5-amino-8-hydroxyquinoline profile

5-amino-8-hydroxyquinoline: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	416002
CHEMBL ID	449298
SCHEMBL ID	688655
MeSH ID	M0521011

Synonym
13207-66-4
AC-7829
BB 0221209
AS-0308-225 ,
5-aminoquinolin-8-ol
5-amino-quinolin-8-ol
AKOS000111586
CHEMBL449298
FT-0659557
A806359
5-amino-8-hydroxyquinoline
BRD-K00624318-300-01-3
STK737829
8-quinolinol, 5-amino-
SCHEMBL688655
5-amino-8-quinolinol
5-amino-8-quinolinol #
AM85404
bdbm32142
cid_416002
5-azanylquinolin-8-ol
DTXSID20328975
J-516727
5-amino-8-hydroxyquinoline hclsalt
CS-W001023
GS-5740
mfcd00185837
CCG-321501
5-aminoquinoline-8-ol
5-aminooxin
SY045850
SB67953
HY-W001023
PD119507

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
90-kda heat shock protein beta HSP90 beta, partial	Homo sapiens (human)	IC50 (µMol)	22.2914	0.1736	9.8032	29.2701	AID712; AID754
heat shock protein HSP 90-alpha isoform 2	Homo sapiens (human)	IC50 (µMol)	22.2914	0.1736	9.8032	29.2701	AID712; AID754
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	IC50 (µMol)	2.0500	0.0002	2.4585	9.9600	AID1640021
Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)	IC50 (µMol)	3.0000	0.0537	3.0757	10.0000	AID443993
Catechol O-methyltransferase	Rattus norvegicus (Norway rat)	IC50 (µMol)	29.5121	0.0022	2.8127	7.0795	AID1149251
Proteasome subunit beta type-5	Homo sapiens (human)	IC50 (µMol)	0.6000	0.0005	0.9394	10.0000	AID1301250; AID1301251; AID1301252; AID1301253; AID1301254; AID1301255; AID1301256; AID1301257
Indoleamine 2,3-dioxygenase 1	Mus musculus (house mouse)	IC50 (µMol)	1.0000	0.0060	1.6251	10.0000	AID443995
Tryptophan 2,3-dioxygenase	Mus musculus (house mouse)	IC50 (µMol)	5.0000	1.0000	2.4867	5.0000	AID443997
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
regulation of activated T cell proliferation	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
positive regulation of T cell tolerance induction	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
positive regulation of chronic inflammatory response	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
positive regulation of type 2 immune response	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
tryptophan catabolic process	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
inflammatory response	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
female pregnancy	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
tryptophan catabolic process to kynurenine	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
response to lipopolysaccharide	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
negative regulation of interleukin-10 production	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
positive regulation of interleukin-12 production	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
multicellular organismal response to stress	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
kynurenic acid biosynthetic process	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
swimming behavior	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
T cell proliferation	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
negative regulation of T cell proliferation	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
negative regulation of T cell apoptotic process	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
positive regulation of T cell apoptotic process	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
'de novo' NAD biosynthetic process from tryptophan	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
proteolysis	Proteasome subunit beta type-5	Homo sapiens (human)
response to oxidative stress	Proteasome subunit beta type-5	Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic process	Proteasome subunit beta type-5	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
3'-5'-RNA exonuclease activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
RNA-dependent RNA polymerase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
cysteine-type endopeptidase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
mRNA 5'-cap (guanine-N7-)-methyltransferase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
mRNA (nucleoside-2'-O-)-methyltransferase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
mRNA guanylyltransferase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
RNA endonuclease activity, producing 3'-phosphomonoesters	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
ISG15-specific peptidase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
5'-3' RNA helicase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
protein guanylyltransferase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
electron transfer activity	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
heme binding	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
indoleamine 2,3-dioxygenase activity	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
metal ion binding	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
tryptophan 2,3-dioxygenase activity	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
threonine-type endopeptidase activity	Proteasome subunit beta type-5	Homo sapiens (human)
protein binding	Proteasome subunit beta type-5	Homo sapiens (human)
peptidase activity	Proteasome subunit beta type-5	Homo sapiens (human)
endopeptidase activity	Proteasome subunit beta type-5	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
double membrane vesicle viral factory outer membrane	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
cytosol	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
smooth muscle contractile fiber	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
stereocilium bundle	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
cytoplasm	Indoleamine 2,3-dioxygenase 1	Homo sapiens (human)
nucleus	Proteasome subunit beta type-5	Homo sapiens (human)
cytoplasm	Proteasome subunit beta type-5	Homo sapiens (human)
proteasome complex	Proteasome subunit beta type-5	Homo sapiens (human)
nucleus	Proteasome subunit beta type-5	Homo sapiens (human)
nucleoplasm	Proteasome subunit beta type-5	Homo sapiens (human)
centrosome	Proteasome subunit beta type-5	Homo sapiens (human)
cytosol	Proteasome subunit beta type-5	Homo sapiens (human)
extracellular exosome	Proteasome subunit beta type-5	Homo sapiens (human)
proteasome core complex	Proteasome subunit beta type-5	Homo sapiens (human)
proteasome core complex, beta-subunit complex	Proteasome subunit beta type-5	Homo sapiens (human)
cytosol	Proteasome subunit beta type-5	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (33)

Assay ID	Title	Year	Journal	Article
AID443993	Inhibition of human recombinant IDO expressed in Escherichia coli BL21 AI	2010	Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3	Rational design of indoleamine 2,3-dioxygenase inhibitors.
AID443997	Inhibition of mouse recombinant TDO expressed in mouse P815B cells assessed as blockade of tryptophan degradation by HPLC	2010	Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3	Rational design of indoleamine 2,3-dioxygenase inhibitors.
AID568480	Antifungal activity against Aspergillus niger KCTC 1231 after 2 days by twofold broth dilution method	2011	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3	Synthesis and antifungal activity of furo[2,3-f]quinolin-5-ols.
AID444000	Cytotoxicity against mouse P815B cells expressing mouse recombinant TDO by MTT assay	2010	Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3	Rational design of indoleamine 2,3-dioxygenase inhibitors.
AID1244907	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	2015	European journal of medicinal chemistry, Sep-18, Volume: 102	Antitumor activity of endoperoxide-iron chelator conjugates-design, synthesis and biological evaluation.
AID568481	Antifungal activity against Aspergillus flavus KCCM 11899 after 2 days by twofold broth dilution method	2011	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3	Synthesis and antifungal activity of furo[2,3-f]quinolin-5-ols.
AID568477	Antifungal activity against Candida tropicalis KCCM 50662 after 1 day by twofold broth dilution method	2011	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3	Synthesis and antifungal activity of furo[2,3-f]quinolin-5-ols.
AID568478	Antifungal activity against Candida krusei KCCM 11655 after 1 day by twofold broth dilution method	2011	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3	Synthesis and antifungal activity of furo[2,3-f]quinolin-5-ols.
AID1244912	Selectivity ratio of IC50 for human HL7702 cells to IC50 for human SMMC7721 cells	2015	European journal of medicinal chemistry, Sep-18, Volume: 102	Antitumor activity of endoperoxide-iron chelator conjugates-design, synthesis and biological evaluation.
AID1301256	Inhibition of human 20S proteasome chymotryptic-like activity using Suc-LLVY-AMC as substrate expressed in human MDAY-D2 cells assessed as free 7-amino-4-methylcoumarin release preincubated for 22 hrs followed by substrate addition by fluorescent spectrop	2016	Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11	Substituted quinolines as noncovalent proteasome inhibitors.
AID1301254	Inhibition of human 20S proteasome chymotryptic-like activity using Suc-LLVY-AMC as substrate expressed in human NB4 cells assessed as free 7-amino-4-methylcoumarin release preincubated for 22 hrs followed by substrate addition by fluorescent spectrophoto	2016	Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11	Substituted quinolines as noncovalent proteasome inhibitors.
AID412143	Antifungal activity against Candida tropicalis KCCM 50662 after 1 day	2009	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 19, Issue:1	Synthesis and antifungal activity of 1H-pyrrolo[3,2-g]quinoline-4,9-diones and 4,9-dioxo-4,9-dihydro-1H-benzo[f]indoles.
AID1244911	Cytotoxicity against human HL7702 cells after 48 hrs by MTT assay	2015	European journal of medicinal chemistry, Sep-18, Volume: 102	Antitumor activity of endoperoxide-iron chelator conjugates-design, synthesis and biological evaluation.
AID1244909	Cytotoxicity against human SW480 cells after 48 hrs by MTT assay	2015	European journal of medicinal chemistry, Sep-18, Volume: 102	Antitumor activity of endoperoxide-iron chelator conjugates-design, synthesis and biological evaluation.
AID1301251	Inhibition of human 20S proteasome chymotryptic-like activity using Suc-LLVY-AMC as substrate expressed in human KMH11 cells assessed as free 7-amino-4-methylcoumarin release preincubated for 22 hrs followed by substrate addition by fluorescent spectropho	2016	Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11	Substituted quinolines as noncovalent proteasome inhibitors.
AID1301257	Inhibition of human 20S proteasome chymotryptic-like activity using Suc-LLVY-AMC as substrate expressed in human K562 cells assessed as free 7-amino-4-methylcoumarin release preincubated for 22 hrs followed by substrate addition by fluorescent spectrophot	2016	Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11	Substituted quinolines as noncovalent proteasome inhibitors.
AID412146	Antifungal activity against Cryptococcus neoformans KCCM 50564 after 1 day	2009	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 19, Issue:1	Synthesis and antifungal activity of 1H-pyrrolo[3,2-g]quinoline-4,9-diones and 4,9-dioxo-4,9-dihydro-1H-benzo[f]indoles.
AID1301250	Inhibition of human 20S proteasome chymotryptic-like activity using Suc-LLVY-AMC as substrate expressed in human UTMC2 cells assessed as free 7-amino-4-methylcoumarin release preincubated for 22 hrs followed by substrate addition by fluorescent spectropho	2016	Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11	Substituted quinolines as noncovalent proteasome inhibitors.
AID1301253	Inhibition of human 20S proteasome chymotryptic-like activity using Suc-LLVY-AMC as substrate expressed in human OCI-AML2 cells assessed as free 7-amino-4-methylcoumarin release preincubated for 22 hrs followed by substrate addition by fluorescent spectro	2016	Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11	Substituted quinolines as noncovalent proteasome inhibitors.
AID568479	Antifungal activity against Cryptococcus neoformans KCCM 50564 after 2 days by twofold broth dilution method	2011	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3	Synthesis and antifungal activity of furo[2,3-f]quinolin-5-ols.
AID443996	Inhibition of human recombinant IDO expressed in HEK293 cells assessed as blockade of tryptophan degradation by HPLC	2010	Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3	Rational design of indoleamine 2,3-dioxygenase inhibitors.
AID443999	Cytotoxicity against HEK293 cells expressing human recombinant IDO by MTT assay	2010	Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3	Rational design of indoleamine 2,3-dioxygenase inhibitors.
AID443995	Inhibition of mouse recombinant IDO expressed in mouse P815B cells assessed as blockade of tryptophan degradation by HPLC	2010	Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3	Rational design of indoleamine 2,3-dioxygenase inhibitors.
AID1301255	Inhibition of human 20S proteasome chymotryptic-like activity using Suc-LLVY-AMC as substrate expressed in human KG1A cells assessed as free 7-amino-4-methylcoumarin release preincubated for 22 hrs followed by substrate addition by fluorescent spectrophot	2016	Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11	Substituted quinolines as noncovalent proteasome inhibitors.
AID412144	Antifungal activity against Candida albicans KCCM 50235 after 1 day	2009	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 19, Issue:1	Synthesis and antifungal activity of 1H-pyrrolo[3,2-g]quinoline-4,9-diones and 4,9-dioxo-4,9-dihydro-1H-benzo[f]indoles.
AID1149251	Inhibition of Sprague-Dawley rat liver COMT after 10 mins using 0.05 uCi [14CH3]-SAM as substrate	1976	Journal of medicinal chemistry, Apr, Volume: 19, Issue:4	Catechol O-methyltransferase. 8. Structure-activity relationships for inhibtion by 8-hydroxyquinolines.
AID1244910	Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay	2015	European journal of medicinal chemistry, Sep-18, Volume: 102	Antitumor activity of endoperoxide-iron chelator conjugates-design, synthesis and biological evaluation.
AID568476	Antifungal activity against Candida albicans KCCM 50235 after 1 day by twofold broth dilution method	2011	Bioorganic & medicinal chemistry letters, Feb-01, Volume: 21, Issue:3	Synthesis and antifungal activity of furo[2,3-f]quinolin-5-ols.
AID412145	Antifungal activity against Candida krusei KCCM 11655 after 1 day	2009	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 19, Issue:1	Synthesis and antifungal activity of 1H-pyrrolo[3,2-g]quinoline-4,9-diones and 4,9-dioxo-4,9-dihydro-1H-benzo[f]indoles.
AID1301252	Inhibition of human 20S proteasome chymotryptic-like activity using Suc-LLVY-AMC as substrate expressed in human KMS18 cells assessed as free 7-amino-4-methylcoumarin release preincubated for 22 hrs followed by substrate addition by fluorescent spectropho	2016	Bioorganic & medicinal chemistry, 06-01, Volume: 24, Issue:11	Substituted quinolines as noncovalent proteasome inhibitors.
AID1244908	Cytotoxicity against human A549 cells after 48 hrs by MTT assay	2015	European journal of medicinal chemistry, Sep-18, Volume: 102	Antitumor activity of endoperoxide-iron chelator conjugates-design, synthesis and biological evaluation.
AID412147	Antifungal activity against Aspergillus niger KCTC 1231 after 2 days	2009	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 19, Issue:1	Synthesis and antifungal activity of 1H-pyrrolo[3,2-g]quinoline-4,9-diones and 4,9-dioxo-4,9-dihydro-1H-benzo[f]indoles.
AID443998	Cytotoxicity against mouse P815B cells expressing mouse recombinant IDO by MTT assay	2010	Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3	Rational design of indoleamine 2,3-dioxygenase inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (9.09)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (18.18)	29.6817
2010's	7 (63.64)	24.3611
2020's	1 (9.09)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (9.09%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	10 (90.91%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
protocatechuic acid protocatechuic acid: RN given refers to parent cpd; structure. 3,4-dihydroxybenzoic acid : A dihydroxybenzoic acid in which the hydroxy groups are located at positions 3 and 4.	2.11	1	catechols; dihydroxybenzoic acid	antineoplastic agent; EC 1.1.1.25 (shikimate dehydrogenase) inhibitor; EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor; human xenobiotic metabolite; plant metabolite
oxyquinoline Oxyquinoline: An antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes, and its halogenated derivatives are used in addition as topical anti-infective agents and oral antiamebics.. quinolin-8-ol : A monohydroxyquinoline that is quinoline substituted by a hydroxy group at position 8. Its fungicidal properties are used for the control of grey mould on vines and tomatoes.	2.38	2	monohydroxyquinoline	antibacterial agent; antifungal agrochemical; antiseptic drug; iron chelator
broxyquinoline broxyquinoline: structure	1.95	1	organohalogen compound; quinolines
chloroquine Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.	3.16	1	aminoquinoline; organochlorine compound; secondary amino compound; tertiary amino compound	anticoronaviral agent; antimalarial; antirheumatic drug; autophagy inhibitor; dermatologic drug
clioquinol Clioquinol: A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.. 5-chloro-7-iodoquinolin-8-ol : A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.	3.48	2	monohydroxyquinoline; organochlorine compound; organoiodine compound	antibacterial agent; antifungal agent; antimicrobial agent; antineoplastic agent; antiprotozoal drug; chelator; copper chelator
cloxyquin cloxyquin: has antitubercular activity; structure in first source	1.95	1	organochlorine compound; quinolines
deferoxamine Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.. desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.	2.11	1	acyclic desferrioxamine	bacterial metabolite; ferroptosis inhibitor; iron chelator; siderophore
dichlorophen Dichlorophen: Nontoxic laxative vermicide effective for taenia infestation. It tends to produce colic and nausea. It is also used as a veterinary fungicide, anthelmintic, and antiprotozoan. (From Merck, 11th ed.)	2.05	1	bridged diphenyl fungicide; diarylmethane
benzophenone benzophenone : The simplest member of the class of benzophenones, being formaldehyde in which both hydrogens are replaced by phenyl groups.	2.05	1	benzophenones	photosensitizing agent; plant metabolite
fluconazole Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.. fluconazole : A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.	2.46	2	conazole antifungal drug; difluorobenzene; tertiary alcohol; triazole antifungal drug	environmental contaminant; P450 inhibitor; xenobiotic
flucytosine Flucytosine: A fluorinated cytosine analog that is used as an antifungal agent.. flucytosine : An organofluorine compound that is cytosine that is substituted at position 5 by a fluorine. A prodrug for the antifungal 5-fluorouracil, it is used for the treatment of systemic fungal infections.	2.46	2	aminopyrimidine; nucleoside analogue; organofluorine compound; pyrimidine antifungal drug; pyrimidone	prodrug
iodoquinol Iodoquinol: One of the halogenated 8-quinolinols widely used as an intestinal antiseptic, especially as an antiamebic agent. It is also used topically in other infections and may cause CNS and eye damage. It is known by very many similar trade names world-wide.. iodoquinol : A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by iodine. It is considered the drug of choice for treating asymptomatic or moderate forms of amoebiasis.	1.95	1	monohydroxyquinoline; organoiodine compound	antiamoebic agent; antibacterial agent; antiprotozoal drug; antiseptic drug
threonine Threonine: An essential amino acid occurring naturally in the L-form, which is the active form. It is found in eggs, milk, gelatin, and other proteins.. threonine : An alpha-amino acid in which one of the hydrogens attached to the alpha-carbon of glycine is substituted by a 1-hydroxyethyl group.	3.16	1	amino acid zwitterion; aspartate family amino acid; L-alpha-amino acid; proteinogenic amino acid; threonine	algal metabolite; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
8-hydroxyquinoline-5-sulfonic acid 8-hydroxyquinoline-5-sulfonic acid: RN given refers to parent cpd	1.95	1
2-methylquinoline 2-methylquinoline: RN given refers to parent cpd. methylquinoline : Any member of the class of quinolines carrying at least one methyl substituent.. quinaldine : A quinoline compound in which the quinoline skeleton is substituted at C-2 with a methyl group.	2.13	1	quinolines
4-aminodiphenylamine 4-aminodiphenylamine: RN given refers to parent cpd. p-aminodiphenylamine : An aromatic amine that is the 4-amino derivative of diphenylamine.	2.05	1	aromatic amine; secondary amino compound	allergen
pyrroles 1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.	3.16	1	pyrrole; secondary amine
pyrazines Pyrazines: A heterocyclic aromatic organic compound with the chemical formula C4H4N2.. pyrazine : A diazine that is benzene in which the carbon atoms at positions 1 and 4 have been replaced by nitrogen atoms.	3.56	2	diazine; pyrazines	Daphnia magna metabolite
9-fluorenone fluoren-9-one : The simplest member of the class fluoren-9-ones that is 9H-fluorene bearing an oxo substituent at position 9.	2.05	1	fluoren-9-ones	fungal xenobiotic metabolite
8-hydroxy-7-iodo-5-quinolinesulfonic acid 8-hydroxy-7-iodo-5-quinolinesulfonic acid: used with iodine isotopes in radioisotope scanning; structure	1.95	1	hydroxyquinoline
1,4-naphthohydroquinone naphthohydroquinone : A hydroxynaphthalene that is naphthalene-1,4-diol and its C-substituted derivatives.	2.05	1	naphthalenediol; naphthohydroquinone
3-methylquinoline [no description available]	2.13	1	methylquinoline	xenobiotic
nitroxoline nitroxoline: structure in Merck Index, 9th ed, #6475; RN given refers to parent cpd. nitroxoline : A monohydroxyquinoline in which the hydroxy group is positioned at C-8 with a nitro group trans to it at C-5.	1.95	1	C-nitro compound; monohydroxyquinoline	antifungal agent; antiinfective agent; antimicrobial agent; renal agent
cadmium Cadmium: An element with atomic symbol Cd, atomic number 48, and atomic weight 112.41. It is a metal and ingestion will lead to CADMIUM POISONING.. elemental cadmium : An element in the zinc group of the periodic table with atomic number 48, atomic mass 112, M.P. 321degreeC, and B.P. 765degreeC). An odourless, tasteless, and highly poisonous soft, ductile, lustrous metal with electropositive properties. It has eight stable isotopes: (106)Cd, (108)Cd,(110)Cd, (111)Cd, (112)Cd, (113)Cd, (114)Cd and (116)Cd, with (112)Cd and (114)Cd being the most common.	2.04	1	cadmium molecular entity; zinc group element atom
gold Gold: A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.	7.04	1	copper group element atom; elemental gold
phenthiazamine phenthiazamine: RN given refers to parent cpd	2.05	1
5-methyl-8-hydroxyquinoline 5-methyl-8-hydroxyquinoline: RN given refers to parent cpd; structure in first source & in Negwer, 5th ed, #1202	1.95	1	hydroxyquinoline
fluoren-9-ol fluoren-9-ol : A member of the class of hydroxyfluorenes that is 9H-fluorene substituted by a hydroxy group at position 9 (the non-aromatic carbon).	2.05	1	hydroxyfluorenes; secondary alcohol	animal metabolite
4-hydroxycarbazole 4-hydroxycarbazole: structure in first source	2.05	1
bortezomib [no description available]	3.87	3	amino acid amide; L-phenylalanine derivative; pyrazines	antineoplastic agent; antiprotozoal drug; protease inhibitor; proteasome inhibitor
indoximod [no description available]	2.05	1
1-methyltryptophan 1-methyltryptophan: an immunomodulator. 1-methyltryptophan : A tryptophan derivative that is tryptophan carrying a single methyl substituent at position 1 on the indole.	2.05	1	indolyl carboxylic acid
4-phenyl-3H-thiazole-2-thione [no description available]	2.05	1	benzenes
artenimol artenimol: derivative of antimalarial drug artemisinin (quinghaosu)	2.11	1
marizomib marizomib: a proteasome inhibitor from a marine bacterium Salinospora; structure in first source	3.16	1	beta-lactone; gamma-lactam; organic heterobicyclic compound; organochlorine compound; salinosporamide	antineoplastic agent; proteasome inhibitor
carfilzomib [no description available]	3.16	1	epoxide; morpholines; tetrapeptide	antineoplastic agent; proteasome inhibitor
chiniofon Hydroxyquinolines: The 8-hydroxy derivatives inhibit various enzymes and their halogenated derivatives, though neurotoxic, are used as topical anti-infective agents, among other uses.	4.29	5
delanzomib [no description available]	3.16	1	C-terminal boronic acid peptide; phenylpyridine; secondary alcohol; threonine derivative	antineoplastic agent; apoptosis inducer; proteasome inhibitor
oprozomib ONX 0912: antineoplastic; an orally active proteasome inhibitor; structure in first source	3.16	1

Condition	Relationship Strength	Studies
Benign Neoplasms [description not available]	3.42	2
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	3.42	2
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.05	1
Kahler Disease [description not available]	2.05	1
Multiple Myeloma A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.	2.05	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.04	1

5-amino-8-hydroxyquinoline

Description

Cross-References

Synonyms (34)

Protein Targets (8)

Inhibition Measurements

Biological Processes (22)

Molecular Functions (19)

Ceullar Components (12)

Bioassays (33)

Research

Studies (11)

Market Indicators

Research Demand Index: 21.28

Study Types

5-amino-8-hydroxyquinoline

Description

Cross-References

Synonyms (34)

Protein Targets (8)

Inhibition Measurements

Biological Processes (22)

Molecular Functions (19)

Ceullar Components (12)

Bioassays (33)

Research

Studies (11)

Market Indicators

Research Demand Index: 21.28

Study Types

Related Drugs (39)

Related Conditions (6)