Leukoplakia, Hairy

Epithelial hyperplasia of the oral mucosa associated with Epstein-Barr virus (HERPESVIRUS 4, HUMAN) and found almost exclusively in persons with HIV infection. The lesion consists of a white patch that is often corrugated or hairy.

Synonym
Leukoplakia, Hairy, Oral
Oral Hairy Leukoplakia
Leukoplakia, Hairy

Excerpt	Reference
"Oral hairy leukoplakia is a common, benign, opportunistic EBV infection of the oral cavity of patients with HIV."	( Walling, DM, 2000)

Excerpt	Reference
"Significant resolution of hairy leukoplakia was noted on the treatment side compared with the control side at the 2-, 7-, and 30-day levels; the 2-day results were the most significant."	( Carpenter, WM; Gowdey, G; Lee, RK, 1995)
"We describe a case of oral hairy leukoplakia that presented with an atypical appearance in a patient on long-term anticonvulsant treatment with an aromatic antiepileptic, lamotrigine."	( Gordins, P; Sloan, P; Spickett, GP; Staines, KS, 2011)
"We report a case of atypical oral hairy leukoplakia (OHL) in a 9-year-old immunocompetent girl treated with fluticasone propionate nasal spray for allergic rhinitis."	( Anbinder, AL; Costa, FH; Costa, V; Kaminagakura, E; León, JE; Ribeiro-Silva, A, 2020)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	22 (32.84)	12.5806
2000's	34 (50.75)	18.1394
2010's	9 (13.43)	28.8240
2020's	2 (2.99)	9.53

Drug	Relationship Strength	Studies	Trials
formaldehyde	low	1	0
dapsone	low	1	0
brl 42810	low	2	0
fluconazole	low	1	0
foscarnet	low	2	0
ketoconazole	low	1	0
lamotrigine	low	1	0
prednisolone	low	1	0
prednisone	low	1	0
bromodeoxyuridine	low	1	0
valine	medium	6	2
betamethasone	low	1	0
2-aminopurine	low	2	0
hematoxylin	low	1	0
eosine yellowish-(ys)	low	1	0
gentian violet	low	2	0
zinc oxide	low	1	0
betamethasone valerate	low	1	0
transferrin	low	1	0
zidovudine	low	4	0
lamivudine	low	1	0
methotrexate	low	1	0
biotin	low	1	0
inositol 3-phosphate	low	1	0
tretinoin	low	1	0
amphotericin b	low	1	0
clobetasol	low	2	0
fluticasone	low	1	0
indinavir sulfate	low	1	0
nystatin a1	low	2	0
podophyllin	medium	4	3
transforming growth factor beta	low	1	0
cyclosporine	low	3	0
acyclovir	medium	10	4
guanine	medium	1	1
ganciclovir	low	1	0
valacyclovir	medium	6	2
penciclovir	medium	1	1

Protein Targets (664)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Beta-lactamase	4	0	0	4
thioredoxin reductase	8	0	0	8
aldehyde dehydrogenase 1 family, member A1	10	0	0	10
IDH1	5	0	0	5
Phosphatidylinositol 4-kinase alpha	0	2	0	2
Xanthine dehydrogenase/oxidase	0	1	0	1
Guanine nucleotide-binding protein G	1	0	0	1
TAR DNA-binding protein 43	3	0	0	3
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	2
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	2
Phosphatidylinositol 4-kinase beta	0	2	0	2
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	7	0	0	7
Chain B, HADH2 protein	7	0	0	7
Chain A, ATP-DEPENDENT DNA HELICASE Q1	4	0	0	4
Chain A, Ferritin light chain	4	0	0	4
Thymidine kinase	0	3	0	3
phosphopantetheinyl transferase	8	0	0	8
GLS protein	5	0	0	5
TDP1 protein	15	0	0	15
Smad3	3	0	0	3
thyroid stimulating hormone receptor	4	0	0	4
EWS/FLI fusion protein	5	0	0	5
arylsulfatase A	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	10	0	0	10
activating transcription factor 6	3	0	0	3
Histone H2A.x	4	0	0	4
Bloom syndrome protein isoform 1	7	0	0	7
hemoglobin subunit beta	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
lamin isoform A-delta10	8	0	0	8
Solute carrier family 22 member 1	0	2	0	5
ATP-binding cassette sub-family C member 3	0	14	0	14
Multidrug resistance-associated protein 4	0	14	0	15
Solute carrier family 22 member 6	0	0	0	2
Bile salt export pump	0	5	0	5
Bile salt export pump	0	15	0	15
Purine nucleoside phosphorylase	0	3	0	3
Thymidine kinase, cytosolic	0	3	0	5
POU domain, class 2, transcription factor 2	0	0	0	3
Cytochrome P450 2C9	0	5	1	6
Cytochrome P450 2J2	0	3	0	3
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Purine nucleoside phosphorylase	0	0	2	2
Solute carrier family 22 member 6	0	0	0	4
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	4
Canalicular multispecific organic anion transporter 1	0	14	0	14
Thymidine kinase	0	2	0	2
Chain A, Cruzipain	4	0	0	4
interleukin 8	3	0	0	3
glucocorticoid receptor [Homo sapiens]	12	0	0	12
farnesoid X nuclear receptor	7	0	0	7
peroxisome proliferator-activated receptor delta	6	0	0	6
vitamin D (1,25- dihydroxyvitamin D3) receptor	9	0	0	9
tumor necrosis factor	3	0	0	3
vitamin D3 receptor isoform VDRA	8	0	0	8
nuclear factor erythroid 2-related factor 2 isoform 1	10	0	0	10
peripheral myelin protein 22	7	0	0	7
Cytochrome P450 1A2	0	2	1	3
Cytochrome P450 3A4	0	8	1	11
Cytochrome P450 2D6	0	3	1	4
Cytochrome P450 2C19	0	1	1	2
Nuclear receptor ROR-gamma	7	1	1	9
Potassium voltage-gated channel subfamily H member 2	0	4	0	4
Aurora kinase B	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	3
pregnane X receptor	6	0	0	6
GLI family zinc finger 3	9	0	0	9
AR protein	12	0	0	12
progesterone receptor	8	0	0	8
cytochrome P450 family 3 subfamily A polypeptide 4	11	0	0	11
estrogen-related nuclear receptor alpha	11	0	0	11
pregnane X nuclear receptor	10	0	0	10
estrogen nuclear receptor alpha	15	0	0	15
aryl hydrocarbon receptor	7	0	0	7
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	6	0	0	6
nuclear receptor subfamily 1, group I, member 2	5	0	0	5
thyroid hormone receptor beta isoform a	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 2	8	0	0	8
galanin receptor type 3	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	8	0	0	8
Glucocorticoid receptor	0	6	2	13
Glycine receptor subunit alpha-1	0	6	0	6
Glutamate receptor 2	8	0	0	8
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
ORF73	0	0	1	1
RAR-related orphan receptor gamma	10	0	0	10
SMAD family member 2	3	0	0	3
SMAD family member 3	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	9	0	0	9
retinoic acid nuclear receptor alpha variant 1	10	0	0	10
retinoid X nuclear receptor alpha	9	0	0	9
G	8	0	0	8
cytochrome P450 2D6	6	0	0	6
peroxisome proliferator activated receptor gamma	7	0	0	7
thyroid stimulating hormone receptor	5	0	0	5
v-jun sarcoma virus 17 oncogene homolog (avian)	5	0	0	5
thyroid hormone receptor beta isoform 2	9	0	0	9
Interferon beta	10	0	0	10
HLA class I histocompatibility antigen, B alpha chain	8	0	0	8
Inositol hexakisphosphate kinase 1	8	0	0	8
cytochrome P450 2C9, partial	8	0	0	8
Chain A, Avidin	0	0	1	1
Chain A, Protein (streptavidin)	0	0	1	1
Chain B, Protein (streptavidin)	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin Complex With Biotin	0	0	1	1
Chain D, Circularly Permuted Core-streptavidin E51/a46	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
apical membrane antigen 1, AMA1	3	0	0	3
nonstructural protein 1	0	1	0	1
green fluorescent protein, partial	0	1	0	1
insulin-degrading enzyme isoform 1	0	0	1	1
Streptavidin	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
Chain A, 2-oxoglutarate Oxygenase	6	0	0	6
acetylcholinesterase	3	0	0	3
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	4	0	0	4
relaxin receptor 1 isoform 1	1	0	0	1
Cellular tumor antigen p53	8	0	0	8
ATAD5 protein, partial	3	0	0	3
Microtubule-associated protein tau	7	0	0	8
bromodomain adjacent to zinc finger domain 2B	5	0	0	5
cellular tumor antigen p53 isoform a	5	0	0	5
Nuclear hormone receptor family member daf-12	0	0	1	1
chromobox protein homolog 1	6	0	0	6
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
oxysterols receptor LXR-beta isoform 1	0	0	1	1
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
geminin	11	0	0	11
survival motor neuron protein isoform d	7	0	0	7
muscarinic acetylcholine receptor M1	3	0	0	3
Thymidine phosphorylase	0	0	0	1
Thymidylate kinase	0	1	0	1
Spike glycoprotein	5	0	0	5
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	2	0	2
ATPase family AAA domain-containing protein 5	6	0	0	6
Ataxin-2	6	0	0	6
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	7	0	0	7
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase	0	1	0	1
67.9K protein	5	0	0	5
cytochrome P450 2C9 precursor	2	0	0	2
cytochrome P450 3A4 isoform 1	7	0	0	7
muscleblind-like protein 1 isoform 1	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	7	0	0	7
Myeloperoxidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	7	0	0	7
Dihydrofolate reductase	0	3	0	3
Gamma-aminobutyric acid receptor subunit delta	7	0	0	7
Gamma-aminobutyric acid receptor subunit gamma-2	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-5	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-3	7	0	0	7
Gamma-aminobutyric acid receptor subunit gamma-1	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-2	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-4	7	0	0	7
Gamma-aminobutyric acid receptor subunit gamma-3	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-6	7	0	0	7
Histamine H2 receptor	4	0	0	4
5-hydroxytryptamine receptor 6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	7	0	0	7
Gamma-aminobutyric acid receptor subunit beta-3	7	0	0	7
Gamma-aminobutyric acid receptor subunit beta-2	7	0	0	7
GABA theta subunit	7	0	0	7
Gamma-aminobutyric acid receptor subunit epsilon	7	0	0	7
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
unnamed protein product	0	1	0	1
transcriptional regulator ERG isoform 3	2	0	0	2
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
DNA polymerase iota isoform a (long)	6	0	0	6
bcl-2-like protein 11 isoform 1	0	0	1	1
Histone deacetylase 3	0	1	0	1
Rap guanine nucleotide exchange factor 3	2	0	0	2
Chymotrypsinogen A	0	2	0	2
Beta-lactamase	0	2	0	2
Steroid 17-alpha-hydroxylase/17,20 lyase	0	3	0	3
Heme oxygenase 1	0	1	0	1
ATP-dependent translocase ABCB1	0	3	0	3
ATP-dependent translocase ABCB1	0	5	0	5
Lanosterol 14-alpha demethylase	0	1	1	2
Aromatase	0	3	0	3
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Cytochrome P450 11B2, mitochondrial	0	2	0	2
ATP-dependent translocase ABCB1	0	3	0	3
Heme oxygenase 2	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	2	0	2
Histone deacetylase 4	0	1	0	1
Cytochrome P450 144	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Mycocyclosin synthase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Histone deacetylase 1	0	1	0	1
Lanosterol 14-alpha demethylase	0	3	2	5
Sterol 14-alpha demethylase	0	0	1	1
Sterol 14-alpha demethylase	0	1	1	2
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
14-alpha sterol demethylase	0	0	1	1
Histone deacetylase 8	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
heat shock protein 90, putative	0	0	0	1
likely tRNA 2'-phosphotransferase	0	1	0	1
Chain A, probable fosfomycin resistance protein	0	0	1	1
Chain B, probable fosfomycin resistance protein	0	0	1	1
Carbonic anhydrase 1	0	0	0	1
Carbonic anhydrase 2	0	1	1	2
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase alpha catalytic subunit	0	1	0	1
Carbonic anhydrase 4	0	1	0	1
DNA polymerase delta catalytic subunit	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase 9	0	1	0	1
Reverse transcriptase/RNaseH	0	2	4	9
endonuclease IV	1	0	0	1
ClpP	2	0	0	2
Fumarate hydratase	2	0	0	2
NFKB1 protein, partial	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	5	0	0	5
polyprotein	2	0	0	2
Transitional endoplasmic reticulum ATPase	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	5	0	0	5
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
Luciferase	4	0	0	4
beta-amyloid peptide, A beta {N-terminal} [human, cerebrospinal fluid, conditioned medium of mixed-brain cell cultures, Peptide Partial, 33 aa]	1	0	0	1
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
USP1 protein, partial	5	0	0	5
caspase 7, apoptosis-related cysteine protease	2	0	0	2
alpha synuclein, partial	1	0	0	1
estrogen receptor 2 (ER beta)	4	0	0	4
hypothetical protein, conserved	3	0	0	3
glucocerebrosidase	2	0	0	2
luciferase	2	0	0	2
caspase-3	2	0	0	2
thyrotropin-releasing hormone receptor	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
Caspase-7	3	0	0	3
polyunsaturated fatty acid lipoxygenase ALOX12	3	0	0	3
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
caspase-3	3	0	0	3
histone deacetylase 9 isoform 3	1	0	0	1
heat shock protein beta-1	3	0	0	3
huntingtin isoform 2	1	0	0	1
mitogen-activated protein kinase 1	4	0	0	4
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
nuclear receptor ROR-gamma isoform 1	5	0	0	5
DNA polymerase kappa isoform 1	4	0	0	4
lethal factor (plasmid)	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
Epidermal growth factor receptor	0	1	0	1
Integrin beta-3	4	0	0	4
Tyrosine-protein kinase Fyn	0	1	0	1
Muscarinic acetylcholine receptor M2	0	4	0	5
Muscarinic acetylcholine receptor M4	0	2	0	3
Integrin alpha-IIb	4	0	0	4
Muscarinic acetylcholine receptor M5	0	2	0	3
Alpha-2A adrenergic receptor	0	4	0	4
60 kDa chaperonin	0	2	0	2
Adenosine receptor A3	0	6	0	6
60 kDa heat shock protein, mitochondrial	0	2	0	2
Muscarinic acetylcholine receptor M1	0	2	0	3
D(2) dopamine receptor	0	2	0	2
Androgen receptor	0	3	0	3
Alpha-1B adrenergic receptor	0	7	0	7
Alpha-2B adrenergic receptor	0	4	0	4
Alpha-2C adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	3
Substance-K receptor	0	6	0	6
D(1A) dopamine receptor	0	2	0	2
Acetylcholinesterase	0	1	0	1
Glutamate receptor ionotropic, kainate 1	1	0	0	1
Histamine H2 receptor	0	4	0	4
Alpha-1D adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
Adenosine receptor A2a	0	3	0	3
Mu-type opioid receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
Glutamate receptor ionotropic, kainate 2	1	0	0	1
Glutamate receptor ionotropic, kainate 3	1	0	0	1
Alpha-1A adrenergic receptor	0	7	0	7
10 kDa heat shock protein, mitochondrial	0	2	0	2
Fatty-acid amide hydrolase 1	1	0	0	1
Inositol monophosphatase 1	3	0	0	3
Glutamate receptor ionotropic, kainate 4	1	0	0	1
Sodium-dependent dopamine transporter	0	4	0	4
Leukotriene B4 receptor 1	1	0	0	2
Thiosulfate sulfurtransferase	0	2	0	2
60 kDa chaperonin	0	2	0	2
Glutamate receptor ionotropic, kainate 5	1	0	0	1
10 kDa chaperonin	0	2	0	2
Leukotriene B4 receptor 2	1	0	0	2
ATP-dependent phosphofructokinase	6	0	0	6
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Ricin	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Shiga toxin subunit A	0	1	0	1
Guanine deaminase	0	0	0	1
Chain E, Fibrin beta chain	0	1	0	1
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
15-lipoxygenase, partial	2	0	0	2
WRN	1	0	0	1
Mcl-1	0	1	0	1
MPI protein	0	1	0	1
Cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0	0	0	1
PPM1D protein	1	0	0	1
alkaline phosphatase, intestinal	0	0	1	1
thioredoxin glutathione reductase	4	0	0	4
regulator of G-protein signaling 4	3	0	0	3
pyruvate kinase	1	0	0	1
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
CDK5	0	0	0	1
serine-protein kinase ATM isoform a	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
major prion protein preproprotein Prp precursor	0	1	0	1
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	0	1	1
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
intestinal alkaline phosphatase precursor	0	0	1	1
DNA polymerase beta	2	0	0	2
flap endonuclease 1	2	0	0	2
serine/threonine-protein kinase PLK1	3	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
DNA polymerase eta isoform 1	2	0	0	2
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
Vif	0	1	0	1
Tat	0	1	0	1
histone acetyltransferase KAT2A isoform 1	4	0	0	4
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	0	1	0	1
alkaline phosphatase, germ cell type preproprotein	0	0	1	1
endoribonuclease toxin MazF	0	0	1	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Pyruvate kinase PKM	0	1	0	1
Endothelin receptor type B	1	0	0	1
Endothelin-1 receptor	1	0	0	1
phosphoglycerate kinase	1	0	0	1
hypothetical protein CAALFM_CR05890CA	0	0	0	1
H3 histone acetyltransferase	0	0	0	1
large T antigen	0	1	0	1
Chain A, PROTEIN (PROTEASE)	0	1	0	1
Chain B, PROTEIN (PROTEASE)	0	1	0	1
Chain A, PROTEIN (PROTEASE)	0	1	0	1
Chain B, PROTEIN (PROTEASE)	0	1	0	1
Chain A, HIV-1 PROTEASE	0	1	0	1
Chain B, HIV-1 PROTEASE	0	1	0	1
Chain A, HIV-II PROTEASE	0	1	0	1
Chain B, HIV-II PROTEASE	0	1	0	1
Chain A, POL polyprotein	0	0	1	1
Chain B, POL polyprotein	0	0	1	1
Chain A, POL polyprotein	0	0	1	1
Chain B, POL polyprotein	0	0	1	1
Chain A, POL polyprotein	0	0	1	1
Chain B, POL polyprotein	0	0	1	1
Chain A, POL polyprotein	0	0	1	1
Chain B, POL polyprotein	0	0	1	1
Chain A, protease RETROPEPSIN	0	1	0	1
Chain B, protease RETROPEPSIN	0	1	0	1
Chain A, protease RETROPEPSIN	0	1	0	1
Chain B, protease RETROPEPSIN	0	1	0	1
Chain A, protease RETROPEPSIN	0	1	0	1
Chain B, protease RETROPEPSIN	0	1	0	1
Chain A, POL polyprotein	0	1	0	1
Chain B, POL polyprotein	0	1	0	1
Chain A, POL polyprotein	0	1	0	1
Chain B, POL polyprotein	0	1	0	1
Chain A, HIV-1 protease	0	1	0	1
Chain B, HIV-1 protease	0	1	0	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
Chain A, Hiv-1 Protease	0	1	0	1
Chain B, Hiv-1 Protease	0	1	0	1
Chain A, Hiv-1 Protease	0	1	0	1
Chain B, Hiv-1 Protease	0	1	0	1
Chain A, Hiv-1 Protease	0	1	0	1
Chain B, Hiv-1 Protease	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Albumin	0	0	2	4
Gag-Pol polyprotein	0	2	0	2
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Gag polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Gag-Pol polyprotein	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
Thromboxane-A synthase	0	3	0	3
Gag-Pol polyprotein	0	1	0	1
Thromboxane-A synthase	0	0	0	1
Genome polyprotein	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Protease	0	3	2	7
Multidrug and toxin extrusion protein 2	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
Protease	0	2	1	3
Protease	0	1	0	1
Estrogen receptor beta	0	1	0	1
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	1	0	1
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	0	2	0	2
Cytochrome P450 26A1	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Camphor 5-monooxygenase	0	0	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Epoxide hydrolase 1	0	0	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Cytochrome P450 2C11	0	1	0	1
Steroid 21-hydroxylase	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Cholesterol side-chain cleavage enzyme, mitochondrial	0	1	0	1
5-hydroxytryptamine receptor 2A	0	4	0	4
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Cytochrome P450 2A2	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Translocator protein	0	1	0	1
Cytochrome P450 7A1	0	1	0	1
Estrogen receptor	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
Sodium-dependent noradrenaline transporter	0	2	0	2
Gonadotropin-releasing hormone receptor	0	1	1	2
Sodium-dependent serotonin transporter	0	2	0	2
Type-1 angiotensin II receptor	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Cytochrome P450 4F2	0	1	0	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	2	0	2
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Cytochrome P450 7A1	0	1	0	1
Lanosterol 14-alpha demethylase	0	2	0	2
Hsf1 protein	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1D	0	3	0	3
Capsid protein	0	1	1	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	5
GALC protein	2	0	0	2
cytochrome P450 2D6 isoform 1	2	0	0	2
peripheral myelin protein 22 isoform 1	2	0	0	2
D(1A) dopamine receptor	2	0	0	2
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Dihydrofolate reductase	0	4	2	6
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	2	0	3
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	2	0	2
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
acid sphingomyelinase	1	0	0	1
dopamine D1 receptor	1	0	0	1
Thymidylate synthase	0	1	0	1
alpha-galactosidase	1	0	0	1
Thymidylate synthase	0	1	0	1
importin subunit beta-1 isoform 1	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
snurportin-1	1	0	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
M-phase phosphoprotein 8	3	0	0	3
caspase-1 isoform alpha precursor	1	0	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Folate receptor alpha	0	1	0	1
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	2
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier organic anion transporter family member 1B3	0	0	0	1
Solute carrier family 22 member 11	0	0	0	2
Protein-arginine deiminase type-4	0	1	0	1
Thrombopoietin	1	0	0	1
nonstructural protein 1	2	0	0	2
Parkin	2	0	0	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
beta-2 adrenergic receptor	1	0	0	1
cytochrome P450 2C19 precursor	1	0	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
eyes absent homolog 2 isoform a	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Potassium channel subfamily K member 2	0	0	1	1
Glutathione reductase, mitochondrial	0	2	0	2
Phospholipase A2, membrane associated	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Platelet-activating factor receptor	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
5-hydroxytryptamine receptor 2C	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Adenosine receptor A1	0	2	0	2
Adenosine receptor A2a	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
C-C chemokine receptor type 2	0	2	0	2
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Potassium voltage-gated channel subfamily A member 1	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Myosin light chain kinase, smooth muscle	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Potassium channel subfamily K member 2	0	1	0	1
Beta-2 adrenergic receptor	0	0	0	1
Indoleamine 2,3-dioxygenase 2	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Ornithine decarboxylase	0	0	0	1
Amyloid-beta precursor protein	0	1	0	1
Ornithine decarboxylase	0	0	0	1
Retinoic acid receptor alpha	0	2	2	7
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor alpha	0	1	2	3
Retinoic acid receptor gamma	0	2	2	7
Alpha-1A adrenergic receptor	0	1	0	1
Retinoic acid receptor gamma	0	1	2	3
5-hydroxytryptamine receptor 1A	0	1	0	1
Retinoic acid receptor RXR-alpha	0	2	2	4
Retinoic acid receptor beta	0	1	2	3
Cellular retinoic acid-binding protein 2	0	0	1	1
Mitogen-activated protein kinase 1	0	1	0	1
Retinoic acid receptor RXR-alpha	0	1	2	3
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-beta	0	1	2	3
Retinoic acid receptor RXR-gamma	0	1	2	3
Nuclear receptor ROR-alpha	0	1	0	1
Alpha-synuclein	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
Retinoic acid receptor RXR-gamma	0	2	2	4
Cellular retinoic acid-binding protein 1	0	0	1	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Nuclear receptor ROR-beta	0	1	0	1
Solute carrier family 15 member 1	0	2	0	3
Solute carrier family 15 member 1	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
Valacyclovir hydrolase	0	0	0	1
Chain A, Arginase 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
pyruvate kinase PKM isoform a	1	0	0	1
tyrosine-protein kinase Yes	1	0	0	1
Ectonucleoside triphosphate diphosphohydrolase 1	0	0	0	1
Protein kinase C beta type	0	1	0	1
DNA polymerase beta	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	0	0	1
Thymidine kinase, cytosolic	0	0	0	1
Protein kinase C epsilon type	0	1	0	1
Thymidine kinase	0	1	0	2
Solute carrier family 22 member 7	0	0	0	1
Thymidine kinase	0	1	0	2
Solute carrier family 22 member 7	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(3)

Research Excerpts

Overview

Treatment

Research

Studies (67)

Protein Targets (664)

Leukoplakia, Hairy

Synonyms(3)

Research Excerpts

Overview

Treatment

Research

Studies (67)

Drugs Studied (43)

Protein Targets (664)