Page last updated: 2024-09-28

Funnel Chest

A developmental anomaly in which the lower sternum is posteriorly dislocated and concavely deformed, resulting in a funnel-shaped thorax.

Synonyms(2)

Synonym
Funnel Chest
Pectus Excavatum

Research Excerpts

Overview

ExcerptReference
"Pectus excavatum is a progressive congenital deformity for which surgical correction is an established procedure."( Akins, CW; McMillan, IK; Sbokos, CG, 1975)
"Pectus excavatum is a common malformation in diseases of elastic tissue (Marfan, Ehlers-Danlos."( Bonnet, J; Bricaud, H; Chanudet, X; Duret, JC; Larrue, J; Saint-Mézard, G, 1986)
"Pectus excavatum is the most common congenital hereditary chest-wall deformity."( Morcate, JJ; Saxena, AK; Schaarschmidt, K; Schleef, J; Willital, GH, 1999)
"Pectus excavatum is a congenital chest abnormality which may become more marked during childhood and teenage growth."( Haller, JA; Loughlin, GM, 2000)
"Funnel chest is the most common anterior chest wall deformity, it results from posterior depression of the sternum and cartilages, from the third to the eighth; it occurs more frequently in boys than in girls (4:1 ratio)."( Fiorini, E; Moretto, G; Nardo, A; Pellini, F; Pollini, GP; Sandrini, R; Stimamiglio, P, 2000)
"Meanwhile, although funnel chest is generally a subclinical condition, patients with this deformity may sometimes present with cardiac failure and chest pain."( Akami, T; Matsumura, A; Matsuyama, T; Mugitani, T; Nishibeppu, K; Ogino, S; Shimode, Y; Takemura, M, 2013)
"Surgery for pectus excavatum is associated with significant postoperative pain."( Archer, V; Fitzgerald, P; Kattail, D; Robinson, T; Walton, JM, 2020)
"Pectus excavatum is a common chest wall deformity amenable to surgical correction, most commonly by a technique known as the Nuss Procedure."( Chun, Y; Garcia, A; Hunsberger, J; Jelin, E; Stewart, D; Wharton, K, 2020)
"Pectus excavatum is often managed with the Nuss procedure."( Bouchard, ME; Kane, TD; Petrosyan, M, 2021)
"Pectus excavatum is the most common congenital chest wall abnormality, with the Nuss procedure being the most commonly performed repair."( DeAngelo, N; Perez Holguin, RA; Shen, C; Sinha, A; Tsai, AY, 2023)
"The Nuss repair for pectus excavatum is associated with significant postoperative pain."( Cockrell, HC; Hrachovec, J; Meehan, J; Nchinda, N; Schnuck, J, 2023)

Research

Studies (169)

TimeframeStudies, This Condition (%)All Conditions %
pre-199030 (17.75)23.3326
1990's18 (10.65)12.5806
2000's24 (14.20)18.1394
2010's54 (31.95)28.8240
2020's43 (25.44)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0low10
lactic acid0low40
nickel0low90
nitrous oxide0low20
taurine0low10
amiodarone0low10
bupivacaine0medium115
clonidine0medium21
diclofenac0medium21
enflurane0low20
fentanyl0medium97
fluorouracil0low10
gabapentin0low20
halothane0low20
ibuprofen0low10
lidocaine0medium31
ketamine0medium21
ketoprofen0medium11
khellin0low10
methadone0medium11
midazolam0medium11
neostigmine0low10
nimodipine0low10
oxonic acid0low10
sevoflurane0low20
succinylcholine0low10
tegafur0low10
hydroxyproline0low10
cyanides0low10
isoprene0low30
acrylonitrile0low10
framycetin0low10
isoxazoles0low10
cyanogen bromide0low10
molybdenum0low10
palladium0low10
samarium0low10
technetium0low10
titanium0medium172
chromium0low40
palladium chloride0low10
barium sulfate0low10
trolamine salicylate0low10
cefazolin0low10
epirubicin0low10
fomesafen0low10
xenon radioisotopes0low10
homocysteine0low10
levobupivacaine0medium21
titanium nitride (tin)0low10
cobalt0low30
pyridinoline0low10
parecoxib0low10
ivabradine0low10
docetaxel anhydrous0low10
atropine0low10
ropivacaine0medium31
glycogen0low20
elastin0low10
clindamycin0low10
dipyrone0low10
safranine t0low10
cobaltous chloride0low10
nitinol0low20
vitamin k semiquinone radical0low10
rutin0low10
hydromorphone0medium22
oxycodone0medium11
morphine0medium163
tin0low10
silicon0low10
troxerutin0low10
enerbol0low10
mme0low10
chondroitin0low10
s 1 (combination)0low10
technetium tc 99m sulfur colloid0low10
technetium tc 99m medronate0low10
muramidase0low10

Protein Targets (782)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
GLI family zinc finger 3130013
aldehyde dehydrogenase 1 family, member A19009
thyroid stimulating hormone receptor7007
retinoic acid nuclear receptor alpha variant 1120012
estrogen nuclear receptor alpha190019
thyroid hormone receptor beta isoform 2100010
Cellular tumor antigen p53100010
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
acetylcholinesterase8008
phosphopantetheinyl transferase3003
hypoxia-inducible factor 1 alpha subunit4004
RAR-related orphan receptor gamma120012
SMAD family member 23003
ATAD5 protein, partial5005
Fumarate hydratase3003
USP1 protein, partial8008
NFKB1 protein, partial2002
PPM1D protein4004
SMAD family member 33003
TDP1 protein8008
Thrombopoietin2002
AR protein160016
caspase 7, apoptosis-related cysteine protease3003
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
estrogen receptor 2 (ER beta)5005
nuclear receptor subfamily 1, group I, member 3100010
progesterone receptor7007
EWS/FLI fusion protein6006
glucocorticoid receptor [Homo sapiens]120012
retinoid X nuclear receptor alpha7007
estrogen-related nuclear receptor alpha120012
farnesoid X nuclear receptor7007
pregnane X nuclear receptor110011
G5005
cytochrome P450 2D67007
polyprotein3003
peroxisome proliferator-activated receptor delta6006
peroxisome proliferator activated receptor gamma8008
caspase-33003
euchromatic histone-lysine N-methyltransferase 2180018
thyroid stimulating hormone receptor6006
v-jun sarcoma virus 17 oncogene homolog (avian)6006
Histone H2A.x6006
cytochrome P450 2D6 isoform 15005
cellular tumor antigen p53 isoform a4004
cytochrome P450 2C9 precursor2002
D(1A) dopamine receptor4004
chromobox protein homolog 1110011
thyroid hormone receptor beta isoform a2002
potassium voltage-gated channel subfamily H member 2 isoform d4004
heat shock protein beta-12002
huntingtin isoform 22002
mitogen-activated protein kinase 15005
flap endonuclease 14004
serine/threonine-protein kinase mTOR isoform 13003
nuclear factor erythroid 2-related factor 2 isoform 1120012
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
nuclear receptor ROR-gamma isoform 14004
geminin130013
peripheral myelin protein 228008
survival motor neuron protein isoform d5005
cytochrome P450 3A4 isoform 16006
muscarinic acetylcholine receptor M15005
lethal factor (plasmid)3003
lamin isoform A-delta10160016
Gamma-aminobutyric acid receptor subunit pi6309
Polyunsaturated fatty acid lipoxygenase ALOX15B3003
ATP-binding cassette sub-family C member 3010010
Multidrug resistance-associated protein 4010011
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Solute carrier organic anion transporter family member 1A40202
Voltage-dependent L-type calcium channel subunit alpha-1F0303
5-hydroxytryptamine receptor 40606
Lysine-specific demethylase PHF20101
Bile salt export pump018018
Interferon beta8008
HLA class I histocompatibility antigen, B alpha chain 5005
Thyroid hormone receptor alpha0101
Receptor tyrosine-protein kinase erbB-20202
Integrin beta-34004
Tyrosine-protein kinase Fyn0303
ATP-dependent translocase ABCB10303
Aldo-keto reductase family 1 member B10505
Muscarinic acetylcholine receptor M206110
Muscarinic acetylcholine receptor M40619
ATP-dependent translocase ABCB108210
Integrin alpha-IIb4004
Beta-1 adrenergic receptor0404
Muscarinic acetylcholine receptor M50619
Alpha-2A adrenergic receptor0729
Adenosine receptor A30505
Cytochrome P450 2C80101
Thyroid hormone receptor alpha0101
Thyroid hormone receptor beta0101
Muscarinic acetylcholine receptor M106110
Beta-3 adrenergic receptor0404
D(2) dopamine receptor0606
Androgen receptor0404
Gamma-aminobutyric acid receptor subunit beta-16309
Alpha-1B adrenergic receptor0505
Lethal factor0202
Alpha-2B adrenergic receptor0628
Thyroid hormone receptor beta0101
Gamma-aminobutyric acid receptor subunit delta6309
Gamma-aminobutyric acid receptor subunit gamma-263110
Gamma-aminobutyric acid receptor subunit alpha-56309
Gamma-aminobutyric acid receptor subunit alpha-36309
Muscarinic acetylcholine receptor M30619
ATP-dependent translocase ABCB10303
Substance-K receptor0404
D(1A) dopamine receptor0404
D(4) dopamine receptor0606
Gamma-aminobutyric acid receptor subunit gamma-16309
Gamma-aminobutyric acid receptor subunit alpha-26309
Carnitine O-palmitoyltransferase 2, mitochondrial0101
Sodium-dependent noradrenaline transporter 0404
Histamine H2 receptor0404
Endothelin-1 receptor0202
5-hydroxytryptamine receptor 2A0404
5-hydroxytryptamine receptor 2C0606
Gamma-aminobutyric acid receptor subunit alpha-46309
Gamma-aminobutyric acid receptor subunit gamma-36309
Lysine-specific demethylase 5A0101
Gamma-aminobutyric acid receptor subunit alpha-66309
B2 bradykinin receptor0404
Sodium-dependent serotonin transporter0404
Melanocortin receptor 40404
C-8 sterol isomerase0202
Melanocortin receptor 50404
Mu-type opioid receptor012417
D(3) dopamine receptor0606
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0303
Squalene synthase0101
Delta-type opioid receptor010213
Kappa-type opioid receptor010314
5-hydroxytryptamine receptor 2B0404
C-C chemokine receptor type 20202
Melanocortin receptor 30404
Alpha-1A adrenergic receptor0516
Histamine H2 receptor4005
D(1A) dopamine receptor2002
5-hydroxytryptamine receptor 60404
Carnitine O-palmitoyltransferase 1, liver isoform0101
C-C chemokine receptor type 40202
Spike glycoprotein110112
Gamma-aminobutyric acid receptor subunit alpha-163110
Gamma-aminobutyric acid receptor subunit beta-36309
Gamma-aminobutyric acid receptor subunit beta-263110
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0303
Sodium-dependent dopamine transporter 0404
Potassium voltage-gated channel subfamily H member 20909
Voltage-dependent L-type calcium channel subunit alpha-1S0303
Voltage-dependent L-type calcium channel subunit alpha-1C0404
Sodium channel protein type 5 subunit alpha0202
Squalene monooxygenase0101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0314
Sodium channel protein type 9 subunit alpha0202
Lysine-specific demethylase 7A0101
GABA theta subunit6309
Carnitine O-palmitoyltransferase 1, muscle isoform0101
Inositol hexakisphosphate kinase 15005
Canalicular multispecific organic anion transporter 1010010
Sodium channel protein type 2 subunit alpha0101
Ataxin-24004
Sigma non-opioid intracellular receptor 10819
Gamma-aminobutyric acid receptor subunit epsilon6309
NAD-dependent protein deacetylase sirtuin-3, mitochondrial0011
Sodium channel protein type 3 subunit alpha0202
Sodium channel protein type 11 subunit alpha0101
Histone lysine demethylase PHF80101
Sodium channel protein type 8 subunit alpha0101
Sodium channel protein type 10 subunit alpha0101
cytochrome P450 2C9, partial5005
ATP-dependent phosphofructokinase6006
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE9009
Chain A, Mutant Al2 6e7p9g0011
Chain A, Beta-lactamase7007
Chain A, 2-oxoglutarate Oxygenase5005
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, Cruzipain5005
Beta-lactamase 0002
acid sphingomyelinase1001
GLS protein5005
apical membrane antigen 1, AMA13003
Beta-lactamase 0102
Beta-lactamase 0002
Metallo-beta-lactamase type 20002
Metallo-beta-lactamase VIM-11 0002
Metallo-beta-lactamase VIM-20002
Beta-lactamase 0103
Metallo-beta-lactamase0002
Beta-lactamase 0102
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
DNA polymerase beta3003
DNA polymerase eta isoform 11001
DNA polymerase iota isoform a (long)3003
DNA polymerase kappa isoform 14004
Carbonic anhydrase 10404
Carbonic anhydrase 20404
60 kDa heat shock protein, mitochondrial0101
Beta-lactamase OXA-70001
Solute carrier family 15 member 10404
Solute carrier family 15 member 10101
10 kDa heat shock protein, mitochondrial0101
Angiopoietin-1 receptor0011
Beta-lactamase 0103
Beta-lactamase 0103
Beta-lactamase 0103
Solute carrier family 15 member 20202
Thiosulfate sulfurtransferase0101
Metallo-beta-lactamase VIM-130002
Efflux transporter 0001
Beta-lactamase 0002
Beta-lactamase Toho-10002
Beta-lactamase 0001
Class D beta-lactamase0102
60 kDa chaperonin 0101
Metallo-beta-lactamase0002
Solute carrier family 15 member 20202
Beta-lactamase 0103
Beta-lactamase 0001
10 kDa chaperonin 0101
Metallo-b-lactamase 0003
Carbapenem-hydrolyzing beta-lactamase KPC0103
Histamine H3 receptor0002
Beta-lactamase class B VIM-2 0003
Beta-lactamase VIM-1 0002
Chain A, Hyaluronidase, phage associated0101
thioredoxin glutathione reductase4004
cytochrome P450 family 3 subfamily A polypeptide 49009
vitamin D (1,25- dihydroxyvitamin D3) receptor110011
IDH16006
nuclear factor erythroid 2-related factor 2 isoform 22002
lethal(3)malignant brain tumor-like protein 1 isoform I1001
Polyphenol oxidase 20202
Pancreatic alpha-amylase0202
Albumin0303
Urease0101
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0101
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
cystic fibrosis transmembrane conductance regulator0101
short transient receptor potential channel 6 isoform 10011
Solute carrier family 22 member 1 08010
Muscarinic acetylcholine receptor M10316
Muscarinic acetylcholine receptor M30316
Muscarinic acetylcholine receptor M40316
Muscarinic acetylcholine receptor M50316
Muscarinic acetylcholine receptor M20317
Muscarinic acetylcholine receptor M10001
Alpha-1D adrenergic receptor0617
Muscarinic acetylcholine receptor M40101
5-hydroxytryptamine receptor 70303
Reverse transcriptase/RNaseH 0001
Muscarinic acetylcholine receptor0112
Potassium channel subfamily K member 30303
Potassium channel subfamily K member 30101
Potassium channel subfamily K member 20112
Potassium channel subfamily K member 90101
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Chain A, JmjC domain-containing histone demethylation protein 3A3003
Luciferase7007
thioredoxin reductase8008
Smad31001
vitamin D3 receptor isoform VDRA4004
Solute carrier family 22 member 60404
Solute carrier family 22 member 60505
Solute carrier family 22 member 80404
Solute carrier family 22 member 110202
Solute carrier family 22 member 80202
Beta-lactamase 0001
Beta-lactamase 0102
Beta-lactamase 0001
Beta-lactamase 0102
Beta-lactamase 0001
Beta-lactamase 0102
Metallo-beta-lactamase VIM-19 0001
Beta-lactamase 0102
Albumin0437
Beta-lactamase SHV-10001
Beta-lactamase SHV-10102
Beta-lactamase0102
Kappa-type opioid receptor0506
B2 metallo-beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0102
Metallo-beta-lactamase VIM-20001
Beta-lactamase 0001
Solute carrier family 22 member 70202
Beta-lactamase 0001
BlaVIM-1 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Solute carrier family 22 member 70101
Protein-arginine deiminase type-40101
Chain A, Ferritin light chain5005
regulator of G-protein signaling 48008
Beta-1 adrenergic receptor 0011
arylsulfatase A8008
Alpha-1B adrenergic receptor 0011
cytochrome P450 2C19 precursor3003
Membrane primary amine oxidase 0101
5-hydroxytryptamine receptor 3A0011
Solute carrier family 22 member 30203
5-hydroxytryptamine receptor 1A0101
Alpha-1A adrenergic receptor0011
Alpha-2C adrenergic receptor0314
D0101
D(3) dopamine receptor0101
5-hydroxytryptamine receptor 1A0505
Alpha-2B adrenergic receptor0202
Amine oxidase [flavin-containing] A0202
Alpha-2C adrenergic receptor0202
Alpha-2A adrenergic receptor0202
Alpha-1D adrenergic receptor0101
D(1B) dopamine receptor0101
Amine oxidase [flavin-containing] B0202
5-hydroxytryptamine receptor 1B0404
Adenosine receptor A2b0011
Adenosine receptor A2a0213
Alpha-2B adrenergic receptor0001
D(4) dopamine receptor0101
Delta-type opioid receptor0405
Alpha-1A adrenergic receptor0112
Alpha-1B adrenergic receptor0112
D(2) dopamine receptor0101
Mu-type opioid receptor0606
Inositol monophosphatase 12002
Alpha-2C adrenergic receptor0001
Alpha-2A adrenergic receptor0001
Alpha-2A adrenergic receptor0101
Nischarin0202
Solute carrier family 22 member 10101
Multidrug and toxin extrusion protein 10303
Nischarin0101
Carbonic anhydrase 40101
Carbonic anhydrase0101
Carbonic anhydrase 150101
Aldo-keto reductase family 1 member B100101
UDP-glucuronosyltransferase 1A90102
Prostaglandin G/H synthase 1 0202
Transient receptor potential cation channel subfamily A member 10011
Dihydrofolate reductase0202
Cytochrome c oxidase subunit 20101
Fatty acid-binding protein, liver0202
Transthyretin0013
Prostaglandin G/H synthase 10404
Cytochrome P450 3A40617
Interleukin-80101
Calcium/calmodulin-dependent protein kinase type II subunit alpha0101
Cytochrome P450 2C9 0607
Fatty acid-binding protein, intestinal0303
Aldo-keto reductase family 1 member B10202
UDP-glucuronosyltransferase 2B70206
UDP-glucuronosyltransferase 1-60303
UDP-glucuronosyltransferase 1A1 0303
UDP-glucuronosyltransferase 1A40203
Prostaglandin G/H synthase 10404
Sodium- and chloride-dependent GABA transporter 10202
C-X-C chemokine receptor type 10101
Sodium- and chloride-dependent GABA transporter 20202
Sodium- and chloride-dependent GABA transporter 30202
Prostaglandin G/H synthase 20404
Prostaglandin G/H synthase 2 0203
UDP-glucuronosyltransferase 1A30004
UDP-glucuronosyltransferase 2B10 0202
Sodium- and chloride-dependent betaine transporter0202
Cytochrome P450 2J20404
Prostaglandin G/H synthase 20404
Prostaglandin G/H synthase 20202
Carbonic anhydrase 90101
Prostaglandin G/H synthase 1 0203
Carbonic anhydrase 40101
P2Y purinoceptor 120101
UDP-glucuronosyltransferase 1A70101
UDP-glucuronosyltransferase 1A100101
15-lipoxygenase, partial1001
Microtubule-associated protein tau7007
polyunsaturated fatty acid lipoxygenase ALOX121001
histone acetyltransferase KAT2A isoform 15005
67.9K protein4004
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a5005
nuclear receptor subfamily 1, group I, member 21001
Serum paraoxonase/arylesterase 10202
Kinesin-like protein KIF110101
ATPase family AAA domain-containing protein 53003
Nucleotide-binding oligomerization domain-containing protein 20101
Genome polyprotein 0101
Nuclear receptor subfamily 1 group I member 20022
Delta-type opioid receptor0517
Mu-type opioid receptor05210
Kappa-type opioid receptor0416
Histamine H1 receptor0101
Mu-type opioid receptor0327
Sigma non-opioid intracellular receptor 10202
Sigma non-opioid intracellular receptor 10112
Chain A, Uracil Phosphoribosyltransferase0101
interleukin 82002
endonuclease IV2002
glp-1 receptor, partial3003
Skn7p0001
pregnane X receptor2002
nonstructural protein 13003
peripheral myelin protein 22 isoform 13003
hemoglobin subunit beta1001
Vpr1001
muscleblind-like protein 1 isoform 13003
Voltage-dependent calcium channel gamma-2 subunit3003
Solute carrier family 22 member 80001
Epidermal growth factor receptor0404
Amyloid-beta precursor protein1001
Thymidylate synthase0101
Aromatase0101
Glutamate receptor 23003
HSP40, subfamily A [Plasmodium falciparum 3D7]0001
Menin0011
Lecithin retinol acyltransferase0101
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
50S ribosomal protein L36 20101
Protein Rev 0011
Aminoglycoside 3'-phosphotransferase 0001
Tyrosyl-DNA phosphodiesterase 10101
Bloom syndrome protein isoform 14004
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
Voltage-dependent calcium channel subunit alpha-2/delta-10101
Gamma-aminobutyric acid 0011
Gamma-aminobutyric acid receptor subunit rho-30011
Hsf1 protein0011
bromodomain adjacent to zinc finger domain 2B3003
transcriptional regulator ERG isoform 33003
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
neuropeptide S receptor isoform A2002
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Histone deacetylase 30101
Gamma-aminobutyric acid type B receptor subunit 20011
Gamma-aminobutyric acid type B receptor subunit 20101
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit alpha-60011
Gamma-aminobutyric acid receptor subunit beta-10112
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit delta0011
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit gamma-30011
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit rho-20011
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0202
Gamma-aminobutyric acid receptor subunit alpha-50112
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-30112
Gamma-aminobutyric acid receptor subunit alpha-20112
Gamma-aminobutyric acid receptor subunit beta-20112
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-40112
Gamma-aminobutyric acid receptor subunit beta-10011
Histone deacetylase 40101
Gamma-aminobutyric acid receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit beta-30011
Gamma-aminobutyric acid receptor subunit epsilon0101
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
TAR DNA-binding protein 433003
Histone deacetylase 10101
Gamma-aminobutyric acid receptor subunit alpha-60112
Sterol O-acyltransferase 10011
Proton-coupled amino acid transporter 10303
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit pi0011
Histone deacetylase 70101
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Gamma-aminobutyric acid receptor subunit gamma-30101
Histone deacetylase 80101
Gamma-aminobutyric acid receptor subunit alpha-40011
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0011
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10011
Histone deacetylase 60101
Gamma-aminobutyric acid type B receptor subunit 10011
Histone deacetylase 90101
Gamma-aminobutyric acid receptor subunit theta0101
Histone deacetylase 50101
Gamma-aminobutyric acid type B receptor subunit 10101
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10101
Neutral amino acid transporter A0101
Asc-type amino acid transporter 10101
Neutral amino acid transporter B(0)0101
Amino acid transporter0101
aryl hydrocarbon receptor5005
importin subunit beta-1 isoform 12002
snurportin-12002
Acid-sensing ion channel 30101
Prostaglandin G/H synthase 2 0101
Bile salt export pump0101
Albumin0011
Cholinesterase0303
Polyunsaturated fatty acid 5-lipoxygenase0102
Acetylcholinesterase0404
Prostaglandin G/H synthase 10101
Adenosine receptor A10101
Caspase-10202
Substance-P receptor0202
Aldo-keto reductase family 1 member C30101
Caspase-30202
Solute carrier organic anion transporter family member 1A10101
Caspase-40202
4-aminobutyrate aminotransferase, mitochondrial0101
Caspase-50202
Caspase-90202
Acid-sensing ion channel 10101
Fatty-acid amide hydrolase 10101
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Dehydrogenase/reductase SDR family member 90101
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 20011
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 10011
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 40011
Glutamate receptor ionotropic, NMDA 2D0101
Acetylcholinesterase0404
Glutamate receptor ionotropic, NMDA 3B0101
Rap guanine nucleotide exchange factor 32002
Glutamate receptor ionotropic, NMDA 1 0202
Cholinesterase0202
Glutamate receptor ionotropic, NMDA 2A 0202
Glutamate receptor ionotropic, NMDA 2B0202
Glutamate receptor ionotropic, NMDA 2C0202
Glutamate receptor ionotropic, NMDA 10202
Glutamate receptor ionotropic, NMDA 2A0202
Glutamate receptor ionotropic, NMDA 2B0202
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, NMDA 2D0202
Glutamate receptor ionotropic, NMDA 3A0101
Glutamate receptor ionotropic, NMDA 3B0202
Glutamate receptor ionotropic, NMDA 3A0202
GTP-binding protein (rab7)0011
ras protein, partial0011
Rac1 protein0011
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
activating transcription factor 64004
Seed linoleate 13S-lipoxygenase-10101
Ras-related protein Rab-2A0011
Guanine nucleotide-binding protein G1001
Solute carrier organic anion transporter family member 1A30101
Lactoylglutathione lyase0101
GALC protein2002
GTP-binding nuclear protein Ran isoform 11001
Cytochrome P450 1A10202
Cytochrome P450 1A20202
Cytochrome P450 2D60202
Cytochrome P450 2C190202
Cytochrome P450 1B10101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Potassium voltage-gated channel subfamily A member 50101
Potassium voltage-gated channel subfamily D member 20101
Potassium channel subfamily K member 180101
Cytochrome P450 2B60202
Mas-related G-protein coupled receptor member X20022
Aldehyde oxidase 1 0101
Translocator protein0112
Opioid receptor, delta 1b 0101
Opioid receptor homologue0101
Acyl-CoA desaturase 10101
Histidine decarboxylase0011
Proteinase-activated receptor 10112
Sodium-dependent serotonin transporter0101
Kappa-type opioid receptor0225
Nociceptin receptor0101
Mu-type opioid receptor0101
Beta-2 adrenergic receptor0101
Mu-type opioid receptor0101
Parkin1001
M-phase phosphoprotein 82002
Voltage-dependent L-type calcium channel subunit beta-40101
Voltage-dependent P/Q-type calcium channel subunit alpha-1A0101
Voltage-dependent T-type calcium channel subunit alpha-1G0101
Voltage-dependent calcium channel gamma-3 subunit0101
Voltage-dependent T-type calcium channel subunit alpha-1H0101
Cannabinoid receptor 10202
Voltage-dependent L-type calcium channel subunit beta-30101
Voltage-dependent calcium channel subunit alpha-2/delta-10101
Voltage-dependent calcium channel gamma-7 subunit0101
Voltage-dependent N-type calcium channel subunit alpha-1B0101
Voltage-dependent L-type calcium channel subunit beta-10101
Voltage-dependent calcium channel gamma-1 subunit0101
Voltage-dependent L-type calcium channel subunit beta-20101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
Voltage-dependent R-type calcium channel subunit alpha-1E0101
Voltage-dependent calcium channel subunit alpha-2/delta-40101
Transient receptor potential cation channel subfamily A member 10011
Voltage-dependent calcium channel subunit alpha-2/delta-30101
Voltage-dependent calcium channel gamma-8 subunit0101
Rap guanine nucleotide exchange factor 41001
Bile acid receptor0101
Voltage-dependent calcium channel gamma-6 subunit0101
Voltage-dependent calcium channel subunit alpha-2/delta-20101
Voltage-dependent T-type calcium channel subunit alpha-1I0101
Voltage-dependent calcium channel gamma-4 subunit0101
Voltage-dependent calcium channel gamma-5 subunit0101
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Voltage-dependent calcium channel gamma-2 subunit0101
Nuclear receptor subfamily 4 group A member 20101
Genome polyprotein 0101
Neuraminidase 0202
lysosomal alpha-glucosidase preproprotein1001
glycogen synthase kinase-3 beta isoform 10011
Lysine-specific histone demethylase 1A0101
L-lactate dehydrogenase A chain0101
Chymotrypsinogen A0101
Neuraminidase0101
Beta-lactamase0202
Sialidase0101
Cystic fibrosis transmembrane conductance regulator0011
Dipeptidyl peptidase 40101
Bifunctional epoxide hydrolase 20101
Xanthine dehydrogenase/oxidase0101
Prolyl endopeptidase0101
Mitogen-activated protein kinase 100101
Mitogen-activated protein kinase 140101
Dihydroorotate dehydrogenase 0101
Substance-K receptor0101
Neuromedin-U receptor 20011
Glucocorticoid receptor0001
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Acetylcholinesterase0101
Beta-lactamase 0101
Beta-lactamase0101
Beta-lactamase0101
Replicase polyprotein 1ab0112
Beta-lactamase OXA-10101
Metallo-beta-lactamase type 20101
Angiotensin-converting enzyme0101
Beta-lactamase TEM0202
Beta-lactamase 0101
Chain A, CES1 protein0101
DNA polymerase III, partial1001
glucocerebrosidase2002
thyrotropin-releasing hormone receptor1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
Caspase-71001
Spike glycoprotein0011
Replicase polyprotein 1ab0011
NPC intracellular cholesterol transporter 1 precursor1001
interferon gamma precursor0001
caspase-31001
ubiquitin-conjugating enzyme E2 N0101
ras-related protein Rab-9A1001
streptokinase A precursor0011
Transmembrane protease serine 20011
Serine/threonine-protein kinase D30101
Estrogen receptor0214
Lysosomal acid glucosylceramidase0011
Protein kinase C gamma type0101
Protein kinase C alpha type0101
Protein kinase C beta type0101
Estrogen receptor0012
Tyrosine-protein kinase Lck0101
Progesterone receptor0101
Procathepsin L0011
Protein kinase C delta type0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Steroid hormone receptor ERR10101
Transcriptional activator protein LuxR0101
Angiotensin-converting enzyme0202
Protein kinase C alpha type0101
Thromboxane-A synthase 0101
Protein kinase C eta type0101
Substance-P receptor0202
Adenosine receptor A2a0202
Adenosine receptor A10202
Alpha-synuclein1001
Protein kinase C iota type0101
Estrogen-related receptor gamma0101
Protein kinase C gamma type0101
Protein kinase C beta type0101
Phospholipase D1 0101
Protein kinase C epsilon type0101
Protein kinase C theta type0101
Protein kinase C zeta type0101
Protein kinase C delta type0101
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Platelet-activating factor acetylhydrolase0101
Phospholipase D10101
Serine/threonine-protein kinase D10101
Estrogen receptor beta0012
Protein kinase C eta type0101
Nuclear receptor subfamily 3 group C member 3 0202
Estrogen receptor beta0213
Emopamil-binding protein-like0101
Angiotensin-converting enzyme 2 0011
7-dehydrocholesterol reductase0112
Protein kinase C theta type0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]