ketamine has been researched along with Alcohol Problem in 5 studies
Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Subjects were diagnosed with either major depressive disorder (MDD) or bipolar depression." | 2.55 | Symptomatology and predictors of antidepressant efficacy in extended responders to a single ketamine infusion. ( Luckenbaugh, DA; Niciu, MJ; Pennybaker, SJ; Zarate, CA, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vranjkovic, O | 1 |
| Winkler, G | 1 |
| Winder, DG | 1 |
| Niciu, MJ | 2 |
| Luckenbaugh, DA | 2 |
| Ionescu, DF | 1 |
| Richards, EM | 1 |
| Vande Voort, JL | 2 |
| Ballard, ED | 1 |
| Brutsche, NE | 1 |
| Furey, ML | 1 |
| Zarate, CA | 2 |
| Schak, KM | 1 |
| Johnson, EK | 1 |
| Kung, S | 1 |
| Leung, JG | 1 |
| Rasmussen, KG | 1 |
| Palmer, BA | 1 |
| Frye, MA | 1 |
| Pennybaker, SJ | 1 |
| Kim, SY | 1 |
| Anderson, IB | 1 |
| Dyer, JE | 1 |
| Barker, JC | 1 |
| Blanc, PD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Investigation of the Rapid (Next Day) Antidepressant Effects of an NMDA Antagonist[NCT00088699] | Phase 1/Phase 2 | 67 participants (Actual) | Interventional | 2004-07-26 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Antidepressant effects were assessed using the Montgomery-Åsberg Depression Rating Scale (MADRS). It is a ten-item diagnostic questionnaire which psychiatrists use to measure the severity of depressive episodes. Higher MADRS score indicates more severe depression, and each item yields a score of 0 to 6. The overall score ranges from 0 to 60. (NCT00088699)
Timeframe: Baseline
| Intervention | units on a scale (Mean) |
|---|---|
| Ketamine - Healthy Volunteers | 1.17 |
| Placebo - Healthy Volunteers | 1.48 |
| Ketamine - MDD Patients | 33.83 |
| Placebo - MDD Patients | 31.82 |
Antidepressant effects were assessed using the Montgomery-Åsberg Depression Rating Scale (MADRS). It is a ten-item diagnostic questionnaire which psychiatrists use to measure the severity of depressive episodes. Higher MADRS score indicates more severe depression, and each item yields a score of 0 to 6. The overall score ranges from 0 to 60. (NCT00088699)
Timeframe: Day 1
| Intervention | units on a scale (Mean) |
|---|---|
| Ketamine - Healthy Volunteers | 2.45 |
| Placebo - Healthy Volunteers | 0.67 |
| Ketamine - MDD Patients | 23.73 |
| Placebo - MDD Patients | 30.68 |
1 review available for ketamine and Alcohol Problem
| Article | Year |
|---|---|
Symptomatology and predictors of antidepressant efficacy in extended responders to a single ketamine infusion.
Topics: Adult; Alcohol-Related Disorders; Antidepressive Agents; Bipolar Disorder; Depressive Disorder, Majo | 2017 |
1 trial available for ketamine and Alcohol Problem
| Article | Year |
|---|---|
Ketamine's antidepressant efficacy is extended for at least four weeks in subjects with a family history of an alcohol use disorder.
Topics: Adolescent; Adult; Aged; Alcohol-Related Disorders; Antidepressive Agents; Depressive Disorder, Majo | 2014 |
3 other studies available for ketamine and Alcohol Problem
| Article | Year |
|---|---|
Ketamine administration during a critical period after forced ethanol abstinence inhibits the development of time-dependent affective disturbances.
Topics: Affect; Alcohol-Related Disorders; Animals; Disease Models, Animal; Female; Ketamine; Long-Term Pote | 2018 |
Potential Risks of Poorly Monitored Ketamine Use in Depression Treatment.
Topics: Alcohol-Related Disorders; Analgesics; Antidepressive Agents; Depressive Disorder, Major; Depressive | 2016 |
High-risk behaviors and hospitalizations among gamma hydroxybutyrate (GHB) users.
Topics: Adult; Alcohol Withdrawal Delirium; Alcohol-Related Disorders; Analgesics; Automobile Driving; Comor | 2007 |