fluconazole has been researched along with Aneuploid in 15 studies
Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.
fluconazole : A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, 50% of isolates that are resistant to fluconazole (FLC), the most widely used antifungal, are aneuploid and some aneuploidies can confer FLC resistance." | 7.80 | A tetraploid intermediate precedes aneuploid formation in yeasts exposed to fluconazole. ( Bavli, D; Berman, J; Bibi, M; Harrison, BD; Hashemi, J; Nahmias, Y; Pulver, R; Sapiro, G; Wellington, M, 2014) |
| " neoformans adapts to high concentrations of the antifungal fluconazole (FLC) by acquisition of aneuploidy, especially duplication of chromosome 1 (Chr1)." | 7.77 | Deletion of Cryptococcus neoformans AIF ortholog promotes chromosome aneuploidy and fluconazole-resistance in a metacaspase-independent manner. ( Averette, AF; Heitman, J; Perfect, JR; Semighini, CP, 2011) |
| "Widespread aneuploidy was observed in evolved replicates from some strain backgrounds." | 5.72 | Acquisition of cross-azole tolerance and aneuploidy in Candida albicans strains evolved to posaconazole. ( Adamu Bukari, AR; Chapel, M; Gerstein, AC; Kukurudz, RJ; Sidney, B; Sierhuis, R; Wonitowy, Q, 2022) |
| " Although polyploid titan cells generated haploid daughter cell progeny upon in vitro replication under nutrient-replete conditions, titan cells treated with the antifungal drug fluconazole produced fluconazole-resistant diploid and aneuploid daughter cells." | 3.81 | Polyploid titan cells produce haploid and aneuploid progeny to promote stress adaptation. ( Berman, J; Fraser, JA; Fu, MS; Gerstein, AC; Li, Z; Mukaremera, L; Nielsen, K; Ormerod, KL, 2015) |
| " Here, we describe an approach to isolate aneuploids or haploids induced by the short-term (12-16 h) exposure of diploid reference strains SC5314 and CAI4 to the most commonly used antifungal drug, fluconazole, followed by repeated single-cell separation among small morphologically distinct colonies in the inhibition zone." | 3.80 | Short-term exposure to fluconazole induces chromosome loss in Candida albicans: an approach to produce haploid cells. ( Chang, FM; Chang, KD; Cheng, WN; Chin, YP; Chou, ML; Lee, KC; Lin, CP; Lin, CT; Ou, TY; Su, CH, 2014) |
| " Resistance to fluconazole, the most widely used antifungal, is often associated with acquired aneuploidy." | 3.75 | Acquisition of aneuploidy provides increased fitness during the evolution of antifungal drug resistance. ( Anderson, JB; Berman, J; Cowen, LE; Dulmage, K; Selmecki, AM, 2009) |
| "Widespread aneuploidy was observed in evolved replicates from some strain backgrounds." | 1.72 | Acquisition of cross-azole tolerance and aneuploidy in Candida albicans strains evolved to posaconazole. ( Adamu Bukari, AR; Chapel, M; Gerstein, AC; Kukurudz, RJ; Sidney, B; Sierhuis, R; Wonitowy, Q, 2022) |
| "In contrast, aneuploidy can also be advantageous and in fungi confers antifungal drug resistance and enables rapid adaptive evolution." | 1.39 | Unisexual and heterosexual meiotic reproduction generate aneuploidy and phenotypic diversity de novo in the yeast Cryptococcus neoformans. ( Dietrich, FS; Feretzaki, M; Floyd-Averette, A; Heitman, J; Li, W; Mieczkowski, P; Ni, M, 2013) |
| "We found that aneuploidy in general and a specific segmental aneuploidy, consisting of an isochromosome composed of the two left arms of chromosome 5, were associated with azole resistance." | 1.33 | Aneuploidy and isochromosome formation in drug-resistant Candida albicans. ( Berman, J; Forche, A; Selmecki, A, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 9 (60.00) | 24.3611 |
| 2020's | 3 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, F | 1 |
| Gritsenko, V | 1 |
| Lu, H | 1 |
| Zhen, C | 1 |
| Gao, L | 1 |
| Berman, J | 7 |
| Jiang, YY | 1 |
| Kukurudz, RJ | 1 |
| Chapel, M | 1 |
| Wonitowy, Q | 1 |
| Adamu Bukari, AR | 1 |
| Sidney, B | 1 |
| Sierhuis, R | 1 |
| Gerstein, AC | 2 |
| Bing, J | 1 |
| Hu, T | 1 |
| Zheng, Q | 1 |
| Muñoz, JF | 1 |
| Cuomo, CA | 1 |
| Huang, G | 1 |
| Ni, M | 1 |
| Feretzaki, M | 1 |
| Li, W | 1 |
| Floyd-Averette, A | 1 |
| Mieczkowski, P | 1 |
| Dietrich, FS | 1 |
| Heitman, J | 2 |
| Harrison, BD | 1 |
| Hashemi, J | 1 |
| Bibi, M | 1 |
| Pulver, R | 1 |
| Bavli, D | 1 |
| Nahmias, Y | 1 |
| Wellington, M | 1 |
| Sapiro, G | 1 |
| Robinson, R | 1 |
| Chang, FM | 1 |
| Ou, TY | 1 |
| Cheng, WN | 1 |
| Chou, ML | 1 |
| Lee, KC | 1 |
| Chin, YP | 1 |
| Lin, CP | 1 |
| Chang, KD | 1 |
| Lin, CT | 1 |
| Su, CH | 1 |
| Ford, CB | 1 |
| Funt, JM | 1 |
| Abbey, D | 1 |
| Issi, L | 1 |
| Guiducci, C | 1 |
| Martinez, DA | 1 |
| Delorey, T | 1 |
| Li, BY | 1 |
| White, TC | 1 |
| Cuomo, C | 1 |
| Rao, RP | 1 |
| Thompson, DA | 1 |
| Regev, A | 1 |
| Chen, G | 1 |
| Mulla, WA | 1 |
| Kucharavy, A | 1 |
| Tsai, HJ | 1 |
| Rubinstein, B | 1 |
| Conkright, J | 1 |
| McCroskey, S | 1 |
| Bradford, WD | 1 |
| Weems, L | 1 |
| Haug, JS | 1 |
| Seidel, CW | 1 |
| Li, R | 1 |
| Fu, MS | 1 |
| Mukaremera, L | 1 |
| Li, Z | 1 |
| Ormerod, KL | 1 |
| Fraser, JA | 1 |
| Nielsen, K | 1 |
| Selmecki, AM | 1 |
| Dulmage, K | 1 |
| Cowen, LE | 1 |
| Anderson, JB | 1 |
| Semighini, CP | 1 |
| Averette, AF | 1 |
| Perfect, JR | 1 |
| Ngamskulrungroj, P | 1 |
| Chang, Y | 1 |
| Hansen, B | 1 |
| Bugge, C | 1 |
| Fischer, E | 1 |
| Kwon-Chung, KJ | 1 |
| Selmecki, A | 1 |
| Forche, A | 1 |
| Perepnikhatka, V | 1 |
| Fischer, FJ | 1 |
| Niimi, M | 1 |
| Baker, RA | 1 |
| Cannon, RD | 1 |
| Wang, YK | 1 |
| Sherman, F | 1 |
| Rustchenko, E | 1 |
15 other studies available for fluconazole and Aneuploid
| Article | Year |
|---|---|
Adaptation to Fluconazole via Aneuploidy Enables Cross-Adaptation to Amphotericin B and Flucytosine in Cryptococcus neoformans.
Topics: Adaptation, Physiological; Amphotericin B; Aneuploidy; Antifungal Agents; Cryptococcosis; Cryptococc | 2021 |
Acquisition of cross-azole tolerance and aneuploidy in Candida albicans strains evolved to posaconazole.
Topics: Aneuploidy; Antifungal Agents; Azoles; Candida albicans; Drug Resistance, Fungal; Fluconazole; Micro | 2022 |
Experimental Evolution Identifies Adaptive Aneuploidy as a Mechanism of Fluconazole Resistance in Candida auris.
Topics: Aneuploidy; Antifungal Agents; Candida; Drug Resistance, Fungal; Fluconazole; Humans; Microbial Sens | 2020 |
Unisexual and heterosexual meiotic reproduction generate aneuploidy and phenotypic diversity de novo in the yeast Cryptococcus neoformans.
Topics: Aneuploidy; Antifungal Agents; Cryptococcosis; Cryptococcus neoformans; Drug Resistance, Fungal; Flu | 2013 |
A tetraploid intermediate precedes aneuploid formation in yeasts exposed to fluconazole.
Topics: Aneuploidy; Antifungal Agents; Candida albicans; Cell Enlargement; Drug Resistance, Fungal; Fluconaz | 2014 |
Antifungal fluconazole induces aneuploidy, sowing the seeds of its own failure.
Topics: Aneuploidy; Antifungal Agents; Candida albicans; Fluconazole; Tetraploidy | 2014 |
Short-term exposure to fluconazole induces chromosome loss in Candida albicans: an approach to produce haploid cells.
Topics: Aneuploidy; Antifungal Agents; Candida albicans; Chromosomes, Fungal; Comparative Genomic Hybridizat | 2014 |
The evolution of drug resistance in clinical isolates of Candida albicans.
Topics: Adhesiveness; Aneuploidy; Candida albicans; Candidiasis; Drug Resistance, Fungal; Evolution, Molecul | 2015 |
Targeting the adaptability of heterogeneous aneuploids.
Topics: Aneuploidy; Antifungal Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Candida albicans; Ce | 2015 |
Polyploid titan cells produce haploid and aneuploid progeny to promote stress adaptation.
Topics: Aneuploidy; Animals; Antifungal Agents; Cryptococcosis; Cryptococcus neoformans; Disease Models, Ani | 2015 |
Acquisition of aneuploidy provides increased fitness during the evolution of antifungal drug resistance.
Topics: Aneuploidy; Candida albicans; Chromosomes, Fungal; Drug Resistance, Fungal; Evolution, Molecular; Fl | 2009 |
Deletion of Cryptococcus neoformans AIF ortholog promotes chromosome aneuploidy and fluconazole-resistance in a metacaspase-independent manner.
Topics: Aneuploidy; Antifungal Agents; Apoptosis; Apoptosis Inducing Factor; Caspase 1; Caspase 2; Cryptococ | 2011 |
Cryptococcus neoformans Yop1 , an endoplasmic reticulum curvature-stabilizing protein, participates with Sey1 in influencing fluconazole-induced disomy formation.
Topics: Aneuploidy; Antifungal Agents; Cryptococcus neoformans; Drug Resistance, Fungal; Endoplasmic Reticul | 2012 |
Aneuploidy and isochromosome formation in drug-resistant Candida albicans.
Topics: Aneuploidy; Antifungal Agents; Azoles; Candida albicans; Centromere; Chromosomes, Fungal; Cytochrome | 2006 |
Specific chromosome alterations in fluconazole-resistant mutants of Candida albicans.
Topics: Aneuploidy; Antifungal Agents; Arabinose; Candida albicans; Chromosomes, Fungal; Drug Resistance, Mi | 1999 |