Page last updated: 2024-09-27

Otomycosis

Fungus infection of the external ear, usually by ASPERGILLUS species

Synonyms(1)

Synonym
Otomycosis

Research Excerpts

Overview

ExcerptReference
"Otomycosis is frequently seen in Shanghai and is a challenging problem due to recurrence and resistance to therapy."( Cao, W; Chi, F; Jia, X; Liang, Q, 2012)
"Otomycosis is a common clinical condition seen in outpatient department of otorhinolaryngology."( Behera, IC; Das, A; Sahu, MC; Swain, SK, 2018)
"Fungal otitis (otomycosis) is a common infection encountered by otolaryngologists."( Chappe, M; de Gentile, L; Lagarce, F; Le Govic, Y; Legrand, G; Vrignaud, S, 2018)
"Otomycosis is one of the relatively common diseases in the world which is caused by different fungi especially saprophytes."( Karami, M; Kiakojuri, K; Mahdavi Omran, S; Pournajaf, A; Rajabnia, R; Taghizadeh Armaki, M, 2019)
"Refractory otomycosis is a common condition that is difficult to treat."( Hu, S; Jin, M; Zhang, S; Zhang, Y; Zhou, G, 2021)
"Otomycosis is a fungal infection of the outer ear, which may be treated with topical antifungal medications."( Lee, A; Saeed, SR; Tysome, JR, 2021)
"Otomycosis is considered a recurring fungal ear infection."( Abastabar, M; Al-Hatmi, AMS; Alipour, A; Darini, A; Faeli, L; Haghani, I; Mayahi, S; Nemati, S; Roohi, B; Shalchizadeh, M; Shokohi, T, 2023)
"Otomycosis is a common mycotic infection of the external auditory canal, and Aspergillus species are one of the most frequent causative agents worldwide."( Abastabar, M; Abbasi, K; Aghili, SR; Badali, H; Espahbodi, A; Faeli, L; Haghani, I; Hedayati, MT; Javidnia, J; Khojasteh, S; Moazeni, M; Nosratabadi, M; Roohi, B; Saeedi, M; Shokohi, T, 2023)
"Otomycosis is a common mycotic infection of the external auditory canal, and Aspergillus species are one of the most frequent causative agents worldwide."( Abastabar, M; Abbasi, K; Aghili, SR; Badali, H; Espahbodi, A; Faeli, L; Haghani, I; Hedayati, MT; Javidnia, J; Khojasteh, S; Moazeni, M; Nosratabadi, M; Roohi, B; Saeedi, M; Shokohi, T, 2023)

Context

ExcerptReference
"Two cases of otomycosis have been reported in patients undergoing tympanomastoidectomy."( Alves, AI; Bezerra, JD; Buonafina-Paz, MD; Leal, MC; Leite-Andrade, MC; Lima-Neto, RG; Neves, RP; Pape, PL; Robert, E; Santos, FA, 2022)
"Two cases of otomycosis have been reported in patients undergoing tympanomastoidectomy."( Alves, AI; Bezerra, JD; Buonafina-Paz, MD; Leal, MC; Leite-Andrade, MC; Lima-Neto, RG; Neves, RP; Pape, PL; Robert, E; Santos, FA, 2022)
"Two cases of otomycosis have been reported in patients undergoing tympanomastoidectomy."( Alves, AI; Bezerra, JD; Buonafina-Paz, MD; Leal, MC; Leite-Andrade, MC; Lima-Neto, RG; Neves, RP; Pape, PL; Robert, E; Santos, FA, 2022)

Treatment

ExcerptReference
"However, sometime it is difficult to treat otomycosis along with mastoid cavity, chronic suppurative otitis media, immunocompromised patient, etc."( Behera, IC; Das, A; Sahu, MC; Swain, SK, 2018)

Research

Studies (40)

TimeframeStudies, This Condition (%)All Conditions %
pre-19904 (10.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's15 (37.50)28.8240
2020's21 (52.50)9.53
DrugIndicatedRelationship StrengthStudiesTrials
salicylic acid0low10
glycerol0low10
bay h 45020low10
clioquinol0low20
clotrimazole0medium103
econazole0medium32
fluconazole0low50
ketoconazole0low50
merbromin0low10
miconazole0low10
ofloxacin0low10
triacetin0low10
triamcinolone acetonide0medium32
peracetic acid0low20
alpha-pinene0low10
boric acid0medium32
fusarium0low10
flumethasone0low10
streptomycin0low10
mercury0low10
itraconazole0low60
voriconazole0low80
eberconazole0low10
povidone-iodine0medium11
l 743,8720low10
terbinafine0medium51
amphotericin b0low20
nystatin a10medium61
hachimycin0low10

Protein Targets (445)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
RAR-related orphan receptor gamma8008
thyroid stimulating hormone receptor3003
mitogen-activated protein kinase 17007
Nuclear receptor ROR-gamma4004
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, Cruzipain2002
interleukin 81001
phosphopantetheinyl transferase3003
GLS protein2002
glucocorticoid receptor [Homo sapiens]140014
farnesoid X nuclear receptor8008
peroxisome proliferator-activated receptor delta8008
vitamin D (1,25- dihydroxyvitamin D3) receptor7007
tumor necrosis factor1001
vitamin D3 receptor isoform VDRA8008
nuclear factor erythroid 2-related factor 2 isoform 1100010
peripheral myelin protein 227007
lamin isoform A-delta10120012
Cytochrome P450 1A20303
Cytochrome P450 3A408010
Cytochrome P450 2D60404
Cytochrome P450 2C9 0639
Cytochrome P450 2C190606
Potassium voltage-gated channel subfamily H member 20505
Aurora kinase B0101
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE5005
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, JmjC domain-containing histone demethylation protein 3A6006
Chain A, Ferritin light chain4004
Luciferase3003
acetylcholinesterase5005
calpain II, partial0101
hypoxia-inducible factor 1 alpha subunit7007
ATAD5 protein, partial5005
USP1 protein, partial6006
TDP1 protein8008
GLI family zinc finger 3100010
Microtubule-associated protein tau5005
AR protein100010
aldehyde dehydrogenase 1 family, member A17007
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)5005
PINK11001
estrogen receptor 2 (ER beta)5005
nuclear receptor subfamily 1, group I, member 37007
progesterone receptor8008
isocitrate dehydrogenase 1, partial3003
cytochrome P450 family 3 subfamily A polypeptide 4120012
nonstructural protein 13003
retinoid X nuclear receptor alpha120012
estrogen-related nuclear receptor alpha7007
pregnane X nuclear receptor120012
estrogen nuclear receptor alpha140014
G9009
cytochrome P450 2D68008
glucocerebrosidase2002
Parkin1001
bromodomain adjacent to zinc finger domain 2B5005
shiga toxin 1 variant A subunit1001
shiga toxin 1 B subunit1001
peroxisome proliferator activated receptor gamma4004
IDH17007
euchromatic histone-lysine N-methyltransferase 2100010
aryl hydrocarbon receptor8008
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a8008
thyroid stimulating hormone receptor2002
activating transcription factor 68008
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a7007
v-jun sarcoma virus 17 oncogene homolog (avian)6006
Histone H2A.x5005
cellular tumor antigen p53 isoform a4004
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 14004
phospholipase A2 precursor0101
nuclear factor erythroid 2-related factor 2 isoform 26006
parathyroid hormone/parathyroid hormone-related peptide receptor precursor4004
potassium voltage-gated channel subfamily H member 2 isoform d7007
thyroid hormone receptor beta isoform 2100010
heat shock protein beta-17007
ubiquitin carboxyl-terminal hydrolase 2 isoform a3003
serine/threonine-protein kinase PLK12002
eyes absent homolog 2 isoform a1001
heat shock protein HSP 90-alpha isoform 20106
DNA polymerase iota isoform a (long)4004
nuclear receptor ROR-gamma isoform 17007
cysteine protease ATG4B isoform a0101
geminin120012
cytochrome P450 3A4 isoform 16006
neuropeptide S receptor isoform A2002
Gamma-aminobutyric acid receptor subunit pi6107
ATP-binding cassette sub-family C member 30808
Multidrug resistance-associated protein 40808
Bile salt export pump015015
Interferon beta100010
HLA class I histocompatibility antigen, B alpha chain 9009
Cellular tumor antigen p53110011
Steroid 17-alpha-hydroxylase/17,20 lyase0909
Indoleamine 2,3-dioxygenase 10505
Gamma-aminobutyric acid receptor subunit beta-16107
Gamma-aminobutyric acid receptor subunit delta6107
Gamma-aminobutyric acid receptor subunit gamma-26107
Gamma-aminobutyric acid receptor subunit alpha-56107
Gamma-aminobutyric acid receptor subunit alpha-36107
Gamma-aminobutyric acid receptor subunit gamma-16107
Gamma-aminobutyric acid receptor subunit alpha-26107
Gamma-aminobutyric acid receptor subunit alpha-46107
Gamma-aminobutyric acid receptor subunit gamma-36107
Gamma-aminobutyric acid receptor subunit alpha-66107
Alpha-synuclein4004
Spike glycoprotein5005
Gamma-aminobutyric acid receptor subunit alpha-16107
Gamma-aminobutyric acid receptor subunit beta-36107
Gamma-aminobutyric acid receptor subunit beta-26107
Disintegrin and metalloproteinase domain-containing protein 173003
Inositol monophosphatase 11001
TAR DNA-binding protein 436006
Lanosterol 14-alpha demethylase08210
Rap guanine nucleotide exchange factor 44004
GABA theta subunit6107
Inositol hexakisphosphate kinase 19009
Canalicular multispecific organic anion transporter 10808
Gamma-aminobutyric acid receptor subunit epsilon6107
cytochrome P450 2C9, partial9009
heat shock protein 90, putative0005
retinoic acid nuclear receptor alpha variant 1110011
Beta-lactamase0101
Beta-lactamase0606
Chain A, 2-oxoglutarate Oxygenase3003
glp-1 receptor, partial5005
thioredoxin reductase4004
mu opioid receptor, partial0011
15-lipoxygenase, partial2002
90-kda heat shock protein beta HSP90 beta, partial0101
SMAD family member 23003
Fumarate hydratase6006
SMAD family member 33003
thioredoxin glutathione reductase1001
Smad34004
regulator of G-protein signaling 44004
polyprotein6006
LAP40011
MEP20011
polyunsaturated fatty acid lipoxygenase ALOX121001
delta-type opioid receptor0112
kappa-type opioid receptor isoform 10101
huntingtin isoform 22002
nuclear factor NF-kappa-B p105 subunit isoform 11001
flap endonuclease 13003
survival motor neuron protein isoform d4004
DNA dC->dU-editing enzyme APOBEC-3F isoform a1001
Histone deacetylase 30202
Carbonic anhydrase 120102
Voltage-dependent calcium channel gamma-2 subunit3003
Carbonic anhydrase 10203
Carbonic anhydrase 20304
Amyloid-beta precursor protein0101
Integrin beta-33003
Carbonic anhydrase 30102
Integrin alpha-IIb3003
Botulinum neurotoxin type A 0101
Spike glycoprotein0101
Alpha-1B adrenergic receptor0617
Glutamate receptor 23003
Catechol O-methyltransferase0101
Carbonic anhydrase 40102
Carbonic anhydrase 60102
Alpha-1D adrenergic receptor0011
Carbonic anhydrase 5A, mitochondrial0102
Alpha-1A adrenergic receptor0617
Carbonic anhydrase 70102
Histone deacetylase 40202
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Histone deacetylase 10202
Carbonic anhydrase 90102
Beta-galactosidase0011
Histone deacetylase 70202
Histone deacetylase 20202
Polyamine deacetylase HDAC100202
Histone deacetylase 11 0202
ATPase family AAA domain-containing protein 54004
Ataxin-24004
Carbonic anhydrase 150202
Histone deacetylase 80202
Carbonic anhydrase 130102
Histone deacetylase 60202
Histone deacetylase 90202
Carbonic anhydrase 140102
Histone deacetylase 50202
HSP40, subfamily A [Plasmodium falciparum 3D7]0003
endonuclease IV1001
NFKB1 protein, partial1001
PPM1D protein3003
Thrombopoietin1001
EWS/FLI fusion protein7007
arylsulfatase A3003
alpha-galactosidase1001
pyruvate kinase1001
heat shock protein 900011
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
calcineurin A1, putative0011
thyrotropin-releasing hormone receptor1001
nuclear receptor subfamily 1, group I, member 25005
Caspase-71001
beta-2 adrenergic receptor0011
Bloom syndrome protein isoform 11001
cytochrome P450 2D6 isoform 12002
peripheral myelin protein 22 isoform 11001
cytochrome P450 2C19 precursor3003
cytochrome P450 2C9 precursor3003
chromobox protein homolog 14004
caspase-31001
ras-related protein Rab-9A2002
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
lethal(3)malignant brain tumor-like protein 1 isoform I1001
M-phase phosphoprotein 81001
streptokinase A precursor0022
muscarinic acetylcholine receptor M12002
Solute carrier family 22 member 1 0202
Polyunsaturated fatty acid lipoxygenase ALOX15B3003
Intermediate conductance calcium-activated potassium channel protein 40101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
5-hydroxytryptamine receptor 40808
Transient receptor potential cation channel subfamily M member 20202
Epidermal growth factor receptor0303
Chymotrypsinogen A0505
Glucocorticoid receptor0404
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Receptor tyrosine-protein kinase erbB-20303
Histidine-rich protein PFHRP-II0101
Estrogen receptor0011
Tyrosine-protein kinase Fyn0303
Heme oxygenase 1 0505
ATP-dependent translocase ABCB10707
Epoxide hydrolase 10003
Glycine receptor subunit alpha-10404
Aldo-keto reductase family 1 member B1010010
Muscarinic acetylcholine receptor M20808
Muscarinic acetylcholine receptor M40606
ATP-dependent translocase ABCB10707
Beta-1 adrenergic receptor0606
Alpha-2A adrenergic receptor010010
Adenosine receptor A30606
Muscarinic acetylcholine receptor M10606
Aromatase0505
Beta-3 adrenergic receptor0606
D(2) dopamine receptor0606
Androgen receptor0606
Alpha-2B adrenergic receptor0808
Potassium-transporting ATPase subunit beta0101
Potassium-transporting ATPase alpha chain 10101
5-hydroxytryptamine receptor 1A0606
Muscarinic acetylcholine receptor M30606
Glycine receptor subunit beta0404
ATP-dependent translocase ABCB10707
Substance-K receptor0808
D(1A) dopamine receptor0606
D(4) dopamine receptor0606
Potassium voltage-gated channel subfamily A member 30101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Acetylcholinesterase0404
Glycine receptor subunit alpha-20404
Heme oxygenase 20505
Sodium-dependent noradrenaline transporter 010010
Glycine receptor subunit alpha-30404
Thromboxane-A synthase 0404
Histamine H2 receptor0808
C-X-C chemokine receptor type 10101
Alpha-1D adrenergic receptor0606
Substance-P receptor0606
Platelet-activating factor receptor0202
5-hydroxytryptamine receptor 2A0808
5-hydroxytryptamine receptor 2C0808
5-hydroxytryptamine receptor 1B0606
Indoleamine 2,3-dioxygenase 10303
Adenosine receptor A2a0606
Vasopressin V2 receptor0101
Adenosine receptor A10606
Sodium-dependent serotonin transporter0808
Prostaglandin G/H synthase 20303
Histamine H1 receptor0202
Mu-type opioid receptor0606
D(3) dopamine receptor0606
Malate dehydrogenase, cytoplasmic0505
Delta-type opioid receptor0808
Kappa-type opioid receptor0606
5-hydroxytryptamine receptor 2B0808
Histamine H2 receptor4004
5-hydroxytryptamine receptor 60606
C-C chemokine receptor type 40101
Transitional endoplasmic reticulum ATPase0101
Guanine nucleotide-binding protein G2002
Cytochrome P450 1440066
Steroid C26-monooxygenase0066
Cytochrome P450 1300022
Cytochrome P450 1300022
Steroid C26-monooxygenase0066
Mycocyclosin synthase0044
Lanosterol 14-alpha demethylase0044
Sodium-dependent dopamine transporter 0808
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Nuclear receptor subfamily 1 group I member 3 0202
Sterol 14-alpha demethylase0033
Estrogen receptor beta0011
Indoleamine 2,3-dioxygenase 20303
Bile acid receptor0101
14-alpha sterol demethylase 0033
Cysteinyl leukotriene receptor 10202
ATP-dependent phosphofructokinase1001
Acetylcholinesterase0202
Matrix metalloproteinase-90101
Cannabinoid receptor 10404
Nitric oxide synthase, brain 0202
Melanocortin receptor 50404
Melanocortin receptor 30404
Neuropeptide Y receptor type 20202
Cholinesterase0202
Calcium release-activated calcium channel protein 10202
Sigma non-opioid intracellular receptor 10606
Chain A, BCL-2-RELATED PROTEIN A10022
apical membrane antigen 1, AMA12002
unnamed protein product0101
transcriptional regulator ERG isoform 32002
bcl-2-like protein 11 isoform 10022
Rap guanine nucleotide exchange factor 31001
Lanosterol 14-alpha demethylase0123
Cytochrome P450 11B1, mitochondrial0202
Cytochrome P450 11B2, mitochondrial0202
Lanosterol 14-alpha demethylase0011
Sterol 14-alpha demethylase0112
likely tRNA 2'-phosphotransferase0101
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E0011
thyroid hormone receptor beta isoform a1001
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Vpr3003
GALC protein1001
Estrogen receptor beta0102
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial0101
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial0202
Cytochrome P450 26A10101
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Bile salt export pump0303
3',5'-cyclic-AMP phosphodiesterase 0101
Camphor 5-monooxygenase0001
Phospholipase A2, major isoenzyme0101
Cytochrome P450 2C11 0101
Steroid 21-hydroxylase0101
Cytochrome P450 2C80101
Steroid 17-alpha-hydroxylase/17,20 lyase 0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Polyunsaturated fatty acid lipoxygenase ALOX150101
Cholesterol side-chain cleavage enzyme, mitochondrial 0101
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 2A20101
Cytochrome P450 11B1, mitochondrial 0101
Translocator protein0101
Cytochrome P450 7A1 0101
Estrogen receptor0102
UDP-glucuronosyltransferase 1A1 0101
Gonadotropin-releasing hormone receptor0112
Type-1 angiotensin II receptor0101
Cytochrome P450 4F20101
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0202
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0101
Sodium/bile acid cotransporter0101
Cytochrome P450 7A10101
Lanosterol 14-alpha demethylase 0202
cystic fibrosis transmembrane conductance regulator0202
Metabotropic glutamate receptor 60101
Cytochrome P450 1A20101
Cytochrome P450 1A2 0101
Aromatase0011
Melanocortin receptor 40202
Type-2 angiotensin II receptor0202
Beta-lactamase TEM0101
methionyl-tRNA synthetase, putative0101
STE240001
CAAX prenyl protease0001
histone acetyltransferase KAT2A isoform 13003
Trypsin0001
Albumin0112
DNA gyrase subunit A0102
DNA gyrase subunit B0102
DNA gyrase subunit B0102
DNA gyrase subunit A0102
Tyrosine-protein phosphatase non-receptor type 10204
chaperonin-containing TCP-1 beta subunit homolog1001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Solute carrier family 22 member 60101
Polyphenol oxidase 20102
5'-AMP-activated protein kinase subunit beta-20001
Polymerase acidic protein0011
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Prostaglandin G/H synthase 10101
Cystathionine gamma-lyase0101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase0101
Solute carrier family 22 member 60101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 80101
Solute carrier family 22 member 60101
Ubiquitin-like domain-containing CTD phosphatase 10101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
Carbonic anhydrase 5B, mitochondrial0101
5'-AMP-activated protein kinase subunit beta-10001
Enoyl-[acyl-carrier-protein] reductase [NADH]0001
Protein-arginine deiminase type-40202
C-8 sterol isomerase0101
Squalene monooxygenase 0101
Squalene monooxygenase0202
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Potassium channel subfamily K member 30101
Amine oxidase [flavin-containing] A0101
cGMP-gated cation channel alpha-10011
Sodium channel protein type 7 subunit alpha0101
Sodium channel protein type 5 subunit alpha0101
Sodium channel protein type 9 subunit alpha0202
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Sodium channel protein type 8 subunit alpha0101
DNA polymerase kappa isoform 11001
lethal factor (plasmid)1001
67.9K protein1001
Chain A, Beta-lactamase1001
Sterol 14-alpha-demethylase0011
14-alpha sterol demethylase 0011
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Cholesterol side-chain cleavage enzyme, mitochondrial 0011
Cytochrome P450 2B60101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
14-alpha sterol demethylase 0011
Cholesterol 24-hydroxylase0213
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]