Iris Neoplasms

Tumors of the iris characterized by increased pigmentation of melanocytes. Iris nevi are composed of proliferated melanocytes and are associated with neurofibromatosis and malignant melanoma of the choroid and ciliary body. Malignant melanoma of the iris often originates from preexisting nevi.

Synonym
Neoplasms, Iris
Iris Neoplasms

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	80 (31.13)	23.3326
1990's	50 (19.46)	12.5806
2000's	44 (17.12)	18.1394
2010's	49 (19.07)	28.8240
2020's	34 (13.23)	9.53

Drug	Relationship Strength	Studies
adenine	low	1
salicylic acid	low	1
iodine	low	1
nickel	low	1
vanilmandelic acid	low	1
homovanillic acid	low	1
acetazolamide	low	1
pentetic acid	low	1
fluconazole	low	1
fluorouracil	low	4
gentamicin	low	1
iofetamine	low	1
2-propanol	medium	199
letrozole	low	1
mitomycin	low	2
prednisone	low	2
pilocarpine	low	1
cytarabine	low	1
framycetin	low	1
hematoporphyrin	low	1
deoxycytidine	low	1
palladium	low	5
tantalum	low	2
technetium	low	1
gadolinium	low	1
timolol	low	2
etoposide	low	1
epirubicin	low	1
propiconazole	low	3
capecitabine	low	1
fluorodeoxyglucose f18	low	1
voriconazole	low	1
gefitinib	low	1
msh (11-13)	low	1
methotrexate	low	2
n-(2-(diethylamino)ethyl)-4-iodobenzamide	low	1
bromochloroacetic acid	low	5
mercaptopurine	low	1
latanoprost	low	3
iridal	low	1
benzoporphyrin d	low	2
gadolinium dtpa	low	1
mart-1 antigen	low	1
indocyanine green	low	3
gdc-0973	low	1
pci 32765	low	1
plx4032	low	1
piperidines	low	2
abemaciclib	low	1
osimertinib	low	1
eye	low	10

Protein Targets (1,111)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
hypoxia-inducible factor 1 alpha subunit	5	0	0	5
RAR-related orphan receptor gamma	13	0	0	13
GLI family zinc finger 3	11	0	0	11
AR protein	14	0	0	14
aldehyde dehydrogenase 1 family, member A1	8	0	0	8
retinoic acid nuclear receptor alpha variant 1	13	0	0	13
retinoid X nuclear receptor alpha	12	0	0	12
estrogen nuclear receptor alpha	16	0	0	16
peroxisome proliferator-activated receptor delta	7	0	0	7
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	10	0	0	10
activating transcription factor 6	3	0	0	3
v-jun sarcoma virus 17 oncogene homolog (avian)	5	0	0	5
Histone H2A.x	7	0	0	7
thyroid hormone receptor beta isoform a	4	0	0	4
heat shock protein beta-1	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 1	12	0	0	12
lamin isoform A-delta10	10	0	0	10
Voltage-dependent calcium channel gamma-2 subunit	11	0	0	11
Glutamate receptor 2	11	0	0	11
PPM1D protein	5	0	0	5
cytochrome P450 family 3 subfamily A polypeptide 4	11	0	0	11
cytochrome P450 2D6	7	0	0	7
Bone morphogenetic protein receptor type-1B	0	0	6	6
Cell division cycle 7-related protein kinase	0	0	3	3
Serine/threonine-protein kinase PLK4	0	0	6	6
ATP-dependent RNA helicase DDX3X	0	0	6	6
Pyridoxal kinase	0	0	6	6
Citron Rho-interacting kinase	0	0	6	6
Serine/threonine-protein kinase Chk1	0	0	6	6
Aurora kinase A	0	0	6	6
Cyclin-G-associated kinase	0	1	6	7
Ephrin type-B receptor 6	0	0	6	6
Peroxisomal acyl-coenzyme A oxidase 3	0	0	6	6
Receptor-interacting serine/threonine-protein kinase 2	0	0	6	6
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	6	6
Dynamin-like 120 kDa protein, mitochondrial	0	0	6	6
Cyclin-T1	0	2	0	2
Eukaryotic translation initiation factor 5B	0	0	3	3
Rho-associated protein kinase 2	0	0	6	6
Serine/threonine-protein kinase ULK1	0	0	6	6
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	6	6
Ribosomal protein S6 kinase alpha-5	0	0	6	6
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	6	6
Ribosomal protein S6 kinase alpha-4	0	0	6	6
Serine/threonine-protein kinase 16	0	0	6	6
Cyclin-K	0	1	0	1
Cyclin-dependent kinase-like 5	0	0	4	4
Serine/threonine-protein kinase 10	0	0	6	6
Serine/threonine-protein kinase D3	0	0	6	6
Structural maintenance of chromosomes protein 2	0	0	6	6
Mitogen-activated protein kinase kinase kinase 6	0	0	6	6
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	6	6
Serine/threonine-protein kinase LATS1	0	0	6	6
Serine/threonine-protein kinase PAK 4	0	0	6	6
Tyrosine-protein kinase ABL1	0	1	7	8
Epidermal growth factor receptor	0	9	9	19
Interferon beta	10	0	0	10
High affinity nerve growth factor receptor	0	0	6	6
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	5	5
ADP/ATP translocase 2	0	0	6	6
Protein kinase C beta type	0	0	6	6
Insulin receptor	0	3	6	9
Tyrosine-protein kinase Lck	0	1	6	7
Tyrosine-protein kinase Fyn	0	2	6	8
Cyclin-dependent kinase 1	0	3	6	9
Glycogen phosphorylase, liver form	0	0	6	6
Tyrosine-protein kinase Fes/Fps	0	0	6	6
Tyrosine-protein kinase Yes	0	1	6	7
Tyrosine-protein kinase Lyn	0	1	6	7
Proto-oncogene tyrosine-protein kinase receptor Ret	0	2	6	8
Insulin-like growth factor 1 receptor	0	2	6	8
Signal recognition particle receptor subunit alpha	0	0	5	5
Cytochrome c1, heme protein, mitochondrial	0	0	6	6
Hepatocyte growth factor receptor	0	1	5	6
Tyrosine-protein kinase HCK	0	2	6	8
Platelet-derived growth factor receptor beta	0	1	6	7
Replicase polyprotein 1ab	0	2	0	2
Serine/threonine-protein kinase A-Raf	0	1	6	7
Glycogen phosphorylase, brain form	0	0	6	6
Breakpoint cluster region protein	0	0	6	6
Serine/threonine-protein kinase pim-1	0	1	6	7
Fibroblast growth factor receptor 1	0	0	6	6
DNA topoisomerase 2-alpha	0	1	7	13
Cyclin-dependent kinase 4	0	2	6	9
ADP/ATP translocase 3	0	0	6	6
Inosine-5'-monophosphate dehydrogenase 2	0	0	6	6
Proto-oncogene tyrosine-protein kinase Src	0	2	6	8
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	6	6
G2/mitotic-specific cyclin-B1	0	2	0	2
Serine/threonine-protein kinase B-raf	0	3	7	11
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	6	6
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	0	6	6
Tyrosine-protein kinase Fer	0	0	6	6
Protein kinase C alpha type	0	0	6	6
cAMP-dependent protein kinase catalytic subunit alpha	0	0	6	6
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	6	6
Casein kinase II subunit alpha'	0	0	6	6
Cyclin-A2	0	1	0	1
Ras-related protein Rab-6A	0	0	6	6
Ephrin type-A receptor 1	0	0	6	6
Multifunctional protein ADE2	0	0	6	6
cAMP-dependent protein kinase catalytic subunit gamma	0	0	5	5
cAMP-dependent protein kinase catalytic subunit beta	0	0	6	6
Ferrochelatase, mitochondrial	0	0	7	7
Ribosomal protein S6 kinase beta-1	0	0	5	5
Tyrosine-protein kinase JAK1	0	2	6	8
G1/S-specific cyclin-D1	0	2	0	2
G1/S-specific cyclin-E1	0	3	0	3
Cyclin-dependent kinase 2	0	3	7	10
Beta-adrenergic receptor kinase 1	0	0	6	6
Probable ATP-dependent RNA helicase DDX6	0	0	6	6
Mitogen-activated protein kinase 3	0	0	6	6
MAP/microtubule affinity-regulating kinase 3	0	0	6	6
Deoxycytidine kinase	0	0	6	8
Mitogen-activated protein kinase 1	0	0	6	6
Ephrin type-A receptor 2	0	1	6	7
Ephrin type-B receptor 2	0	0	6	6
Non-receptor tyrosine-protein kinase TYK2	0	0	6	6
G1/S-specific cyclin-D3	0	2	0	2
Wee1-like protein kinase	0	0	6	6
Heme oxygenase 2	0	0	6	6
S-adenosylmethionine synthase isoform type-2	0	0	6	6
DnaJ homolog subfamily A member 1	0	0	6	6
RAC-alpha serine/threonine-protein kinase	0	0	6	6
RAC-beta serine/threonine-protein kinase	0	0	6	6
Dual specificity protein kinase TTK	0	0	3	3
DNA replication licensing factor MCM4	0	0	6	6
Dual specificity mitogen-activated protein kinase kinase 2	0	3	6	9
Receptor-type tyrosine-protein kinase FLT3	0	2	6	8
Bone morphogenetic protein receptor type-1A	0	0	6	6
Activin receptor type-1B	0	0	6	6
TGF-beta receptor type-1	0	0	6	6
TGF-beta receptor type-2	0	0	5	5
Tyrosine-protein kinase CSK	0	1	6	7
Glycine--tRNA ligase	0	0	6	6
Protein kinase C iota type	0	0	6	6
Exosome RNA helicase MTR4	0	0	6	6
Tyrosine-protein kinase Tec	0	1	6	7
Tyrosine-protein kinase ABL2	0	0	6	6
Tyrosine-protein kinase FRK	0	1	6	7
Tyrosine-protein kinase SYK	0	1	6	7
26S proteasome regulatory subunit 6B	0	0	6	6
Mitogen-activated protein kinase 8	0	0	6	6
Mitogen-activated protein kinase 9	0	0	6	6
Dual specificity mitogen-activated protein kinase kinase 3	0	0	6	6
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	6	6
Casein kinase I isoform alpha	0	1	5	6
Casein kinase I isoform delta	0	0	6	6
MAP kinase-activated protein kinase 2	0	0	6	6
Elongation factor Tu, mitochondrial	0	0	6	6
Choline-phosphate cytidylyltransferase A	0	0	3	3
Casein kinase I isoform epsilon	0	0	6	6
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	6	6
Dual specificity protein kinase CLK1	0	0	6	6
Dual specificity protein kinase CLK3	0	0	3	3
Glycogen synthase kinase-3 alpha	0	0	6	6
Glycogen synthase kinase-3 beta	0	0	6	6
Cyclin-dependent kinase 7	0	2	6	8
Cyclin-dependent kinase 9	0	2	6	8
Ras-related protein Rab-27A	0	0	6	6
Interleukin-1 receptor-associated kinase 1	0	0	6	6
Ribosomal protein S6 kinase alpha-3	0	0	6	6
Cyclin-H	0	2	0	2
CDK-activating kinase assembly factor MAT1	0	2	0	2
Serine/threonine-protein kinase Nek2	0	0	6	6
Serine/threonine-protein kinase Nek3	0	0	6	6
Dual specificity mitogen-activated protein kinase kinase 6	0	0	6	6
LIM domain kinase 1	0	0	6	6
LIM domain kinase 2	0	0	6	6
Tyrosine--tRNA ligase, cytoplasmic	0	0	6	6
5'-AMP-activated protein kinase subunit gamma-1	0	0	6	7
Ephrin type-B receptor 3	0	0	6	6
Ephrin type-A receptor 5	0	0	6	6
Ephrin type-B receptor 4	0	1	6	7
Ephrin type-A receptor 4	0	0	6	6
Adenylate kinase 2, mitochondrial	0	0	6	6
Adenosine kinase	0	0	5	5
Spike glycoprotein	10	0	0	10
Ras-related protein Rab-10	0	0	6	6
Actin-related protein 3	0	1	6	7
Actin-related protein 2	0	0	5	5
GTP-binding nuclear protein Ran	0	0	6	6
Casein kinase I isoform gamma-2	0	0	6	6
Cyclin-dependent kinase 6	0	2	6	9
Cyclin-dependent-like kinase 5	0	1	6	7
Cyclin-dependent kinase 16	0	0	6	6
Cyclin-dependent kinase 17	0	0	6	6
ATP-dependent 6-phosphofructokinase, platelet type	0	0	6	6
Dual specificity mitogen-activated protein kinase kinase 1	0	2	6	8
DNA topoisomerase 2-beta	0	1	7	14
Protein kinase C theta type	0	0	6	6
Activin receptor type-1	0	0	6	6
Macrophage-stimulating protein receptor	0	0	6	6
Focal adhesion kinase 1	0	0	6	6
Protein kinase C zeta type	0	0	2	2
Protein kinase C delta type	0	0	6	6
Tyrosine-protein kinase BTK	0	2	7	9
Activated CDC42 kinase 1	0	0	6	6
Epithelial discoidin domain-containing receptor 1	0	0	6	6
Potassium voltage-gated channel subfamily H member 2	0	5	0	5
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	6	6
Serine/threonine-protein kinase 4	0	0	6	6
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	6	7
Dual specificity mitogen-activated protein kinase kinase 5	0	0	6	6
Mitogen-activated protein kinase 7	0	0	6	6
Serine/threonine-protein kinase PAK 2	0	0	6	6
Serine/threonine-protein kinase 3	0	0	6	6
Mitogen-activated protein kinase kinase kinase 1	0	0	6	6
Rho-associated protein kinase 1	0	0	6	6
Non-receptor tyrosine-protein kinase TNK1	0	0	6	6
Serine/threonine-protein kinase ATR	0	0	3	3
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	6	6
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	6	6
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	1	6	7
Activin receptor type-2B	0	0	6	6
Bone morphogenetic protein receptor type-2	0	0	6	6
Protein-tyrosine kinase 6	0	1	6	7
cGMP-dependent protein kinase 1	0	0	6	6
Cyclin-dependent kinase 13	0	0	6	6
Calcium/calmodulin-dependent protein kinase type 1	0	1	1	2
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	6	6
Protein-tyrosine kinase 2-beta	0	0	6	6
Maternal embryonic leucine zipper kinase	0	0	6	6
Structural maintenance of chromosomes protein 1A	0	0	6	6
Chromodomain-helicase-DNA-binding protein 4	0	0	6	6
Cyclin-dependent kinase 5 activator 1	0	1	0	1
Delta(24)-sterol reductase	0	0	6	6
Ribosomal protein S6 kinase alpha-1	0	1	6	7
Dual specificity testis-specific protein kinase 1	0	0	3	3
Myosin light chain kinase, smooth muscle	0	0	6	6
Mitogen-activated protein kinase 11	0	0	6	6
Serine/threonine-protein kinase STK11	0	0	6	6
Serine/threonine-protein kinase N1	0	0	6	6
Serine/threonine-protein kinase N2	0	0	6	6
Mitogen-activated protein kinase 14	0	0	6	6
Calcium/calmodulin-dependent protein kinase type IV	0	0	6	6
Mitogen-activated protein kinase kinase kinase 11	0	0	6	6
MAP kinase-activated protein kinase 3	0	0	4	4
Discoidin domain-containing receptor 2	0	0	6	6
AP2-associated protein kinase 1	0	0	6	6
Myosin light chain kinase 3	0	0	6	6
Uncharacterized aarF domain-containing protein kinase 5	0	0	3	3
Putative heat shock protein HSP 90-beta 2	0	0	6	6
Rab-like protein 3	0	0	4	4
Serine/threonine-protein kinase MRCK alpha	0	0	6	6
Serine/threonine-protein kinase MRCK gamma	0	0	5	5
Serine/threonine-protein kinase N3	0	0	5	5
Serine/threonine-protein kinase ULK3	0	0	6	6
Uncharacterized protein FLJ45252	0	0	6	6
Acyl-CoA dehydrogenase family member 11	0	0	5	5
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	6	6
Serine/threonine-protein kinase MARK2	0	0	6	6
Serine/threonine-protein kinase TAO1	0	0	6	6
STE20-related kinase adapter protein alpha	0	0	6	6
Myosin-14	0	0	6	6
AarF domain-containing protein kinase 1	0	0	6	6
ATP-dependent RNA helicase DDX42	0	0	6	6
Homeodomain-interacting protein kinase 1	0	1	1	2
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	6	6
MAP kinase-activated protein kinase 5	0	0	6	6
Atypical kinase COQ8A, mitochondrial	0	0	6	6
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	6	6
Mitogen-activated protein kinase 15	0	0	6	6
Serine/threonine-protein kinase Nek9	0	0	6	6
ATP-dependent RNA helicase DDX1	0	0	6	6
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	6	6
Aurora kinase B	0	0	6	6
MAP/microtubule affinity-regulating kinase 4	0	0	6	6
Serine/threonine-protein kinase Nek1	0	0	6	6
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	6	6
EKC/KEOPS complex subunit TP53RK	0	0	6	6
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	6	6
Mitogen-activated protein kinase kinase kinase 5	0	0	6	6
Mitogen-activated protein kinase kinase kinase 3	0	0	6	6
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	6	6
Nucleolar GTP-binding protein 1	0	0	6	6
Serine/threonine-protein kinase D2	0	0	6	6
NUAK family SNF1-like kinase 2	0	0	5	5
RNA cytidine acetyltransferase	0	0	6	6
Serine/threonine-protein kinase SIK2	0	0	6	6
STE20-like serine/threonine-protein kinase	0	0	6	6
Serine/threonine-protein kinase TAO3	0	0	6	6
dCTP pyrophosphatase 1	0	0	6	6
Dual specificity protein kinase CLK4	0	0	6	6
Casein kinase I isoform gamma-1	0	0	6	6
Phenylalanine--tRNA ligase beta subunit	0	0	6	6
Isoleucine--tRNA ligase, mitochondrial	0	0	3	3
BMP-2-inducible protein kinase	0	0	6	6
Midasin	0	0	6	6
Interleukin-1 receptor-associated kinase 4	0	0	6	6
Mitogen-activated protein kinase kinase kinase 20	0	1	6	7
Cyclin-dependent kinase 12	0	0	6	6
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	6	6
Serine/threonine-protein kinase 26	0	0	6	6
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	6	6
Serine/threonine-protein kinase NLK	0	0	6	6
5'-AMP-activated protein kinase subunit gamma-2	0	0	6	7
Serine/threonine-protein kinase TBK1	0	0	6	6
Septin-9	0	0	6	6
Ribosomal protein S6 kinase alpha-6	0	0	6	6
TRAF2 and NCK-interacting protein kinase	0	0	6	6
Serine/threonine-protein kinase TAO2	0	0	6	6
Serine/threonine-protein kinase ICK	0	0	6	6
RAC-gamma serine/threonine-protein kinase	0	0	6	6
Serine/threonine-protein kinase SIK3	0	0	6	6
Mitogen-activated protein kinase kinase kinase 2	0	0	6	6
Thyroid hormone receptor-associated protein 3	0	0	6	6
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	6	6
Receptor-interacting serine/threonine-protein kinase 3	0	0	6	6
Serine/threonine-protein kinase MRCK beta	0	0	6	6
Interleukin-1 receptor-associated kinase 3	0	0	6	6
Serine/threonine-protein kinase 24	0	0	4	4
Casein kinase I isoform gamma-3	0	0	6	6
Mitogen-activated protein kinase kinase kinase 4	0	0	6	6
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	7	0	0	7
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	5	0	0	5
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
thioredoxin reductase	9	0	0	9
GALC protein	2	0	0	2
nuclear receptor subfamily 1, group I, member 3	12	0	0	12
glucocorticoid receptor [Homo sapiens]	10	0	0	10
estrogen-related nuclear receptor alpha	12	0	0	12
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
arylsulfatase A	7	0	0	7
Carbonic anhydrase	0	1	0	1
euchromatic histone-lysine N-methyltransferase 2	9	0	0	9
Bloom syndrome protein isoform 1	4	0	0	4
geminin	11	0	0	11
peripheral myelin protein 22	6	0	0	6
survival motor neuron protein isoform d	5	0	0	5
muscleblind-like protein 1 isoform 1	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	4	1	1	6
ATP-binding cassette sub-family C member 3	0	10	0	10
Multidrug resistance-associated protein 4	0	10	0	11
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	2	0	2
Carbonic anhydrase 12	0	3	1	6
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Bile salt export pump	0	15	0	15
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	2	0	2
Carbonic anhydrase 1	0	4	1	9
Carbonic anhydrase 2	0	5	2	10
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	3	0	3
Carbonic anhydrase 3	0	3	1	6
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	7	0	8
Steryl-sulfatase	0	2	0	2
5-hydroxytryptamine receptor 2C	0	3	0	4
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Cytochrome P450 2C8	0	3	0	4
Cytochrome P450 2D6	0	3	0	3
Cytochrome P450 2A6	0	2	1	3
Cytochrome P450 2C9	0	5	0	6
5-hydroxytryptamine receptor 2A	0	3	0	3
Androgen receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	4	1	1	6
Translocator protein	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	4	1	1	6
Gamma-aminobutyric acid receptor subunit gamma-2	4	1	1	6
Gamma-aminobutyric acid receptor subunit alpha-5	4	1	1	6
Gamma-aminobutyric acid receptor subunit alpha-3	4	1	1	6
Cannabinoid receptor 1	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Cytochrome P450 2B6	0	3	0	4
Carbonic anhydrase 4	0	3	1	5
Carbonic anhydrase 6	0	3	1	5
Gamma-aminobutyric acid receptor subunit gamma-1	4	1	1	6
Gamma-aminobutyric acid receptor subunit alpha-2	4	1	1	6
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Adenosine receptor A1	0	1	0	1
Serum paraoxonase/arylesterase 1	0	2	0	2
Dipeptidyl peptidase 4	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	4	1	1	6
Gamma-aminobutyric acid receptor subunit gamma-3	4	1	1	6
Endochitinase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	4	1	1	6
Adenosine receptor A2a	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
Sodium-dependent serotonin transporter	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Cytochrome P450 2C19	0	4	0	5
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Carbonic anhydrase 5A, mitochondrial	0	3	1	6
Carbonic anhydrase	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Carbonic anhydrase 7	0	3	1	5
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	1	1	0	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	4	1	1	6
Gamma-aminobutyric acid receptor subunit beta-3	4	1	1	6
Gamma-aminobutyric acid receptor subunit beta-2	4	1	1	6
Cholinesterase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Fatty-acid amide hydrolase 1	0	2	0	2
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	2
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Carbonic anhydrase 9	0	3	1	6
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	1
Sigma intracellular receptor 2	0	2	0	2
Delta carbonic anhydrase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Renin	0	1	0	1
Carbonic anhydrase	0	1	0	1
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	2	1	4
GABA theta subunit	4	1	1	6
Canalicular multispecific organic anion transporter 1	0	11	0	12
Carbonic anhydrase 4	0	2	0	2
Carbonic anhydrase 15	0	2	0	3
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	3	0	4
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	4	1	1	6
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 14	0	3	1	6
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	3	1	6
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	6	0	0	6
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
TDP1 protein	15	0	0	15
pregnane X nuclear receptor	9	0	0	9
nuclear factor erythroid 2-related factor 2 isoform 2	7	0	0	7
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Heat shock protein HSP 90-beta	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
TAR DNA-binding protein 43	4	0	0	4
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	1	3
ATPase family AAA domain-containing protein 5	7	0	0	7
Ataxin-2	9	0	0	9
thyroid stimulating hormone receptor	3	0	0	3
Cellular tumor antigen p53	12	0	0	12
Nuclear receptor ROR-gamma	2	0	0	2
Liver carboxylesterase 1	0	0	0	1
endonuclease IV	3	0	0	3
glp-1 receptor, partial	4	0	0	4
phosphopantetheinyl transferase	4	0	0	4
USP1 protein, partial	4	0	0	4
EWS/FLI fusion protein	11	0	0	11
G	6	0	0	6
67.9K protein	6	0	0	6
LMP1 [Human herpesvirus 4]	0	0	0	3
chromobox protein homolog 1	9	0	0	9
thyroid hormone receptor beta isoform 2	9	0	0	9
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	3	0	3
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
DNA polymerase iota isoform a (long)	6	0	0	6
transactivating tegument protein VP16 [Human herpesvirus 1]	0	3	0	3
nuclear receptor coactivator 3 isoform a	0	3	0	3
Thymidine kinase 2, mitochondrial	0	1	0	1
HLA class I histocompatibility antigen, B alpha chain	6	0	0	6
Thymidine kinase, cytosolic	0	1	0	1
Thymidine kinase	0	1	0	1
Thymidylate synthase	0	3	0	4
Thymidine kinase	0	1	0	1
Probable deoxycytidylate deaminase	0	0	0	2
Cytidine deaminase	0	1	0	3
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Inositol hexakisphosphate kinase 1	6	0	0	6
Thymidine kinase	0	1	0	1
Deoxynucleoside kinase	0	1	0	1
cytochrome P450 2C9, partial	6	0	0	6
ATP-dependent phosphofructokinase	9	0	0	9
Thymidine kinase 2	0	1	0	1
AAA family ATPase	0	0	0	1
Reverse transcriptase/RNaseH	0	0	1	1
Genome polyprotein	0	1	0	1
Fumarate hydratase	6	0	0	6
polyprotein	6	0	0	6
UDP-glucuronosyltransferase 2B7	0	0	0	1
SMAD family member 2	2	0	0	2
SMAD family member 3	2	0	0	2
caspase 7, apoptosis-related cysteine protease	3	0	0	3
progesterone receptor	9	0	0	9
peroxisome proliferator activated receptor gamma	6	0	0	6
vitamin D (1,25- dihydroxyvitamin D3) receptor	5	0	0	5
caspase-3	3	0	0	3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
urokinase-type plasminogen activator precursor	4	0	0	4
plasminogen precursor	4	0	0	4
urokinase plasminogen activator surface receptor precursor	4	0	0	4
Prothrombin	0	0	0	1
Regulatory protein E2	0	0	1	1
ATP-dependent translocase ABCB1	0	2	0	2
ATP-dependent translocase ABCB1	0	4	1	6
DNA topoisomerase 1	0	1	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
DNA topoisomerase 2	0	0	0	1
ATP-dependent translocase ABCB1	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	0	0	1
Glutamate receptor ionotropic, NMDA 1	0	0	0	1
Caspase-3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	1
Glutamate receptor ionotropic, NMDA 2C	0	0	0	1
DNA topoisomerase 2-alpha	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	0	0	1
Tubulin beta-2B chain	0	1	0	1
Integrase	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	0	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Glutamate receptor ionotropic, NMDA 3A	0	0	0	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
acetylcholinesterase	4	0	0	4
apical membrane antigen 1, AMA1	2	0	0	2
unnamed protein product	0	1	0	1
transcriptional regulator ERG isoform 3	3	0	0	3
heat shock protein HSP 90-alpha isoform 2	0	0	0	2
cytochrome P450 3A4 isoform 1	4	0	0	4
bcl-2-like protein 11 isoform 1	0	0	1	1
Histone deacetylase 3	0	2	0	2
Rap guanine nucleotide exchange factor 3	1	0	0	1
Chymotrypsinogen A	0	1	0	1
Beta-lactamase	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Heme oxygenase 1	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	2	3
Aromatase	0	4	0	4
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Cytochrome P450 11B2, mitochondrial	0	2	0	2
Heme oxygenase 2	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Histone deacetylase 4	0	2	0	2
Cytochrome P450 144	0	0	2	2
Steroid C26-monooxygenase	0	0	2	2
Steroid C26-monooxygenase	0	0	2	2
Mycocyclosin synthase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Histone deacetylase 1	0	2	0	2
Lanosterol 14-alpha demethylase	0	1	1	2
Sterol 14-alpha demethylase	0	0	2	2
Sterol 14-alpha demethylase	0	1	1	2
Histone deacetylase 7	0	2	0	2
Histone deacetylase 2	0	2	0	2
Polyamine deacetylase HDAC10	0	2	0	2
Histone deacetylase 11	0	2	0	2
14-alpha sterol demethylase	0	0	2	2
Histone deacetylase 8	0	2	0	2
Histone deacetylase 6	0	2	0	2
Histone deacetylase 9	0	2	0	2
Histone deacetylase 5	0	2	0	2
heat shock protein 90, putative	0	0	0	2
likely tRNA 2'-phosphotransferase	0	1	0	1
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Luciferase	2	0	0	2
interleukin 8	1	0	0	1
Skn7p	0	0	0	1
pregnane X receptor	3	0	0	3
ATAD5 protein, partial	3	0	0	3
Microtubule-associated protein tau	4	0	0	4
Thrombopoietin	1	0	0	1
thyroid stimulating hormone receptor	4	0	0	4
estrogen receptor 2 (ER beta)	7	0	0	7
nonstructural protein 1	3	0	0	3
farnesoid X nuclear receptor	6	0	0	6
IDH1	3	0	0	3
peripheral myelin protein 22 isoform 1	2	0	0	2
hemoglobin subunit beta	2	0	0	2
huntingtin isoform 2	1	0	0	1
flap endonuclease 1	5	0	0	5
Vpr	1	0	0	1
Solute carrier family 22 member 8	0	0	0	2
Amyloid-beta precursor protein	1	0	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Menin	0	0	1	1
Lecithin retinol acyltransferase	0	1	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Lethal factor	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Protein Rev	0	0	1	1
Aminoglycoside 3'-phosphotransferase	0	0	0	1
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
Membrane-associated progesterone receptor component 1	0	0	3	3
Phosphatidylethanolamine-binding protein 1	0	0	5	5
Electron transfer flavoprotein subunit beta	0	0	4	4
Dual specificity mitogen-activated protein kinase kinase 4	0	0	3	3
Cysteine--tRNA ligase, cytoplasmic	0	0	4	4
Dual specificity protein kinase CLK2	0	0	5	5
Serine/threonine-protein kinase PLK1	0	0	4	4
Mitogen-activated protein kinase 10	0	0	5	5
Ras-related C3 botulinum toxin substrate 1	0	0	1	1
Integrin-linked protein kinase	0	0	5	5
Peroxisomal acyl-coenzyme A oxidase 1	0	0	4	4
Ephrin type-A receptor 7	0	0	4	4
Acyl-CoA dehydrogenase family member 10	0	0	5	5
ATP-dependent RNA helicase DHX30	0	0	3	3
Misshapen-like kinase 1	0	0	4	4
Serine/threonine-protein kinase Nek7	0	0	5	5
Dual specificity testis-specific protein kinase 2	0	0	3	3
Serine/threonine-protein kinase PAK 6	0	0	3	3
Long-chain-fatty-acid--CoA ligase 5	0	0	3	3
Serine/threonine-protein kinase 38-like	0	0	3	3
Leukotriene C4 synthase	0	0	1	1
aryl hydrocarbon receptor	5	0	0	5
Caspase-7	1	0	0	1
vitamin D3 receptor isoform VDRA	5	0	0	5
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
caspase-3	1	0	0	1
epidermal growth factor receptor isoform a precursor	1	1	0	2
tyrosine-protein kinase Yes	3	0	0	3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	1	1	2
Serine/threonine-protein kinase 25	0	0	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	0	1	1
Serine/threonine-protein kinase RIO3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 7	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	1	2
Peripheral plasma membrane protein CASK	0	0	1	1
Serine/threonine-protein kinase DCLK1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	0	1	1
Muscle, skeletal receptor tyrosine-protein kinase	0	0	1	1
Mitogen-activated protein kinase 13	0	0	1	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
3-phosphoinositide-dependent protein kinase 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase 13	0	0	1	1
Death-associated protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
NUAK family SNF1-like kinase 1	0	0	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	1	1
Tyrosine-protein kinase JAK2	0	2	2	4
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	1	1
Serine/threonine-protein kinase PAK 3	0	0	1	1
Serine/threonine-protein kinase 17B	0	0	1	1
Cyclin-dependent kinase 14	0	0	1	1
Serine/threonine-protein kinase OSR1	0	0	1	1
Serine/threonine-protein kinase Chk2	0	0	1	1
RAF proto-oncogene serine/threonine-protein kinase	0	1	2	4
Receptor tyrosine-protein kinase erbB-2	0	3	3	6
Cytochrome P450 2E1	0	1	0	1
Macrophage colony-stimulating factor 1 receptor	0	1	1	2
Adenine phosphoribosyltransferase	0	0	4	4
Proto-oncogene tyrosine-protein kinase ROS	0	0	1	1
Tyrosine-protein kinase Fgr	0	1	2	3
Quinolone resistance protein NorA	0	1	0	1
Wee1-like protein kinase 2	0	0	1	1
Uncharacterized serine/threonine-protein kinase SBK3	0	0	1	1
Mast/stem cell growth factor receptor Kit	0	0	1	1
Myosin light chain kinase, smooth muscle	0	0	1	1
Insulin receptor-related protein	0	0	1	1
Platelet-derived growth factor receptor alpha	0	0	1	1
Vascular endothelial growth factor receptor 1	0	0	1	1
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	1	1
Serine/threonine-protein kinase MAK	0	0	1	1
Cyclin-dependent kinase 11B	0	0	1	1
Fibroblast growth factor receptor 2	0	0	1	1
Receptor tyrosine-protein kinase erbB-3	0	3	1	4
Fibroblast growth factor receptor 4	0	0	1	1
Fibroblast growth factor receptor 3	0	0	1	1
Sodium-dependent dopamine transporter	0	1	0	1
Protein kinase C eta type	0	0	1	1
Cruzipain	0	1	0	1
Activin receptor type-2A	0	0	1	1
Ephrin type-A receptor 3	0	0	1	1
Ephrin type-A receptor 8	0	0	1	1
Leukocyte tyrosine kinase receptor	0	0	1	1
UMP-CMP kinase	0	0	3	3
Tyrosine-protein kinase receptor UFO	0	0	1	1
Mitogen-activated protein kinase 4	0	0	1	1
G protein-coupled receptor kinase 4	0	0	1	1
Type-1 angiotensin II receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	1	1	2
Tyrosine-protein kinase receptor Tie-1	0	0	1	1
Vascular endothelial growth factor receptor 3	0	0	1	1
Vascular endothelial growth factor receptor 2	0	2	1	3
Serine/threonine-protein kinase receptor R3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 8	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	1	1	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	1	1	2
Serine/threonine-protein kinase mTOR	0	1	1	2
Megakaryocyte-associated tyrosine-protein kinase	0	0	1	1
Tyrosine-protein kinase TXK	0	1	2	3
G protein-coupled receptor kinase 6	0	0	4	4
Tyrosine-protein kinase ZAP-70	0	0	1	1
Histamine H2 receptor	4	0	0	4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	1	2
Cyclin-dependent kinase 8	0	0	1	1
Tyrosine-protein kinase Blk	0	1	2	3
Cytoplasmic tyrosine-protein kinase BMX	0	2	2	4
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	2	2
Serine/threonine-protein kinase Nek4	0	0	1	1
Tyrosine-protein kinase JAK3	0	2	2	4
Death-associated protein kinase 1	0	0	1	1
Mitogen-activated protein kinase 12	0	0	1	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	1	2
Ephrin type-B receptor 1	0	0	1	1
Beta-secretase 1	0	1	0	1
Hormonally up-regulated neu tumor-associated kinase	0	0	1	1
Serine/threonine-protein kinase SIK1	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 4	0	0	1	1
Cell division control protein 2 homolog	0	0	1	1
Calcium-dependent protein kinase 1	0	0	1	1
Tubulin alpha-1A chain	0	0	1	1
Casein kinase II subunit alpha	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	1	1
SRSF protein kinase 2	0	0	1	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Mitogen-activated protein kinase kinase kinase 9	0	0	1	1
Serine/threonine-protein kinase PknB	0	0	1	1
Cyclin-dependent kinase 3	0	0	4	4
Cyclin-dependent kinase-like 1	0	0	1	1
Synaptic vesicular amine transporter	0	1	0	1
Protein kinase C epsilon type	0	0	1	1
Angiopoietin-1 receptor	0	0	1	1
Mitogen-activated protein kinase kinase kinase 10	0	0	1	1
Transcription factor p65	0	1	0	1
Tyrosine-protein kinase receptor TYRO3	0	0	1	1
Cyclin-dependent kinase 18	0	0	1	1
Tyrosine-protein kinase ITK/TSK	0	1	2	3
Myotonin-protein kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 12	0	0	1	1
Tyrosine-protein kinase Mer	0	0	3	3
Serine/threonine-protein kinase PAK 1	0	0	1	1
cGMP-dependent protein kinase 2	0	0	1	1
Serine/threonine-protein kinase PRP4 homolog	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	1	1
Serine/threonine-protein kinase D1	0	0	1	1
Serine/threonine-protein kinase 38	0	0	3	3
Receptor tyrosine-protein kinase erbB-4	0	3	2	5
Ribosomal protein S6 kinase alpha-2	0	0	1	1
Rhodopsin kinase GRK1	0	0	1	1
NT-3 growth factor receptor	0	0	1	1
BDNF/NT-3 growth factors receptor	0	0	1	1
Mitogen-activated protein kinase 6	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	1	1
Serine/threonine-protein kinase ULK3	0	0	1	1
Serine/threonine-protein kinase SBK1	0	0	1	1
Mitogen-activated protein kinase kinase kinase 19	0	0	1	1
Serine/threonine-protein kinase TNNI3K	0	0	1	1
Serine/threonine-protein kinase Nek5	0	0	1	1
Dual serine/threonine and tyrosine protein kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 15	0	0	1	1
Serine/threonine-protein kinase tousled-like 2	0	0	1	1
Serine/threonine-protein kinase 32C	0	0	1	1
Serine/threonine-protein kinase pim-3	0	0	1	1
Serine/threonine-protein kinase VRK2	0	0	1	1
Myosin light chain kinase family member 4	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1D	0	0	1	1
Cyclin-dependent kinase-like 3	0	0	1	1
Serine/threonine-protein kinase BRSK2	0	0	1	1
Serine/threonine-protein kinase NIM1	0	0	1	1
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	0	0	3	3
Serine/threonine-protein kinase ULK2	0	0	1	1
Serine/threonine-protein kinase DCLK2	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	1	1
Casein kinase I isoform alpha-like	0	0	1	1
Homeodomain-interacting protein kinase 4	0	0	1	1
Myosin-IIIa	0	0	1	1
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	1	1
Serine/threonine-protein kinase Nek11	0	0	1	1
Serine/threonine-protein kinase BRSK1	0	0	1	1
Serine/threonine-protein kinase 35	0	0	1	1
Rhodopsin kinase GRK7	0	0	1	1
Serine/threonine-protein kinase 32A	0	0	1	1
Myosin-IIIb	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	1	1
Cyclin-dependent kinase-like 2	0	0	1	1
Serine/threonine-protein kinase Sgk3	0	0	1	1
Atypical kinase COQ8B, mitochondrial	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1G	0	0	3	3
Cyclin-dependent kinase 15	0	0	1	1
PAS domain-containing serine/threonine-protein kinase	0	0	2	2
SRSF protein kinase 1	0	0	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	1	1
Serine/threonine-protein kinase RIO1	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase RIO2	0	0	1	1
Cyclin-dependent kinase 19	0	0	1	1
Transient receptor potential cation channel subfamily M member 6	0	0	1	1
Testis-specific serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase 33	0	0	1	1
Serine/threonine-protein kinase DCLK3	0	0	1	1
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	1	1
Homeodomain-interacting protein kinase 2	0	0	1	1
Tyrosine-protein kinase Srms	0	0	1	1
Homeodomain-interacting protein kinase 3	0	0	1	1
Serine/threonine-protein kinase PLK3	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 2	0	0	1	1
Serine/threonine-protein kinase Nek6	0	0	1	1
SNF-related serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase LATS2	0	0	1	1
Serine/threonine-protein kinase 36	0	0	1	1
Obg-like ATPase 1	0	0	4	4
Serine/threonine-protein kinase 32B	0	0	1	1
Serine/threonine-protein kinase PLK2	0	0	1	1
Serine/threonine-protein kinase MARK1	0	0	1	1
Serine/threonine-protein kinase pim-2	0	0	2	2
Serine/threonine-protein kinase PAK 5	0	0	1	1
eIF-2-alpha kinase GCN2	0	0	1	1
Phosphatidylinositol 4-kinase beta	0	0	1	1
Serine/threonine-protein kinase 17A	0	0	1	1
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	1	1
Ephrin type-A receptor 6	0	0	1	1
Death-associated protein kinase 2	0	0	1	1
Serine/threonine-protein kinase tousled-like 1	0	0	1	1
ALK tyrosine kinase receptor	0	1	2	3
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	1	3
SRSF protein kinase 3	0	0	1	1
Cyclin-dependent kinase 11A	0	0	1	1
Aurora kinase C	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	1	1
Microtubule-associated serine/threonine-protein kinase 1	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	3	3
ClpP	2	0	0	2
NFKB1 protein, partial	2	0	0	2
GLS protein	3	0	0	3
regulator of G-protein signaling 4	3	0	0	3
lysosomal alpha-glucosidase preproprotein	1	0	0	1
M-phase phosphoprotein 8	3	0	0	3
muscarinic acetylcholine receptor M1	2	0	0	2
Solute carrier family 22 member 8	0	0	0	1
histone deacetylase 9 isoform 3	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
Chain A, 2-oxoglutarate Oxygenase	5	0	0	5
beta-2 adrenergic receptor	1	0	0	1
mitogen-activated protein kinase 1	2	0	0	2
Solute carrier organic anion transporter family member 2A1	0	1	0	1
cytochrome P450 2C19 precursor	3	0	0	3
runt-related transcription factor 1 isoform AML1b	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
Estrogen receptor	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
thioredoxin glutathione reductase	3	0	0	3
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
cellular tumor antigen p53 isoform a	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
histone acetyltransferase KAT2A isoform 1	3	0	0	3
UDP-glucose 6-dehydrogenase	0	1	0	1
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Integrin beta-3	2	0	0	2
Integrin alpha-IIb	2	0	0	2
UDP-glucose 6-dehydrogenase	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Purine nucleoside phosphorylase	0	0	1	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
Chain A, Ferritin light chain	2	0	0	2
acid sphingomyelinase	1	0	0	1
dopamine D1 receptor	1	0	0	1
15-lipoxygenase, partial	2	0	0	2
Thymidylate synthase	0	1	0	1
alpha-galactosidase	1	0	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
DNA polymerase beta	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
DNA polymerase kappa isoform 1	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Bile salt export pump	0	2	0	2
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	2
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	1	0	2
Solute carrier family 22 member 6	0	2	0	2
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier family 22 member 11	0	0	0	1
Protein-arginine deiminase type-4	0	1	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Lysine-specific histone demethylase 1A	0	1	0	1
Putative nucleoside diphosphate kinase	0	0	2	2
Nucleoside diphosphate kinase B	0	0	2	2
Myosin-10	0	0	3	3
von Hippel-Lindau disease tumor suppressor	0	1	0	1
Dipeptidyl peptidase 1	0	1	0	1
Epidermal growth factor receptor	0	2	0	2
Echinoderm microtubule-associated protein-like 4	0	0	1	1
Smad3	1	0	0	1
Testosterone 17-beta-dehydrogenase 3	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Nuclear receptor subfamily 4 group A member 3	0	1	0	1
Peroxiredoxin-like 2A	0	1	0	1
Platelet glycoprotein VI	0	1	0	1
cytochrome P450 2C9 precursor	1	0	0	1
Muscarinic acetylcholine receptor M2	0	1	1	2
Muscarinic acetylcholine receptor M1	0	2	0	3
Muscarinic acetylcholine receptor M3	0	2	0	3
Muscarinic acetylcholine receptor M4	0	2	0	3
Muscarinic acetylcholine receptor M5	0	2	0	3
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M2	0	2	0	3
Muscarinic acetylcholine receptor M1	0	1	2	3
Muscarinic acetylcholine receptor M1	0	0	1	1
Muscarinic acetylcholine receptor DM1	0	1	0	1
Cytochrome P450 2A13	0	1	1	2
Chain A, AKAP9-BRAF fusion protein	0	1	0	1
Pirin	0	1	0	1
GTPase KRas	0	1	0	1
Serine/threonine-protein kinase B-raf	0	1	0	1
Dual specificity mitogen-activated protein kinase kinase 4	0	0	1	1
Heat shock factor protein 1	0	1	0	1
Aspartyl/asparaginyl beta-hydroxylase	0	1	0	1
Cyclin-dependent kinase 10	0	0	1	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
nuclear receptor ROR-gamma isoform 1	2	0	0	2
Glucocorticoid receptor	0	2	1	3
Glycine receptor subunit alpha-1	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
Guanine nucleotide-binding protein G	1	0	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Polyphenol oxidase 2	0	1	0	2
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Albumin	0	1	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Acetylcholinesterase	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Beta-1 adrenergic receptor	0	0	1	1
cytochrome P450 2D6 isoform 1	1	0	0	1
Beta-2 adrenergic receptor	0	2	0	2
Beta-1 adrenergic receptor	0	2	0	2
Beta-3 adrenergic receptor	0	2	0	2
Beta-1 adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 1A	0	2	1	3
5-hydroxytryptamine receptor 1B	0	2	0	2
Beta-2 adrenergic receptor	0	0	1	1
Chain A, Cruzipain	1	0	0	1
neuropeptide S receptor isoform A	1	0	0	1
Sterol 14-alpha-demethylase	0	0	1	1
14-alpha sterol demethylase	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
14-alpha sterol demethylase	0	0	1	1
Cholesterol 24-hydroxylase	0	2	1	3
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

Research

Studies (257)

Protein Targets (1,111)

Iris Neoplasms

Synonyms(2)

Research

Studies (257)

Drugs Studied (58)

Protein Targets (1,111)