Page last updated: 2024-11-13

8-hydroxywarfarin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

8-hydroxywarfarin: metabolic marker for (S)-mephenytoin hydroxylase (P4502C19); structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID54697550
CHEMBL ID368081
MeSH IDM0265920

Synonyms (22)

Synonym
8-hydroxywarfarin
NCGC00165931-01
CHEMBL368081
17834-04-7
A812361
8-hydroxywarfarin;
t1ck4e3s36 ,
2h-1-benzopyran-2-one, 4,8-dihydroxy-3-(3-oxo-1-phenylbutyl)-
unii-t1ck4e3s36
8-hydroxy warfarin
FT-0637613
8-hydroxywarfarin, (rs)-
AKOS030239608
(r)-8-hydroxy warfarin
J-011370
(s)-8-hydroxy warfarin
4,8-dihydroxy-3-(3-oxo-1-phenylbutyl)chromen-2-one
4,8-dihydroxy-3-(3-oxo-1-phenylbutyl)-2h-chromen-2-one
2,8-dihydroxy-3-(3-oxo-1-phenylbutyl)-4h-1-benzopyran-4-one
DTXSID70939075
2h-1-benzopyran-2-one, 4,8-dihydroxy-3-(3-oxo-1-phenylbutyl)-; coumarin, 3-(?-acetonylbenzyl)-4,8-dihydroxy- (8ci); 8-hydroxywarfarin
Q27289540
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
DNA polymerase kappa isoform 1Homo sapiens (human)Potency37.68580.031622.3146100.0000AID588579
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency39.81070.251215.843239.8107AID504327
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID16339Amount of deuterium retained was reported after normal workup in beta-naphthoflavone-treated male rats with the substrate rac 7-D1985Journal of medicinal chemistry, Aug, Volume: 28, Issue:8
Substrate probes for the mechanism of aromatic hydroxylation catalyzed by cytochrome P-450: selectively deuterated analogues of warfarin.
AID16342Amount of deuterium retained was reported after reincubation followed by normal workup in phenobarbital treated male rats with rac 8-D1985Journal of medicinal chemistry, Aug, Volume: 28, Issue:8
Substrate probes for the mechanism of aromatic hydroxylation catalyzed by cytochrome P-450: selectively deuterated analogues of warfarin.
AID16345Compound incubated with microsomal preparations from phenobarbital treated male rats with the substrate rac 8-D and the amount of deuterium retained was reported after normal workup1985Journal of medicinal chemistry, Aug, Volume: 28, Issue:8
Substrate probes for the mechanism of aromatic hydroxylation catalyzed by cytochrome P-450: selectively deuterated analogues of warfarin.
AID16341Amount of deuterium retained was reported after reincubation followed by normal workup in phenobarbital treated male rats1985Journal of medicinal chemistry, Aug, Volume: 28, Issue:8
Substrate probes for the mechanism of aromatic hydroxylation catalyzed by cytochrome P-450: selectively deuterated analogues of warfarin.
AID16340Amount of deuterium retained was reported after normal workup in rats1985Journal of medicinal chemistry, Aug, Volume: 28, Issue:8
Substrate probes for the mechanism of aromatic hydroxylation catalyzed by cytochrome P-450: selectively deuterated analogues of warfarin.
AID16343Compound incubated with microsomal preparations from beta-naphthoflavone-treated male rats with the substrate rac 7-D and the amount of deuterium retained was reported after reincubation followed by normal workup1985Journal of medicinal chemistry, Aug, Volume: 28, Issue:8
Substrate probes for the mechanism of aromatic hydroxylation catalyzed by cytochrome P-450: selectively deuterated analogues of warfarin.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (12.50)18.7374
1990's1 (12.50)18.2507
2000's2 (25.00)29.6817
2010's4 (50.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.60

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.60 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.80 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.60)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]