fluconazole has been researched along with Corneal Diseases in 9 studies
Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.
fluconazole : A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.
Corneal Diseases: Diseases of the cornea.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A prospective clinical trial of topical fluconazole solution (2 mg/ml) was undertaken in six consecutive eyes of microbiologically proven Candida keratitis with abscess formation." | 9.08 | Topical fluconazole therapy of Candida keratitis. ( Angra, SK; Panda, A; Sharma, N, 1996) |
| "A prospective clinical trial of topical fluconazole solution (2 mg/ml) was undertaken in six consecutive eyes of microbiologically proven Candida keratitis with abscess formation." | 5.08 | Topical fluconazole therapy of Candida keratitis. ( Angra, SK; Panda, A; Sharma, N, 1996) |
| "In an established Candida albicans murine keratitis model, combination therapy with ophthalmic preparations of fluconazole and cyclosporine A (CsA) demonstrated in vivo drug synergy and effectively resolved wild-type C." | 3.73 | Calcineurin promotes infection of the cornea by Candida albicans and can be targeted to enhance fluconazole therapy. ( Afshari, NA; Heitman, J; Onyewu, C, 2006) |
| "Poor bioavailability of antifungal drugs due to the various protective mechanisms of the eye is a serious concern for the treatment of corneal fungal infections in today's world." | 1.39 | Fluconazole loaded chitin nanogels as a topical ocular drug delivery agent for corneal fungal infections. ( Biswas, R; Jayakumar, R; Mangalathillam, S; Mohammed, N; Nair, SV; Rejinold, NS, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Matsumoto, Y | 1 |
| Yoshikawa, A | 1 |
| Nagamachi, T | 1 |
| Sugiyama, Y | 1 |
| Yamada, T | 1 |
| Sugita, T | 1 |
| Mohammed, N | 1 |
| Rejinold, NS | 1 |
| Mangalathillam, S | 1 |
| Biswas, R | 1 |
| Nair, SV | 1 |
| Jayakumar, R | 1 |
| Li, L | 1 |
| Wang, Z | 1 |
| Li, R | 1 |
| Luo, S | 1 |
| Sun, X | 1 |
| Posteraro, B | 1 |
| Mattei, R | 1 |
| Trivella, F | 1 |
| Maffei, A | 1 |
| Torre, A | 1 |
| De Carolis, E | 1 |
| Posteraro, P | 1 |
| Fadda, G | 1 |
| Sanguinetti, M | 1 |
| Pathak, MK | 1 |
| Chhabra, G | 1 |
| Pathak, K | 1 |
| Onyewu, C | 1 |
| Afshari, NA | 1 |
| Heitman, J | 1 |
| Zadok, D | 1 |
| Karpuch, J | 1 |
| Panda, A | 1 |
| Sharma, N | 1 |
| Angra, SK | 1 |
| Ainbinder, DJ | 1 |
| Parmley, VC | 1 |
| Mader, TH | 1 |
| Nelson, ML | 1 |
1 trial available for fluconazole and Corneal Diseases
| Article | Year |
|---|---|
Topical fluconazole therapy of Candida keratitis.
Topics: Abscess; Administration, Topical; Adolescent; Adult; Aged; Candidiasis; Child; Corneal Diseases; Fem | 1996 |
8 other studies available for fluconazole and Corneal Diseases
| Article | Year |
|---|---|
A critical role of calcineurin in stress responses, hyphal formation, and virulence of the pathogenic fungus Trichosporon asahii.
Topics: Amphotericin B; Antifungal Agents; Basidiomycota; Caffeine; Calcineurin; Calcium; Calcium Chloride; | 2022 |
Fluconazole loaded chitin nanogels as a topical ocular drug delivery agent for corneal fungal infections.
Topics: Administration, Ophthalmic; Administration, Topical; Animals; Antifungal Agents; Chitin; Corneal Dis | 2013 |
In vitro evaluation of combination antifungal activity against Fusarium species isolated from ocular tissues of keratomycosis patients.
Topics: Amphotericin B; Antifungal Agents; Corneal Diseases; Drug Evaluation; Drug Synergism; Eye; Eye Infec | 2008 |
Uncommon Neosartorya udagawae fungus as a causative agent of severe corneal infection.
Topics: Adult; Antifungal Agents; Corneal Diseases; Debridement; DNA, Fungal; DNA, Ribosomal; DNA, Ribosomal | 2011 |
Design and development of a novel pH triggered nanoemulsified in-situ ophthalmic gel of fluconazole: ex-vivo transcorneal permeation, corneal toxicity and irritation testing.
Topics: Acrylates; Administration, Ophthalmic; Animals; Antifungal Agents; Cornea; Corneal Diseases; Delayed | 2013 |
Calcineurin promotes infection of the cornea by Candida albicans and can be targeted to enhance fluconazole therapy.
Topics: Animals; Antifungal Agents; Calcineurin; Calcineurin Inhibitors; Candida albicans; Candidiasis; Corn | 2006 |
Treatment of multiple corneal abscesses with fluconazole.
Topics: Abscess; Aged; Aged, 80 and over; Candidiasis; Corneal Diseases; Female; Fluconazole; Humans | 1994 |
Infectious crystalline keratopathy caused by Candida guilliermondii.
Topics: Aged; Amphotericin B; Biopsy; Candida; Candidiasis; Cornea; Corneal Diseases; Drug Resistance, Micro | 1998 |