| Assay ID | Title | Year | Journal | Article |
|---|
| AID763656 | Displacement of [3H]-ketanserin from 5HT2A receptor in rat brain cortical membranes after 15 mins by liquid scintillation counting | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Synthesis and pharmacological evaluation of new N-phenylpiperazine derivatives designed as homologues of the antipsychotic lead compound LASSBio-579. |
| AID734514 | Displacement of [3H]-YM-09151-2 from human D4 dopamine receptor after 120 mins by liquid scintillation counting | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound. |
| AID734509 | Displacement of [3H]-prazosin from alpha1B adrenergic receptor in Wistar rat liver membrane after 45 mins by liquid scintillation counting | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound. |
| AID457691 | Selectivity index, ratio of Ki for Wistar rat striatum D2-like receptor to Ki for Wistar rat cortex 5HT2A receptor | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5
| Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors. |
| AID763635 | Antipsychotic activity in CF1 mouse assessed as prevention of apomorphine-induced climbing behaviour at 0.1 to 10 mg/kg, ip administered 30 mins prior apomorphine challenge measured 5 to 30 mins post challenge | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Synthesis and pharmacological evaluation of new N-phenylpiperazine derivatives designed as homologues of the antipsychotic lead compound LASSBio-579. |
| AID734512 | Displacement of [3H]-OH-8-DPAT from 5HT1A receptor in Wistar rat hippocampal membrane after 15 mins by liquid scintillation counting | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound. |
| AID763657 | Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in rat brain hippocampal membranes after 15 mins by liquid scintillation counting | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Synthesis and pharmacological evaluation of new N-phenylpiperazine derivatives designed as homologues of the antipsychotic lead compound LASSBio-579. |
| AID734510 | Displacement of [3H]-RX821002 from alpha2A adrenergic receptor in Wistar rat cortical membrane after 45 mins by liquid scintillation counting | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound. |
| AID457697 | Toxicity in CF1 mouse assessed as induction of catalepsy by measuring time spent on elevated wood bar at 15 mg/kg, po after 30 mins (Rvb = 1.8 +/- 1.1 sec) | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5
| Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors. |
| AID734511 | Displacement of [3H]-mesulergine from human 5HT2C receptor after 60 mins by liquid scintillation counting | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound. |
| AID457689 | Displacement of [3H]ketanserin from 5HT2A receptor in Wistar rat cortex homogenate | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5
| Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors. |
| AID457700 | Toxicity in CF1 mouse assessed as induction of catalepsy by measuring time spent on elevated wood bar at 30 mg/kg, po after 30 mins (Rvb = 1.8 +/- 1.1 sec) | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5
| Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors. |
| AID457687 | Displacement of [3H]nemonapride from D2-like receptor in Wistar rat striatum homogenate | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5
| Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors. |
| AID457699 | Toxicity in CF1 mouse assessed as induction of catalepsy by measuring time spent on elevated wood bar at 15 mg/kg, po after 90 mins (Rvb = 2.4 +/- 2.6 sec) | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5
| Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors. |
| AID457692 | Selectivity index, ratio of Ki for Wistar rat hippocampus 5HT1A receptor to Ki for Wistar rat cortex 5HT2A receptor | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5
| Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors. |
| AID734520 | Drug metabolism in Wistar rat assessed as CYP1A2-mediated p-hydroxylated metabolite formation at 50 mg/kg, ip after 48 hrs by HPLC analysis | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound. |
| AID457696 | Antipsychotic activity in CF1 mouse assessed as reduction in apomorphine-induced climbing at 15 mg/kg, po | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5
| Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors. |
| AID457706 | Toxicity in CF1 mouse assessed as induction of motor impairment by measuring permanence time at 15 mg/kg, po by rotarod test (Rvb = 241.4 +/- 18.0 sec) | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5
| Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors. |
| AID763654 | Displacement of [3H]-RX821002 from alpha2 adrenoreceptor in rat brain cortical membranes after 45 mins by liquid scintillation counting | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Synthesis and pharmacological evaluation of new N-phenylpiperazine derivatives designed as homologues of the antipsychotic lead compound LASSBio-579. |
| AID734513 | Displacement of [3H]-ketanserin from 5HT2A receptor in Wistar rat cortical membrane after 15 mins by liquid scintillation counting | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound. |
| AID457688 | Displacement of [3H]-8-OH-DPAT from 5HT1A receptor in Wistar rat hippocampus homogenate | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5
| Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors. |
| AID734517 | Drug metabolism in Wistar rat assessed as CYP1A2-mediated decrease in parent compound level at 50 mg/kg, ip after 30 mins by HPLC analysis | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound. |
| AID734515 | Displacement of [3H]-YM-09151-2 from D2 dopamine receptor in Wistar rat brain striatal membrane after 60 mins by liquid scintillation counting | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound. |
| AID734518 | Drug metabolism in Wistar rat assessed as CYP1A2-mediated p-hydroxylated metabolite formation at 50 mg/kg, ip after 30 mins by HPLC analysis | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound. |
| AID763652 | Displacement of [3H]-prozosin from alpha1B adrenoreceptor in rat liver membranes after 45 mins by liquid scintillation counting | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Synthesis and pharmacological evaluation of new N-phenylpiperazine derivatives designed as homologues of the antipsychotic lead compound LASSBio-579. |
| AID763651 | Displacement of [3H]-QNB from muscarinic receptor in rat brain cortical membranes at 30 uM after 60 mins by liquid scintillation counting | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Synthesis and pharmacological evaluation of new N-phenylpiperazine derivatives designed as homologues of the antipsychotic lead compound LASSBio-579. |
| AID763659 | Displacement of [3H]-YM-09151-2 from D2 receptor in rat brain striatal membranes after 60 mins by liquid scintillation counting | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Synthesis and pharmacological evaluation of new N-phenylpiperazine derivatives designed as homologues of the antipsychotic lead compound LASSBio-579. |
| AID734516 | Drug metabolism in Wistar rat plasma assessed as p-hydroxylated metabolite level at 50 mg/kg, ip after 24 hrs | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound. |
| AID457698 | Toxicity in CF1 mouse assessed as induction of catalepsy by measuring time spent on elevated wood bar at 15 mg/kg, po after 60 mins (Rvb = 2.7 +/- 2.9 sec) | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5
| Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors. |
| AID763629 | Selectivity ratio of Ki for dopamine D2 receptor in rat brain striatal membranes to Ki for 5HT2A receptor in rat brain cortical membranes | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Synthesis and pharmacological evaluation of new N-phenylpiperazine derivatives designed as homologues of the antipsychotic lead compound LASSBio-579. |
| AID457701 | Toxicity in CF1 mouse assessed as induction of catalepsy by measuring time spent on elevated wood bar at 30 mg/kg, po after 60 mins (Rvb = 2.7 +/- 2.9 sec) | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5
| Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors. |
| AID734519 | Drug metabolism in Wistar rat assessed as CYP1A2-mediated decrease in parent compound level at 50 mg/kg, ip after 48 hrs by HPLC analysis | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound. |
| AID763655 | Displacement of [3H]-mesulergine from human 5HT2C receptor after 60 mins by liquid scintillation counting | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Synthesis and pharmacological evaluation of new N-phenylpiperazine derivatives designed as homologues of the antipsychotic lead compound LASSBio-579. |
| AID457690 | Selectivity index, ratio of Ki for Wistar rat striatum D2-like receptor to Ki for Wistar rat hippocampus 5HT1A receptor | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5
| Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors. |
| AID734508 | Displacement of [3H]-QNB from muscarinic receptor in Wistar rat brain membrane after 60 mins by liquid scintillation counting | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound. |
| AID763658 | Displacement of [3H]-YM-09151-2 from human D4 receptor after 120 mins by liquid scintillation counting | 2013 | European journal of medicinal chemistry, Aug, Volume: 66 | Synthesis and pharmacological evaluation of new N-phenylpiperazine derivatives designed as homologues of the antipsychotic lead compound LASSBio-579. |
| AID457702 | Toxicity in CF1 mouse assessed as induction of catalepsy by measuring time spent on elevated wood bar at 30 mg/kg, po after 90 mins (Rvb = 2.4 +/- 2.6 sec) | 2010 | Bioorganic & medicinal chemistry, Mar-01, Volume: 18, Issue:5
| Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |