Compounds > streptomycin sulfate
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streptomycin sulfate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Streptomycin sulfate is a salt formed from the antibiotic streptomycin and sulfuric acid. Streptomycin is a naturally occurring aminoglycoside antibiotic produced by the bacterium *Streptomyces griseus*. It was discovered in 1943 and was the first effective treatment for tuberculosis. It works by binding to the 30S ribosomal subunit of bacteria, inhibiting protein synthesis and leading to bacterial cell death. Streptomycin is effective against a variety of bacterial infections, including tuberculosis, plague, tularemia, and some gram-negative infections. However, its use is limited by its toxicity, which can include ototoxicity (damage to the auditory nerve) and nephrotoxicity (damage to the kidneys). Streptomycin sulfate is still used to treat some infections, but it is generally reserved for cases where other antibiotics are not effective. Researchers continue to study streptomycin sulfate to understand its mechanism of action, to develop new antibiotics, and to improve its safety profile.'

Cross-References

ID SourceID
PubMed CID19648
CHEMBL ID3184791
CHEBI ID32158
MeSH IDM0329735

Synonyms (89)

Synonym
nsc14083
streotitgebat
plantomycin
streptomycin sulfate (2:3) (salt)
strep-gran
agristrep
streptomyzinsulfat
estreptopanto
estreptomicina
strepcin
strepvet
streptomycin, sulfate (2:3) (salt)
nsc 14083
agrimycin 17
streptomycin sulphate b.p
vetstrep
epa pesticide chemical code 006310
strepsulfat
streptomycin sulfate (2:3)
streoikub
streptorex
einecs 223-286-0
caswell no. 804a
ai3-50158
bis-(4-o-(2-o-(2-desoxy-2-methylamino-alpha-l-glucopyranosyl)-alpha-l-streptosyl)-l-streptidin)-trisulfat
streptomycin a sulfate
agri-strep
phytomycin
streptomycinium sulfuricum
ccris 5934
streptomycin sesquisulfate
ambistryn s
as-15
NCGC00159339-02
streptomycin sulfate (jp17/usp)
D01350
streptomycin sulfate (tn)
d-streptamine, o-2-deoxy-2-(methylamino)-alpha-l-glucopyranosyl-(1-2)-o-5-deoxy-3-c-formyl-alpha-l-lyxofuranosyl-(1-4)-n,n'-bis(aminoiminomethyl)-, sulfate (2:3) (salt)
streptomycin sulfate (2:3) salt
tox21_111583
dtxsid9026053 ,
dtxcid306053
cas-3810-74-0
nsc-757316
cw25ikj202 ,
d-streptamine, o-2-deoxy-2-(methylamino)-alpha-l-glucopyranosyl-(1->2)-o-5-deoxy-3-c-formyl-alpha-l-lyxofuranosyl-(1->4)-n1,n3-bis(aminoiminomethyl)-, sulfate (2:3)
unii-cw25ikj202
streptomycin sulfate [usp:jan]
d-streptamine, o-2-deoxy-2-(methylamino)-alpha-l-glucopyranosyl-(1.fwdarw.2)-o-5-deoxy-3-c-formyl-alpha-l-lyxofuranosyl-(1.fwdarw.4)-n,n'-bis(aminoiminomethyl)-, sulfate (2:3) (salt)
streptomycini sulfas
d-streptamine, o-2-deoxy-2-(methylamino)-.alpha.-l-glucopyranosyl-(1->2)-o-5-deoxy-3-c-formyl-.alpha.-l-lyxofuranosyl-(1->4)-n,n'-bis(aminoiminomethyl)-, sulfate (2:3) (salt)
streptomycin sulfate [green book]
streptomycin sesquisulfate [mi]
streptomycin sulfate [who-ip]
streptomycin sulfate [usp-rs]
streptomycin sulfate [mart.]
streptomycin sulfate [ep monograph]
streptomycin sulfate [jan]
streptomycin sulfate [orange book]
streptomycin sulfate [usp monograph]
streptomycin sulphate (2:3) (salt)
streptomycin sulfate (non-injectable) [who-ip]
streptomycin (as sulfate)
d-streptamine, o-2-deoxy-2-(methylamino)-.alpha.-l-glucopyranosyl-(1->2)-o-5-deoxy-3-c-formyl-.alpha.-l-lyxofuranosyl-(1->4)-n,n'-bis(aminoiminomethyl)-, sulphate (2:3) (salt)
streptomycin sulfate [vandf]
streptomycini sulfas [who-ip latin]
agrimycin sulfate
streptomycin sulfate [who-dd]
S2572
CHEMBL3184791
AKOS026749776
CHEBI:32158 ,
streptomycin sulfate 100 microg/ml in water
CCG-270684
Q27275850
A913061
AKOS040732169
streptomycin oral solution
streptomycin sulfate (usp monograph)
d-streptamine, o-2-deoxy-2-(methylamino)-alpha-l-glucopyranosyl-(1->2)-o-5-deoxy-3-c-formyl-alpha-l-lyxofuranosyl-(1->4)-n,n'-bis(aminoiminomethyl)-, sulphate (2:3) (salt)
d-streptamine, o-2-deoxy-2-(methylamino)-alpha-l-glucopyranosyl-(1-2)-o-5-deoxy-3-c-formyl-alpha-l-lyxofuranosyl-(1-4)-n,n'-bis(aminoiminomethyl)-, sulfate(2:3)(salt)
d-streptamine, o-2-deoxy-2-(methylamino)-alpha-l-glucopyranosyl-(1->2)-o-5-deoxy-3-c-formyl-alpha-l-lyxofuranosyl-(1->4)-n,n'-bis(aminoiminomethyl)-, sulfate (2:3) (salt)
streptomycin sulfate (non-injectable)
2-deoxy-2-methylamino-alpha-l-glucopyranosyl-(1->2)-5-deoxy-3-c-formyl-alpha-l-lyxofuranosyl-(1->4)-n,n'-diamidino-d-streptamine sesquisulfate
streptomycin sulfate (mart.)
strep sol
streptomycin sulfate (usp:jan)
streptomycin sulfate (ep monograph)
streptomycin sulfate (usp-rs)

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019)		0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
aminoglycoside sulfate salt
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency10.68220.000214.376460.0339AID720691
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (29)

Assay IDTitleYearJournalArticle
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1311669Antibacterial activity against Salmonella paratyphi assessed as zone of inhibition at 100 ug/well measured after 24 hrs by agar well diffusion method2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
Synthesis, characterization and antimicrobial activity of novel Schiff base tethered boronate esters of 1,2-O-isopropylidene-α-d-xylofuranose.
AID1311678Antibacterial activity against Salmonella typhi measured after 24 hrs by NCCL protocol based broth dilution method2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
Synthesis, characterization and antimicrobial activity of novel Schiff base tethered boronate esters of 1,2-O-isopropylidene-α-d-xylofuranose.
AID1327234Antibacterial activity against Ralstonia solanacearum ATCC 11696 by broth dilution colorimetric assay2016Journal of natural products, 08-26, Volume: 79, Issue:8
Bioactive Dibenzo-α-pyrone Derivatives from the Endophytic Fungus Rhizopycnis vagum Nitaf22.
AID1311670Antibacterial activity against Salmonella typhi assessed as zone of inhibition at 100 ug/well measured after 24 hrs by agar well diffusion method2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
Synthesis, characterization and antimicrobial activity of novel Schiff base tethered boronate esters of 1,2-O-isopropylidene-α-d-xylofuranose.
AID1174924Antitubercular activity against Mycobacterium tuberculosis isolate 439/11 after 7 days by REMA resazurin microtiter assay2014Bioorganic & medicinal chemistry, Dec-15, Volume: 22, Issue:24
Antitubercular activity of quinolizidinyl/pyrrolizidinylalkyliminophenazines.
AID1311667Antibacterial activity against Micrococcus luteus MTCC 106 assessed as zone of inhibition at 100 ug/well measured after 24 hrs by agar well diffusion method2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
Synthesis, characterization and antimicrobial activity of novel Schiff base tethered boronate esters of 1,2-O-isopropylidene-α-d-xylofuranose.
AID1327236Antibacterial activity against Xanthomonas vesicatoria ATCC 11633 by broth dilution colorimetric assay2016Journal of natural products, 08-26, Volume: 79, Issue:8
Bioactive Dibenzo-α-pyrone Derivatives from the Endophytic Fungus Rhizopycnis vagum Nitaf22.
AID1311666Antibacterial activity against Streptococcus mutans MTCC 497 assessed as zone of inhibition at 100 ug/well measured after 24 hrs by agar well diffusion method2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
Synthesis, characterization and antimicrobial activity of novel Schiff base tethered boronate esters of 1,2-O-isopropylidene-α-d-xylofuranose.
AID1327235Antibacterial activity against Staphylococcus haemolyticus ATCC 29970 by broth dilution colorimetric assay2016Journal of natural products, 08-26, Volume: 79, Issue:8
Bioactive Dibenzo-α-pyrone Derivatives from the Endophytic Fungus Rhizopycnis vagum Nitaf22.
AID1327233Antibacterial activity against Pseudomonas lachrymans ATCC 11921 by broth dilution colorimetric assay2016Journal of natural products, 08-26, Volume: 79, Issue:8
Bioactive Dibenzo-α-pyrone Derivatives from the Endophytic Fungus Rhizopycnis vagum Nitaf22.
AID1327231Antibacterial activity against Agrobacterium tumefaciens ATCC 11158 by broth dilution colorimetric assay2016Journal of natural products, 08-26, Volume: 79, Issue:8
Bioactive Dibenzo-α-pyrone Derivatives from the Endophytic Fungus Rhizopycnis vagum Nitaf22.
AID1174923Antitubercular activity against Mycobacterium tuberculosis isolate 29/10 after 7 days by REMA resazurin microtiter assay2014Bioorganic & medicinal chemistry, Dec-15, Volume: 22, Issue:24
Antitubercular activity of quinolizidinyl/pyrrolizidinylalkyliminophenazines.
AID1174926Antitubercular activity against Mycobacterium tuberculosis isolate 778/10 after 7 days by REMA resazurin microtiter assay2014Bioorganic & medicinal chemistry, Dec-15, Volume: 22, Issue:24
Antitubercular activity of quinolizidinyl/pyrrolizidinylalkyliminophenazines.
AID1327232Antibacterial activity against Bacillus subtilis ATCC 11562 by broth dilution colorimetric assay2016Journal of natural products, 08-26, Volume: 79, Issue:8
Bioactive Dibenzo-α-pyrone Derivatives from the Endophytic Fungus Rhizopycnis vagum Nitaf22.
AID1311676Antibacterial activity against Staphylococcus aureus MTCC 3160 measured after 24 hrs by NCCL protocol based broth dilution method2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
Synthesis, characterization and antimicrobial activity of novel Schiff base tethered boronate esters of 1,2-O-isopropylidene-α-d-xylofuranose.
AID1311679Antibacterial activity against Klebsiella pneumoniae MTCC 3384 measured after 24 hrs by NCCL protocol based broth dilution method2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
Synthesis, characterization and antimicrobial activity of novel Schiff base tethered boronate esters of 1,2-O-isopropylidene-α-d-xylofuranose.
AID1311674Antibacterial activity against Streptococcus mutans MTCC 497 measured after 24 hrs by NCCL protocol based broth dilution method2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
Synthesis, characterization and antimicrobial activity of novel Schiff base tethered boronate esters of 1,2-O-isopropylidene-α-d-xylofuranose.
AID1174920Antitubercular activity against Mycobacterium tuberculosis H37Rv after 7 days by REMA resazurin microtiter assay2014Bioorganic & medicinal chemistry, Dec-15, Volume: 22, Issue:24
Antitubercular activity of quinolizidinyl/pyrrolizidinylalkyliminophenazines.
AID1454206Antibacterial activity against Mycobacterium smegmatis NBRC 3207 at 5 ug/disc incubated at 37 degC for 2 days by paper disc method2017Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15
Anti-mycobacterial alkaloids, cyclic 3-alkyl pyridinium dimers, from the Indonesian marine sponge Haliclona sp.
AID1311671Antibacterial activity against Klebsiella pneumoniae MTCC 3384 assessed as zone of inhibition at 100 ug/well measured after 24 hrs by agar well diffusion method2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
Synthesis, characterization and antimicrobial activity of novel Schiff base tethered boronate esters of 1,2-O-isopropylidene-α-d-xylofuranose.
AID1174927Antitubercular activity against Mycobacterium tuberculosis isolate 917/10 after 7 days by REMA resazurin microtiter assay2014Bioorganic & medicinal chemistry, Dec-15, Volume: 22, Issue:24
Antitubercular activity of quinolizidinyl/pyrrolizidinylalkyliminophenazines.
AID1311677Antibacterial activity against Salmonella paratyphi measured after 24 hrs by NCCL protocol based broth dilution method2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
Synthesis, characterization and antimicrobial activity of novel Schiff base tethered boronate esters of 1,2-O-isopropylidene-α-d-xylofuranose.
AID1454205Antibacterial activity against Mycobacterium smegmatis NBRC 3207 at 1 ug/disc incubated at 37 degC for 2 days by paper disc method2017Bioorganic & medicinal chemistry letters, 08-01, Volume: 27, Issue:15
Anti-mycobacterial alkaloids, cyclic 3-alkyl pyridinium dimers, from the Indonesian marine sponge Haliclona sp.
AID1311675Antibacterial activity against Micrococcus luteus MTCC 106 measured after 24 hrs by NCCL protocol based broth dilution method2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
Synthesis, characterization and antimicrobial activity of novel Schiff base tethered boronate esters of 1,2-O-isopropylidene-α-d-xylofuranose.
AID1311668Antibacterial activity against Staphylococcus aureus MTCC 3160 assessed as zone of inhibition at 100 ug/well measured after 24 hrs by agar well diffusion method2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
Synthesis, characterization and antimicrobial activity of novel Schiff base tethered boronate esters of 1,2-O-isopropylidene-α-d-xylofuranose.
AID1174925Antitubercular activity against Mycobacterium tuberculosis isolate 756/10 after 7 days by REMA resazurin microtiter assay2014Bioorganic & medicinal chemistry, Dec-15, Volume: 22, Issue:24
Antitubercular activity of quinolizidinyl/pyrrolizidinylalkyliminophenazines.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (83.33)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 53.78

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index53.78 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index82.67 (26.88)
Search Engine Supply Index2.06 (0.95)

This Compound (53.78)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
clofazimine
Clofazimine: A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619). clofazimine : 3-Isopropylimino-3,5-dihydro-phenazine in which the hydrogen at position 5 is substituted substituted by a 4-chlorophenyl group, and that at position 2 is substituted by a (4-chlorophenyl)amino group. A dark red crystalline solid, clofazimine is an antimycobacterial and is one of the main drugs used for the treatment of multi-bacillary leprosy. However, it can cause red/brown discolouration of the skin, so other treatments are often preferred in light-skinned patients.		2.110monochlorobenzenes;
phenazines		dye;
leprostatic drug;
non-steroidal anti-inflammatory drug
fluconazole
Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.. fluconazole : A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.		2.1310conazole antifungal drug;
difluorobenzene;
tertiary alcohol;
triazole antifungal drug		environmental contaminant;
P450 inhibitor;
xenobiotic
isoniazid
Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.. hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).		2.110carbohydrazideantitubercular agent;
drug allergen
cycloheximide
Cycloheximide: Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.. cycloheximide : A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.		2.1310antibiotic fungicide;
cyclic ketone;
dicarboximide;
piperidine antibiotic;
piperidones;
secondary alcohol		anticoronaviral agent;
bacterial metabolite;
ferroptosis inhibitor;
neuroprotective agent;
protein synthesis inhibitor
ethambutol
Ethambutol: An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inhibit the synthesis of spermidine in mycobacteria. The action is usually bactericidal, and the drug can penetrate human cell membranes to exert its lethal effect. (From Smith and Reynard, Textbook of Pharmacology, 1992, p863). ethambutol : An ethylenediamine derivative that is ethane-1,2-diamine in which one hydrogen attached to each of the nitrogens is sutstituted by a 1-hydroxybutan-2-yl group (S,S-configuration). It is a bacteriostatic antimycobacterial drug, effective against Mycobacterium tuberculosis and some other mycobacteria. It is used (as the dihydrochloride salt) in combination with other antituberculous drugs in the treatment of pulmonary and extrapulmonary tuberculosis; resistant strains of M. tuberculosis are readily produced if ethambutol is used alone.		2.110ethanolamines;
ethylenediamine derivative		antitubercular agent;
environmental contaminant;
xenobiotic
carbendazim
carbendazim: carcinogen when combined with sodium nitrite; principle metabolite of thiophanate methyl & benomyl; structure. carbendazim : A member of the class of benzimidazoles that is 2-aminobenzimidazole in which the primary amino group is substituted by a methoxycarbonyl group. A fungicide, carbendazim controls Ascomycetes, Fungi Imperfecti, and Basidiomycetes on a wide variety of crops, including bananas, cereals, cotton, fruits, grapes, mushrooms, ornamentals, peanuts, sugarbeet, soybeans, tobacco, and vegetables.		2.1310benzimidazole fungicide;
benzimidazoles;
benzimidazolylcarbamate fungicide;
carbamate ester		antifungal agrochemical;
antinematodal drug;
metabolite;
microtubule-destabilising agent
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		2.1310taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
alternariol
alternariol: structure. alternariol : A benzochromenone that is 6H-benzo[c]chromen-6-one which is substituted by a methyl group at position 1 and by hydroxy groups at positions 3, 7, and 9. It is the most important mycotoxin produced by the black mould Alternaria species, which are the most common mycoflora infecting small grain cereals worldwide.		2.1310benzochromenone;
phenols		EC 3.1.1.8 (cholinesterase) inhibitor;
metabolite;
mycotoxin
alternariol monomethyl ether
djalonensone : A benzochromenone that is alternariol in which the hydroxy group at position 9 has been converted into the corresponding methyl ether. A natural product found in Chaetomium globosum as well as being one of the two most important compounds belonging to the group of Altenaria mycotoxins.		2.1310aromatic ether;
benzochromenone		antifungal agent;
fungal metabolite;
mycotoxin
rifampin
Rifampin: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)		2.110cyclic ketal;
hydrazone;
N-iminopiperazine;
N-methylpiperazine;
rifamycins;
semisynthetic derivative;
zwitterion		angiogenesis inhibitor;
antiamoebic agent;
antineoplastic agent;
antitubercular agent;
DNA synthesis inhibitor;
EC 2.7.7.6 (RNA polymerase) inhibitor;
Escherichia coli metabolite;
geroprotector;
leprostatic drug;
neuroprotective agent;
pregnane X receptor agonist;
protein synthesis inhibitor
ConditionIndicatedRelationship StrengthStudiesTrials
Koch's Disease
[description not available]		02.110
Tuberculosis
Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM TUBERCULOSIS.		14.110
Atypical Mycobacterial Infection, Disseminated
[description not available]		02.1510