Page last updated: 2024-09-28

Pars Planitis

Form of granulomatous uveitis occurring in the region of the pars plana. This disorder is a common condition with no detectable focal pathology. It causes fibrovascular proliferation at the inferior ora serrata.

Synonyms(1)

Synonym
Pars Planitis

Research Excerpts

Overview

ExcerptReference
"Pars planitis is an intraocular inflammatory disorder which usually affects children or young adults and is characterized by vitreous cells and debris ('snowballs'), exudate, and 'snowbank' formation along the pars plana, variable periphlebitis, and cystoid macular edema."( Lee, AG, 1995)
"Pars planitis is defined as an intermediate uveitis of unknown background of systemic disease with characteristic formations such as vitreous snowballs, snowbanks and changes in peripheral retina."( Misiuk-Hojło, M; Przeździecka-Dołyk, J; Turno-Kręcicka, A; Węgrzyn, A, 2016)

Research

Studies (21)

TimeframeStudies, This Condition (%)All Conditions %
pre-19901 (4.76)23.3326
1990's8 (38.10)12.5806
2000's5 (23.81)18.1394
2010's7 (33.33)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
azathioprine0low10
fluconazole0low10
indomethacin0low10
2-propanol0low10
sulfasalazine0low10
mitomycin0low10
prednisolone0low30
prednisolone acetate0low10
prednisone0low30
fluprednisolone0low10
methylprednisolone acetate0low10
triamcinolone acetonide0low10
methylprednisolone0low30
triamcinolone0low20
propiconazole0low10
methotrexate0low20
cortisone0low10
glucosamine0low10
difluprednate0low10
bromochloroacetic acid0low10
amphotericin b0low10
cyclosporine0low30
eye0low20

Protein Targets (383)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
hypoxia-inducible factor 1 alpha subunit6006
RAR-related orphan receptor gamma110011
GLI family zinc finger 3110011
AR protein180018
aldehyde dehydrogenase 1 family, member A16006
retinoic acid nuclear receptor alpha variant 1120012
retinoid X nuclear receptor alpha110011
estrogen nuclear receptor alpha180018
peroxisome proliferator-activated receptor delta9009
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a130013
activating transcription factor 62002
v-jun sarcoma virus 17 oncogene homolog (avian)5005
Histone H2A.x5005
thyroid hormone receptor beta isoform a3003
heat shock protein beta-16006
nuclear factor erythroid 2-related factor 2 isoform 1110011
lamin isoform A-delta10100010
Voltage-dependent calcium channel gamma-2 subunit8008
Glutamate receptor 28008
Chain A, HADH2 protein5005
Chain B, HADH2 protein5005
Chain A, Cruzipain3003
interleukin 83003
phosphopantetheinyl transferase4004
GLS protein3003
glucocorticoid receptor [Homo sapiens]160016
farnesoid X nuclear receptor7007
vitamin D (1,25- dihydroxyvitamin D3) receptor7007
tumor necrosis factor1001
vitamin D3 receptor isoform VDRA5005
peripheral myelin protein 223003
Cytochrome P450 1A20101
Cytochrome P450 3A40303
Cytochrome P450 2D60101
Cytochrome P450 2C9 0505
Cytochrome P450 2C190101
Nuclear receptor ROR-gamma5005
Potassium voltage-gated channel subfamily H member 20202
Aurora kinase B0101
Broad substrate specificity ATP-binding cassette transporter ABCG20203
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE6006
Chain A, TYROSYL-DNA PHOSPHODIESTERASE3003
Chain A, Ferritin light chain4004
acetylcholinesterase4004
thioredoxin reductase4004
SMAD family member 25005
ATAD5 protein, partial5005
Fumarate hydratase2002
SMAD family member 35005
TDP1 protein110011
Microtubule-associated protein tau4004
thioredoxin glutathione reductase3003
nuclear receptor subfamily 1, group I, member 37007
EWS/FLI fusion protein4004
estrogen-related nuclear receptor alpha130013
pregnane X nuclear receptor9009
G5005
polyprotein2002
P531001
peroxisome proliferator activated receptor gamma7007
arylsulfatase A2002
IDH17007
euchromatic histone-lysine N-methyltransferase 26006
aryl hydrocarbon receptor7007
thyroid stimulating hormone receptor3003
Bloom syndrome protein isoform 13003
peripheral myelin protein 22 isoform 14004
hemoglobin subunit beta1001
cellular tumor antigen p53 isoform a2002
thyroid hormone receptor beta isoform 26006
DNA polymerase iota isoform a (long)7007
geminin100010
survival motor neuron protein isoform d3003
cytochrome P450 3A4 isoform 14004
M-phase phosphoprotein 84004
muscleblind-like protein 1 isoform 14004
muscarinic acetylcholine receptor M12002
Gamma-aminobutyric acid receptor subunit pi4004
ATP-binding cassette sub-family C member 30808
Multidrug resistance-associated protein 40809
Bile salt export pump0202
Bile salt export pump0909
Interferon beta9009
HLA class I histocompatibility antigen, B alpha chain 5005
Cellular tumor antigen p53110011
Gamma-aminobutyric acid receptor subunit beta-14004
Gamma-aminobutyric acid receptor subunit delta4004
Gamma-aminobutyric acid receptor subunit gamma-24004
Gamma-aminobutyric acid receptor subunit alpha-54004
Gamma-aminobutyric acid receptor subunit alpha-34004
Gamma-aminobutyric acid receptor subunit gamma-14004
Gamma-aminobutyric acid receptor subunit alpha-24004
Gamma-aminobutyric acid receptor subunit alpha-44004
Gamma-aminobutyric acid receptor subunit gamma-34004
Gamma-aminobutyric acid receptor subunit alpha-64004
Gamma-aminobutyric acid receptor subunit alpha-14004
Gamma-aminobutyric acid receptor subunit beta-34004
Gamma-aminobutyric acid receptor subunit beta-24004
GABA theta subunit4004
Inositol hexakisphosphate kinase 15005
Canalicular multispecific organic anion transporter 10707
ATPase family AAA domain-containing protein 57007
Ataxin-27007
Gamma-aminobutyric acid receptor subunit epsilon4004
Protein-arginine deiminase type-40202
cytochrome P450 2C9, partial5005
endonuclease IV1001
dopamine D1 receptor2002
pregnane X receptor3003
progesterone receptor120012
regulator of G-protein signaling 41001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
atrial natriuretic peptide receptor 1 precursor1001
chromobox protein homolog 16006
flap endonuclease 12002
Glucocorticoid receptor012219
Sex hormone-binding globulin0011
Glycine receptor subunit alpha-1012012
Corticosteroid-binding globulin0202
Glycine receptor subunit beta012012
Glycine receptor subunit alpha-2012012
Glycine receptor subunit alpha-3012012
Potassium voltage-gated channel subfamily A member 10011
TAR DNA-binding protein 435005
Multidrug and toxin extrusion protein 10202
Chain A, Beta-lactamase3003
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)8008
nuclear receptor subfamily 1, group I, member 28008
importin subunit beta-1 isoform 13003
snurportin-13003
GTP-binding nuclear protein Ran isoform 12002
neuropeptide S receptor isoform A2002
Chain A, BCL-2-RELATED PROTEIN A10011
apical membrane antigen 1, AMA11001
cytochrome P450 family 3 subfamily A polypeptide 45005
cytochrome P450 2D64004
unnamed protein product0101
transcriptional regulator ERG isoform 33003
heat shock protein HSP 90-alpha isoform 20002
bcl-2-like protein 11 isoform 10011
Histone deacetylase 30101
Rap guanine nucleotide exchange factor 31001
Chymotrypsinogen A0101
Beta-lactamase0101
Steroid 17-alpha-hydroxylase/17,20 lyase0101
Heme oxygenase 1 0101
ATP-dependent translocase ABCB10101
ATP-dependent translocase ABCB10213
Lanosterol 14-alpha demethylase0112
Aromatase0101
Cytochrome P450 11B1, mitochondrial0101
Cytochrome P450 11B2, mitochondrial0101
ATP-dependent translocase ABCB10101
Heme oxygenase 20101
Malate dehydrogenase, cytoplasmic0101
Histone deacetylase 40101
Cytochrome P450 1440011
Steroid C26-monooxygenase0011
Steroid C26-monooxygenase0011
Mycocyclosin synthase0011
Lanosterol 14-alpha demethylase0011
Lanosterol 14-alpha demethylase0011
Histone deacetylase 10101
Lanosterol 14-alpha demethylase0112
Sterol 14-alpha demethylase0011
Sterol 14-alpha demethylase0112
Histone deacetylase 70101
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
14-alpha sterol demethylase 0011
Histone deacetylase 80101
Histone deacetylase 60101
Histone deacetylase 90101
Histone deacetylase 50101
heat shock protein 90, putative0002
likely tRNA 2'-phosphotransferase0101
Chain A, membrane-associated prostaglandin E synthase-20101
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, 2-oxoglutarate Oxygenase2002
Luciferase2002
estrogen receptor 2 (ER beta)5005
67.9K protein3003
glucocerebrosidase1001
Parkin1001
bromodomain adjacent to zinc finger domain 2B2002
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)2002
cytochrome P450 2D6 isoform 11001
cytochrome P450 2C9 precursor2002
ras-related protein Rab-9A1001
serine/threonine-protein kinase mTOR isoform 11001
nuclear receptor ROR-gamma isoform 14004
DNA polymerase kappa isoform 12002
Prostaglandin-H2 D-isomerase0101
Prostaglandin E synthase0101
Solute carrier family 22 member 60101
Prostaglandin G/H synthase 1 0102
Prostaglandin G/H synthase 2 0102
3',5'-cyclic-AMP phosphodiesterase 0101
Solute carrier organic anion transporter family member 2B1 0404
Cytochrome c oxidase subunit 20101
Epidermal growth factor receptor0101
Phospholipase A2, major isoenzyme0101
Albumin0112
Prostaglandin G/H synthase 10203
Procathepsin L0101
Neuronal acetylcholine receptor subunit alpha-40101
Interleukin-80101
Androgen receptor0213
Neuronal acetylcholine receptor subunit beta-20101
Polyunsaturated fatty acid 5-lipoxygenase0102
Aldo-keto reductase family 1 member B10101
Aldo-keto reductase family 1 member B10101
Aldo-keto reductase family 1 member C40101
Prostaglandin G/H synthase 10101
Prostaglandin G/H synthase 10101
Sodium-dependent dopamine transporter0101
Sodium- and chloride-dependent GABA transporter 10101
Thromboxane-A synthase 0202
Adenosine receptor A10101
Serum paraoxonase/arylesterase 10101
Indoleamine 2,3-dioxygenase 10101
Caspase-10102
Nitric oxide synthase, inducible0101
Adenosine receptor A2a0101
Substance-P receptor0101
Prostaglandin E2 receptor EP3 subtype0101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Prostaglandin E2 receptor EP4 subtype0101
Multidrug resistance-associated protein 1 0102
Bifunctional epoxide hydrolase 20101
Prostaglandin G/H synthase 20314
Prostaglandin G/H synthase 2 0101
Prostaglandin E2 receptor EP1 subtype0101
Peroxisome proliferator-activated receptor gamma0011
Aldo-keto reductase family 1 member C30202
Histamine H2 receptor3003
Sodium- and chloride-dependent betaine transporter0101
C-X-C chemokine receptor type 30101
Aldo-keto reductase family 1 member C2 0101
Spike glycoprotein3003
Guanine nucleotide-binding protein G2002
Prostaglandin D2 receptor 0202
Solute carrier organic anion transporter family member 1A30102
Prostaglandin G/H synthase 20202
Lactoylglutathione lyase0101
Aldo-keto reductase family 1 member C10101
Prostaglandin G/H synthase 20102
Uracil nucleotide/cysteinyl leukotriene receptor0101
Solute carrier family 22 member 60102
Solute carrier family 22 member 70001
Sigma intracellular receptor 20101
Prostaglandin E2 receptor EP2 subtype0101
Rho-associated protein kinase 20101
Prostaglandin G/H synthase 1 0101
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 80102
Dehydrogenase/reductase SDR family member 90101
P2Y purinoceptor 120101
Solute carrier organic anion transporter family member 1B30405
Cytosolic phospholipase A2 gamma0101
Prostaglandin D2 receptor 20112
Solute carrier organic anion transporter family member 1B10404
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
acid sphingomyelinase1001
ClpP1001
15-lipoxygenase, partial1001
USP1 protein, partial4004
Thymidylate synthase 0101
alpha-galactosidase1001
Thymidylate synthase 0101
polyunsaturated fatty acid lipoxygenase ALOX121001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
nuclear factor erythroid 2-related factor 2 isoform 29009
DNA polymerase beta1001
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
histone acetyltransferase KAT2A isoform 11001
caspase-1 isoform alpha precursor1001
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Tyrosine-protein kinase ABL10011
Carbonic anhydrase 20213
Thymidylate synthase0202
Integrin beta-31001
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Thymidylate synthase0202
Integrin alpha-IIb1001
5-hydroxytryptamine receptor 2C0102
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Glucose-6-phosphate 1-dehydrogenase0202
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
5-hydroxytryptamine receptor 2A0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0303
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Kappa-type opioid receptor0101
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Caspase-71001
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Solute carrier family 22 member 200101
Dihydrofolate reductase 0101
Solute carrier family 22 member 60101
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
Solute carrier family 22 member 110001
ATP-dependent phosphofructokinase2002
PPM1D protein2002
nonstructural protein 12002
Nuclear receptor subfamily 1 group I member 20011
Androgen receptor0505
Nuclear receptor subfamily 1 group I member 20011
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
caspase 7, apoptosis-related cysteine protease1001
caspase-31001
Indoleamine 2,3-dioxygenase 10101
luciferase0001
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Mineralocorticoid receptor 0213
Glutamine synthetase0011
Histamine H1 receptor0011
Nociceptin receptor0011
Cytochrome P450 2J20303
Estrogen receptor beta0202
glp-1 receptor, partial2002
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Chain A, Glutathione S-transferase0101
thyroid stimulating hormone receptor1001
Replicase polyprotein 1ab0011
histone deacetylase 9 isoform 31001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
Carbonic anhydrase 10202
Tumor necrosis factor0011
Interstitial collagenase0101
Fibroblast growth factor 10011
Mitogen-activated protein kinase 10101
Flavin reductase (NADPH)0011
Disintegrin and metalloproteinase domain-containing protein 171001
Sodium/bile acid cotransporter0101
Cystine/glutamate transporter0101
NFKB1 protein, partial1001
Smad31001
procathepsin L isoform 1 preproprotein0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]