Compounds > sodium artesunate
Page last updated: 2024-11-13

sodium artesunate

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ID SourceID
PubMed CID44410736
CHEMBL ID207675
MeSH IDM0118764

Synonyms (4)

Synonym
sodium artesunate
sodium aresunate
CHEMBL207675
Q27275549
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (97)

Assay IDTitleYearJournalArticle
AID446171Antimalarial activity against Plasmodium falciparum K1 assessed as [3H]hypoxanthine incorporation by scintillation counting2010Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
Synthesis and antiplasmodial activity of new indolone N-oxide derivatives.
AID1177972Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcB1 infected in human RBC assessed as [3H]-hypoxanthine incorporation after 48 hrs by liquid scintillation counting analysis2014European journal of medicinal chemistry, Apr-09, Volume: 76Amino derivatives of indolone-N-oxide: preparation and antiplasmodial properties.
AID671461Antimalarial activity against asexual erythrocyte stage of chloroquine-sensitive Plasmodium falciparum D10 by parasite lactate dehydrogenase assay2012Bioorganic & medicinal chemistry, Aug-01, Volume: 20, Issue:15
Synthesis, antimalarial activity and cytotoxicity of 10-aminoethylether derivatives of artemisinin.
AID1698022Antileishmanial activity against Leishmania major IR-173 promastigotes assessed as inhibition of parasite growth incubated for 72 hrs by resazurin dye based assay2020Bioorganic & medicinal chemistry letters, 11-15, Volume: 30, Issue:22
In vitro efficacy of synthesized artemisinin derivatives against Leishmania promastigotes.
AID112571In vivo antimalarial activity against Plasmodium berghei. Activity expressed as ED90.1995Journal of medicinal chemistry, Feb-17, Volume: 38, Issue:4
Structure-activity relationships of lactone ring-opened analogs of the antimalarial 1,2,4-trioxane artemisinin.
AID383806Cytotoxicity against mouse Ehrlich Ascites carcinoma by trypan blue exclusion assay2008European journal of medicinal chemistry, Feb, Volume: 43, Issue:2
Bioactive peroxides as potential therapeutic agents.
AID1698024Selectivity index, ratio of IC50 for CHO cells to IC50 for antileishmanial activity against Leishmania donovani 1S by resazurin dye based assay2020Bioorganic & medicinal chemistry letters, 11-15, Volume: 30, Issue:22
In vitro efficacy of synthesized artemisinin derivatives against Leishmania promastigotes.
AID157668In vitro antimalarial activity for Plasmodium falciparum NF54 infected mice (Mus musculus)2004Journal of medicinal chemistry, Feb-26, Volume: 47, Issue:5
Anticancer and antimalarial efficacy and safety of artemisinin-derived trioxane dimers in rodents.
AID362330Binding affinity to methemoglobin in phosphate buffer at pH 7.0 over 30 mins by spectrophotometry2008Bioorganic & medicinal chemistry, Aug-15, Volume: 16, Issue:16
Heme activates artemisinin more efficiently than hemin, inorganic iron, or hemoglobin.
AID158673Effective dose against Plasmodium berghei N in mice (Mus musculus) malaria model after subcutaneous administration2002Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19
Structure-activity relationships of the antimalarial agent artemisinin. 7. Direct modification of (+)-artemisinin and in vivo antimalarial screening of new, potential preclinical antimalarial candidates.
AID332809Inhibition of Plasmodium berghei trophozoite cytochrome oxidase at 1 mM after 30 min by osmium black staining
AID235614Therapeutic index expressed as maximum tolerated / ED50 intravenously was determined2004Journal of medicinal chemistry, Feb-26, Volume: 47, Issue:5
Anticancer and antimalarial efficacy and safety of artemisinin-derived trioxane dimers in rodents.
AID107463Compound was tested for number of animals that remain safe when administered intraperitoneally in mice (total no of deaths =250); 1/32004Journal of medicinal chemistry, Feb-26, Volume: 47, Issue:5
Anticancer and antimalarial efficacy and safety of artemisinin-derived trioxane dimers in rodents.
AID113177In vivo antimalarial activity against Plasmodium berghei. Activity expressed as ED50.1995Journal of medicinal chemistry, Feb-17, Volume: 38, Issue:4
Structure-activity relationships of lactone ring-opened analogs of the antimalarial 1,2,4-trioxane artemisinin.
AID1698018Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 by LDH assay2020Bioorganic & medicinal chemistry letters, 11-15, Volume: 30, Issue:22
In vitro efficacy of synthesized artemisinin derivatives against Leishmania promastigotes.
AID319199Antimalarial activity against Plasmodium falciparum PH32008Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles.
AID362331Binding affinity to oxyhemoglobin in ammonium acetate buffer at pH 8.0 over 24 hrs by spectrophotometry2008Bioorganic & medicinal chemistry, Aug-15, Volume: 16, Issue:16
Heme activates artemisinin more efficiently than hemin, inorganic iron, or hemoglobin.
AID366932Antiplasmodial activity as survival in Plasmodium berghei ANKA infected BALB/c mice (Mus musculus) at 30 mg/kg peroral dose2009Journal of medicinal chemistry, Feb-26, Volume: 52, Issue:4
Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells.
AID113175In vivo antimalarial activity in mice (Mus musculus) infected with Plasmodium berghei NY malaria parasite after oral administration for 4 days (Experiment 1)2003Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6
Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers with high stability and efficacy.
AID118435Antimalarial activity against Plasmodium berghei in mice (Mus musculus) expressed as number of cures was determined at a dose of 160 mg/kg1987Journal of medicinal chemistry, Nov, Volume: 30, Issue:11
Antimalarial activity of new water-soluble dihydroartemisinin derivatives.
AID446172Cytotoxicity against human KB cells after 72 hrs by alamar blue assay2010Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
Synthesis and antiplasmodial activity of new indolone N-oxide derivatives.
AID753935Antiviral activity against Cytomegalovirus infected in HFF after 72 hrs by luciferase reporter gene assay2013Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13
Artemisinin-derived dimer phosphate esters as potent anti-cytomegalovirus (anti-CMV) and anti-cancer agents: a structure-activity study.
AID130254In vivo antimalarial activity against Plasmodium yoelii when administered subcutaneously2001Journal of medicinal chemistry, Jan-04, Volume: 44, Issue:1
Synthesis, antimalarial activity, biomimetic iron(II) chemistry, and in vivo metabolism of novel, potent C-10-phenoxy derivatives of dihydroartemisinin.
AID158674Effective dose ED90 against Plasmodium berghei N in mice (Mus musculus) malaria model after subcutaneous administration2002Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19
Structure-activity relationships of the antimalarial agent artemisinin. 7. Direct modification of (+)-artemisinin and in vivo antimalarial screening of new, potential preclinical antimalarial candidates.
AID130253In vivo antimalarial activity against Plasmodium berghei when administered perorally2001Journal of medicinal chemistry, Jan-04, Volume: 44, Issue:1
Synthesis, antimalarial activity, biomimetic iron(II) chemistry, and in vivo metabolism of novel, potent C-10-phenoxy derivatives of dihydroartemisinin.
AID158639Effective dose ED50 against Plasmodium berghei N in mice (Mus musculus) malaria model after peroral administration2002Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19
Structure-activity relationships of the antimalarial agent artemisinin. 7. Direct modification of (+)-artemisinin and in vivo antimalarial screening of new, potential preclinical antimalarial candidates.
AID319201Antimalarial activity against Plasmodium berghei ANKA infected mice (Mus musculus) by peroral dose2008Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles.
AID1251266Antiplasmodial activity against Plasmodium berghei ANKA early trophozoite stage by parasite LDH assay2015Journal of medicinal chemistry, Oct-08, Volume: 58, Issue:19
NO-Donor Dihydroartemisinin Derivatives as Multitarget Agents for the Treatment of Cerebral Malaria.
AID332808Inhibition of Plasmodium berghei trophozoite cytochrome oxidase after 30 min by osmium black staining
AID1594994Antileishmanial activity against late log/stationary phase of promastigote stage of Leishmania donovani MHOM/NP/02/BPK282/0c14 assessed as parasite growth inhibition after 72 hrs by plate reader based Alamar blue assay2019European journal of medicinal chemistry, May-15, Volume: 170Evaluation of synthetic substituted 1,2-dioxanes as novel agents against human leishmaniasis.
AID1595003Antileishmanial activity against promastigote stage of Leishmania donovani NLB-065 assessed as parasite growth inhibition after 72 hrs by microscopic analysis2019European journal of medicinal chemistry, May-15, Volume: 170Evaluation of synthetic substituted 1,2-dioxanes as novel agents against human leishmaniasis.
AID118436Antimalarial activity against Plasmodium berghei in mice (Mus musculus) expressed as number of cures was determined at a dose of 40 mg/kg1987Journal of medicinal chemistry, Nov, Volume: 30, Issue:11
Antimalarial activity of new water-soluble dihydroartemisinin derivatives.
AID1698019Cytotoxicity against CHO cells assessed as reduction in cell viability by MTT assay2020Bioorganic & medicinal chemistry letters, 11-15, Volume: 30, Issue:22
In vitro efficacy of synthesized artemisinin derivatives against Leishmania promastigotes.
AID319196Antimalarial activity against Plasmodium falciparum GC032008Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles.
AID158671Effective dose ED90 against Plasmodium berghei N in mice (Mus musculus) malaria model after peroral administration2002Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19
Structure-activity relationships of the antimalarial agent artemisinin. 7. Direct modification of (+)-artemisinin and in vivo antimalarial screening of new, potential preclinical antimalarial candidates.
AID446166Resistance index, ratio of IC50 for chloroquine-resistant Plasmodium falciparum FcB1 to IC50 for drug-sensitive Plasmodium falciparum 3D72010Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
Synthesis and antiplasmodial activity of new indolone N-oxide derivatives.
AID113176In vivo antimalarial activity in mice (Mus musculus) infected with Plasmodium berghei NY malaria parasite after oral administration for 4 days (Experiment 2)2003Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6
Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers with high stability and efficacy.
AID107464Compound was tested for number of animals that remain safe when administered intraperitoneally in mice (total no of deaths =500); 3/32004Journal of medicinal chemistry, Feb-26, Volume: 47, Issue:5
Anticancer and antimalarial efficacy and safety of artemisinin-derived trioxane dimers in rodents.
AID107475Compound was tested for weight gain in mice; markedly reduced2004Journal of medicinal chemistry, Feb-26, Volume: 47, Issue:5
Anticancer and antimalarial efficacy and safety of artemisinin-derived trioxane dimers in rodents.
AID158669Effective dose ED50 against Plasmodium berghei N and Plasmodium species infected mice (Mus musculus) after peroral dose2002Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19
Structure-activity relationships of the antimalarial agent artemisinin. 7. Direct modification of (+)-artemisinin and in vivo antimalarial screening of new, potential preclinical antimalarial candidates.
AID158642Effective dose ED50 against Plasmodium berghei N in mice (Mus musculus) malaria model after subcutaneous administration2002Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19
Structure-activity relationships of the antimalarial agent artemisinin. 7. Direct modification of (+)-artemisinin and in vivo antimalarial screening of new, potential preclinical antimalarial candidates.
AID461623Antiplasmodial activity against Plasmodium yoelii infected in perorally dosed mice (Mus musculus)2010Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
Structure-activity relationship and mechanism of action studies of manzamine analogues for the control of neuroinflammation and cerebral infections.
AID753933Cytotoxicity against PHA-stimulated human PBMC cells after 48 hrs by Alamar Blue assay2013Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13
Artemisinin-derived dimer phosphate esters as potent anti-cytomegalovirus (anti-CMV) and anti-cancer agents: a structure-activity study.
AID117994In vivo antimalarial activity in mice (Mus musculus) infected with Plasmodium berghei NY malaria parasite after oral administration determined as parasite suppression at 10 mg/kg (Experiment 1)2003Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6
Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers with high stability and efficacy.
AID1594995Cytotoxicity against African green monkey Vero cells after 72 hrs by plate reader based Alamar blue assay2019European journal of medicinal chemistry, May-15, Volume: 170Evaluation of synthetic substituted 1,2-dioxanes as novel agents against human leishmaniasis.
AID319197Antimalarial activity against Plasmodium falciparum V1/S2008Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles.
AID1126850Cytotoxicity against human MCF7 cells after 48 hrs by XTT reduction assay2014European journal of medicinal chemistry, May-06, Volume: 782-Aryl-3H-indol-3-ones: synthesis, electrochemical behaviour and antiplasmodial activities.
AID319194Antimalarial activity against Plasmodium falciparum DD22008Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles.
AID362333Binding affinity to methemoglobin in phosphate buffer at pH 5.0 over 30 mins by spectrophotometry2008Bioorganic & medicinal chemistry, Aug-15, Volume: 16, Issue:16
Heme activates artemisinin more efficiently than hemin, inorganic iron, or hemoglobin.
AID362328Binding affinity to oxyhemoglobin in phosphate buffer at pH 7.0 at room temperature over 24 hrs by spectrophotometry2008Bioorganic & medicinal chemistry, Aug-15, Volume: 16, Issue:16
Heme activates artemisinin more efficiently than hemin, inorganic iron, or hemoglobin.
AID112570In vivo antimalarial activity in mice (Mus musculus) infected with Plasmodium berghei NY malaria parasite after oral administration for 4 days (Experiment 2)2003Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6
Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers with high stability and efficacy.
AID158862Intrinsic equimolar activity against Plasmodium falciparum D6 (Sierra Leone) relative to QHS1988Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
Arteether, a new antimalarial drug: synthesis and antimalarial properties.
AID1698017Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 by LDH assay2020Bioorganic & medicinal chemistry letters, 11-15, Volume: 30, Issue:22
In vitro efficacy of synthesized artemisinin derivatives against Leishmania promastigotes.
AID1177973Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 48 hrs by XTT assay2014European journal of medicinal chemistry, Apr-09, Volume: 76Amino derivatives of indolone-N-oxide: preparation and antiplasmodial properties.
AID132763In vivo antimalarial activity against Plasmodium berghei when administered subcutaneously2001Journal of medicinal chemistry, Jan-04, Volume: 44, Issue:1
Synthesis, antimalarial activity, biomimetic iron(II) chemistry, and in vivo metabolism of novel, potent C-10-phenoxy derivatives of dihydroartemisinin.
AID671462Antimalarial activity against asexual erythrocyte stage of chloroquine-resistant Plasmodium falciparum Dd2 by parasite lactate dehydrogenase assay2012Bioorganic & medicinal chemistry, Aug-01, Volume: 20, Issue:15
Synthesis, antimalarial activity and cytotoxicity of 10-aminoethylether derivatives of artemisinin.
AID319198Antimalarial activity against Plasmodium falciparum HB32008Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles.
AID11254790% effective dose against Plasmodium yoelii in mice (Mus musculus)2002Journal of medicinal chemistry, Feb-28, Volume: 45, Issue:5
Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of new diamine containing analogues.
AID11005250% effective dose against Plasmodium yoelii in mice (Mus musculus)2002Journal of medicinal chemistry, Feb-28, Volume: 45, Issue:5
Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of new diamine containing analogues.
AID446169Selectivity index, ratio of CC50 for human MCF7 cells to IC50 for chloroquine-resistant Plasmodium falciparum FcB12010Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
Synthesis and antiplasmodial activity of new indolone N-oxide derivatives.
AID671464Resistance index ratio of IC50 for asexual erythrocyte stage of chloroquine-resistant Plasmodium falciparum Dd2 to IC50 for asexual erythrocyte stage of chloroquine-sensitive Plasmodium falciparum D102012Bioorganic & medicinal chemistry, Aug-01, Volume: 20, Issue:15
Synthesis, antimalarial activity and cytotoxicity of 10-aminoethylether derivatives of artemisinin.
AID446168Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay2010Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
Synthesis and antiplasmodial activity of new indolone N-oxide derivatives.
AID157682In vivo antimalarial activity against Plasmodium falciparum NF54 in mice (Mus musculus) by peroral dose2004Journal of medicinal chemistry, Feb-26, Volume: 47, Issue:5
Anticancer and antimalarial efficacy and safety of artemisinin-derived trioxane dimers in rodents.
AID446173Selectivity index, ratio of CC50 for human KB cells to IC50 for drug-sensitive Plasmodium falciparum 3D72010Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
Synthesis and antiplasmodial activity of new indolone N-oxide derivatives.
AID118437Antimalarial activity against Plasmodium berghei in mice (Mus musculus) expressed as number of cures was determined at a dose of 640 mg/kg1987Journal of medicinal chemistry, Nov, Volume: 30, Issue:11
Antimalarial activity of new water-soluble dihydroartemisinin derivatives.
AID753934Cytotoxicity against human JURKAT-TALL cells after 48 hrs by Alamar Blue assay2013Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13
Artemisinin-derived dimer phosphate esters as potent anti-cytomegalovirus (anti-CMV) and anti-cancer agents: a structure-activity study.
AID264146Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 in mice (Mus musculus) by subcutaneous dose2006Journal of medicinal chemistry, May-04, Volume: 49, Issue:9
Second generation, orally active, antimalarial, artemisinin-derived trioxane dimers with high stability, efficacy, and anticancer activity.
AID319200Antimalarial activity against Plasmodium falciparum TM42008Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles.
AID158641Effective dose Plasmodium berghei N in mice (Mus musculus) malaria model after subcutaneous administration2002Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19
Structure-activity relationships of the antimalarial agent artemisinin. 7. Direct modification of (+)-artemisinin and in vivo antimalarial screening of new, potential preclinical antimalarial candidates.
AID319193Antimalarial activity against Plasmodium falciparum 3D72008Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles.
AID1698023Selectivity index, ratio of IC50 for CHO cells to IC50 for antileishmanial activity against Leishmania donovani 9515 by resazurin dye based assay2020Bioorganic & medicinal chemistry letters, 11-15, Volume: 30, Issue:22
In vitro efficacy of synthesized artemisinin derivatives against Leishmania promastigotes.
AID1594996Selectivity index, ratio of CC50 for African green monkey Vero cells to IC50 for Leishmania donovani MHOM/NP/02/BPK282/0c142019European journal of medicinal chemistry, May-15, Volume: 170Evaluation of synthetic substituted 1,2-dioxanes as novel agents against human leishmaniasis.
AID158670Effective dose ED90 against Plasmodium berghei N in mice (Mus musculus) malaria model after peroral administration2002Journal of medicinal chemistry, Sep-12, Volume: 45, Issue:19
Structure-activity relationships of the antimalarial agent artemisinin. 7. Direct modification of (+)-artemisinin and in vivo antimalarial screening of new, potential preclinical antimalarial candidates.
AID1126849Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcB1 infected in RBC assessed as inhibition of [3H]-hypoxanthine incorporation after 48 hrs by beta-counting2014European journal of medicinal chemistry, May-06, Volume: 782-Aryl-3H-indol-3-ones: synthesis, electrochemical behaviour and antiplasmodial activities.
AID362332Binding affinity to oxyhemoglobin in phosphate buffer at pH 7.0 at 37 degC over 24 hrs by spectrophotometry2008Bioorganic & medicinal chemistry, Aug-15, Volume: 16, Issue:16
Heme activates artemisinin more efficiently than hemin, inorganic iron, or hemoglobin.
AID117995In vivo antimalarial activity in mice (Mus musculus) infected with Plasmodium berghei NY malaria parasite after oral administration determined as parasite suppression at 10 mg/kg (Experiment 2)2003Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6
Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers with high stability and efficacy.
AID338835Cytotoxicity against mouse EAC after 3 days by MTT assay1993Journal of natural products, Jun, Volume: 56, Issue:6
Cytotoxicity of artemisinin-related endoperoxides to Ehrlich ascites tumor cells.
AID446174Resistance index, ratio of IC50 for chloroquine-resistant Plasmodium falciparum K1 to IC50 for drug-sensitive Plasmodium falciparum 3D72010Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
Synthesis and antiplasmodial activity of new indolone N-oxide derivatives.
AID446167Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1 assessed as [3H]hypoxanthine incorporation after 48 hrs by beta-counter2010Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
Synthesis and antiplasmodial activity of new indolone N-oxide derivatives.
AID1698020Antileishmanial activity against Leishmania donovani 1S promastigotes assessed as inhibition of parasite growth incubated for 72 hrs by resazurin dye based assay2020Bioorganic & medicinal chemistry letters, 11-15, Volume: 30, Issue:22
In vitro efficacy of synthesized artemisinin derivatives against Leishmania promastigotes.
AID753932Therapeutic index, ratio of IC50 for PHA-stimulated human PBMC cells to IC50 for human JURKAT-TALL cells2013Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13
Artemisinin-derived dimer phosphate esters as potent anti-cytomegalovirus (anti-CMV) and anti-cancer agents: a structure-activity study.
AID319195Antimalarial activity against Plasmodium falciparum K12008Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles.
AID157681In vivo antimalarial activity against Plasmodium falciparum NF54 in mice (Mus musculus) by intravenous dose2004Journal of medicinal chemistry, Feb-26, Volume: 47, Issue:5
Anticancer and antimalarial efficacy and safety of artemisinin-derived trioxane dimers in rodents.
AID107462Compound was tested for number of animals that remain safe when administered intraperitoneally in mice (total no of deaths =125); 0/32004Journal of medicinal chemistry, Feb-26, Volume: 47, Issue:5
Anticancer and antimalarial efficacy and safety of artemisinin-derived trioxane dimers in rodents.
AID158863Intrinsic equimolar activity against Plasmodium falciparum W2 Indochina relative to QHS1988Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
Arteether, a new antimalarial drug: synthesis and antimalarial properties.
AID332811Inhibition of cytochrome oxidase in intraerythrocytic trophozoite of Plasmodium berghei infected CF1 mice (Mus musculus) at 100 mg/kg intravenous dose
AID1698025Selectivity index, ratio of IC50 for CHO cells to IC50 for antileishmanial activity against Leishmania major IR-173 by resazurin dye based assay2020Bioorganic & medicinal chemistry letters, 11-15, Volume: 30, Issue:22
In vitro efficacy of synthesized artemisinin derivatives against Leishmania promastigotes.
AID158856Inhibitory concentration against Plasmodium falciparum W2 Indochina1988Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
Arteether, a new antimalarial drug: synthesis and antimalarial properties.
AID332810Inhibition of Plasmodium berghei trophozoite cytochrome oxidase at 100 nM after 30 min by osmium black staining
AID1698021Antileishmanial activity against Leishmania donovani 9515 promastigotes assessed as inhibition of parasite growth incubated for 72 hrs by resazurin dye based assay2020Bioorganic & medicinal chemistry letters, 11-15, Volume: 30, Issue:22
In vitro efficacy of synthesized artemisinin derivatives against Leishmania promastigotes.
AID1177974Selectivity index, ratio of CC50 for human MCF7 cells to IC50 for chloroquine-resistant Plasmodium falciparum FcB12014European journal of medicinal chemistry, Apr-09, Volume: 76Amino derivatives of indolone-N-oxide: preparation and antiplasmodial properties.
AID1126851Selectivity index, ratio of CC50 for human MCF7 cells to IC50 for chloroquine-resistant Plasmodium falciparum FcB1 infected in RBC2014European journal of medicinal chemistry, May-06, Volume: 782-Aryl-3H-indol-3-ones: synthesis, electrochemical behaviour and antiplasmodial activities.
AID264147Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 in mice (Mus musculus) by peroral dose2006Journal of medicinal chemistry, May-04, Volume: 49, Issue:9
Second generation, orally active, antimalarial, artemisinin-derived trioxane dimers with high stability, efficacy, and anticancer activity.
AID446170Antimalarial activity against drug-sensitive Plasmodium falciparum 3D7 assessed as [3H]hypoxanthine incorporation by scintillation counting2010Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
Synthesis and antiplasmodial activity of new indolone N-oxide derivatives.
AID132762In vivo antimalarial activity against Plasmodium berghei when administered perorally2001Journal of medicinal chemistry, Jan-04, Volume: 44, Issue:1
Synthesis, antimalarial activity, biomimetic iron(II) chemistry, and in vivo metabolism of novel, potent C-10-phenoxy derivatives of dihydroartemisinin.
AID112569In vivo antimalarial activity in mice (Mus musculus) infected with Plasmodium berghei NY malaria parasite after oral administration for 4 days (Experiment 1)2003Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6
Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers with high stability and efficacy.
AID158855Inhibitory concentration against Plasmodium falciparum D6 (Sierra Leone)1988Journal of medicinal chemistry, Mar, Volume: 31, Issue:3
Arteether, a new antimalarial drug: synthesis and antimalarial properties.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (23)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (8.70)18.7374
1990's2 (8.70)18.2507
2000's10 (43.48)29.6817
2010's8 (34.78)24.3611
2020's1 (4.35)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.70

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index23.70 (24.57)
Research Supply Index3.22 (2.92)
Research Growth Index5.06 (4.65)
Search Engine Demand Index23.70 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (23.70)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (4.17%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other23 (95.83%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
caffeine
[no description available]		2.0510purine alkaloid;
trimethylxanthine		adenosine A2A receptor antagonist;
adenosine receptor antagonist;
adjuvant;
central nervous system stimulant;
diuretic;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
environmental contaminant;
food additive;
fungal metabolite;
geroprotector;
human blood serum metabolite;
mouse metabolite;
mutagen;
plant metabolite;
psychotropic drug;
ryanodine receptor agonist;
xenobiotic
chloroquine
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.		3.6490aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug
ciprofloxacin
Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.		2.0510aminoquinoline;
cyclopropanes;
fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone;
zwitterion		antibacterial drug;
antiinfective agent;
antimicrobial agent;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
environmental contaminant;
topoisomerase IV inhibitor;
xenobiotic
fluconazole
Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.. fluconazole : A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.		2.2110conazole antifungal drug;
difluorobenzene;
tertiary alcohol;
triazole antifungal drug		environmental contaminant;
P450 inhibitor;
xenobiotic
miltefosine
miltefosine: hexadecyl phosphocholine derivative of cisplatin; did not substantially activate HIV long terminal repeat; less toxic than cisplatin. miltefosine : A phospholipid that is the hexadecyl monoester of phosphocholine.		2.2110phosphocholines;
phospholipid		anti-inflammatory agent;
anticoronaviral agent;
antifungal agent;
antineoplastic agent;
antiprotozoal drug;
apoptosis inducer;
immunomodulator;
protein kinase inhibitor
mefloquine hydrochloride
[2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol : An organofluorine compound that consists of quinoline bearing trifluoromethyl substituents at positions 2 and 8 as well as a (2-piperidinyl)hydroxymethyl substituent at position 4.		2.3920organofluorine compound;
piperidines;
quinolines;
secondary alcohol
4-nitroquinoline-1-oxide
4-nitroquinoline N-oxide : A quinoline N-oxide carrying a nitro substituent at position 4.		2.0410C-nitro compound;
quinoline N-oxide		carcinogenic agent
cycloheximide
Cycloheximide: Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.. cycloheximide : A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.		3.1410antibiotic fungicide;
cyclic ketone;
dicarboximide;
piperidine antibiotic;
piperidones;
secondary alcohol		anticoronaviral agent;
bacterial metabolite;
ferroptosis inhibitor;
neuroprotective agent;
protein synthesis inhibitor
emetine
Emetine: The principal alkaloid of ipecac, from the ground roots of Uragoga (or Cephaelis) ipecacuanha or U. acuminata, of the Rubiaceae. It is used as an amebicide in many different preparations and may cause serious cardiac, hepatic, or renal damage and violent diarrhea and vomiting. Emetine inhibits protein synthesis in EUKARYOTIC CELLS but not PROKARYOTIC CELLS.. emetine : A pyridoisoquinoline comprising emetam having methoxy substituents at the 6'-, 7'-, 10- and 11-positions. It is an antiprotozoal agent and emetic. It inhibits SARS-CoV2, Zika and Ebola virus replication and displays antimalarial, antineoplastic and antiamoebic properties.		2.5320isoquinoline alkaloid;
pyridoisoquinoline		antiamoebic agent;
anticoronaviral agent;
antiinfective agent;
antimalarial;
antineoplastic agent;
antiprotozoal drug;
antiviral agent;
autophagy inhibitor;
emetic;
expectorant;
plant metabolite;
protein synthesis inhibitor
ascaridole
ascaridole: monoterpene endoperoxide with anthelmintic properties; structure given in first source. ascaridole : A p-menthane monoterpenoid that is p-menth-2-ene with a peroxy group across position 1 to 4.		1.9810organic heterobicyclic compound;
organic peroxide;
p-menthane monoterpenoid		antileishmanial agent;
antinematodal drug;
plant metabolite
2-anthramine
2-anthramine: structure		2.0410anthracenamine
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		3.1410taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
sitamaquine
[no description available]		2.2110
gemcitabine hydrochloride
[no description available]		2.0210hydrochloride;
organofluorine compound		anticoronaviral agent;
antimetabolite;
antineoplastic agent;
antiviral drug;
EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor;
immunosuppressive agent;
radiosensitizing agent
verapamil hydrochloride
verapamil hydrochloride : A racemate comprising equimolar amounts of dexverapamil hydrochloride and (S)-verapamil hydrochloride.		2.0510
artemisinin
(+)-artemisinin : A sesquiterpene lactone obtained from sweet wormwood, Artemisia annua, which is used as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria.		2.2110organic peroxide;
sesquiterpene lactone		antimalarial;
plant metabolite
artemether
Artemether: An artemisinin derivative that is used in the treatment of MALARIA.. artemether : An artemisinin derivative that is artemisinin in which the lactone has been converted to the corresponding lactol methyl ether. It is used in combination with lumefantrine as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria.		4.91110artemisinin derivative;
cyclic acetal;
organic peroxide;
semisynthetic derivative;
sesquiterpenoid		antimalarial
2-phenylisatogen
2-phenylisatogen: inhibitor of mitochondrial oxidative phosphorylation; structure		2.0510
2-phenylindolone
[no description available]		2.110
paromomycin
Paromomycin: An aminoglycoside antibacterial and antiprotozoal agent produced by species of STREPTOMYCES.. paromomycin : An amino cyclitol glycoside that is the 1-O-(2-amino-2-deoxy-alpha-D-glucopyranoside) and the 3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranoside of 4,6-diamino-2,3-dihydroxycyclohexane (the 1R,2R,3S,4R,6S diastereoisomer). It is obtained from various Streptomyces species. A broad-spectrum antibiotic, it is used (generally as the sulfate salt) for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoal infections. It is also used as a therapeutic against visceral leishmaniasis.		2.2110amino cyclitol glycoside;
aminoglycoside antibiotic		anthelminthic drug;
antibacterial drug;
antiparasitic agent;
antiprotozoal drug
mefloquine hydrochloride
[no description available]		2.0510
artemotil
artemotil: structure given in first source; RN given refers to cpd without isomeric designation		3.7830artemisinin derivative
quinine
[no description available]		2.4320cinchona alkaloidantimalarial;
muscle relaxant;
non-narcotic analgesic
epinephrine
ircinal A: from an Indonesian Acanthostrongylophora sponge with activity against infectious, tropical parasitic, and Alzheimer's diseases; structure in first source		2.0510
amphotericin b
Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.		2.8330antibiotic antifungal drug;
macrolide antibiotic;
polyene antibiotic		antiamoebic agent;
antiprotozoal drug;
bacterial metabolite
eupatoriopicrine
[no description available]		1.9810germacranolide
ergosterol-5,8-peroxide
ergosterol-5,8-peroxide: also inhibits sulfatase; isolated from fungus Cercospora kikuchii; structure given in first source. ergosterol peroxide : An ergostanoid that is ergosta-6,22-dien-3-ol with a peroxy group between positions 5 and 8 (the 3beta,5alpha,8alpha,22E stereoisomer). Isolated from Ganoderma lucidum and Cordyceps sinensis, it exhibits antimycobacterial, trypanocidal and antineoplastic activities.		3.14103beta-sterol;
ergostanoid;
organic peroxide;
phytosterols		antimycobacterial drug;
antineoplastic agent;
metabolite;
trypanocidal drug
manzamine a
manzamine A: RN given refers to (1R-(1R*,9Z,13S*,13aR*,20aR*,21aR*)-isomer; RN for cpd without isomeric designation not avail 12/92. manzamine A : An alkaloid of the class of beta-carbolines isolated from Haliclona and Acanthostrongylophora. It exhibits inhibitory activity against Glycogen Synthase Kinase-3 (EC 2.7.11.26).		2.0510alkaloid;
beta-carbolines;
isoquinolines		animal metabolite;
anti-HSV-1 agent;
antimalarial;
antineoplastic agent;
EC 2.7.11.26 (tau-protein kinase) inhibitor;
marine metabolite
arteannuin b
[no description available]		1.9810
dihydroartemisinin
[no description available]		2.6320sesquiterpenoidantimalarial
artenimol
artenimol: derivative of antimalarial drug artemisinin (quinghaosu)		4.3560
arterolane
arterolane: a trioxolane with antimalarial activity; structure in first source. arterolane : An oxaspiro compound that is dispiro[cyclohexane-1,3'-[1,2,4]trioxolane-5',2''-tricyclo[3.3.1.1(3,7)]decane] substituted by a 2-[(2-amino-2-methylpropyl)amino]-2-oxoethyl group at position 4s. Its maleic acid salt is used as an antimalarial drug in combination with piperaquine.		2.0510
artemisic acid
artemisic acid: isolated from Artemisia annua; MF: C28-H58-O; RN from Toxline. (+)-artemisinic acid : A monocarboxylic acid that is prop-2-enoic acid which is substituted at position 2 by a 4,7-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalen-1-yl group (the 1S,4R,4aS,8aR diastereoisomer). It is a sesquiterpenoid precursor of artemisinin, obtained from sweet wormwood, Artemisia annua.		1.9810carbobicyclic compound;
monocarboxylic acid;
octahydronaphthalenes;
sesquiterpenoid		metabolite
deoxyartemisinin
[no description available]		1.9710
amodiaquine hydrochloride
[no description available]		2.0410
rifampin
Rifampin: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)		2.0510cyclic ketal;
hydrazone;
N-iminopiperazine;
N-methylpiperazine;
rifamycins;
semisynthetic derivative;
zwitterion		angiogenesis inhibitor;
antiamoebic agent;
antineoplastic agent;
antitubercular agent;
DNA synthesis inhibitor;
EC 2.7.7.6 (RNA polymerase) inhibitor;
Escherichia coli metabolite;
geroprotector;
leprostatic drug;
neuroprotective agent;
pregnane X receptor agonist;
protein synthesis inhibitor
ganciclovir
[no description available]		2.08102-aminopurines;
oxopurine		antiinfective agent;
antiviral drug
ConditionIndicatedRelationship StrengthStudiesTrials
Infections, Plasmodium
[description not available]		03.2660
Malaria
A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.		03.2660
Carcinoma, Ehrlich Tumor
A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.		01.9810
Adenocarcinoma, Basal Cell
[description not available]		02.0210
Cancer of Prostate
[description not available]		02.0210
Adenocarcinoma
A malignant epithelial tumor with a glandular organization.		02.0210
Prostatic Neoplasms
Tumors or cancer of the PROSTATE.		02.0210
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.0410
Parasitemia
The presence of parasites (especially malarial parasites) in the blood. (Dorland, 27th ed)		02.0510
Neurogenic Inflammation
Inflammation caused by an injurious stimulus of peripheral neurons and resulting in release of neuropeptides which affect vascular permeability and help initiate proinflammatory and immune reactions at the site of injury.		02.0510
Cerebellar Diseases
Diseases that affect the structure or function of the cerebellum. Cardinal manifestations of cerebellar dysfunction include dysmetria, GAIT ATAXIA, and MUSCLE HYPOTONIA.		02.0510
Cytomegalic Inclusion Disease
[description not available]		02.0810
Leucocythaemia
[description not available]		02.0810
Cytomegalovirus Infections
Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.		02.0810
Cytomegalovirus
A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.		02.0810
Leukemia
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)		02.0810
Cerebral Malaria
[description not available]		02.1110
Muscle Relaxation
That phase of a muscle twitch during which a muscle returns to a resting position.		02.1110
Leishmania Infection
[description not available]		02.2110
Leishmaniasis
A disease caused by any of a number of species of protozoa in the genus LEISHMANIA. There are four major clinical types of this infection: cutaneous (Old and New World) (LEISHMANIASIS, CUTANEOUS), diffuse cutaneous (LEISHMANIASIS, DIFFUSE CUTANEOUS), mucocutaneous (LEISHMANIASIS, MUCOCUTANEOUS), and visceral (LEISHMANIASIS, VISCERAL).		02.2110