fluconazole has been researched along with Liver Dysfunction in 38 studies
Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.
fluconazole : A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fluconazole is a safe and effective agent with significant activity against chronic disseminated candidiasis." | 9.07 | Fluconazole therapy for chronic disseminated candidiasis in patients with leukemia and prior amphotericin B therapy. ( Anaissie, E; Barnett, K; Bodey, GP; Bow, E; David, C; Defelice, R; Downs, N; File, T; Kantarjian, H; Karam, G, 1991) |
| " The fungal infection was successfully controlled using fluconazole, and the patient has been disease-free for more than 11 months after antileukemic chemotherapy without any recurrence of Candida infections." | 7.71 | Successful treatment of hepatosplenic candidiasis in an elderly patient with acute myeloid leukemia using liposomal daunorubicin and fluconazole. ( Barbera, V; Gambino, R; Mariani, G; Minardi, V; Quintini, G; Spadola, V, 2001) |
| "The bis triazole agent fluconazole is used widely in the treatment of superficial and deep mycoses." | 7.69 | Clinical pharmacokinetics of fluconazole in superficial and systemic mycoses. ( Debruyne, D, 1997) |
| " We report a case of hepatosplenic candidiasis in a patient with acute myelogenous leukemia who had clinical and radiographic improvement during fluconazole therapy." | 7.68 | Fluconazole in the treatment of hepatosplenic candidiasis. ( Adelman, HM; Altus, P; Flannery, MT; Saba, H; Simmons, DB; Wallach, PM, 1992) |
| "To determine if fluconazole is effective treatment for hepatosplenic candidiasis that has not resolved with amphotericin B and flucytosine treatment." | 7.68 | Hepatosplenic candidiasis: successful treatment with fluconazole. ( Bradley, SF; Kauffman, CA; Ross, SC; Weber, DR, 1991) |
| "Fluconazole is a safe and effective agent with significant activity against chronic disseminated candidiasis." | 5.07 | Fluconazole therapy for chronic disseminated candidiasis in patients with leukemia and prior amphotericin B therapy. ( Anaissie, E; Barnett, K; Bodey, GP; Bow, E; David, C; Defelice, R; Downs, N; File, T; Kantarjian, H; Karam, G, 1991) |
| "To report a case of fluconazole worsening of liver dysfunction." | 4.79 | Worsening of liver function with fluconazole and review of azole antifungal hepatotoxicity. ( Gearhart, MO, 1994) |
| "A 73-year-old white man taking nitrofurantoin 50 mg/day for 5 years developed combined hepatic and pulmonary toxicity after taking fluconazole acutely for onychomycosis." | 3.72 | Pulmonary and hepatic toxicity due to nitrofurantoin and fluconazole treatment. ( Linnebur, SA; Parnes, BL, 2004) |
| " The fungal infection was successfully controlled using fluconazole, and the patient has been disease-free for more than 11 months after antileukemic chemotherapy without any recurrence of Candida infections." | 3.71 | Successful treatment of hepatosplenic candidiasis in an elderly patient with acute myeloid leukemia using liposomal daunorubicin and fluconazole. ( Barbera, V; Gambino, R; Mariani, G; Minardi, V; Quintini, G; Spadola, V, 2001) |
| "Candida krusei is a cause of invasive candidiasis (IC), with numerous cases reported among leukemia patients after bone marrow transplantation and treatment with fluconazole." | 3.69 | Invasive infection due to Candida krusei in immunocompromised patients not treated with fluconazole. ( Hinrichs, SH; Iwen, PC; Kelly, DM; Reed, EC, 1995) |
| "Two pediatric leukemic patients with hepatosplenic candidiasis during multidrug antileukemic chemotherapy successfully underwent bone marrow transplantation (BMT) after aggressive antifungal chemotherapy employing fluconazole and amphotericin B with or without splenectomy." | 3.69 | Successful peritransplant therapy in children with active hepatosplenic candidiasis. ( Ichihara, T; Katayama, K; Koizumi, S; Konishi, M; Maekawa, S; Seki, H; Tamaru, Y; Taniguchi, N; Yamagami, M, 1994) |
| "The bis triazole agent fluconazole is used widely in the treatment of superficial and deep mycoses." | 3.69 | Clinical pharmacokinetics of fluconazole in superficial and systemic mycoses. ( Debruyne, D, 1997) |
| " We report a case of hepatosplenic candidiasis in a patient with acute myelogenous leukemia who had clinical and radiographic improvement during fluconazole therapy." | 3.68 | Fluconazole in the treatment of hepatosplenic candidiasis. ( Adelman, HM; Altus, P; Flannery, MT; Saba, H; Simmons, DB; Wallach, PM, 1992) |
| "To determine if fluconazole is effective treatment for hepatosplenic candidiasis that has not resolved with amphotericin B and flucytosine treatment." | 3.68 | Hepatosplenic candidiasis: successful treatment with fluconazole. ( Bradley, SF; Kauffman, CA; Ross, SC; Weber, DR, 1991) |
| "Fosfluconazole was more rapidly converted to FLCZ in the hepatically impaired subjects but the FLCZ pharmacokinetic parameters (except t(max)) were not statistically significantly affected by hepatic impairment." | 2.71 | The effects of hepatic impairment on the pharmacokinetics of fosfluconazole and fluconazole following a single intravenous bolus injection of fosfluconazole. ( Haug-Pihale, G; Sobue, S; Tan, K, 2005) |
| "Oral itraconazole solution has adequate bioavailability in liver transplant recipients for effective antifungal prophylaxis." | 2.70 | Randomized controlled trial of oral itraconazole solution versus intravenous/oral fluconazole for prevention of fungal infections in liver transplant recipients. ( Busuttil, RW; Winston, DJ, 2002) |
| "We report a patient with acute myeloid leukemia who developed HSC during post-remission consolidation chemotherapy and was treated with a prolonged course of caspofungin followed by fluconazole." | 2.45 | Successful intensive chemotherapy followed by autologous hematopoietic cell transplantation in a patient with acute myeloid leukemia and hepatosplenic candidiasis: case report and review of literature. ( Chia, HY; Koh, LP; Liu, TC; Poon, LM; Tan, LK, 2009) |
| "Of a total of 17 (8." | 1.43 | Caspofungin versus fluconazole as prophylaxis of invasive fungal infection in high-risk liver transplantation recipients: A propensity score analysis. ( Aguado, JM; Bodro, M; Carratalá, J; Casafont, F; Cervera, C; Fariñas, C; Fortún, J; Fresco, G; Gavaldá, J; Goikoetxea, J; Len, O; Martín-Dávila, P; Montejo, M; Moreno, A; Muñoz, P; Muriel, A; Pozo, JC; Silva, JT; Torre-Cisneros, J; Vena, A, 2016) |
| "Coccidioidomycosis is an infection caused by Coccidioides species, which are endemic for the Southwestern United States and parts of Central America and South America." | 1.37 | Coccidioidomycosis in liver transplant recipients in an endemic area. ( Blair, JE; Carey, EJ; Vucicevic, D, 2011) |
| "This syndrome has a favorable prognosis." | 1.29 | A radiologic syndrome after high dose chemotherapy and autologous bone marrow transplantation, with clinical and pathologic features of systemic candidiasis. ( Hussein, A; Meisenberg, B; Mudad, R; Paulson, EK; Peters, WP; Ross, M; Vredenburgh, J, 1994) |
| "Fluconazole is considered to be a potent, safe antifungal agent for the treatment of suspected fungal infections associated with hematological diseases." | 1.29 | [Clinical efficacy of fluconazole against fungal infections in hematological diseases]. ( Asahara, F; Hisano, S; Kawasaki, C; Kimura, N; Morioka, E; Nagano, M; Nakashima, H; Okumura, M; Suzumiya, J; Uchida, T; Yoshida, T, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (7.89) | 18.7374 |
| 1990's | 17 (44.74) | 18.2507 |
| 2000's | 12 (31.58) | 29.6817 |
| 2010's | 6 (15.79) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Islam, S | 1 |
| Singer, M | 1 |
| Kulhanjian, JA | 1 |
| Winston, DJ | 2 |
| Limaye, AP | 1 |
| Pelletier, S | 1 |
| Safdar, N | 1 |
| Morris, MI | 1 |
| Meneses, K | 1 |
| Busuttil, RW | 2 |
| Singh, N | 1 |
| Huprikar, S | 1 |
| Fortún, J | 1 |
| Muriel, A | 1 |
| Martín-Dávila, P | 1 |
| Montejo, M | 1 |
| Len, O | 1 |
| Torre-Cisneros, J | 1 |
| Carratalá, J | 1 |
| Muñoz, P | 1 |
| Fariñas, C | 1 |
| Moreno, A | 1 |
| Fresco, G | 1 |
| Goikoetxea, J | 1 |
| Gavaldá, J | 1 |
| Pozo, JC | 1 |
| Bodro, M | 1 |
| Vena, A | 1 |
| Casafont, F | 1 |
| Cervera, C | 1 |
| Silva, JT | 1 |
| Aguado, JM | 1 |
| Poon, LM | 1 |
| Chia, HY | 1 |
| Tan, LK | 1 |
| Liu, TC | 1 |
| Koh, LP | 1 |
| Teyton, P | 1 |
| Baillet, G | 1 |
| Hindié, E | 1 |
| Filmont, JE | 1 |
| Sarandi, F | 1 |
| Toubert, ME | 1 |
| Moretti, JL | 1 |
| Vucicevic, D | 1 |
| Carey, EJ | 1 |
| Blair, JE | 1 |
| Beam, E | 1 |
| Mansfield, AS | 1 |
| Thompson, CA | 1 |
| Biancofiore, G | 1 |
| Bindi, ML | 1 |
| Baldassarri, R | 1 |
| Romanelli, AM | 1 |
| Catalano, G | 1 |
| Filipponi, F | 1 |
| Vagelli, A | 1 |
| Mosca, F | 1 |
| PATRICK, RS | 1 |
| CHENG, KK | 2 |
| SIRNES, TB | 1 |
| Linnebur, SA | 1 |
| Parnes, BL | 1 |
| Sobue, S | 1 |
| Tan, K | 1 |
| Haug-Pihale, G | 1 |
| Krause, DS | 1 |
| Upton, A | 1 |
| McCune, JS | 1 |
| Kirby, KA | 1 |
| Leisenring, W | 1 |
| McDonald, G | 1 |
| Batchelder, A | 1 |
| Marr, KA | 1 |
| Medlicott, SA | 1 |
| Cox, H | 1 |
| Dupre, M | 1 |
| Lategan, J | 1 |
| Auer, I | 1 |
| Hollaar, G | 1 |
| Debru, E | 1 |
| Conly, J | 1 |
| Mudad, R | 1 |
| Vredenburgh, J | 1 |
| Paulson, EK | 1 |
| Ross, M | 1 |
| Meisenberg, B | 1 |
| Hussein, A | 1 |
| Peters, WP | 1 |
| Chmel, H | 1 |
| Jacobson, MA | 1 |
| Hanks, DK | 1 |
| Ferrell, LD | 1 |
| Kung, N | 1 |
| Fisher, N | 1 |
| Gunson, B | 1 |
| Hastings, M | 1 |
| Mutimer, D | 1 |
| Iwen, PC | 1 |
| Kelly, DM | 1 |
| Reed, EC | 1 |
| Hinrichs, SH | 1 |
| Gearhart, MO | 1 |
| Katayama, K | 1 |
| Koizumi, S | 1 |
| Yamagami, M | 1 |
| Tamaru, Y | 1 |
| Ichihara, T | 1 |
| Konishi, M | 1 |
| Maekawa, S | 1 |
| Seki, H | 1 |
| Taniguchi, N | 1 |
| Trujillo, MA | 1 |
| Galgiani, JN | 1 |
| Sampliner, RE | 1 |
| Ong, ST | 1 |
| Kueh, YK | 1 |
| Morioka, E | 1 |
| Asahara, F | 1 |
| Nagano, M | 1 |
| Kawasaki, C | 1 |
| Yoshida, T | 1 |
| Uchida, T | 1 |
| Nakashima, H | 1 |
| Suzumiya, J | 1 |
| Kimura, N | 1 |
| Hisano, S | 1 |
| Okumura, M | 1 |
| Debruyne, D | 1 |
| Colović, M | 1 |
| Lazarević, V | 1 |
| Colović, R | 1 |
| Janković, G | 1 |
| Suvajdzić, N | 1 |
| Bogdanović, A | 1 |
| Bila, J | 1 |
| Gangadharan, VP | 1 |
| Sasidharan, K | 1 |
| Preetha, S | 1 |
| Chithrathara, K | 1 |
| Quintini, G | 1 |
| Barbera, V | 1 |
| Gambino, R | 1 |
| Spadola, V | 1 |
| Minardi, V | 1 |
| Mariani, G | 1 |
| Rókusz, L | 1 |
| Liptay, L | 1 |
| Kádár, K | 1 |
| Flannery, MT | 1 |
| Simmons, DB | 1 |
| Saba, H | 1 |
| Altus, P | 1 |
| Wallach, PM | 1 |
| Adelman, HM | 1 |
| Kauffman, CA | 1 |
| Bradley, SF | 1 |
| Ross, SC | 1 |
| Weber, DR | 1 |
| Anaissie, E | 1 |
| Bodey, GP | 1 |
| Kantarjian, H | 1 |
| David, C | 1 |
| Barnett, K | 1 |
| Bow, E | 1 |
| Defelice, R | 1 |
| Downs, N | 1 |
| File, T | 1 |
| Karam, G | 1 |
| Jakab, K | 2 |
| Kelemen, E | 2 |
| Prinz, G | 1 |
| Török, I | 2 |
| Váradi, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Anidulafungin Versus Fluconazole for the Prevention of Invasive Fungal Infections in High-risk Liver Transplant Recipients: a Randomized, Double-blind Trial[NCT00841971] | Phase 4 | 200 participants (Actual) | Interventional | 2010-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00841971)
Timeframe: 90 days post enrollment
| Intervention | participants (Number) |
|---|---|
| Anidulafungin | 5 |
| Fluconazole | 8 |
(NCT00841971)
Timeframe: 90 days post enrollment
| Intervention | participants (Number) |
|---|---|
| Anidulafungin | 11 |
| Fluconazole | 11 |
3 reviews available for fluconazole and Liver Dysfunction
| Article | Year |
|---|---|
Toxic epidermal necrolysis in a neonate receiving fluconazole.
Topics: Disease Progression; Fatal Outcome; Female; Fluconazole; Humans; Infant, Newborn; Infant, Premature; | 2014 |
Successful intensive chemotherapy followed by autologous hematopoietic cell transplantation in a patient with acute myeloid leukemia and hepatosplenic candidiasis: case report and review of literature.
Topics: Adult; Antifungal Agents; Candida tropicalis; Candidiasis; Caspofungin; Cytarabine; Echinocandins; F | 2009 |
Worsening of liver function with fluconazole and review of azole antifungal hepatotoxicity.
Topics: Administration, Oral; Alanine Transaminase; Aspartate Aminotransferases; Candidiasis; Chemical and D | 1994 |
6 trials available for fluconazole and Liver Dysfunction
| Article | Year |
|---|---|
Randomized, double-blind trial of anidulafungin versus fluconazole for prophylaxis of invasive fungal infections in high-risk liver transplant recipients.
Topics: Adolescent; Adult; Aged; Anidulafungin; Antibiotic Prophylaxis; Antifungal Agents; Double-Blind Meth | 2014 |
Antifungal prophylaxis in liver transplant recipients: a randomized placebo-controlled study.
Topics: Adult; Amphotericin B; Antifungal Agents; Aspergillosis; Candidiasis; Drug Administration Schedule; | 2002 |
Randomized controlled trial of oral itraconazole solution versus intravenous/oral fluconazole for prevention of fungal infections in liver transplant recipients.
Topics: Administration, Oral; Adult; Aged; Drug Therapy, Combination; Female; Fluconazole; Fungi; Humans; Im | 2002 |
The effects of hepatic impairment on the pharmacokinetics of fosfluconazole and fluconazole following a single intravenous bolus injection of fosfluconazole.
Topics: Adult; Antifungal Agents; Female; Fluconazole; Humans; Injections, Intravenous; Liver Diseases; Male | 2005 |
Fluconazole coadministration concurrent with cyclophosphamide conditioning may reduce regimen-related toxicity postmyeloablative hematopoietic cell transplantation.
Topics: Antifungal Agents; Aryl Hydrocarbon Hydroxylases; Chemical and Drug Induced Liver Injury; Cohort Stu | 2007 |
Fluconazole therapy for chronic disseminated candidiasis in patients with leukemia and prior amphotericin B therapy.
Topics: Adult; Aged; Amphotericin B; Candidiasis; Child, Preschool; Chronic Disease; Female; Fluconazole; Hu | 1991 |
29 other studies available for fluconazole and Liver Dysfunction
| Article | Year |
|---|---|
Revisiting antifungal prophylaxis in high-risk liver transplant recipients.
Topics: Antibiotic Prophylaxis; Echinocandins; Female; Fluconazole; Graft Rejection; Humans; Liver Diseases; | 2014 |
Caspofungin versus fluconazole as prophylaxis of invasive fungal infection in high-risk liver transplantation recipients: A propensity score analysis.
Topics: Adult; Aged; Alanine Transaminase; Antifungal Agents; Aspergillosis; Bilirubin; Caspofungin; Cohort | 2016 |
Hepatosplenic candidiasis imaged with F-18 FDG PET/CT.
Topics: Antifungal Agents; Candidiasis; Fluconazole; Fluorodeoxyglucose F18; Humans; Leukemia, Myeloid, Acut | 2009 |
Coccidioidomycosis in liver transplant recipients in an endemic area.
Topics: Adult; Antifungal Agents; Arizona; Coccidioidomycosis; Endemic Diseases; Female; Fluconazole; Humans | 2011 |
68-year-old man with neutropenic fever and upper extremity hematoma.
Topics: Aged; Antibodies, Monoclonal, Murine-Derived; Antifungal Agents; Antineoplastic Combined Chemotherap | 2012 |
The influence of cortisone and ACTH on experimental zonal necrosis of the liver.
Topics: Adrenocorticotropic Hormone; Cortisone; Fluconazole; Leadership; Liver Diseases; Necrosis | 1955 |
Experimental studies on the mechanism of the zonal distribution of beryllium liver necrosis.
Topics: Beryllium; Fluconazole; Liver; Liver Diseases | 1956 |
Experimental studies on the mechanism of the zonal distribution of beryllium liver necrosis.
Topics: Beryllium; Fluconazole; Liver; Liver Diseases | 1956 |
Experimental studies on the mechanism of the zonal distribution of beryllium liver necrosis.
Topics: Beryllium; Fluconazole; Liver; Liver Diseases | 1956 |
Experimental studies on the mechanism of the zonal distribution of beryllium liver necrosis.
Topics: Beryllium; Fluconazole; Liver; Liver Diseases | 1956 |
The blood alcohol curve in zonal necrosis of the liver.
Topics: Ethanol; Fluconazole; Humans; Liver Diseases | 1952 |
Pulmonary and hepatic toxicity due to nitrofurantoin and fluconazole treatment.
Topics: Aged; Antifungal Agents; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Fluconaz | 2004 |
Posaconazole prophylaxis in hematologic cancer.
Topics: Antifungal Agents; Bilirubin; Chemical and Drug Induced Liver Injury; Fluconazole; Graft vs Host Dis | 2007 |
Systemic illnesses unexpectedly presenting as acute appendicitis: case studies.
Topics: Acute Disease; Adult; Amphotericin B; Antifungal Agents; Appendicitis; Candidiasis; Female; Fluconaz | 2008 |
A radiologic syndrome after high dose chemotherapy and autologous bone marrow transplantation, with clinical and pathologic features of systemic candidiasis.
Topics: Adult; Amphotericin B; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Purging; Bone Mar | 1994 |
Fatal acute hepatic necrosis due to fluconazole.
Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Cimetidine; Fatal Outcome; Fluconazole; Human | 1995 |
Fatal acute hepatic necrosis due to fluconazole.
Topics: Acute Disease; Adult; AIDS-Related Opportunistic Infections; Chemical and Drug Induced Liver Injury; | 1994 |
Fluconazole prophylaxis for high-risk liver transplant recipients.
Topics: Adult; Candidiasis; Fluconazole; Hepatic Encephalopathy; Humans; Liver Diseases; Liver Transplantati | 1995 |
Invasive infection due to Candida krusei in immunocompromised patients not treated with fluconazole.
Topics: Abdominal Injuries; Adult; Aged; Breast Neoplasms; Candidiasis; Child; Child, Preschool; Female; Flu | 1995 |
Successful peritransplant therapy in children with active hepatosplenic candidiasis.
Topics: Amphotericin B; Bone Marrow Transplantation; Candidiasis; Child, Preschool; Female; Fluconazole; Hum | 1994 |
Evaluation of hepatic injury arising during fluconazole therapy.
Topics: Adult; Chemical and Drug Induced Liver Injury; Fluconazole; Humans; Liver Diseases; Liver Function T | 1994 |
Hepatic candidiasis: persistent pyrexia in a patient with acute myeloid leukaemia after recovery from consolidation therapy-induced neutropenia.
Topics: Adult; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Candidiasis; Cytosine; Eto | 1993 |
[Clinical efficacy of fluconazole against fungal infections in hematological diseases].
Topics: Adult; Antifungal Agents; Female; Fluconazole; Fungemia; Humans; Injections, Intravenous; Leukemia; | 1996 |
Clinical pharmacokinetics of fluconazole in superficial and systemic mycoses.
Topics: Age Factors; Antifungal Agents; Dose-Response Relationship, Drug; Fluconazole; Humans; Kidney Diseas | 1997 |
Hepatosplenic candidiasis after neutropenic phase of acute leukaemia.
Topics: Adult; Amphotericin B; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Candidiasi | 1999 |
Chronic systemic (hepatosplenic) candidiasis in a patient with granulocytic sarcoma.
Topics: Adult; Amphotericin B; Antifungal Agents; Antineoplastic Combined Chemotherapy Protocols; Candidiasi | 2000 |
Successful treatment of hepatosplenic candidiasis in an elderly patient with acute myeloid leukemia using liposomal daunorubicin and fluconazole.
Topics: Antibiotics, Antineoplastic; Antifungal Agents; Antineoplastic Agents; Candidiasis; Daunorubicin; Di | 2001 |
Successful treatment of chronic disseminated candidiasis with fluconazole and a granulocyte-macrophage colony-stimulating factor combination.
Topics: Adult; Antifungal Agents; Candidiasis; Drug Therapy, Combination; Female; Fluconazole; Granulocyte-M | 2001 |
Fluconazole in the treatment of hepatosplenic candidiasis.
Topics: Candidiasis; Fluconazole; Humans; Immunocompromised Host; Leukemia, Myeloid, Acute; Liver Diseases; | 1992 |
Hepatosplenic candidiasis: successful treatment with fluconazole.
Topics: Acute Disease; Adolescent; Adult; Amphotericin B; Candidiasis; Child; Child, Preschool; Fluconazole; | 1991 |
Amphotericin-resistant invasive hepatosplenic candidiasis controlled by fluconazole.
Topics: Adult; Amphotericin B; Candida albicans; Candidiasis; Drug Administration Schedule; Drug Resistance; | 1990 |
[Amphotericin B resistant severe hepato-splenic candidiasis, responding to fluconazole, in a patient following bone marrow transplantation].
Topics: Adult; Amphotericin B; Bone Marrow Transplantation; Candidiasis; Female; Fluconazole; Humans; Leukem | 1991 |