Page last updated: 2024-10-29

ketamine and Elevated ICP (Intracranial Pressure)

ketamine has been researched along with Elevated ICP (Intracranial Pressure) in 11 studies

Ketamine: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE) and may interact with sigma receptors.
ketamine : A member of the class of cyclohexanones in which one of the hydrogens at position 2 is substituted by a 2-chlorophenyl group, while the other is substituted by a methylamino group.

Research Excerpts

ExcerptRelevanceReference
"In ventilation-treated patients with intracranial hypertension, ketamine effectively decreased ICP and prevented untoward ICP elevations during potentially distressing interventions, without lowering blood pressure and CPP."9.14Effectiveness of ketamine in decreasing intracranial pressure in children with intracranial hypertension. ( Bar-Joseph, G; Guilburd, JN; Guilburd, Y; Tamir, A, 2009)
"Traditionally, the use of ketamine for patients with traumatic brain injuries is contraindicated due to the concern of increasing intracranial pressure (ICP)."8.89The emerging use of ketamine for anesthesia and sedation in traumatic brain injuries. ( Bailard, NS; Chang, LC; Mathew, SJ; Ortiz, J; Raty, SR, 2013)
"Ketamine has traditionally been avoided as an induction agent for tracheal intubation in patients with neurologic conditions at risk for intracranial hypertension due to conflicting data in the literature."8.31Co-administration of Ketamine in Pediatric Patients with Neurologic Conditions at Risk for Intracranial Hypertension. ( Ampah, SB; Beaulieu, F; Francoeur, C; Gajjar, AA; Griffis, H; Heuer, GG; Huh, JW; Kilbaugh, TJ; Kirschen, MP; Lang, SS; Mazandi, VM; Nishisaki, A; Rahman, RK; Storm, PB; Topjian, AA; Tucker, AM; Yuan, I; Zhang, B, 2023)
"In ventilation-treated patients with intracranial hypertension, ketamine effectively decreased ICP and prevented untoward ICP elevations during potentially distressing interventions, without lowering blood pressure and CPP."5.14Effectiveness of ketamine in decreasing intracranial pressure in children with intracranial hypertension. ( Bar-Joseph, G; Guilburd, JN; Guilburd, Y; Tamir, A, 2009)
"Traditionally, the use of ketamine for patients with traumatic brain injuries is contraindicated due to the concern of increasing intracranial pressure (ICP)."4.89The emerging use of ketamine for anesthesia and sedation in traumatic brain injuries. ( Bailard, NS; Chang, LC; Mathew, SJ; Ortiz, J; Raty, SR, 2013)
"Ketamine has traditionally been avoided as an induction agent for tracheal intubation in patients with neurologic conditions at risk for intracranial hypertension due to conflicting data in the literature."4.31Co-administration of Ketamine in Pediatric Patients with Neurologic Conditions at Risk for Intracranial Hypertension. ( Ampah, SB; Beaulieu, F; Francoeur, C; Gajjar, AA; Griffis, H; Heuer, GG; Huh, JW; Kilbaugh, TJ; Kirschen, MP; Lang, SS; Mazandi, VM; Nishisaki, A; Rahman, RK; Storm, PB; Topjian, AA; Tucker, AM; Yuan, I; Zhang, B, 2023)
"Ketamine has a long history of use during pediatric procedural sedation."2.78Pretreatment with midazolam blunts the rise in intracranial pressure associated with ketamine sedation for lumbar puncture in children. ( Berkenbosch, JW; Michalczyk, K; Sullivan, JE, 2013)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (9.09)18.2507
2000's2 (18.18)29.6817
2010's5 (45.45)24.3611
2020's3 (27.27)2.80

Authors

AuthorsStudies
Jeffcote, T1
Weir, T1
Anstey, J1
Mcnamara, R1
Bellomo, R1
Udy, A1
Mazandi, VM1
Lang, SS1
Rahman, RK1
Nishisaki, A1
Beaulieu, F1
Zhang, B1
Griffis, H1
Tucker, AM1
Storm, PB1
Heuer, GG1
Gajjar, AA1
Ampah, SB1
Kirschen, MP1
Topjian, AA1
Yuan, I1
Francoeur, C1
Kilbaugh, TJ1
Huh, JW1
Laws, JC1
Vance, EH1
Betters, KA1
Anderson, JJ1
Fleishman, S1
Bonfield, CM1
Wellons, JC1
Xu, M1
Slaughter, JC1
Giuse, DA1
Patel, N1
Jordan, LC1
Wolf, MS1
Lee, A1
Bhullar, IS1
Chang, LC1
Raty, SR1
Ortiz, J1
Bailard, NS1
Mathew, SJ1
Cohen, L1
Athaide, V1
Wickham, ME1
Doyle-Waters, MM1
Rose, NG1
Hohl, CM1
Loflin, R1
Koyfman, A1
Bar-Joseph, G1
Guilburd, Y1
Tamir, A1
Guilburd, JN1
Michalczyk, K1
Sullivan, JE1
Berkenbosch, JW1
Lele, A1
Ziai, WC1
Hirota, K1
Hashiba, E1
Suzuki, A1
Ishihara, H1
Matsuki, A1

Reviews

5 reviews available for ketamine and Elevated ICP (Intracranial Pressure)

ArticleYear
The Impact of Sedative Choice on Intracranial and Systemic Physiology in Moderate to Severe Traumatic Brain Injury: A Scoping Review.
    Journal of neurosurgical anesthesiology, 2023, Jul-01, Volume: 35, Issue:3

    Topics: Adult; Analgesics, Opioid; Brain Injuries; Brain Injuries, Traumatic; Dexmedetomidine; Humans; Hypno

2023
Intravenous Ketamine for Agitation in Critical Care.
    The American surgeon, 2017, Jul-01, Volume: 83, Issue:7

    Topics: Adult; Burns; Critical Care; Follow-Up Studies; Humans; Infusions, Intravenous; Injury Severity Scor

2017
The emerging use of ketamine for anesthesia and sedation in traumatic brain injuries.
    CNS neuroscience & therapeutics, 2013, Volume: 19, Issue:6

    Topics: Anesthetics, Dissociative; Brain Injuries; Databases, Factual; Emergency Service, Hospital; Humans;

2013
The effect of ketamine on intracranial and cerebral perfusion pressure and health outcomes: a systematic review.
    Annals of emergency medicine, 2015, Volume: 65, Issue:1

    Topics: Anesthetics, Dissociative; Contraindications; Critical Care; Humans; Intracranial Hypertension; Intr

2015
When used for sedation, does ketamine increase intracranial pressure more than fentanyl or sufentanil?
    Annals of emergency medicine, 2015, Volume: 65, Issue:1

    Topics: Anesthetics, Dissociative; Deep Sedation; Fentanyl; Humans; Hypnotics and Sedatives; Intracranial Hy

2015

Trials

3 trials available for ketamine and Elevated ICP (Intracranial Pressure)

ArticleYear
Effectiveness of ketamine in decreasing intracranial pressure in children with intracranial hypertension.
    Journal of neurosurgery. Pediatrics, 2009, Volume: 4, Issue:1

    Topics: Adolescent; Analgesics; Blood Pressure; Brain; Cerebrovascular Circulation; Child; Child, Preschool;

2009
Pretreatment with midazolam blunts the rise in intracranial pressure associated with ketamine sedation for lumbar puncture in children.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2013, Volume: 14, Issue:3

    Topics: Adolescent; Anesthetics, Dissociative; Child; Child, Preschool; Drug Administration Schedule; Female

2013
[Changes in epidural pressure during total intravenous anesthesia with propofol, fentanyl and ketamine].
    Masui. The Japanese journal of anesthesiology, 1997, Volume: 46, Issue:9

    Topics: Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intrave

1997

Other Studies

3 other studies available for ketamine and Elevated ICP (Intracranial Pressure)

ArticleYear
Co-administration of Ketamine in Pediatric Patients with Neurologic Conditions at Risk for Intracranial Hypertension.
    Neurocritical care, 2023, Volume: 38, Issue:2

    Topics: Analgesics; Child; Fentanyl; Humans; Intracranial Hypertension; Ketamine; Midazolam

2023
Acute Effects of Ketamine on Intracranial Pressure in Children With Severe Traumatic Brain Injury.
    Critical care medicine, 2023, 05-01, Volume: 51, Issue:5

    Topics: Brain Injuries, Traumatic; Cerebrovascular Circulation; Child; Humans; Intracranial Hypertension; In

2023
Target-controlled infusion for sedation of traumatic brain-injured patients: role uncertain.
    Critical care medicine, 2005, Volume: 33, Issue:5

    Topics: Analgesics; Brain Injuries; Conscious Sedation; Drug Delivery Systems; Humans; Infusions, Intravenou

2005