Page last updated: 2024-10-27

fluconazole and Granulocytic Leukemia, Chronic

fluconazole has been researched along with Granulocytic Leukemia, Chronic in 5 studies

Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.
fluconazole : A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.

Research Excerpts

ExcerptRelevanceReference
"Fluconazole (FLU) is a new antifungal agent that has been used successfully to treat Candida infections and has modest activity against aspergillosis in animal models."6.67Antifungal prophylaxis during remission induction therapy for acute leukemia fluconazole versus intravenous amphotericin B. ( Anaissie, EJ; Bodey, GP; Elting, LS; Estey, E; Kantarjian, H; O'Brien, S, 1994)
"Fluconazole (FLU) is a new antifungal agent that has been used successfully to treat Candida infections and has modest activity against aspergillosis in animal models."2.67Antifungal prophylaxis during remission induction therapy for acute leukemia fluconazole versus intravenous amphotericin B. ( Anaissie, EJ; Bodey, GP; Elting, LS; Estey, E; Kantarjian, H; O'Brien, S, 1994)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (60.00)18.2507
2000's2 (40.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Turgut, B1
Vural, O1
Demir, M1
Kaldir, M1
Bodey, GP1
Anaissie, EJ1
Elting, LS1
Estey, E1
O'Brien, S1
Kantarjian, H1
Epstein, JB1
Ransier, A1
Lunn, R1
Chin, E1
Jacobson, JJ1
Le, N1
Reece, D1
Takahashi, N1
Maruta, A1
Hashimoto, C1
Kato, K1
Tanabe, J1
Kodama, F1
Oba, R1
Harada, H1
Omine, M1
Jakab, K1
Kelemen, E1
Váradi, G1
Török, I1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase II Trial to Evaluate the Safety and Tolerability of Nebulised Amphotericin B Lipid Complex (ABELCET®) in the Prophylaxis of Invasive Pulmonary Aspergillosis During Prolonged Neutropenia in Paediatric Patients With Acute Leukaemia[NCT01615809]Phase 232 participants (Actual)Interventional2011-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Efficacy of Primary Prophylaxis With Nebulized Abelcet® on the Incidence of Invasive Pulmonary Aspergillosis

The incidence of invasive pulmonary aspergillosis during the Abelcet® prophylactic treatment period was assessed by the relation between the number of patients with invasive pulmonary aspergillosis and the number of paediatric patients on prophylaxis with Acute Leukaemia (AL) undergoing intensive chemotherapy. (NCT01615809)
Timeframe: at the Baseline visit (week 1) and at the end of the profilaxis treatment phase, up to 6 weeks

Interventionparticipants (Number)
Amphotericin B (ABELCET®)3

Invasive Pulmonary Aspergillosis -Related Mortality During Primary Prophylaxis With Abelcet®.

Percentage of deaths related to Invasive Pulmonary Aspergillosis during the prophylactic treatment period with Abelcet® in paediatric patients with Acute Leukaemia undergoing intensive chemotherapy. (NCT01615809)
Timeframe: at the Baseline visit (week 1) and at the end of the profilaxis treatment phase, up to 6 weeks

Interventionpercentage of deaths (Number)
Amphotericin B (ABELCET®)0

Number of Participants With Adverse Events That Results in the Interruption of Treatment, as a Measure of Safety and Tolerability

is assessed by the proportion of patients who discontinue prophylactic treatment with Abelcet® due to an adverse event that is related or not to the study drug or for intolerability to it. The last week of treatment will have a different calendar for each participant, depending on the number of cicles needed by each patient (it has been anticipated up to 5 cicles of 2-6 weeks each). (NCT01615809)
Timeframe: at the Baseline visit (week 1) and during the Last week of treatment, up to 6 weeks

Interventionparticipants (Number)
Amphotericin B (ABELCET®)0

Trials

1 trial available for fluconazole and Granulocytic Leukemia, Chronic

ArticleYear
Antifungal prophylaxis during remission induction therapy for acute leukemia fluconazole versus intravenous amphotericin B.
    Cancer, 1994, Apr-15, Volume: 73, Issue:8

    Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Amphotericin B; Blast Crisis; Female; Flu

1994

Other Studies

4 other studies available for fluconazole and Granulocytic Leukemia, Chronic

ArticleYear
Candida arthritis in a patient with chronic myelogenous leukemia (CML) in blastic transformation, unresponsive to fluconazole, but treated effectively with liposomal amphotericin B.
    Annals of hematology, 2002, Volume: 81, Issue:9

    Topics: Amphotericin B; Arthritis, Infectious; Blast Crisis; Candidiasis; Drug Combinations; Drug Resistance

2002
Prophylaxis of candidiasis in patients with leukemia and bone marrow transplants.
    Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 1996, Volume: 81, Issue:3

    Topics: Adolescent; Adult; Aged; Antifungal Agents; Bone Marrow Transplantation; Candidiasis, Oral; Dental C

1996
[Successful allogeneic bone marrow transplantation following fungal liver abscess treatment in a patient with chronic myeloid leukemia in blastic crisis].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2000, Volume: 41, Issue:12

    Topics: Adult; Amphotericin B; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Blast Cris

2000
[Amphotericin B resistant severe hepato-splenic candidiasis, responding to fluconazole, in a patient following bone marrow transplantation].
    Orvosi hetilap, 1991, Mar-24, Volume: 132, Issue:12

    Topics: Adult; Amphotericin B; Bone Marrow Transplantation; Candidiasis; Female; Fluconazole; Humans; Leukem

1991