleton.	2.17	1	cyclohexanols; secondary alcohol	solvent
thiophenes Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.	2.1	1	mancude organic heteromonocyclic parent; monocyclic heteroarene; thiophenes; volatile organic compound	non-polar solvent
isoxazoles Isoxazoles: Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.. isoxazole : A monocyclic heteroarene with a structure consisting of a 5-membered ring containing three carbon atoms and an oxygen and nitrogen atom adjacent to each other. It is the parent of the class of isoxazoles.. isoxazoles : Oxazoles in which the N and O atoms are adjacent.	1.97	1	isoxazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
oxazoles Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.. 1,3-oxazole : A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.. oxazole : An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.	4.21	15	1,3-oxazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
piperonyl alcohol piperonyl alcohol: structure given in first source	2.21	1	benzodioxoles
carbendazim carbendazim: carcinogen when combined with sodium nitrite; principle metabolite of thiophanate methyl & benomyl; structure. carbendazim : A member of the class of benzimidazoles that is 2-aminobenzimidazole in which the primary amino group is substituted by a methoxycarbonyl group. A fungicide, carbendazim controls Ascomycetes, Fungi Imperfecti, and Basidiomycetes on a wide variety of crops, including bananas, cereals, cotton, fruits, grapes, mushrooms, ornamentals, peanuts, sugarbeet, soybeans, tobacco, and vegetables.	7.57	2	benzimidazole fungicide; benzimidazoles; benzimidazolylcarbamate fungicide; carbamate ester	antifungal agrochemical; antinematodal drug; metabolite; microtubule-destabilising agent
hexafluoron hexafluoron: insect growth regulator against mosquito larva; the active agent in Sonet, a Russian product, is hexaflumuron. hexaflumuron : An N-acylurea that is urea in which a hydrogen attached to one of the nitrogens is replaced by a 2,6-difluorobenzoyl group, while a hycrogen attached to the other nitorgen is replaced by a 3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)phenyl group.	2.41	1	aromatic ether; benzoylurea insecticide; dichlorobenzene; N-acylurea; organochlorine insecticide; organofluorine insecticide
cyclo(prolylglycyl) cyclo(prolylglycyl): RN given is for 17O-labeled cpd	2.07	1
hydroxyl radical Hydroxyl Radical: The univalent radical OH. Hydroxyl radical is a potent oxidizing agent.	2.08	1	oxygen hydride; oxygen radical; reactive oxygen species
brevianamide f brevianamide F: isolated from the endophyte from Aspergillus fumigatus associated with Melia azedarach L that could be used to develop a natural eco-friendly herbicide.structure in first source. brevianamide F : A pyrrolopyrazine that is hexahydropyrrolo[1,2-a]pyrazine-1,4-dione bearing an indol-3-ylmethyl substituent at position 3 (the 3S,8aS-diastereomer, obtained by formal cyclocondensation of L-tryptophan and L-proline).	2.07	1	dipeptide; indoles; pyrrolopyrazine	metabolite
tryptoquivaline fumitremorgin C : An organic heteropentacyclic compound that is a mycotoxic indole alkaloid produced by several fungi. A potent and specific inhibitor of the breast cancer resistance protein multidrug transporter.	2.07	1	aromatic ether; indole alkaloid; organic heteropentacyclic compound	breast cancer resistance protein inhibitor; mycotoxin
glucosamine D-glucosamine : An amino sugar whose structure comprises D-glucose having an amino substituent at position 2.. 2-amino-2-deoxy-D-glucopyranose : A D-glucosamine whose structure comprises D-glucopyranose having an amino substituent at position 2.	2.41	1	D-glucosamine	Escherichia coli metabolite; geroprotector; mouse metabolite
ochratoxin a ochratoxin A: structure in first source & in Merck, 9th ed, #6549. ochratoxin A : A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.	7.6	1	isochromanes; monocarboxylic acid amide; N-acyl-L-phenylalanine; organochlorine compound; phenylalanine derivative	Aspergillus metabolite; calcium channel blocker; carcinogenic agent; mycotoxin; nephrotoxin; Penicillium metabolite; teratogenic agent
ketoconazole (2R,4S)-ketoconazole : A cis-1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine which dioxolane moiety has (2R,4S)-configuration.	2.25	1	cis-1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine
glycosides [no description available]	7.41	1
thiourea Thiourea: A photographic fixative used also in the manufacture of resins. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance may reasonably be anticipated to be a carcinogen (Merck Index, 9th ed). Many of its derivatives are ANTITHYROID AGENTS and/or FREE RADICAL SCAVENGERS.. thiourea : The simplest member of the thiourea class, consisting of urea with the oxygen atom substituted by sulfur.	2.1	1	one-carbon compound; thioureas; ureas	antioxidant; chromophore
helvolic acid helvolic acid: structure. helvolic acid : A steroid C-21 acid having a 29-nordammarane skeleton substituted with an acetoxy group at C-16 and oxo groups at C-3 and -7, with double bonds at C-1, -17(20) and -24.	2.07	1	3-oxo-Delta(1) steroid; acetate ester; monocarboxylic acid; steroid acid	antibacterial agent; fungal metabolite; mycotoxin
jbp 485 JBP 485: has antihepatitis activity	2.07	1
pseurotin pseurotin: metabolite isolated from culture filtrates of Pseudeurotium ovalis Stolk; structure. pseurotin A : A spirocyclic that is 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione bearing 1,2-dihydroxyhex-3-en-1-yl, methyl, methoxy, benzoyl and hydroxy substituents at positions 2, 3, 8, 8 and 9 respectively.	2.07	1	azaspiro compound; lactam; oxaspiro compound	metabolite
toosendanin [no description available]	2.07	1	limonoid
tryprostatin a tryprostatin A: isolated from Aspergillus fumigatus; a mammalian cell cycle inhibitor; structure given in first source. tryprostatin A : A cyclic dipeptide that is brevianamide F (cyclo-L-Trp-L-Pro) substituted at positions 2 and 6 on the indole ring by prenyl and methoxy groups respectively.	2.07	1	aromatic ether; dipeptide; indole alkaloid; indoles; pyrrolopyrazine	breast cancer resistance protein inhibitor
fumiquinazoline f fumiquinazoline F: structure in first source. fumiquinazoline F : A fumiquinazoline that consists of pyrazino[2,1-b]quinazoline-3,6(1H,4H)-dione bearing a methyl substituent at position 1 and an indol-3-yl group at position 4.	2.07	1	fumiquinazoline; indoles; pyrazinoquinazoline
(S)-Isosclerone [no description available]	2.07	1	tetralins
fumiquinazoline a fumiquinazoline A: structure in first source. fumiquinazoline A : A fumiquinazoline that consists of imidazoindole and pyrazinoquinazoline units connected by a methylene group.	2.07	1	fumiquinazoline; imidazoindole; pyrazinoquinazoline
6-methoxyspirotryprostatin b 6-methoxyspirotryprostatin B: cytotoxic compound from the marine-derived fungus Aspergillus sydowi; structure in first source. 6-methoxyspirotryprostatin B : An indole alkaloid isolated from a marine-derived fungal strain Aspergillus sydowii PFW1-13 and has been shown to exhibit cytotoxic activity.	2.07	1	aromatic ether; azaspiro compound; indole alkaloid; indolones	antineoplastic agent; Aspergillus metabolite

Condition	Relationship Strength	Studies
Experimental Neoplasms [description not available]	1.97	1
Abnormalities, Drug-Induced Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.	1.97	1
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	1.97	1
Encephalopathy, Toxic [description not available]	2.41	1

hymexazol

Description

Cross-References

Synonyms (73)

Research Excerpts

Roles (1)

Drug Classes (2)

Protein Targets (1)

Potency Measurements

Bioassays (98)

Research

Studies (27)

Market Indicators

Research Demand Index: 31.55

Study Types

hymexazol

Description

Cross-References

Synonyms (73)

Research Excerpts

Roles (1)

Drug Classes (2)

Protein Targets (1)

Potency Measurements

Bioassays (98)

Research

Studies (27)

Market Indicators

Research Demand Index: 31.55

Study Types

Related Drugs (30)

Related Conditions (4)