fluconazole has been researched along with Abnormalities, Drug-Induced in 28 studies
Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.
fluconazole : A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Oral fluconazole use during the first trimester of pregnancy was marginally associated with an increased risk of congenital malformations (odds ratio [OR] 1." | 9.01 | The safety of oral fluconazole during the first trimester of pregnancy: a systematic review and meta-analysis. ( Jiang, CM; Jiang, HY; Zhang, X; Zhang, Z; Zhou, YY, 2019) |
| " She took a 150-mg dose of fluconazole 2 weeks ago for the treatment of vaginal candidiasis and she is worried about the effect on her child and pregnancy." | 7.81 | Fluconazole exposure during pregnancy. ( Bozzo, P; Kaplan, YC; Koren, G, 2015) |
| "Case reports suggest that long-term, high-dose fluconazole treatment for severe fungal infections during pregnancy causes a pattern of birth defects." | 7.79 | Use of oral fluconazole during pregnancy and the risk of birth defects. ( Hviid, A; Mølgaard-Nielsen, D; Pasternak, B, 2013) |
| "We evaluated pregnancy outcomes in 234 women exposed to fluconazole, 492 exposed to a topically administered azole preparation, 88 exposed to an oral azole preparation other than fluconazole, and 1629 not exposed to any of these agents during the first trimester of pregnancy Relative risks of having a baby with a congenital disorder for women exposed to fluconazole, oral azoles, and topical azoles in the first trimester of pregnancy compared with those who were unexposed were 1." | 7.70 | Pregnancy outcomes after maternal exposure to fluconazole. ( Jick, SS, 1999) |
| "From 1 January 1991 to 31 December 1996 we identified 165 women who had taken fluconazole just before or during pregnancy in the Pregnancy Outcome Section of the North Jutland Pharmacoepidemiological Prescription Database, Denmark, which is linked to the Danish Medical Birth Registry." | 5.09 | Risk of malformations and other outcomes in children exposed to fluconazole in utero. ( Czeizel, AE; Larsen, H; Nielsen, GL; Olesen, C; Olsen, J; Schønheyder, HC; Sorensen, HT; Steffensen, FH, 1999) |
| "Oral fluconazole use during the first trimester of pregnancy was marginally associated with an increased risk of congenital malformations (odds ratio [OR] 1." | 5.01 | The safety of oral fluconazole during the first trimester of pregnancy: a systematic review and meta-analysis. ( Jiang, CM; Jiang, HY; Zhang, X; Zhang, Z; Zhou, YY, 2019) |
| " Because half of all pregnancies are unplanned and pregnant women have an increased risk of VVC recurrence, the likelihood of inadvertently being exposed to fluconazole in pregnancy is increased." | 4.91 | Exposure to fluconazole and risk of congenital malformations in the offspring: A systematic review and meta-analysis. ( Alsaad, AM; Kaplan, YC; Koren, G, 2015) |
| "To examine the risk of congenital malformations associated with exposure to oral fluconazole at commonly used doses in the first trimester of pregnancy for the treatment of vulvovaginal candidiasis." | 3.96 | Oral fluconazole use in the first trimester and risk of congenital malformations: population based cohort study. ( Bateman, BT; Gray, KJ; Hernandez-Diaz, S; Huybrechts, KF; Mogun, H; Straub, L; Zhu, Y, 2020) |
| "Low-dose fluconazole is used commonly to treat vulvovaginal candidiasis, a condition occurring frequently during pregnancy." | 3.83 | Fluconazole use and birth defects in the National Birth Defects Prevention Study. ( Browne, ML; Carter, TC; Cunniff, CM; Druschel, CM; Howley, MM; Romitti, PA, 2016) |
| " She took a 150-mg dose of fluconazole 2 weeks ago for the treatment of vaginal candidiasis and she is worried about the effect on her child and pregnancy." | 3.81 | Fluconazole exposure during pregnancy. ( Bozzo, P; Kaplan, YC; Koren, G, 2015) |
| "Case reports suggest that long-term, high-dose fluconazole treatment for severe fungal infections during pregnancy causes a pattern of birth defects." | 3.79 | Use of oral fluconazole during pregnancy and the risk of birth defects. ( Hviid, A; Mølgaard-Nielsen, D; Pasternak, B, 2013) |
| "Fluconazole is widely used for the treatment of candidiasis." | 3.74 | Maternal use of fluconazole and risk of congenital malformations: a Danish population-based cohort study. ( Erichsen, R; Gislum, M; Nørgaard, M; Pedersen, L; Schønheyder, HC; Søgaard, KK; Sørensen, HT, 2008) |
| "We evaluated pregnancy outcomes in 234 women exposed to fluconazole, 492 exposed to a topically administered azole preparation, 88 exposed to an oral azole preparation other than fluconazole, and 1629 not exposed to any of these agents during the first trimester of pregnancy Relative risks of having a baby with a congenital disorder for women exposed to fluconazole, oral azoles, and topical azoles in the first trimester of pregnancy compared with those who were unexposed were 1." | 3.70 | Pregnancy outcomes after maternal exposure to fluconazole. ( Jick, SS, 1999) |
| " However, patients with this phenotype have been reported with a new dominant mutation at the FGFR2 locus as well as in the offspring of mothers taking the antifungal agent fluconazole during early pregnancy." | 3.70 | Evidence for digenic inheritance in some cases of Antley-Bixler syndrome? ( Adès, L; Baraitser, M; Das, D; DeLozier-Blanchet, C; Hindmarsh, P; Honour, JW; Kelly, T; Kumar, D; Malcolm, S; McKee, S; McKeehan, WL; Nelson, I; Reardon, W; Rumsby, G; Sillence, D; Smith, A; Winter, RM, 2000) |
| "Fluconazole is a bis-triazole agent used in the treatment of superficial and systemic fungal infections, with vaginal candidiasis being one of the commonest indications to fluconazole treatment." | 2.72 | Maternal use of fluconazole and congenital malformations in the progeny: A meta-analysis of the literature. ( Budani, MC; Di Marzio, M; Fensore, S; Tiboni, GM, 2021) |
| "Fluconazole (FCZ) is an antifungal bis-triazole with potent inhibitory effect on the principal CYP-dependent metabolic pathway of PHT." | 2.69 | Teratological interaction between the bis-triazole antifungal agent fluconazole and the anticonvulsant drug phenytoin. ( Bellati, U; Di Ilio, C; Giampietro, F; Iammarrone, E; Lamonaca, D; Tiboni, GM, 1999) |
| "Ketoconazole is a major breakthrough although hepatic side-effects as well as interactions with mammalian steroids might rarely occur during prolonged treatment." | 2.38 | Toxicological profile and safety evaluation of antifungal azole derivatives. ( Coussement, W; De Coster, R; Lampo, A; Marsboom, R; Van Cauteren, H; Vandenberghe, J; Vanparys, P, 1989) |
| " Dose-response relationship was investigated by treating animals with 0 (vehicle), 87." | 1.33 | Murine teratology of fluconazole: evaluation of developmental phase specificity and dose dependence. ( Giampietro, F; Tiboni, GM, 2005) |
| "Fluconazole is a triazole antifungal used to treat mycotic infections." | 1.33 | Prenatal exposure to fluconazole: an identifiable dysmorphic phenotype. ( Lopez-Rangel, E; Van Allen, MI, 2005) |
| "Fluconazole has been associated with various teratisms in animals, including craniofacial ossification defects, thin, wavy ribs, and renal pelvis defects." | 1.29 | Fluconazole-induced congenital anomalies in three infants. ( Abraham, J; Andersen, HF; Bartley, JA; Blomquist, IK; Pursley, TJ, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.57) | 18.7374 |
| 1990's | 10 (35.71) | 18.2507 |
| 2000's | 5 (17.86) | 29.6817 |
| 2010's | 10 (35.71) | 24.3611 |
| 2020's | 2 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, Z | 1 |
| Zhang, X | 1 |
| Zhou, YY | 1 |
| Jiang, CM | 1 |
| Jiang, HY | 1 |
| Zhu, Y | 1 |
| Bateman, BT | 1 |
| Gray, KJ | 1 |
| Hernandez-Diaz, S | 1 |
| Mogun, H | 1 |
| Straub, L | 1 |
| Huybrechts, KF | 1 |
| Budani, MC | 1 |
| Fensore, S | 1 |
| Di Marzio, M | 1 |
| Tiboni, GM | 4 |
| Mølgaard-Nielsen, D | 2 |
| Pasternak, B | 2 |
| Hviid, A | 2 |
| Vlachadis, N | 1 |
| Iliodromiti, Z | 1 |
| Vrachnis, N | 1 |
| Magee, LA | 1 |
| Margo, K | 1 |
| Alsaad, AM | 1 |
| Kaplan, YC | 2 |
| Koren, G | 2 |
| Bozzo, P | 1 |
| Howley, MM | 1 |
| Carter, TC | 1 |
| Browne, ML | 1 |
| Romitti, PA | 1 |
| Cunniff, CM | 1 |
| Druschel, CM | 1 |
| Cassina, M | 1 |
| Cagnoli, GA | 1 |
| Zuccarello, D | 1 |
| Di Gianantonio, E | 1 |
| Clementi, M | 1 |
| Carey, JC | 1 |
| Martinez, L | 1 |
| Balken, E | 1 |
| Leen-Mitchell, M | 1 |
| Robertson, J | 1 |
| Giampietro, F | 2 |
| Lopez-Rangel, E | 1 |
| Van Allen, MI | 1 |
| Nørgaard, M | 1 |
| Pedersen, L | 1 |
| Gislum, M | 1 |
| Erichsen, R | 1 |
| Søgaard, KK | 1 |
| Schønheyder, HC | 2 |
| Sørensen, HT | 1 |
| Pursley, TJ | 1 |
| Blomquist, IK | 1 |
| Abraham, J | 1 |
| Andersen, HF | 1 |
| Bartley, JA | 1 |
| Krcmery, V | 1 |
| Huttova, M | 1 |
| Masar, O | 1 |
| Wray, CM | 1 |
| Sanchez, JM | 1 |
| Moya, G | 1 |
| Albukrek, D | 1 |
| Davidson, S | 1 |
| Merlob, P | 1 |
| Jick, SS | 1 |
| Iammarrone, E | 1 |
| Lamonaca, D | 1 |
| Bellati, U | 1 |
| Di Ilio, C | 1 |
| Sorensen, HT | 1 |
| Nielsen, GL | 1 |
| Olesen, C | 1 |
| Larsen, H | 1 |
| Steffensen, FH | 1 |
| Olsen, J | 1 |
| Czeizel, AE | 1 |
| Reardon, W | 1 |
| Smith, A | 1 |
| Honour, JW | 1 |
| Hindmarsh, P | 1 |
| Das, D | 1 |
| Rumsby, G | 1 |
| Nelson, I | 1 |
| Malcolm, S | 1 |
| Adès, L | 1 |
| Sillence, D | 1 |
| Kumar, D | 1 |
| DeLozier-Blanchet, C | 1 |
| McKee, S | 1 |
| Kelly, T | 1 |
| McKeehan, WL | 1 |
| Baraitser, M | 1 |
| Winter, RM | 1 |
| Lee, BE | 1 |
| Feinberg, M | 1 |
| Abraham, JJ | 1 |
| Murthy, AR | 1 |
| Van Cauteren, H | 1 |
| Lampo, A | 1 |
| Vandenberghe, J | 1 |
| Vanparys, P | 1 |
| Coussement, W | 1 |
| De Coster, R | 1 |
| Marsboom, R | 1 |
6 reviews available for fluconazole and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
The safety of oral fluconazole during the first trimester of pregnancy: a systematic review and meta-analysis.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Antifungal Agents; Candidiasis, Vulvovaginal; Cra | 2019 |
Maternal use of fluconazole and congenital malformations in the progeny: A meta-analysis of the literature.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Antifungal Agents; Candidiasis, Vulvovaginal; Do | 2021 |
Exposure to fluconazole and risk of congenital malformations in the offspring: A systematic review and meta-analysis.
Topics: Abnormalities, Drug-Induced; Antifungal Agents; Candidiasis, Vulvovaginal; Craniofacial Abnormalitie | 2015 |
Determination of human teratogenicity by the astute clinician method: review of illustrative agents and a proposal of guidelines.
Topics: Abnormalities, Drug-Induced; Antifungal Agents; Antirheumatic Agents; Congenital Abnormalities; Evid | 2009 |
[Fluconazole administration during pregnancy].
Topics: Abnormalities, Drug-Induced; Antifungal Agents; Candidiasis; Candidiasis, Vulvovaginal; Female; Fluc | 1998 |
Toxicological profile and safety evaluation of antifungal azole derivatives.
Topics: Abnormalities, Drug-Induced; Animals; Antifungal Agents; Endocrine Glands; Fluconazole; Humans; Itra | 1989 |
2 trials available for fluconazole and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Teratological interaction between the bis-triazole antifungal agent fluconazole and the anticonvulsant drug phenytoin.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Antifungal Agents; Body Weight; Cleft Palate; | 1999 |
Risk of malformations and other outcomes in children exposed to fluconazole in utero.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Antifungal Agents; Denmark; Female; Fluconazole; Fol | 1999 |
20 other studies available for fluconazole and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Oral fluconazole use in the first trimester and risk of congenital malformations: population based cohort study.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Adult; Antifungal Agents; Candidiasis, Vulvovagin | 2020 |
Use of oral fluconazole during pregnancy and the risk of birth defects.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Adult; Antifungal Agents; Cohort Studies; Denmark | 2013 |
Oral fluconazole during pregnancy and risk of birth defects.
Topics: Abnormalities, Drug-Induced; Antifungal Agents; Female; Fluconazole; Humans; Pregnancy | 2013 |
Oral fluconazole during pregnancy and risk of birth defects.
Topics: Abnormalities, Drug-Induced; Antifungal Agents; Female; Fluconazole; Humans; Pregnancy | 2013 |
ACP Journal Club. Fluconazole use during the first trimester of pregnancy was not associated with most major birth defects.
Topics: Abnormalities, Drug-Induced; Antifungal Agents; Female; Fluconazole; Humans; Pregnancy | 2014 |
Review: some clinical tests performed by specialists identify rotator cuff disease or tears.
Topics: Abnormalities, Drug-Induced; Antifungal Agents; Female; Fluconazole; Humans; Pregnancy | 2014 |
Fluconazole exposure during pregnancy.
Topics: Abnormalities, Drug-Induced; Antifungal Agents; Candidiasis, Vulvovaginal; Female; Fluconazole; Huma | 2015 |
Fluconazole use and birth defects in the National Birth Defects Prevention Study.
Topics: Abnormalities, Drug-Induced; Adult; Antifungal Agents; Candidiasis; Case-Control Studies; Female; Fl | 2016 |
Human teratogens and genetic phenocopies. Understanding pathogenesis through human genes mutation.
Topics: Abnormalities, Drug-Induced; Angiotensin-Converting Enzyme Inhibitors; Animals; Female; Fetal Diseas | 2017 |
Murine teratology of fluconazole: evaluation of developmental phase specificity and dose dependence.
Topics: Abnormalities, Drug-Induced; Alcian Blue; Animals; Anthraquinones; Antifungal Agents; Body Weight; C | 2005 |
Prenatal exposure to fluconazole: an identifiable dysmorphic phenotype.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Antifungal Agents; Female; Fluconazole; HIV In | 2005 |
Maternal use of fluconazole and risk of congenital malformations: a Danish population-based cohort study.
Topics: Abnormalities, Drug-Induced; Antifungal Agents; Candidiasis; Cohort Studies; Denmark; Female; Flucon | 2008 |
Second branchial arch anomalies induced by fluconazole, a bis-triazole antifungal agent, in cultured mouse embryos.
Topics: Abnormalities, Drug-Induced; Animals; Branchial Region; Culture Techniques; Embryo, Mammalian; Femal | 1993 |
Fluconazole-induced congenital anomalies in three infants.
Topics: Abnormalities, Drug-Induced; Adult; Antifungal Agents; Bone and Bones; Coccidioidomycosis; Face; Fem | 1996 |
Teratogenicity of fluconazole.
Topics: Abnormalities, Drug-Induced; Adult; Antifungal Agents; Female; Fluconazole; Humans; Pregnancy | 1996 |
Congenital anomalies and fluconazole.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Antifungal Agents; Candidiasis, Vulvo | 1997 |
Fluconazole teratogenicity.
Topics: Abnormalities, Drug-Induced; Adult; Female; Fertilization; Fluconazole; Humans; Male; Pregnancy; Pre | 1998 |
Pregnancy outcomes after maternal exposure to fluconazole.
Topics: Abnormalities, Drug-Induced; Antifungal Agents; Female; Fluconazole; Humans; Limb Deformities, Conge | 1999 |
Evidence for digenic inheritance in some cases of Antley-Bixler syndrome?
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Ankle Joint; Ankylosis; Craniosynostoses; Eye | 2000 |
Congenital malformations in an infant born to a woman treated with fluconazole.
Topics: Abnormalities, Drug-Induced; Coccidioidomycosis; Congenital Abnormalities; Female; Fluconazole; Huma | 1992 |