Compounds > fluconazole

fluconazole and lanosterol

fluconazole has been researched along with lanosterol in 17 studies

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (17.65)18.2507
2000's2 (11.76)29.6817
2010's8 (47.06)24.3611
2020's4 (23.53)2.80

Authors

AuthorsStudies
Ekins, S; Harwood, HJ; Hoover, DJ; Lawton, MP; Mankowski, DC; Treadway, JL1
Kelly, DE; Kelly, SL; Martel, CM; Melo, N; Nes, WD; Parker, JE; Warrilow, AG1
Guengerich, FP; Hargrove, TY; Lepesheva, GI; Nes, WD; Rachakonda, G; Villalta, F; Wawrzak, Z1
Pfaller, M; Riley, J1
Denning, DW; Kelly, SL; Manning, NJ; Venkateswarlu, K1
Casali, AK; Hamdan, JS1
Gao, Y; Ling, X; Lou, H; Sun, S1
Hull, CM; Kelly, DE; Kelly, SL; Lamb, DC; Mullins, JG; Parker, JE; Warrilow, AG1
Kelly, DE; Kelly, SL; Parker, JE; Warrilow, AG1
Li, WJ; Liu, JY; Shi, C; Wang, Y; Xiang, MJ; Zhao, Y1
Keniya, MV; Monk, BC; Sagatova, AA; Tyndall, JD; Wilson, RK1
Garvey, EP; Hoekstra, WJ; Kelly, DE; Kelly, SL; Nes, WD; Parker, JE; Price, CL; Schotzinger, RJ; Warrilow, AG1
Keniya, MV; Monk, BC; Ruma, YN; Tyndall, JDA1
Keniya, MV; Monk, BC; Sabherwal, M; Sagatova, AA; Tyndall, JDA; Wilson, RK; Woods, MA1
Ganeshkumar, A; Rajaram, R; Suvaithenamudhan, S1
Kerksiek, A; Lötsch, J; Lütjohann, D; Oertel, BG; Stellaard, F1
de Lima Silva, WC; de Souza Borges, W; Dutra, JAP; Gonçalves, RCR; Júnior, VL; Kitagawa, RR; Maximino, SC; Morais, PAB; Neto, ÁC; Rodrigues, RP1

Trials

1 trial(s) available for fluconazole and lanosterol

ArticleYear
Serum 4β-hydroxycholesterol increases during fluconazole treatment.
    European journal of clinical pharmacology, 2021, Volume: 77, Issue:5

    Topics: Adult; Age Factors; Antifungal Agents; Bile Acids and Salts; Cross-Over Studies; Cytochrome P-450 CYP3A; Double-Blind Method; Female; Fluconazole; Humans; Hydroxycholesterols; Lanosterol; Lipid Metabolism; Male; Prospective Studies; Sex Factors; Sterols; Young Adult

2021

Other Studies

16 other study(ies) available for fluconazole and lanosterol

ArticleYear
Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors.
    Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:3

    Topics: Amides; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Humans; Indoles; Models, Molecular; Oxidoreductases; Quantitative Structure-Activity Relationship; Sterol 14-Demethylase

2007
Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:10

    Topics: Amino Acid Sequence; Aspergillus fumigatus; Azoles; Clotrimazole; Drug Resistance, Multiple, Fungal; Fluconazole; Fungal Proteins; Isoenzymes; Itraconazole; Lanosterol; Molecular Sequence Data; Protein Binding; Pyrimidines; Sequence Homology, Amino Acid; Sterol 14-Demethylase; Substrate Specificity; Triazoles; Voriconazole

2010
Relaxed Substrate Requirements of Sterol 14α-Demethylase from
    Journal of medicinal chemistry, 2021, 12-09, Volume: 64, Issue:23

    Topics: 14-alpha Demethylase Inhibitors; Ligands; Naegleria fowleri; Sterol 14-Demethylase; Substrate Specificity

2021
Effects of fluconazole on the sterol and carbohydrate composition of four species of Candida.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1992, Volume: 11, Issue:2

    Topics: Candida; Candida albicans; Carbohydrates; Cell Wall; Chitin; Ergosterol; Fluconazole; Glucans; Lanosterol; Mannans; Sterols

1992
Resistance to fluconazole in Candida albicans from AIDS patients correlated with reduced intracellular accumulation of drug.
    FEMS microbiology letters, 1995, Sep-15, Volume: 131, Issue:3

    Topics: AIDS-Related Opportunistic Infections; Antifungal Agents; Candida albicans; Candidiasis, Chronic Mucocutaneous; Cholestadienols; Cytochrome P-450 Enzyme System; Drug Resistance, Microbial; Ergosterol; Fluconazole; Humans; Lanosterol; Microbial Sensitivity Tests; Oxidoreductases; Sterol 14-Demethylase

1995
Effects of three azole derivatives on the lipids of different strains of Sporothrix schenckii.
    Canadian journal of microbiology, 1997, Volume: 43, Issue:12

    Topics: Antifungal Agents; Fluconazole; Itraconazole; Ketoconazole; Lanosterol; Lipids; Sporothrix

1997
The combination effects of phenolic compounds and fluconazole on the formation of ergosterol in Candida albicans determined by high-performance liquid chromatography/tandem mass spectrometry.
    Analytical biochemistry, 2005, Jan-01, Volume: 336, Issue:1

    Topics: Caffeic Acids; Candida albicans; Chromatography, High Pressure Liquid; Ergosterol; Fluconazole; Lanosterol; Naphthalenes; Phenols; Resveratrol; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Squalene; Stilbenes

2005
S279 point mutations in Candida albicans Sterol 14-α demethylase (CYP51) reduce in vitro inhibition by fluconazole.
    Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:4

    Topics: 14-alpha Demethylase Inhibitors; Amino Acid Sequence; Antifungal Agents; Azoles; Binding, Competitive; Candida albicans; DNA, Fungal; Fluconazole; Kinetics; Lanosterol; Models, Molecular; Molecular Sequence Data; Point Mutation; Polymerase Chain Reaction; Protein Binding; Recombinant Proteins; Sterol 14-Demethylase

2012
Azole affinity of sterol 14α-demethylase (CYP51) enzymes from Candida albicans and Homo sapiens.
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:3

    Topics: Antifungal Agents; Candida albicans; Clotrimazole; Escherichia coli; Fluconazole; Fungal Proteins; Humans; Itraconazole; Ketoconazole; Kinetics; Lanosterol; NADP; Protein Binding; Pyrimidines; Recombinant Proteins; Species Specificity; Sterol 14-Demethylase; Triazoles; Voriconazole

2013
Mechanisms of azole resistance in Candida albicans clinical isolates from Shanghai, China.
    Research in microbiology, 2015, Volume: 166, Issue:3

    Topics: Amino Acid Substitution; Antifungal Agents; Azoles; Candida albicans; China; Drug Resistance, Fungal; Ergosterol; Flow Cytometry; Fluconazole; Genes, Fungal; Genes, MDR; Humans; Lanosterol; Mutation, Missense; Real-Time Polymerase Chain Reaction; Sequence Analysis, DNA

2015
Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14α-Demethylase.
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:8

    Topics: Antifungal Agents; Aspergillus fumigatus; Azoles; Candida albicans; Crystallography, X-Ray; Drug Resistance, Multiple, Fungal; Fluconazole; Hydrogen Bonding; Lanosterol; Saccharomyces cerevisiae; Sterol 14-Demethylase; Triazoles

2015
The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme.
    Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:8

    Topics: Antifungal Agents; Clotrimazole; Cryptococcus; Enzyme Activation; Ergosterol; Fluconazole; Humans; Itraconazole; Ketoconazole; Lanosterol; Pyridines; Sterol 14-Demethylase; Tetrazoles; Voriconazole

2016
Heterologous Expression of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provides Tools for Antifungal Discovery.
    Antimicrobial agents and chemotherapy, 2018, Volume: 62, Issue:11

    Topics: Amphotericin B; Antifungal Agents; Azoles; Candida albicans; Candida glabrata; Drug Resistance, Fungal; Ergosterol; Fluconazole; Fungal Proteins; Humans; Itraconazole; Lanosterol; Microbial Sensitivity Tests; Saccharomyces cerevisiae; Sterol 14-Demethylase; Triazoles; Voriconazole

2018
Crystal Structures of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provide Tools for Antifungal Discovery.
    Antimicrobial agents and chemotherapy, 2018, Volume: 62, Issue:11

    Topics: Antifungal Agents; Azoles; Candida albicans; Candida glabrata; Catalytic Domain; Fluconazole; Fungal Proteins; Humans; Itraconazole; Lanosterol; Microbial Sensitivity Tests; Protein Binding; Saccharomyces cerevisiae; Sterol 14-Demethylase; Triazoles

2018
In Vitro and In Silico Analysis of Ascorbic Acid Towards Lanosterol 14-α-Demethylase Enzyme of Fluconazole-Resistant Candida albicans.
    Current microbiology, 2021, Volume: 78, Issue:1

    Topics: Antifungal Agents; Ascorbic Acid; Candida albicans; Drug Resistance, Fungal; Fluconazole; Lanosterol; Microbial Sensitivity Tests; Molecular Docking Simulation; Sterol 14-Demethylase

2021
Anti-Candida, docking studies, and in vitro metabolism-mediated cytotoxicity evaluation of Eugenol derivatives.
    Chemical biology & drug design, 2023, Volume: 101, Issue:2

    Topics: Antifungal Agents; Candida; Candida albicans; Eugenol; Fluconazole; Humans; Lanosterol; Microbial Sensitivity Tests; Molecular Docking Simulation; Sterol 14-Demethylase

2023