Page last updated: 2024-09-27

Wolfram Syndrome

A hereditary condition characterized by multiple symptoms including those of DIABETES INSIPIDUS; DIABETES MELLITUS; OPTIC ATROPHY; and DEAFNESS. This syndrome is also known as DIDMOAD (first letter of each word) and is usually associated with VASOPRESSIN deficiency. It is caused by mutations in gene WFS1 encoding wolframin, a 100-kDa transmembrane protein.

Synonyms(1)

Synonym
Wolfram Syndrome

Research Excerpts

Overview

ExcerptReference
"Wolfram syndrome is an autosomal recessive disorder characterized by juvenile-onset insulin-dependent diabetes mellitus and optic atrophy."( Akiyama, M; Hatanaka, M; Kondo, M; Ohta, Y; Oka, Y; Shinoda, K; Tanabe, K; Tanizawa, Y; Yanai, A, 2011)
"Wolfram syndrome is an autosomal recessive disorder caused by mutations in WFS1 and is characterized by insulin-dependent diabetes mellitus, optic atrophy, and deafness."( Chung, W; Egli, D; Foo, K; Freeby, M; Goland, R; Hua, H; Kahler, DJ; LeDuc, C; Leibel, RL; Martinez, H; Shang, L; Watanabe, K; Zimmer, M, 2014)
"Wolfram syndrome is a genetic disorder characterized by diabetes and neurodegeneration and considered as an endoplasmic reticulum (ER) disease."( Blanner, P; Brown, CM; Greer, PA; Hara, T; Hershey, T; Kanekura, K; Lu, S; Mahadevan, J; Marshall, BA; Martinez, R; Neilson, A; Oslowski, CM; Semenkovich, CF; Spears, LD; Toyoda, M; Umezawa, A; Urano, F; Yamazaki-Inoue, M, 2014)
"Wolfram syndrome is a rare neurodegenerative disorder, characterized by the presence of diabetes insipidus, diabetes mellitus, optic atrophy, and sensorineural deafness."( Scully, KJ; Wolfsdorf, JI, 2020)
"BACKGROUNDWolfram syndrome is a rare ER disorder characterized by insulin-dependent diabetes mellitus, optic nerve atrophy, and progressive neurodegeneration."( Abreu, D; Brown, CM; Bucelli, RC; Gu, H; Hershey, T; Hoekel, J; Hurst, S; Kries, K; Marshall, BA; Onwumere, C; Pearson, TS; Simpson, AN; Stone, SI; Tychsen, L; Urano, F; Van Stavern, GP; White, NH, 2021)
"The Wolfram syndrome is a rare autosomal recessive disease affecting many organs with life-threatening consequences; currently, no treatment is available."( Couly, S; Crouzier, L; Cubedo, N; Danese, A; Delprat, B; Denus, M; Diez, C; Liévens, JC; Maurice, T; Patergnani, S; Pinton, P; Richard, EM; Rossel, M; Su, TP; Thiry, M; Yasui, Y, 2022)
"Wolfram syndrome is a rare genetic disorder characterized by endocrine dysfunction and progressive neurodegeneration."( Ehrlich, BE; Fischer, TT; Nguyen, LD, 2022)
"Wolfram syndrome is a rare multisystem autosomal recessive neurodegenerative disorder that affects the brain and central nervous system."( Al-Salami, H; Koks, S; Li, D; Pfaff, A; Quintas, PC, 2022)
"Wolfram syndrome is a rare disease characterized by diabetes, neurodegeneration, loss of vision, and audition."( Alfaro, R; Doty, T; Hershey, T; Lugar, H; Nicanor-Carreón, JG; Pepino, MY, 2023)
"Wolfram syndrome is a rare autosomal recessive disorder caused by pathogenic variants in the WFS1 gene."( Arroyo, MN; Benabdallah, K; Brown, C; Cai, Y; Carnel, L; Cnop, M; Cosentino, C; Demarez, C; Eizirik, DL; Gilon, P; Gorgogietas, V; Heeyoung, C; Igoillo-Esteve, M; Lytrivi, M; Marchetti, P; Marín-Cañas, S; Moreno-Castro, C; Musuaya, A; Pachera, N; Rajaei, B; Salpea, P; Santacreu, BJ; Sawatani, T; Toivonen, S; Urano, F, 2023)

Treatment

ExcerptReference
"Although there is no treatment for Wolfram syndrome, preclinical studies in cell and rodent models suggest that therapeutic strategies targeting ER calcium homeostasis, including dantrolene sodium, may be beneficial."( Abreu, D; Brown, CM; Bucelli, RC; Gu, H; Hershey, T; Hoekel, J; Hurst, S; Kries, K; Marshall, BA; Onwumere, C; Pearson, TS; Simpson, AN; Stone, SI; Tychsen, L; Urano, F; Van Stavern, GP; White, NH, 2021)

Research

Studies (71)

TimeframeStudies, This Condition (%)All Conditions %
pre-19906 (8.45)23.3326
1990's6 (8.45)12.5806
2000's9 (12.68)18.1394
2010's24 (33.80)28.8240
2020's26 (36.62)9.53
DrugIndicatedRelationship StrengthStudiesTrials
lactic acid0low10
thiamine0low50
dantrolene0medium21
valproic acid0low30
glyburide0low10
ibudilast0low10
idebenone0low10
ketamine0low10
metformin0low10
pentobarbital0low10
4-phenylbutyric acid0low20
potassium chloride0low10
riluzole0low10
tolbutamide0low10
corticosterone0low10
aldosterone0low10
alanine0low10
sucrose0low10
histidine0low10
threonine0low10
arginine0low10
trimethaphan0low10
tungsten0low10
fludrocortisone0low10
glutathione disulfide0low10
fluorodeoxyglucose f180low10
oxytocin0low10
betadex0low10
safingol0low10
sphingosine0low10
deamino arginine vasopressin0low30
6,7-dihydroxyflavone0low10
pituitrin0low50
nad0low10
atrial natriuretic factor0low10
glucagon0low10
liraglutide0low70
glucagon-like peptide 10low10
incretins0low20
c-peptide0low40
ubiquinone0low10
calpain0low10
exenatide0low30
heme0low10
oxyntomodulin0low10

Protein Targets (426)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE100010
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE0011
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE0011
mitogen-activated protein kinase 14004
survival motor neuron protein isoform d4004
Histone deacetylase 30404
Histone deacetylase 40404
Histone deacetylase 10404
Histone deacetylase 70404
Histone deacetylase 20404
Polyamine deacetylase HDAC100303
Histone deacetylase 11 0303
Histone deacetylase 80404
NAD-dependent protein deacylase sirtuin-5, mitochondrial0202
Histone deacetylase 60404
Histone deacetylase 90404
Histone deacetylase 50404
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
Chain A, 2-oxoglutarate Oxygenase2002
Chain A, Ferritin light chain4004
15-lipoxygenase, partial2002
TDP1 protein9009
Microtubule-associated protein tau5005
cellular tumor antigen p53 isoform a3003
polyunsaturated fatty acid lipoxygenase ALOX121001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
DNA polymerase kappa isoform 11001
caspase-1 isoform alpha precursor1001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Integrin beta-33003
Integrin alpha-IIb3003
Aromatase0101
Aldo-keto reductase family 1 member B10101
Histamine H2 receptor4004
Caspase-71001
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
Carbonic anhydrase 10205
Carbonic anhydrase 20317
Alanine racemase, biosynthetic0001
5-hydroxytryptamine receptor 1D0002
Glutamate receptor ionotropic, NMDA 1 0304
Proton-coupled amino acid transporter 10101
Adenosine deaminase0001
Carbonic anhydrase 40002
AR protein110011
glucocorticoid receptor [Homo sapiens]100010
thyroid hormone receptor beta isoform a4004
nuclear factor erythroid 2-related factor 2 isoform 23003
geminin8008
Sex hormone-binding globulin0022
Corticosteroid-binding globulin0202
Mineralocorticoid receptor 0134
Androgen receptor0202
Mineralocorticoid receptor0101
Solute carrier organic anion transporter family member 1A10102
Guanine nucleotide-binding protein G2002
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
thioredoxin reductase5005
phosphopantetheinyl transferase5005
NFKB1 protein, partial3003
GLS protein2002
thyroid stimulating hormone receptor5005
alpha-galactosidase2002
euchromatic histone-lysine N-methyltransferase 27007
cytochrome P450 2C19 precursor3003
chromobox protein homolog 15005
flap endonuclease 13003
DNA polymerase iota isoform a (long)2002
muscarinic acetylcholine receptor M13003
lethal factor (plasmid)2002
Cytochrome P450 3A40203
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, brain0001
Nitric oxide synthase, brain 0001
Nitric oxide synthase, inducible0001
Nitric oxide synthase, inducible0013
Cationic amino acid transporter 30101
ATP-dependent phosphofructokinase2002
Atrial natriuretic peptide receptor 10011
Atrial natriuretic peptide receptor 1 0011
Chain A, D-MALTODEXTRIN BINDING PROTEIN0011
Chain A, Limit Dextrinase0011
Chain A, Solute-binding protein0011
Chain A, Solute-binding protein0011
Chain B, SusD0011
Chain A, SusD0011
Chain A, SusD0011
Chain A, Alpha-hemolysin0011
Chain B, Alpha-hemolysin0011
Chain C, Alpha-hemolysin0011
Chain D, Alpha-hemolysin0011
Chain E, Alpha-hemolysin0011
Chain F, Alpha-hemolysin0011
Chain G, Alpha-hemolysin0011
aldehyde dehydrogenase 1 family, member A15005
estrogen receptor 2 (ER beta)3003
retinoic acid nuclear receptor alpha variant 19009
retinoid X nuclear receptor alpha6006
estrogen-related nuclear receptor alpha7007
farnesoid X nuclear receptor3003
activating transcription factor 62002
potassium voltage-gated channel subfamily H member 2 isoform d6006
pregnane X receptor2002
RAR-related orphan receptor gamma5005
GALC protein2002
GLI family zinc finger 35005
Thrombopoietin1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
progesterone receptor4004
nonstructural protein 13003
pregnane X nuclear receptor7007
estrogen nuclear receptor alpha100010
G5005
vitamin D (1,25- dihydroxyvitamin D3) receptor3003
IDH13003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a8008
thyroid stimulating hormone receptor3003
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
thyroid hormone receptor beta isoform 24004
heat shock protein beta-11001
serine/threonine-protein kinase mTOR isoform 12002
nuclear factor erythroid 2-related factor 2 isoform 13003
cytochrome P450 3A4 isoform 16006
Gamma-aminobutyric acid receptor subunit pi6006
Solute carrier family 22 member 20202
Solute carrier family 22 member 1 0405
Solute carrier family 22 member 30101
Solute carrier family 22 member 30101
Interferon beta6006
HLA class I histocompatibility antigen, B alpha chain 5005
Gamma-aminobutyric acid receptor subunit beta-16006
Gamma-aminobutyric acid receptor subunit delta6006
Gamma-aminobutyric acid receptor subunit gamma-26006
Gamma-aminobutyric acid receptor subunit alpha-56006
Gamma-aminobutyric acid receptor subunit alpha-36006
Gamma-aminobutyric acid receptor subunit gamma-16006
Gamma-aminobutyric acid receptor subunit alpha-26006
Gamma-aminobutyric acid receptor subunit alpha-46006
Gamma-aminobutyric acid receptor subunit gamma-36006
Gamma-aminobutyric acid receptor subunit alpha-66006
C-8 sterol isomerase0101
Nuclear receptor ROR-gamma2002
Gamma-aminobutyric acid receptor subunit alpha-16006
Gamma-aminobutyric acid receptor subunit beta-36006
Gamma-aminobutyric acid receptor subunit beta-26006
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Solute carrier family 22 member 10304
GABA theta subunit6006
Inositol hexakisphosphate kinase 15005
Sigma non-opioid intracellular receptor 10101
Gamma-aminobutyric acid receptor subunit epsilon6006
Solute carrier family 22 member 20303
cytochrome P450 2C9, partial5005
Vasopressin V2 receptor0224
Oxytocin receptor0235
Vasopressin V1a receptor0325
Vasopressin V1b receptor0224
Translocator protein0101
Vasopressin V2 receptor 0213
aryl hydrocarbon receptor2002
nuclear receptor subfamily 1, group I, member 21001
histone acetyltransferase KAT2A isoform 13003
Glucagon-like peptide 1 receptor0011
Glucagon-like peptide 1 receptor0336
Glucagon receptor0011
Glucagon receptor0011
Chain A, Putative fructose-1,6-bisphosphate aldolase3003
Glutathione reductase0001
Multidrug resistance-associated protein 1 0001
Histone-lysine N-methyltransferase EHMT20101
Histone-lysine N-methyltransferase EHMT10101
Luciferase5005
SMAD family member 22002
USP1 protein, partial3003
SMAD family member 32002
nuclear receptor subfamily 1, group I, member 34004
regulator of G-protein signaling 43003
cytochrome P450 family 3 subfamily A polypeptide 45005
cytochrome P450 2D64004
Parkin2002
peroxisome proliferator-activated receptor delta3003
peroxisome proliferator activated receptor gamma4004
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
Bloom syndrome protein isoform 14004
cytochrome P450 2D6 isoform 12002
peripheral myelin protein 22 isoform 12002
cytochrome P450 2C9 precursor3003
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
nuclear receptor ROR-gamma isoform 14004
peripheral myelin protein 224004
lamin isoform A-delta107007
ATP-binding cassette sub-family C member 30505
Multidrug resistance-associated protein 40505
Solute carrier family 22 member 60202
ATP-binding cassette sub-family C member 90101
Bile salt export pump0404
Solute carrier organic anion transporter family member 2B1 0001
Potassium channel subfamily K member 20033
Bile salt export pump0707
Chymotrypsinogen A0101
Beta-lactamase0101
ATP synthase subunit beta, mitochondrial0101
ATP synthase subunit delta, mitochondrial0101
ATP synthase subunit gamma, mitochondrial0101
ATP synthase subunit epsilon, mitochondrial0101
Cytochrome P450 2C9 0505
Cystic fibrosis transmembrane conductance regulator0101
5-hydroxytryptamine receptor 1A0101
Cholesteryl ester transfer protein0101
Peroxisome proliferator-activated receptor gamma0101
Malate dehydrogenase, cytoplasmic0101
Solute carrier family 15 member 10101
Inositol monophosphatase 11001
ATP-binding cassette sub-family C member 80101
Potassium voltage-gated channel subfamily H member 20404
ATP-sensitive inward rectifier potassium channel 110101
Solute carrier family 22 member 70101
Solute carrier family 15 member 20101
NACHT, LRR and PYD domains-containing protein 3 0101
NACHT, LRR and PYD domains-containing protein 3 0101
CDGSH iron-sulfur domain-containing protein 10202
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Solute carrier organic anion transporter family member 1B10101
Chain A, HISTIDINE-BINDING PROTEIN0011
ATAD5 protein, partial3003
Carbonic anhydrase 120001
Plasma kallikrein0001
Carbonic anhydrase 30001
Histidine-binding periplasmic protein0011
Carbonic anhydrase 40102
Carbonic anhydrase 60102
Adenosine receptor A10001
Adenosine receptor A2a0001
Carbonic anhydrase 5A, mitochondrial0102
Carbonic anhydrase0001
Carbonic anhydrase 70001
Carbonic anhydrase0001
Glutamate receptor ionotropic, NMDA 2A 0203
Glutamate receptor ionotropic, NMDA 2B0203
Glutamate receptor ionotropic, NMDA 2C0203
Large neutral amino acids transporter small subunit 10101
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase 90214
Carbonic anhydrase 0001
Carbonic anhydrase-like protein, putative0001
Carbonic anhydrase0001
Carbonic anhydrase0001
Glutamate receptor ionotropic, NMDA 2D0203
Carbonic anhydrase 0001
Carbonic anhydrase 130001
Glutamate receptor ionotropic, NMDA 3B0203
Carbonic anhydrase 150001
Carbonic anhydrase 130001
Glutamate receptor ionotropic, NMDA 3A0203
Carbonic anhydrase 140001
Carbonic anhydrase 5B, mitochondrial0001
glp-1 receptor, partial1001
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
neuropeptide S receptor isoform A1001
cGMP-specific 3',5'-cyclic phosphodiesterase0101
Macrophage migration inhibitory factor0112
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0112
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
TAR DNA-binding protein 432002
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
Chain A, Beta-lactamase1001
hypoxia-inducible factor 1 alpha subunit1001
thioredoxin glutathione reductase1001
EWS/FLI fusion protein3003
bromodomain adjacent to zinc finger domain 2B1001
v-jun sarcoma virus 17 oncogene homolog (avian)3003
Histone H2A.x1001
vitamin D3 receptor isoform VDRA2002
huntingtin isoform 21001
Voltage-dependent calcium channel gamma-2 subunit2002
Cellular tumor antigen p534004
Polyunsaturated fatty acid 5-lipoxygenase0101
Cytochrome P450 2D60202
Glutamate receptor 22002
Cytochrome P450 2C190202
Spike glycoprotein1001
NAD-dependent protein deacetylase sirtuin-20101
ATPase family AAA domain-containing protein 53003
Ataxin-23003
NAD-dependent protein deacetylase 0101
Glutamate receptor ionotropic, NMDA 2D0101
Acetylcholinesterase0101
Glutamate receptor ionotropic, NMDA 3B0101
Rap guanine nucleotide exchange factor 31001
Sodium channel protein type 4 subunit alpha0101
Cholinesterase0101
Glutamate receptor ionotropic, NMDA 10202
Glutamate receptor ionotropic, NMDA 2A0202
Glutamate receptor ionotropic, NMDA 2B0202
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, NMDA 3A0101
Canalicular multispecific organic anion transporter 10404
acetylcholinesterase2002
Dihydrofolate reductase0202
Dipeptidyl peptidase 40101
Multidrug and toxin extrusion protein 10101
Chain B, Exotoxin A0011
Chain B, Exotoxin A0011
Chain B, Exotoxin A0011
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0202
Sodium channel protein type 3 subunit alpha0101
Vasopressin V1a receptor0101
Vasopressin V1b receptor0101
Oxytocin receptor0101
Oxytocin receptor0011
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit beta-20011
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Taste receptor type 2 member 310011
Taste receptor type 2 member 600011
Sodium/potassium/calcium exchanger 40112
Taste receptor type 2 member 140011
Taste receptor type 2 member 130011
Taste receptor type 2 member 90011
Taste receptor type 2 member 40011
Sodium/potassium/calcium exchanger 20112
arylsulfatase A1001
pyruvate kinase1001
lysosomal alpha-glucosidase preproprotein1001
NPC intracellular cholesterol transporter 1 precursor1001
mu-type opioid receptor isoform MOR-10011
histone deacetylase 9 isoform 31001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
ras-related protein Rab-9A1001
5-hydroxytryptamine receptor 2A0011
pyruvate kinase PKM isoform b1001
Cytochrome P450 1A20101
Aldo-keto reductase family 1 member B10303
Ornithine decarboxylase1001
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
UDP-glucuronosyltransferase 1A1 0202
Sodium-dependent noradrenaline transporter 0202
Alpha-synuclein1001
Disintegrin and metalloproteinase domain-containing protein 171001
Pteridine reductase 10202
caspase 7, apoptosis-related cysteine protease1001
caspase-31001
Sphingosine kinase 10202
Chain A, Cruzipain1001
acid sphingomyelinase1001
endonuclease IV1001
apical membrane antigen 1, AMA11001
glucocerebrosidase1001
C-X-C chemokine receptor type 5 isoform 10101
DNA polymerase beta1001
ubiquitin-conjugating enzyme E2 N0101
C-C chemokine receptor type 60101
apelin receptor0101
DNA polymerase eta isoform 11001
bcl-2-related protein A10101
streptokinase A precursor0011
Endoglycoceramidase II 0001
Protein kinase C alpha type0101
Estrogen receptor0011
Protein kinase C delta type0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
cAMP-dependent protein kinase catalytic subunit alpha 0101
Protein kinase C gamma type0101
Protein kinase C beta type0101
Estrogen receptor beta0011
Protein kinase C eta type0101
Sphingosine kinase 20101
Protein kinase C theta type0101
Chain A, MALTOPORIN0011
Chain B, MALTOPORIN0011
Chain A, ykoF0011
Chain B, ykoF0011
Chain A, ThiT0011
Thiamine transporter ThiT0011
Transketolase0011
Thiamine-binding periplasmic protein0011
muscleblind-like protein 1 isoform 11001
Albumin0112
Albumin0011
UDP-glucuronosyltransferase 2B70203
UDP-glucuronosyltransferase 1-60102
UDP-glucuronosyltransferase 1A40101
UDP-glucuronosyltransferase 2B10 0101
Lanosterol 14-alpha demethylase0101
Cocaine esterase0101
UDP-glucuronosyltransferase 1A90001
Cytochrome P450 2A60101
Tissue factor0101
Aldo-keto reductase family 1 member A10101
Liver carboxylesterase 10101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member B70101
Sigma non-opioid intracellular receptor 10101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]