Lymphedema And Yellow Nails

A rare condition characterized by the presence of yellow nails, LYMPHEDEMA, and/or PLEURAL EFFUSION with respiratory tract involvement. Abnormal lymphatic network may play a role in its etiology. Occasionally inherited, yellow nail syndrome mostly is sporadic without apparent family history.

Synonym
Lymphedema And Yellow Nails
Yellow Nail Syndrome

Excerpt	Reference
"Yellow nail syndrome is characterized by nail changes, respiratory disorders, and lymphedema."	( Berglund, F; Carlmark, B, 2011)
"Yellow nail syndrome is a very rare clinical entity usually diagnosed from a combination of yellow dystrophic nails, lymphoedema and respiratory diseases."	( Adedayo, O; Clare, A; Cummings, C; Iheonunekwu, N, 2011)
"Yellow nail syndrome is an idiopathic condition characterized by a triad consisting of yellow nail, lymphedema, and pulmonary manifestations."	( Hirotoshi, K; Ikeda, K; Kawashima, H; Kobayashi, Y; Nakagomi, D; Nakajima, H; Suto, A, 2013)
"Yellow nail syndrome is a rare disorder involving characteristic nail changes, lymphedema and chronic respiratory symptoms."	( Kurin, M; Mehta, AC; Wiesen, J, 2017)
"Yellow nail syndrome is a rare condition associated with a triad of symptoms: yellow nails, lung lesions, and lymphedema."	( Itagaki, H; Katuhiko, S, 2019)

Excerpt	Reference
"The pathogenesis and the therapy of the yellow nail syndrome (YNS) are poorly defined."	( Balestri, R; Piraccini, BM; Starace, M; Tosti, A; Urciuoli, B, 2014)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	1 (5.00)	18.1394
2010's	18 (90.00)	28.8240
2020's	1 (5.00)	9.53

Drug	Relationship Strength	Studies
fluconazole	low	2
fluorouracil	low	1
guaifenesin	low	1
prednisolone	low	1
triamcinolone acetonide	low	1
d-alpha tocopherol	low	3
tocopherols	low	1
titanium	low	4
titanium dioxide	low	2
clarithromycin	low	1
methotrexate	low	1
biotin	low	1
picibanil	low	1
bucillamine	low	2
cysteine	low	2

Protein Targets (324)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Avidin	0	0	1	1
Chain A, Protein (streptavidin)	0	0	1	1
Chain B, Protein (streptavidin)	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin Complex With Biotin	0	0	1	1
Chain D, Circularly Permuted Core-streptavidin E51/a46	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
RAR-related orphan receptor gamma	4	0	0	4
apical membrane antigen 1, AMA1	2	0	0	2
nonstructural protein 1	0	1	0	1
estrogen nuclear receptor alpha	10	0	0	10
green fluorescent protein, partial	0	1	0	1
vitamin D3 receptor isoform VDRA	2	0	0	2
insulin-degrading enzyme isoform 1	0	0	1	1
Streptavidin	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
Angiotensin-converting enzyme	0	1	0	1
Chain A, Beta-lactamase	2	0	0	2
acetylcholinesterase	3	0	0	3
USP1 protein, partial	3	0	0	3
TDP1 protein	4	0	0	4
AR protein	6	0	0	6
thyroid stimulating hormone receptor	2	0	0	2
glucocorticoid receptor [Homo sapiens]	5	0	0	5
retinoic acid nuclear receptor alpha variant 1	6	0	0	6
estrogen-related nuclear receptor alpha	7	0	0	7
pregnane X nuclear receptor	5	0	0	5
IDH1	4	0	0	4
euchromatic histone-lysine N-methyltransferase 2	4	0	0	4
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	4	0	0	4
thyroid hormone receptor beta isoform a	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	5	0	0	5
mitogen-activated protein kinase 1	2	0	0	2
geminin	7	0	0	7
Vpr	2	0	0	2
lamin isoform A-delta10	6	0	0	6
ATP-binding cassette sub-family C member 3	0	7	0	7
Multidrug resistance-associated protein 4	0	7	0	8
Bile salt export pump	0	2	0	2
Bile salt export pump	0	8	0	8
Albumin	0	0	1	1
Major prion protein	0	0	1	1
Cellular tumor antigen p53	7	0	0	7
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Cytochrome P450 2C9	0	3	0	3
UDP-glucuronosyltransferase 2B7	0	0	0	1
Cytochrome P450 2B6	0	0	1	1
Sodium channel protein type 4 subunit alpha	0	1	0	2
Cytochrome P450 2J2	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	2	0	2
Frizzled-8	0	0	1	1
Canalicular multispecific organic anion transporter 1	0	7	0	7
P2X purinoceptor 4	0	1	0	1
GLI family zinc finger 3	5	0	0	5
cytochrome P450 family 3 subfamily A polypeptide 4	5	0	0	5
thyroid hormone receptor beta isoform 2	3	0	0	3
importin subunit beta-1 isoform 1	3	0	0	3
snurportin-1	3	0	0	3
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
streptokinase A precursor	0	0	1	1
ATP-dependent translocase ABCB1	0	2	0	2
Cytochrome P450 3A4	0	2	0	2
Solute carrier organic anion transporter family member 1B3	0	1	0	2
Solute carrier organic anion transporter family member 1B1	0	1	0	1
Microtubule-associated protein tau	3	0	0	3
activating transcription factor 6	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
heat shock protein beta-1	2	0	0	2
Rap guanine nucleotide exchange factor 3	3	0	0	3
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
retinoid X nuclear receptor alpha	4	0	0	4
G	1	0	0	1
cytochrome P450 2D6	2	0	0	2
unnamed protein product	0	1	0	1
chromobox protein homolog 1	4	0	0	4
transcriptional regulator ERG isoform 3	2	0	0	2
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
DNA polymerase iota isoform a (long)	2	0	0	2
cytochrome P450 3A4 isoform 1	1	0	0	1
bcl-2-like protein 11 isoform 1	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	1	0	0	1
Histone deacetylase 3	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Beta-lactamase	0	1	0	1
Interferon beta	2	0	0	2
HLA class I histocompatibility antigen, B alpha chain	1	0	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Heme oxygenase 1	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	1	2
Aromatase	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	1	0	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	1	0	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	1	0	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	1	0	0	1
Heme oxygenase 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	1	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	1	0	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Histone deacetylase 4	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-3	1	0	0	1
Gamma-aminobutyric acid receptor subunit beta-2	1	0	0	1
Cytochrome P450 144	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Mycocyclosin synthase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
TAR DNA-binding protein 43	3	0	0	3
Histone deacetylase 1	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	1	2
Sterol 14-alpha demethylase	0	0	1	1
Sterol 14-alpha demethylase	0	1	1	2
Histone deacetylase 7	0	1	0	1
GABA theta subunit	1	0	0	1
Inositol hexakisphosphate kinase 1	1	0	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
14-alpha sterol demethylase	0	0	1	1
Histone deacetylase 8	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	1	0	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
cytochrome P450 2C9, partial	1	0	0	1
heat shock protein 90, putative	0	0	0	1
likely tRNA 2'-phosphotransferase	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	2	0	0	2
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Luciferase	1	0	0	1
interleukin 8	1	0	0	1
endonuclease IV	1	0	0	1
glp-1 receptor, partial	1	0	0	1
Skn7p	0	0	0	1
thioredoxin reductase	2	0	0	2
pregnane X receptor	1	0	0	1
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
ATAD5 protein, partial	3	0	0	3
Thrombopoietin	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	2	0	0	2
estrogen receptor 2 (ER beta)	2	0	0	2
nuclear receptor subfamily 1, group I, member 3	3	0	0	3
progesterone receptor	4	0	0	4
EWS/FLI fusion protein	2	0	0	2
nonstructural protein 1	1	0	0	1
farnesoid X nuclear receptor	3	0	0	3
67.9K protein	3	0	0	3
peroxisome proliferator-activated receptor delta	3	0	0	3
peroxisome proliferator activated receptor gamma	2	0	0	2
arylsulfatase A	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	2	0	0	2
Histone H2A.x	2	0	0	2
peripheral myelin protein 22 isoform 1	1	0	0	1
hemoglobin subunit beta	1	0	0	1
huntingtin isoform 2	1	0	0	1
flap endonuclease 1	3	0	0	3
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	2	0	0	2
peripheral myelin protein 22	2	0	0	2
survival motor neuron protein isoform d	2	0	0	2
muscleblind-like protein 1 isoform 1	2	0	0	2
Voltage-dependent calcium channel gamma-2 subunit	3	0	0	3
Solute carrier family 22 member 8	0	0	0	1
Epidermal growth factor receptor	0	1	0	1
Amyloid-beta precursor protein	1	0	0	1
Thymidylate synthase	0	3	0	3
Glutamate receptor 2	3	0	0	3
ATPase family AAA domain-containing protein 5	4	0	0	4
Ataxin-2	4	0	0	4
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
ATP-dependent phosphofructokinase	2	0	0	2
SMAD family member 2	2	0	0	2
SMAD family member 3	2	0	0	2
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	1	0	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
Chain A, 2-oxoglutarate Oxygenase	1	0	0	1
Chain A, Ferritin light chain	1	0	0	1
acid sphingomyelinase	1	0	0	1
dopamine D1 receptor	1	0	0	1
ClpP	1	0	0	1
15-lipoxygenase, partial	1	0	0	1
phosphopantetheinyl transferase	1	0	0	1
vitamin D (1,25- dihydroxyvitamin D3) receptor	2	0	0	2
Thymidylate synthase	0	1	0	1
alpha-galactosidase	1	0	0	1
Thymidylate synthase	0	1	0	1
Bloom syndrome protein isoform 1	1	0	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
DNA polymerase beta	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
DNA polymerase kappa isoform 1	1	0	0	1
M-phase phosphoprotein 8	1	0	0	1
histone acetyltransferase KAT2A isoform 1	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Carbonic anhydrase 2	0	0	1	1
Thymidylate synthase	0	2	0	2
Integrin beta-3	1	0	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Integrin alpha-IIb	1	0	0	1
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Spike glycoprotein	1	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	0	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	0	0	1
luciferase	0	0	0	1
aryl hydrocarbon receptor	2	0	0	2
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Glucocorticoid receptor	0	4	1	10
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glycine receptor subunit alpha-1	0	4	0	4
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Androgen receptor	0	1	0	1
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Glycine receptor subunit alpha-3	0	4	0	4
Histamine H1 receptor	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
nuclear receptor ROR-gamma isoform 1	1	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Lymphedema And Yellow Nails

Synonyms(2)

Research Excerpts

Overview

Treatment

Research

Studies (20)

Protein Targets (324)

Lymphedema And Yellow Nails

Synonyms(2)

Research Excerpts

Overview

Treatment

Research

Studies (20)

Drugs Studied (17)

Protein Targets (324)