Page last updated: 2024-10-27

fluconazole and Corneal Diseases

fluconazole has been researched along with Corneal Diseases in 9 studies

Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.
fluconazole : A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.

Corneal Diseases: Diseases of the cornea.

Research Excerpts

ExcerptRelevanceReference
"A prospective clinical trial of topical fluconazole solution (2 mg/ml) was undertaken in six consecutive eyes of microbiologically proven Candida keratitis with abscess formation."9.08Topical fluconazole therapy of Candida keratitis. ( Angra, SK; Panda, A; Sharma, N, 1996)
"A prospective clinical trial of topical fluconazole solution (2 mg/ml) was undertaken in six consecutive eyes of microbiologically proven Candida keratitis with abscess formation."5.08Topical fluconazole therapy of Candida keratitis. ( Angra, SK; Panda, A; Sharma, N, 1996)
"In an established Candida albicans murine keratitis model, combination therapy with ophthalmic preparations of fluconazole and cyclosporine A (CsA) demonstrated in vivo drug synergy and effectively resolved wild-type C."3.73Calcineurin promotes infection of the cornea by Candida albicans and can be targeted to enhance fluconazole therapy. ( Afshari, NA; Heitman, J; Onyewu, C, 2006)
"Poor bioavailability of antifungal drugs due to the various protective mechanisms of the eye is a serious concern for the treatment of corneal fungal infections in today's world."1.39Fluconazole loaded chitin nanogels as a topical ocular drug delivery agent for corneal fungal infections. ( Biswas, R; Jayakumar, R; Mangalathillam, S; Mohammed, N; Nair, SV; Rejinold, NS, 2013)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (33.33)18.2507
2000's2 (22.22)29.6817
2010's3 (33.33)24.3611
2020's1 (11.11)2.80

Authors

AuthorsStudies
Matsumoto, Y1
Yoshikawa, A1
Nagamachi, T1
Sugiyama, Y1
Yamada, T1
Sugita, T1
Mohammed, N1
Rejinold, NS1
Mangalathillam, S1
Biswas, R1
Nair, SV1
Jayakumar, R1
Li, L1
Wang, Z1
Li, R1
Luo, S1
Sun, X1
Posteraro, B1
Mattei, R1
Trivella, F1
Maffei, A1
Torre, A1
De Carolis, E1
Posteraro, P1
Fadda, G1
Sanguinetti, M1
Pathak, MK1
Chhabra, G1
Pathak, K1
Onyewu, C1
Afshari, NA1
Heitman, J1
Zadok, D1
Karpuch, J1
Panda, A1
Sharma, N1
Angra, SK1
Ainbinder, DJ1
Parmley, VC1
Mader, TH1
Nelson, ML1

Trials

1 trial available for fluconazole and Corneal Diseases

ArticleYear
Topical fluconazole therapy of Candida keratitis.
    Cornea, 1996, Volume: 15, Issue:4

    Topics: Abscess; Administration, Topical; Adolescent; Adult; Aged; Candidiasis; Child; Corneal Diseases; Fem

1996

Other Studies

8 other studies available for fluconazole and Corneal Diseases

ArticleYear
A critical role of calcineurin in stress responses, hyphal formation, and virulence of the pathogenic fungus Trichosporon asahii.
    Scientific reports, 2022, 09-27, Volume: 12, Issue:1

    Topics: Amphotericin B; Antifungal Agents; Basidiomycota; Caffeine; Calcineurin; Calcium; Calcium Chloride;

2022
Fluconazole loaded chitin nanogels as a topical ocular drug delivery agent for corneal fungal infections.
    Journal of biomedical nanotechnology, 2013, Volume: 9, Issue:9

    Topics: Administration, Ophthalmic; Administration, Topical; Animals; Antifungal Agents; Chitin; Corneal Dis

2013
In vitro evaluation of combination antifungal activity against Fusarium species isolated from ocular tissues of keratomycosis patients.
    American journal of ophthalmology, 2008, Volume: 146, Issue:5

    Topics: Amphotericin B; Antifungal Agents; Corneal Diseases; Drug Evaluation; Drug Synergism; Eye; Eye Infec

2008
Uncommon Neosartorya udagawae fungus as a causative agent of severe corneal infection.
    Journal of clinical microbiology, 2011, Volume: 49, Issue:6

    Topics: Adult; Antifungal Agents; Corneal Diseases; Debridement; DNA, Fungal; DNA, Ribosomal; DNA, Ribosomal

2011
Design and development of a novel pH triggered nanoemulsified in-situ ophthalmic gel of fluconazole: ex-vivo transcorneal permeation, corneal toxicity and irritation testing.
    Drug development and industrial pharmacy, 2013, Volume: 39, Issue:5

    Topics: Acrylates; Administration, Ophthalmic; Animals; Antifungal Agents; Cornea; Corneal Diseases; Delayed

2013
Calcineurin promotes infection of the cornea by Candida albicans and can be targeted to enhance fluconazole therapy.
    Antimicrobial agents and chemotherapy, 2006, Volume: 50, Issue:11

    Topics: Animals; Antifungal Agents; Calcineurin; Calcineurin Inhibitors; Candida albicans; Candidiasis; Corn

2006
Treatment of multiple corneal abscesses with fluconazole.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1994, Volume: 18, Issue:3

    Topics: Abscess; Aged; Aged, 80 and over; Candidiasis; Corneal Diseases; Female; Fluconazole; Humans

1994
Infectious crystalline keratopathy caused by Candida guilliermondii.
    American journal of ophthalmology, 1998, Volume: 125, Issue:5

    Topics: Aged; Amphotericin B; Biopsy; Candida; Candidiasis; Cornea; Corneal Diseases; Drug Resistance, Micro

1998